Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: Regulation of multiple myeloid CSF receptor promoters

Current Topics in Microbiology and Immunology

Volumn 211, Issue , 1996, Pages 137-147

  Zhang, D E ^a   Hohaus, S ^a   Voso, M T ^a   Chen, H M ^a   Smith, L T ^a   Hetherington, C J ^a   Tenen, D G ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TRANSCRIPTION FACTOR;

CELL DIFFERENTIATION; CEREBROSPINAL FLUID; CONFERENCE PAPER; GENE CONTROL; GENE EXPRESSION; HUMAN; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0030047739     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-85232-9_14     Document Type: Conference Paper

References (61)

1. Lubbert M, Herrmann F, Koeffler HP (1991) Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells. Blood 77:909-924
2. Nichols J, Nimer SD (1992) Transcription factors, translocations, and leukemia. Blood 80:2953-2963
3. Rabbitts TH (1994) Chromosomal translocations in human cancer. Nature 372:143-149
4. Rapoport AP, Abboud CN, DiPersio JF (1992) Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF): receptor biology, signal transduction, and neutrophil activation. Blood Rev 6:43-57
5. Nagata S, Fukunaga R (1991) Granulocyte colony-stimulating factor and its receptor. Prog Growth Factor Res 3:131-141
6. Sherr CJ (1990) Colony-stimulating factor-1 receptor. Blood 75:1-12
7. Metcalf D (1993) Hematopoietic Regulators - Redundancy or Subtlety. Blood 82:3515-3523
8. Zhang DE, Hetherington CJ, Chen HM, Tenen DG (1994) The macrophage transcription factor PU.1 directs tissue specific expression of the macrophage colony stimulating factor receptor. Mol Cell Biol 14:373-381
9. Voso MT, Burn TC, Wulf G, Lim B, Leone G, Tenen DG (1994) Inhibition of hematopoiesis by competitive binding of the transcription factor PU.1. Proc Natl Acad Sci U S A 91:7932-7936
10. Chen HM, Zhang P, Voso MT, Hohaus S, Gonzalez DA, Glass CK, Zhang DE, Tenen DG (1995) Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B. Blood 85:2918-2928
11. Zhang DE, Fujioka KI, Hetherington CJ, Shapiro LH, Chen HM, Look AT, Tenen DG (1994) Identification of a region which directs monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol 14:8085-8095
12. Hohaus S, Petrovick MS, Voso MT, Sun Z, Tenen DG (1995) PU.1 (Spi-1) and C/EBPα regulate the expression of the granulocyte-macrophage colony stimuating factor receptor α. Mol Cell Biol, accepted for publication pending revision.
13. Smith LA, Gonzalez DA, Hohaus S, Tenen DG (1994) The myeloid specific granulocyte colony stimulating factor (G-CSF) receptor promoter contains a functional site for the myeloid transcription factor PU.1 (Spi-1). Blood 84:372a
14. Frank R, Zhang J, Hiebert S, Meyers S, Nimer S (1994) AML1B but not the AML1/ETO fusion protein can transactivate the GM-CSF promoter. Blood 84:229a
15. Cameron S, Taylor DS, Tepas EC, Speck NA, Mathey-Prevot B (1994) Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting. Blood 83:2851-2859
16. Goodbourn S, Maniatis T (1988) Overlapping positive and negative regulatory domains of the human beta-interferon gene. Proc Natl Acad Sci USA 85:1447-1451
17. Pahl HL, Rosmarin AG, Tenen DG (1992) Characterization of the myeloid-specific CD11b promoter. Blood 79:865-870
18. Chen HM, Pahl HL, Scheibe RJ, Zhang DE, Tenen DG (1993) The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity. J Biol Chem 268:8230-8239
19. Zhang DE, Hetherington CJ, Tan S, Dziennis SE, Gonzalez DA, Chen HM, Tenen DG (1994) Sp1 is a critical factor for the monocytic specific expression of human CD14. J Biol Chem 269:11425-11434
20. Zhang DE, Hetherington CJ, Gonzalez DA, Chen HM, Tenen DG (1994) Regulation of CD14 expression during monocytic differentiation induced with 1alpha,25-Dihydroxyvitamin D3. J Immunol 153:3276-3284
21. Hagemeier C, Bannister AJ, Cook A, Kouzarides T (1993) The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc Natl Acad Sci U S A 90:1580-1584
22. Eichbaum QG, Iyer R, Raveh DP, Mathieu C, Ezekowitz AB (1994) Restriction of interferon gamma responsiveness and basal expression of the myeloid human FcgammaR1b gene is mediated by a functional PU.1 site and a transcription initiator consensus. J Exp Med 179:1985-1996
23. Moreau-Gachelin F, Tavitian A, Tambourin P (1988) Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature 331:277-280
24. Moreau-Gachelin F (1994) Spi-1/PU.1: an oncogene of the ets family. Biochim Biophys Acta 1198:149-163
25. Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA (1990) The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113-124
26. Scott EW, Simon MC, Anastai J, Singh H (1994) The transcription factor PU.1 is required for the development of multiple hematopoietic lineages. Science 265:1573-1577
27. Pahl HL, Scheibe RJ, Zhang DE, Chen HM, Galson DL, Maki RA, Tenen DG (1993) The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J Biol Chem 268:5014-5020
28. Perez C, Coeffier E, Moreau-Gachelin F, Wietzerbin J, Benech PD (1994) Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor. Mol Cell Biol 14:5023-5031
29. Feinman R, Qiu WQ, Pearse RN, Nikolajczyk BS, Sen R, Sheffery M, Ravetch JV (1994) PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc-gammaRIIIA promoter. EMBO J 13:3852-3860
30. Ahne B, Stratling WH (1994) Characterization of a myeloid-specific enhancer of the chicken lysozyme gene - Major role for an Ets transcription factor-binding site. J Biol Chem 269:17794-17801
31. 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity. Proc Natl Acad Sci U S A 92:801-805
32. Moulton KS, Semple K, Wu H, Glass CK (1994) Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif. Mol Cell Biol 14:4408-4418
33. Kominato Y, Galson DL, Waterman WR, Webb AC, Auron PE (1995) Monocyte-specific expression of the human prointerleukin 1β gene (IL1β) is dependent upon promoter sequences which bind the hematopoietic transcription factor Spi-1/PU.1. Mol Cell Biol 15:58-68
34. Srikanth S, Rado TA (1994) A 30-base pair element is responsible for the myeloid-specific activity of the human neutrophil elastase promoter. J Biol Chem 269:32626-32633
35. Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert S, Friedman AD (1994) PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBPZbeta/CBFbeta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 14:5558-5568
36. Carvalho M, Derse D (1993) The PU.1/Spi-1 proto-oncogene is a transcriptional regulator of a lentivirus promoter. J Virol 67:3885-3890
37. Maury W (1994) Monocyte maturation controls expression of equine infectious anemia virus. J Virol 68:6270-6279
38. Landschulz WH, Johnson PF, McKnight SL (1988) The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240:1759-1764
39. Johnson PF, Landschulz WH, Graves BJ. McKnight SL (1987) Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev 1:133-146
40. Katz S, Kowenzleutz E, Muller C, Meese K, Ness SA, Leutz A (1993) The NF-M transcription factor is related to C/EBP-beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J 12:1321-1332
41. Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, Kishimoto T (1992) Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood 79:460-466
42. Scott LM, Civin CI, Rorth P, Friedman AD (1992) A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80:1725-1735
43. Tsukada J, Saito K, Waterman WR, Webb AC, Auron PE (1994) Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1β gene. Mol Cell Biol 14:7285-7297
44. Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T (1995) Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macroophages. Cell 80:353-361
45. Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M (1991) t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci U S A 88:10431-10434
46. Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y (1993) PEBP2/PEA2 Represents a Family of Transcription Factors Homologous to the Products of the Drosophila Runt Gene and the Human AML1 Gene. Proc Natl Acad Sci U S A 90:6859-6863
47. Wang S, Wang Q, Crute BE, McInikova IN, Keller SR, Speck NA (1993) Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 13:3324-3339
48. Kamachi Y, Ogawa E, Asano M, Ishida S, Murakami Y, Satake M, Ito Y, Shigesada K (1990) Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J Virol 64:4808-4819
49. Levanon D, Negreanu V, Bernstein Y, Baram I, Avivi L, Groner Y (1994) AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics 23:425-432
50. Meyers S, Downing JR, Hiebert SW (1993) Identification of AML-1 and the (8;21) Translocation Protein (AML-1/ETO) as Sequence-Specific DNA-Binding Proteins - The Runt Homology Domain Is Required for DNA Binding and Protein-Protein Interactions. Mol Cell Biol 13:6336-6345
51. Satake M, Nomura S, Yamaguchpiiwai Y, Takahama Y, Hashimot Y, Niki M, Kitamura Y, Ito Y (1995) Expression of the runt domain-encoding PEBP2 alpha genes in T cells during thymic development. Mol Cell Biol 15:1662-1670
52. Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M (1993) The t(8-21) Translocation in Acute Myeloid Leukemia Results in Production of an AML1-MTG8 Fusion Transcript. EMBO J 12:2715-2721
53. Nucifora G, Rowley JD (1994) The AML1 and ETO genes in acute myeloid leukemia with a t(8;21). Leuk Lymphoma 14:353-362
54. Downing JR, Head DR, Curcio-Brint AM, Hulshof MG, Motroni TA, Raimondi SC, Carroll AJ, Drabkin HA, Willman C, Theil KS, et al (1993) An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation. Blood 81:2860-2865
55. Tsai SF, Strauss E, Orkin SH (1991) Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev 5:919-931
56. Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH (1991) Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc Natl Acad Sci U S A 88:10638-10641
57. Chen HM, Ray-Gallet D, Zhang P, Hetherington CJ, Gonzalez DA, Zhang D-E, Moreau-Gachelin F, Tenen DG (1995) PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene, accepted for publication pending revision
58. Christy RJ, Kaestner KH, Geiman DE, Lane MD (1991) CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A 88:2593-2597
59. Timchenko N, Wilson DR, Taylor LR, Abdelsayed S, Wilde M, Sawadogo M, Darlington GJ (1995) Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding. Mol Cell Biol 15:1192-1202
60. Schuetze S, Paul R, Gliniak BC, Kabat D (1992) Role of the PU.1 transcription factor in controlling differentiation of Friend erythroleukemia cells. Mol Cell Biol 12:2967-2975
61. Visvader JE, Elefanty AG, Strasser A, Adams JM (1992) GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO J 11:4557-4564