메뉴 건너뛰기




Volumn 103, Issue 5, 2004, Pages 1883-1890

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CEP 701; FLT3 LIGAND;

EID: 1442307974     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-06-1978     Document Type: Article
Times cited : (141)

References (48)
  • 1
    • 0032519768 scopus 로고    scopus 로고
    • c-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities
    • Lyman SD, Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 1998;91:1101-1134.
    • (1998) Blood , vol.91 , pp. 1101-1134
    • Lyman, S.D.1    Jacobsen, S.E.2
  • 2
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 3
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 4
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: A study on a large series of patients and cell lines
    • Yokota S, Kiyoi H, Nakao M, et al. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: a study on a large series of patients and cell lines. Leukemia. 1997;11:1605-1609.
    • (1997) Leukemia , vol.11 , pp. 1605-1609
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3
  • 5
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 7
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia. 1998;12:1333-1337.
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3
  • 8
    • 0000796896 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells
    • Fenski R, Flesch K, Serve S, et al. Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells. Br J Haematol. 2000;108:322-330.
    • (2000) Br J Haematol , vol.108 , pp. 322-330
    • Fenski, R.1    Flesch, K.2    Serve, S.3
  • 9
    • 0032931560 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia: The Children's Cancer and Leukemia Study Group, Japan
    • Iwai T, Yokota S, Nakao M, et al. Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia: The Children's Cancer and Leukemia Study Group, Japan. Leukemia. 1999;13:38-43.
    • (1999) Leukemia , vol.13 , pp. 38-43
    • Iwai, T.1    Yokota, S.2    Nakao, M.3
  • 10
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi H NT, Nakano Y, Yokota S, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93:3074-3080.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.N.T.1    Nakano, Y.2    Yokota, S.3
  • 11
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3
  • 12
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood. 2000;96:3907-3914.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3
  • 13
    • 0036893435 scopus 로고    scopus 로고
    • Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations
    • Zheng R, Friedman AD, Small D. Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations. Blood. 2002;100:4154-4161.
    • (2002) Blood , vol.100 , pp. 4154-4161
    • Zheng, R.1    Friedman, A.D.2    Small, D.3
  • 14
    • 0037071397 scopus 로고    scopus 로고
    • Transcriptional regulation of granulocyte and monocyte development
    • Friedman AD. Transcriptional regulation of granulocyte and monocyte development. Oncogene. 2002;21:3377-3390.
    • (2002) Oncogene , vol.21 , pp. 3377-3390
    • Friedman, A.D.1
  • 15
    • 0026758202 scopus 로고
    • A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells
    • Scott LM, Civin CI, Rorth P, Friedman AD. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood. 1992;80:1725-1735.
    • (1992) Blood , vol.80 , pp. 1725-1735
    • Scott, L.M.1    Civin, C.I.2    Rorth, P.3    Friedman, A.D.4
  • 16
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
    • Zhang D-E, Zhang P, Wang N-D, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc Natl Acad Sci U S A. 1997;94:569-574.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 569-574
    • Zhang, D.-E.1    Zhang, P.2    Wang, N.-D.3    Hetherington, C.J.4    Darlington, G.J.5    Tenen, D.G.6
  • 17
    • 0031835661 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
    • Radomska HS, Huettner CS, Zhang P, Chang T, Scadden DT, Tenen DG. CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol. 1998;18:4301-4314.
    • (1998) Mol Cell Biol , vol.18 , pp. 4301-4314
    • Radomska, H.S.1    Huettner, C.S.2    Zhang, P.3    Chang, T.4    Scadden, D.T.5    Tenen, D.G.6
  • 18
    • 0033564978 scopus 로고    scopus 로고
    • C/EBPalpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
    • Wang X, Scott E, Sawyers CL, Friedman AD. C/EBPalpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Blood. 1999;94:560-571.
    • (1999) Blood , vol.94 , pp. 560-571
    • Wang, X.1    Scott, E.2    Sawyers, C.L.3    Friedman, A.D.4
  • 19
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
    • Pabst T, Mueller BU, Zhang P, et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet. 2001;27:263-270.
    • (2001) Nat Genet , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3
  • 20
    • 0025246676 scopus 로고
    • The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
    • Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell. 1990;61:113-124.
    • (1990) Cell , vol.61 , pp. 113-124
    • Klemsz, M.J.1    McKercher, S.R.2    Celada, A.3    Van Beveren, C.4    Maki, R.A.5
  • 21
    • 0029001407 scopus 로고
    • Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B
    • Chen HM, Zhang P, Voso MT, et al. Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B. Blood. 1995;85:2918-2928.
    • (1995) Blood , vol.85 , pp. 2918-2928
    • Chen, H.M.1    Zhang, P.2    Voso, M.T.3
  • 22
    • 0029740334 scopus 로고    scopus 로고
    • C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
    • Oelgeschläger M, Nuchprayoon I, Lüscher B, Friedman AD. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol Cell Biol. 1996;16:4717-4725.
    • (1996) Mol Cell Biol , vol.16 , pp. 4717-4725
    • Oelgeschläger, M.1    Nuchprayoon, I.2    Lüscher, B.3    Friedman, A.D.4
  • 23
    • 0029843415 scopus 로고    scopus 로고
    • Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells
    • Cheng T, Shen H, Giokas D, Gere J, Tenen DG, Scadden DT. Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells. Proc Natl Acad Sci U S A. 1996;93:13158-13163.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13158-13163
    • Cheng, T.1    Shen, H.2    Giokas, D.3    Gere, J.4    Tenen, D.G.5    Scadden, D.T.6
  • 24
    • 0028136726 scopus 로고
    • Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
    • Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994;265:1573-1577.
    • (1994) Science , vol.265 , pp. 1573-1577
    • Scott, E.W.1    Simon, M.C.2    Anastasi, J.3    Singh, H.4
  • 25
    • 0242549003 scopus 로고    scopus 로고
    • Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    • McKercher SR, Torbett BE, Anderson KL, et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996;15:5647-5658.
    • (1996) EMBO J , vol.15 , pp. 5647-5658
    • McKercher, S.R.1    Torbett, B.E.2    Anderson, K.L.3
  • 26
    • 0036682473 scopus 로고    scopus 로고
    • Heterozygous PU.1 mutations are associated with acute myeloid leukemia
    • Mueller BU, Pabst T, Osato M, et al. Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood. 2002;100:998-1007.
    • (2002) Blood , vol.100 , pp. 998-1007
    • Mueller, B.U.1    Pabst, T.2    Osato, M.3
  • 27
    • 0142061500 scopus 로고    scopus 로고
    • Cross-talk between regulators of myeloid development: C/EBPalpha binds and activates the promoter of the PU.1 gene
    • Kummalue T, Fdedman AD. Cross-talk between regulators of myeloid development: C/EBPalpha binds and activates the promoter of the PU.1 gene. J Leukoc Biol. 2003;74:464-470.
    • (2003) J Leukoc Biol , vol.74 , pp. 464-470
    • Kummalue, T.1    Fdedman, A.D.2
  • 28
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
    • Mizuki M, Schwable J, Steur C, et al. Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood. 2003;101:3164-3173.
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.1    Schwable, J.2    Steur, C.3
  • 29
    • 0036624916 scopus 로고    scopus 로고
    • A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
    • Levis M, Allebach J, Tse KF, et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 2002;99:3885-3891.
    • (2002) Blood , vol.99 , pp. 3885-3891
    • Levis, M.1    Allebach, J.2    Tse, K.F.3
  • 30
  • 31
    • 0025025904 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors
    • Griffin JD, Spertini O, Ernst TJ, et al. Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. J Immunol. 1990;145:576-584.
    • (1990) J Immunol , vol.145 , pp. 576-584
    • Griffin, J.D.1    Spertini, O.2    Ernst, T.J.3
  • 32
    • 0026031601 scopus 로고
    • CCAAT-enhancer binding protein: A component of a differentiation switch
    • Umek RM, Friedman AD, McKnight SL. CCAAT-enhancer binding protein: a component of a differentiation switch. Science. 1991;251:288-292.
    • (1991) Science , vol.251 , pp. 288-292
    • Umek, R.M.1    Friedman, A.D.2    McKnight, S.L.3
  • 33
    • 16944362760 scopus 로고    scopus 로고
    • Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia
    • Kiyoi H, Naoe T, Yokota S, et al. Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia. 1997;11:1447-1452.
    • (1997) Leukemia , vol.11 , pp. 1447-1452
    • Kiyoi, H.1    Naoe, T.2    Yokota, S.3
  • 34
    • 0033043084 scopus 로고    scopus 로고
    • Molecular evolution of acute myeloid leukaemia in relapse: Unstable N-ras and FLT3 genes compared with p53 gene
    • Nakano Y, Kiyoi H, Miyawaki S, et al. Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene. Br J Haematol. 1999;104:659-664.
    • (1999) Br J Haematol , vol.104 , pp. 659-664
    • Nakano, Y.1    Kiyoi, H.2    Miyawaki, S.3
  • 35
    • 0036093475 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    • Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood. 2002;99:310-318.
    • (2002) Blood , vol.99 , pp. 310-318
    • Kelly, L.M.1    Liu, Q.2    Kutok, J.L.3    Williams, I.R.4    Boulton, C.L.5    Gilliland, D.G.6
  • 36
    • 79960970908 scopus 로고    scopus 로고
    • Transgenic mice expressing a constitutively activated FLT3 receptor display a myeloproliferative disease phenotype
    • Baldwin BR, Tse K-F, Small D. Transgenic mice expressing a constitutively activated FLT3 receptor display a myeloproliferative disease phenotype [abstract]. Blood. 2001;98:801a.
    • (2001) Blood , vol.98
    • Baldwin, B.R.1    Tse, K.-F.2    Small, D.3
  • 37
    • 0028316122 scopus 로고
    • Effect of the acute promyelocytic leukemia PML/RAR alpha protein on differentiation and survival of myeloid precursors
    • Fagioli M, Grignani F, Ferrucci PF, et al. Effect of the acute promyelocytic leukemia PML/RAR alpha protein on differentiation and survival of myeloid precursors. Leukemia. 1994;8(suppl 1):S7-S11.
    • (1994) Leukemia , vol.8 , Issue.SUPPL. 1
    • Fagioli, M.1    Grignani, F.2    Ferrucci, P.F.3
  • 38
    • 0031000207 scopus 로고    scopus 로고
    • Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice
    • He LZ, Tribioli C, Rivi R, et al. Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A. 1997;94:5302-5307.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5302-5307
    • He, L.Z.1    Tribioli, C.2    Rivi, R.3
  • 39
    • 0037062350 scopus 로고    scopus 로고
    • PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model
    • Kelly LM, Kutok JL, Williams IR, et al. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci U S A. 2002;99:8283-8288.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8283-8288
    • Kelly, L.M.1    Kutok, J.L.2    Williams, I.R.3
  • 40
    • 0037443154 scopus 로고    scopus 로고
    • Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells
    • Cammenga J, Mulloy JC, Berguido FJ, MacGrogan D, Viale A, Nimer SD. Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells. Blood. 2003;101:2206-2214.
    • (2003) Blood , vol.101 , pp. 2206-2214
    • Cammenga, J.1    Mulloy, J.C.2    Berguido, F.J.3    MacGrogan, D.4    Viale, A.5    Nimer, S.D.6
  • 41
    • 0026029709 scopus 로고
    • CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
    • Christy RJ, Kaestner KH, Geiman DE, Lane MD. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A. 1991;88:2593-2597.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2593-2597
    • Christy, R.J.1    Kaestner, K.H.2    Geiman, D.E.3    Lane, M.D.4
  • 42
    • 0027276292 scopus 로고
    • High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors
    • Legraverend C, Antonson P, Flodby P, Xanthopoulos KG. High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors. Nucleic Acids Res. 1993;21:1735-1742.
    • (1993) Nucleic Acids Res , vol.21 , pp. 1735-1742
    • Legraverend, C.1    Antonson, P.2    Flodby, P.3    Xanthopoulos, K.G.4
  • 43
    • 0036340784 scopus 로고    scopus 로고
    • BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2
    • Perrotti D, Cesi V, Trotta R, et al. BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2. Nat Genet. 2002;30:48-58.
    • (2002) Nat Genet , vol.30 , pp. 48-58
    • Perrotti, D.1    Cesi, V.2    Trotta, R.3
  • 44
    • 0024725630 scopus 로고
    • CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells
    • Friedman AD, Landschulz WH, McKnight SL. CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 1989;3:1314-1322.
    • (1989) Genes Dev , vol.3 , pp. 1314-1322
    • Friedman, A.D.1    Landschulz, W.H.2    McKnight, S.L.3
  • 45
    • 0028824952 scopus 로고
    • Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen
    • Hendricks-Taylor LR, Darlington GJ. Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen. Nucleic Acids Res. 1995;23:4726-4733.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4726-4733
    • Hendricks-Taylor, L.R.1    Darlington, G.J.2
  • 46
    • 0037307675 scopus 로고    scopus 로고
    • CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
    • Truong BT, Lee YJ, Lodie TA, et al. CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood. 2003;101:1141-1148.
    • (2003) Blood , vol.101 , pp. 1141-1148
    • Truong, B.T.1    Lee, Y.J.2    Lodie, T.A.3
  • 47
    • 0029746172 scopus 로고    scopus 로고
    • Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha
    • Flodby P, Barlow C, Kylefjord H, Ahrlund-Richter L, Xanthopoulos KG. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem. 1996;271:24753-24760.
    • (1996) J Biol Chem , vol.271 , pp. 24753-24760
    • Flodby, P.1    Barlow, C.2    Kylefjord, H.3    Ahrlund-Richter, L.4    Xanthopoulos, K.G.5
  • 48
    • 0032526324 scopus 로고    scopus 로고
    • Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha
    • Iwama A, Zhang P, Darlington GJ, McKercher SR, Maki R, Tenen DG. Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998;26:3034-3043.
    • (1998) Nucleic Acids Res , vol.26 , pp. 3034-3043
    • Iwama, A.1    Zhang, P.2    Darlington, G.J.3    McKercher, S.R.4    Maki, R.5    Tenen, D.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.