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Volumn 4, Issue 5, 2004, Pages 394-400

C/EBPα mutations in acute myeloid leukaemias

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; TRANSCRIPTION FACTOR;

EID: 2342544921     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1363     Document Type: Review
Times cited : (231)

References (57)
  • 1
    • 0037315894 scopus 로고    scopus 로고
    • Disruption of differentiation in human cancer: AML shows the way
    • Tenen, D. G. Disruption of differentiation in human cancer: AML shows the way. Nature Rev. Cancer 3, 89-101 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 89-101
    • Tenen, D.G.1
  • 2
    • 0029160028 scopus 로고
    • Impaired energy homeostasis in C/EBPα knockout mice
    • Wang, N. D. et al. Impaired energy homeostasis in C/EBPα knockout mice. Science 269, 1108-1112 (1995). This paper demonstrates the requirement for C/EBPα during white-fat adipogenesis.
    • (1995) Science , vol.269 , pp. 1108-1112
    • Wang, N.D.1
  • 3
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
    • Zhang, D. E. et al. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl Acad. Sci. USA 94, 569-574 (1997). This paper provided the first demonstration of a block In granulopoiesis in the absence of the C/EBPα protein.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 569-574
    • Zhang, D.E.1
  • 4
    • 0028129499 scopus 로고
    • Ectopic expression of the CCAAT/enhancer-binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells
    • Freytag, S. O., Paielli, D. L. & Gilbert, J. D. Ectopic expression of the CCAAT/enhancer-binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev. 8, 1654-1663 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 1654-1663
    • Freytag, S.O.1    Paielli, D.L.2    Gilbert, J.D.3
  • 5
    • 0031835661 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
    • Radomska, H. S. et al. CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell. Biol. 18, 4301-4314 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4301-4314
    • Radomska, H.S.1
  • 6
    • 0032145528 scopus 로고    scopus 로고
    • Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
    • Nerlov, C., McNagny, K. M., Doderlein, G., Kowenz-Leutz, E. & Graf, T. Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. Genes Dev. 12, 2413-2423 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2413-2423
    • Nerlov, C.1    McNagny, K.M.2    Doderlein, G.3    Kowenz-Leutz, E.4    Graf, T.5
  • 7
    • 0027420920 scopus 로고
    • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: Transcriptional activator lacking antimitotic activity
    • Lin, F. T., MacDougald, O. A., Diehl, A. M. & Lane, M. D. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: transcriptional activator lacking antimitotic activity. Proc. Natl Acad. Sci. USA 90, 9606-9610 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9606-9610
    • Lin, F.T.1    MacDougald, O.A.2    Diehl, A.M.3    Lane, M.D.4
  • 8
    • 0033869876 scopus 로고    scopus 로고
    • Translational control of C/EBPα and C/EBPβ isoform expression
    • Calkhoven, C. F., Muller, C. & Leutz, A. Translational control of C/EBPα and C/EBPβ isoform expression. Genes Dev. 14, 1920-1932 (2000). An elegant demonstration of how translational control can alter the function of a transcription factor by selectively including or excluding functional domains in response to extracellular signalling.
    • (2000) Genes Dev. , vol.14 , pp. 1920-1932
    • Calkhoven, C.F.1    Muller, C.2    Leutz, A.3
  • 9
    • 0027289462 scopus 로고
    • Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2α in response to growth induction by c-myc
    • Rosenwald, I. B., Rhoads, D. B., Callanan, L. D., Isselbacher, K. J. & Schmidt, E. V. Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2α in response to growth induction by c-myc. Proc. Natl Acad. Sci. USA 90, 6175-6178 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6175-6178
    • Rosenwald, I.B.1    Rhoads, D.B.2    Callanan, L.D.3    Isselbacher, K.J.4    Schmidt, E.V.5
  • 10
    • 0142214647 scopus 로고    scopus 로고
    • The amino terminal and E2F interaction domains are critical for C/EBPα-mediated induction of granulopoietic development of hematopoietic cells
    • D'Alo', F. et al. The amino terminal and E2F interaction domains are critical for C/EBPα-mediated induction of granulopoietic development of hematopoietic cells. Blood 102, 3163-3171 (2003).
    • (2003) Blood , vol.102 , pp. 3163-3171
    • D'Alo', F.1
  • 11
    • 0025314596 scopus 로고
    • Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap
    • Lazaris-Karatzas, A., Montine, K. S. & Sonenberg, N. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 345, 544-547 (1990).
    • (1990) Nature , vol.345 , pp. 544-547
    • Lazaris-Karatzas, A.1    Montine, K.S.2    Sonenberg, N.3
  • 12
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
    • Pabst, T. et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nature Genet. 27, 253-270 (2001). The first demonstration of mutations in a lineage-specific transcriptional regulator in patients with AML.
    • (2001) Nature Genet. , vol.27 , pp. 253-270
    • Pabst, T.1
  • 13
    • 0037082508 scopus 로고    scopus 로고
    • Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein α in myelodysplastic syndromes and acute myeloid leukemias
    • Gombart, A. F. et al. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein α in myelodysplastic syndromes and acute myeloid leukemias. Blood 99, 1332-1340 (2002).
    • (2002) Blood , vol.99 , pp. 1332-1340
    • Gombart, A.F.1
  • 14
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
    • Preudhomme, C. et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 100, 2717-2723 (2002).
    • (2002) Blood , vol.100 , pp. 2717-2723
    • Preudhomme, C.1
  • 15
    • 0037591396 scopus 로고    scopus 로고
    • Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML
    • Van Waalwijk Van Doorn-Khosrovani, S. B. et al. Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. Hematol. J. 4, 31-40 (2003).
    • (2003) Hematol. J. , vol.4 , pp. 31-40
    • Van Waalwijk Van Doorn-Khosrovani, S.B.1
  • 16
    • 0037289756 scopus 로고    scopus 로고
    • The emergence of a C/EBPα mutation in the clonal evolution of MDS towards secondary AML
    • Kaeferstein, A. et al. The emergence of a C/EBPα mutation in the clonal evolution of MDS towards secondary AML. Leukemia 17, 343-349 (2003).
    • (2003) Leukemia , vol.17 , pp. 343-349
    • Kaeferstein, A.1
  • 17
    • 0345269758 scopus 로고    scopus 로고
    • Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
    • Snaddon, J. et al. Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2. Genes Chromosom. Cancer 37, 72-78 (2003).
    • (2003) Genes Chromosom. Cancer , vol.37 , pp. 72-78
    • Snaddon, J.1
  • 18
    • 0037300605 scopus 로고    scopus 로고
    • Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPα gene
    • Asou, H. et al. Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPα gene. Genes Chromosom. Cancer 36, 167-174 (2003).
    • (2003) Genes Chromosom. Cancer , vol.36 , pp. 167-174
    • Asou, H.1
  • 19
    • 0035047652 scopus 로고    scopus 로고
    • AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
    • Pabst, T. et al. AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia. Nature Med. 7, 444-451 (2001).
    • (2001) Nature Med. , vol.7 , pp. 444-451
    • Pabst, T.1
  • 20
    • 0141593492 scopus 로고    scopus 로고
    • Down-modulation of the C/EBPα transcription factor in core binding factor acute myeloid leukemias
    • Cilloni, D. et al. Down-modulation of the C/EBPα transcription factor in core binding factor acute myeloid leukemias. Blood 102, 2705-2706 (2003).
    • (2003) Blood , vol.102 , pp. 2705-2706
    • Cilloni, D.1
  • 21
    • 0036340784 scopus 로고    scopus 로고
    • BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2
    • Perrotti, D. et al. BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2. Nature Genet. 30, 48-58 (2002).
    • (2002) Nature Genet. , vol.30 , pp. 48-58
    • Perrotti, D.1
  • 22
    • 0024725630 scopus 로고
    • CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells
    • Friedman, A. D., Landschulz, W. H. & McKnight, S. L. CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 3, 1314-1322 (1989).
    • (1989) Genes Dev. , vol.3 , pp. 1314-1322
    • Friedman, A.D.1    Landschulz, W.H.2    McKnight, S.L.3
  • 23
    • 0024728988 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes
    • Christy, R. J. et al. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3, 1323-1335 (1989).
    • (1989) Genes Dev. , vol.3 , pp. 1323-1335
    • Christy, R.J.1
  • 24
    • 0030854907 scopus 로고    scopus 로고
    • Transcription factors, normal myeloid development, and leukemia
    • Tenen, D. G., Hromas, R., Licht, J. D. & Zhang, D. E. Transcription factors, normal myeloid development, and leukemia. Blood 90, 489-519 (1997).
    • (1997) Blood , vol.90 , pp. 489-519
    • Tenen, D.G.1    Hromas, R.2    Licht, J.D.3    Zhang, D.E.4
  • 25
    • 0032125697 scopus 로고    scopus 로고
    • Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1
    • McNagny, K. M., Sieweke, M. H., Doderlein, G., Graf, T. & Nerlov, C. Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1. EMBO J. 17, 3669-3680 (1998).
    • (1998) EMBO J. , vol.17 , pp. 3669-3680
    • McNagny, K.M.1    Sieweke, M.H.2    Doderlein, G.3    Graf, T.4    Nerlov, C.5
  • 26
    • 0029156782 scopus 로고
    • CCAAT/enhancer binding protein-α amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells
    • Nerlov, C. & Ziff, E. B. CCAAT/enhancer binding protein-α amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells. EMBO J. 14, 4318-4328 (1995).
    • (1995) EMBO J. , vol.14 , pp. 4318-4328
    • Nerlov, C.1    Ziff, E.B.2
  • 27
    • 0141480198 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation
    • Kovacs, K. A., Steinmann, M., Magistretti, P. J., Halfon, O. & Cardinaux, J. R. CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation. J. Biol. Chem. 278, 36959-36965 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 36959-36965
    • Kovacs, K.A.1    Steinmann, M.2    Magistretti, P.J.3    Halfon, O.4    Cardinaux, J.R.5
  • 28
    • 0037450633 scopus 로고    scopus 로고
    • Recruitment of p300 by C/EBPβ triggers phosphorylation of p300 and modulates coactivator activity
    • Schwartz, C. et al. Recruitment of p300 by C/EBPβ triggers phosphorylation of p300 and modulates coactivator activity. EMBO J. 22, 882-892 (2003).
    • (2003) EMBO J. , vol.22 , pp. 882-892
    • Schwartz, C.1
  • 29
    • 0035529053 scopus 로고    scopus 로고
    • Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
    • Pedersen, A., Kowenz-Leutz, E., Leutz, A. & Nerlov, C. Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Genes Dev. 15, 3208-3216 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 3208-3216
    • Pedersen, A.1    Kowenz-Leutz, E.2    Leutz, A.3    Nerlov, C.4
  • 30
    • 0030024112 scopus 로고    scopus 로고
    • CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF α2) synergistically activate the macrophage colony-stimulating factor receptor promoter
    • Zhang, D. E. et al. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF α2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol. Cell. Biol. 16, 1231-1240 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1231-1240
    • Zhang, D.E.1
  • 31
    • 0033566366 scopus 로고    scopus 로고
    • EBPβ and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: Implication for C/EBPβ activity in eosinophil gene expression
    • Yamaguchi, Y., Nishio, H., Kishi, K., Ackerman, S. J. & Suda, T. C. EBPβ and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: implication for C/EBPβ activity in eosinophil gene expression. Blood 94, 1429-1439 (1999).
    • (1999) Blood , vol.94 , pp. 1429-1439
    • Yamaguchi, Y.1    Nishio, H.2    Kishi, K.3    Ackerman, S.J.4    Suda, T.C.5
  • 32
    • 0037100304 scopus 로고    scopus 로고
    • Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU. 1: Possible role in lineage commitment decisions
    • Reddy, V. A. et al. Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU. 1: possible role in lineage commitment decisions. Blood 100, 483-490 (2002).
    • (2002) Blood , vol.100 , pp. 483-490
    • Reddy, V.A.1
  • 33
    • 0026031601 scopus 로고
    • CCAAT-enhancer binding protein: A component of a differentiation switch
    • Umek, R. M., Friedman, A. D. & McKnight, S. L. CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251, 288-292 (1991).
    • (1991) Science , vol.251 , pp. 288-292
    • Umek, R.M.1    Friedman, A.D.2    McKnight, S.L.3
  • 34
    • 0033594813 scopus 로고    scopus 로고
    • Separation of C/EBPα-mediated proliferation arrest and differentiation pathways
    • Muller, C. et al. Separation of C/EBPα-mediated proliferation arrest and differentiation pathways. Proc. Natl Acad. Sci. USA 96, 7276-7281 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7276-7281
    • Muller, C.1
  • 35
    • 0030658965 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein α regulates p21 protein and hepatocyte proliferation in newborn mice
    • Timchenko, N. A. et al. CCAAT/enhancer binding protein α regulates p21 protein and hepatocyte proliferation in newborn mice. Mol. Cell. Biol. 17, 7353-7361 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7353-7361
    • Timchenko, N.A.1
  • 36
    • 0034740215 scopus 로고    scopus 로고
    • C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
    • Wang, H. et al. C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol. Cell 8, 817-828 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 817-828
    • Wang, H.1
  • 37
    • 0034306996 scopus 로고    scopus 로고
    • The Rb/E2F pathway: Expanding roles and emerging paradigms
    • Harbour, J. W. & Dean, D. C. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 14, 2393-2409 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2393-2409
    • Harbour, J.W.1    Dean, D.C.2
  • 38
    • 0033624014 scopus 로고    scopus 로고
    • C/EBPα inhibits cell growth via direct repression of E2F-DP-mediated transcription
    • Slomiany, B. A., D'Arigo, K. L., Kelly, M. M. & Kurtz, D. T. C/EBPα inhibits cell growth via direct repression of E2F-DP-mediated transcription. Mol. Cell. Biol. 20, 5986-5997 (2000). The first demonstration on of the capacity of C/EBPα to repress E2F-dependent transcription.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5986-5997
    • Slomiany, B.A.1    D'Arigo, K.L.2    Kelly, M.M.3    Kurtz, D.T.4
  • 39
    • 0035913913 scopus 로고    scopus 로고
    • E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo
    • Porse, B. T. et al. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell 107, 247-258 (2001). An in vivo demonstration of the coupling between cell-cycle control and terminal differentiation by C/EBPα.
    • (2001) Cell , vol.107 , pp. 247-258
    • Porse, B.T.1
  • 40
    • 0035005526 scopus 로고    scopus 로고
    • c-Myc is a critical target for c/EBPα in granulopoiesis
    • Johansen, L. M. et al. c-Myc is a critical target for c/EBPα in granulopoiesis. Mol. Cell. Biol. 21, 3789-3806 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3789-3806
    • Johansen, L.M.1
  • 41
    • 0028824952 scopus 로고
    • Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen
    • Hendricks-Taylor, L. R. & Darlington, G. J. Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen. Nucleic Acids Res. 23, 4726-4733 (1995).
    • (1995) Nucleic Acids Res. , vol.23 , pp. 4726-4733
    • Hendricks-Taylor, L.R.1    Darlington, G.J.2
  • 42
    • 0037854628 scopus 로고    scopus 로고
    • Cell cycle inhibition mediated by the outer surface of the C/EBPα basic region is required but not sufficient for granulopoiesis
    • Wang, Q. F., Cleaves, R., Kummalue, T., Nerlov, C. & Friedman, A. D. Cell cycle inhibition mediated by the outer surface of the C/EBPα basic region is required but not sufficient for granulopoiesis. Oncogene 22, 2548-2557 (2003).
    • (2003) Oncogene , vol.22 , pp. 2548-2557
    • Wang, Q.F.1    Cleaves, R.2    Kummalue, T.3    Nerlov, C.4    Friedman, A.D.5
  • 43
    • 1342346543 scopus 로고    scopus 로고
    • The CCAAT enhancer-binding protein α (C/EBPα) requires a SWI/SNF complex for proliferation arrest
    • Muller, C., Calkhoven, C. F., Sha, X. & Leutz, A. The CCAAT enhancer-binding protein α (C/EBPα) requires a SWI/SNF complex for proliferation arrest. J. Biol. Chem. 279, 7353-7358 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 7353-7358
    • Muller, C.1    Calkhoven, C.F.2    Sha, X.3    Leutz, A.4
  • 44
    • 0035962638 scopus 로고    scopus 로고
    • Rb-mediated chromatin structure regulation and transcriptional repression
    • Zhang, H. S. & Dean, D. C. Rb-mediated chromatin structure regulation and transcriptional repression. Oncogene 20, 3134-3138 (2001).
    • (2001) Oncogene , vol.20 , pp. 3134-3138
    • Zhang, H.S.1    Dean, D.C.2
  • 45
    • 0031975921 scopus 로고    scopus 로고
    • E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation
    • Strom, D. K., Cleveland, J. L., Chellappan, S., Nip, J. & Hiebert, S. W. E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation. Cell Growth Differ. 9, 59-69 (1998).
    • (1998) Cell Growth Differ. , vol.9 , pp. 59-69
    • Strom, D.K.1    Cleveland, J.L.2    Chellappan, S.3    Nip, J.4    Hiebert, S.W.5
  • 46
    • 0038819118 scopus 로고    scopus 로고
    • The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow
    • Bjerregaard, M. D., Jurlander, J., Klausen, P., Borregaard, N. & Cowland, J. B. The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow. Blood 101, 4322-4332 (2003).
    • (2003) Blood , vol.101 , pp. 4322-4332
    • Bjerregaard, M.D.1    Jurlander, J.2    Klausen, P.3    Borregaard, N.4    Cowland, J.B.5
  • 47
    • 0242389807 scopus 로고    scopus 로고
    • C/EBPβ: A major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells
    • Duprez, E., Wagner, K., Koch, H. & Tenen, D. G. C/EBPβ: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells. EMBO J. 22, 5806-5816 (2003).
    • (2003) EMBO J. , vol.22 , pp. 5806-5816
    • Duprez, E.1    Wagner, K.2    Koch, H.3    Tenen, D.G.4
  • 48
    • 1442302765 scopus 로고    scopus 로고
    • C/EBPε interacts with retinoblastoma and E2F1 during granulopoiesis
    • Gery, S., Gombart, A. F., Fung, Y. K. & Koeffler, H. P. C/EBPε interacts with retinoblastoma and E2F1 during granulopoiesis. Blood 103, 828-835 (2003).
    • (2003) Blood , vol.103 , pp. 828-835
    • Gery, S.1    Gombart, A.F.2    Fung, Y.K.3    Koeffler, H.P.4
  • 50
    • 0037085568 scopus 로고    scopus 로고
    • Expression of C/EBPβ from the C/ebpα gene locus is sufficient for normal hematopoiesis in vivo
    • Jones, L. C. et al. Expression of C/EBPβ from the C/ebpα gene locus is sufficient for normal hematopoiesis in vivo. Blood 99, 2032-2036 (2002).
    • (2002) Blood , vol.99 , pp. 2032-2036
    • Jones, L.C.1
  • 51
    • 0037307675 scopus 로고    scopus 로고
    • CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
    • Truong, B. T. et al. CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood 101, 1141-1148 (2003).
    • (2003) Blood , vol.101 , pp. 1141-1148
    • Truong, B.T.1
  • 52
    • 0029976068 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein α (C/EBPα) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein
    • Timchenko, N. A., Wilde, M., Nakanishi, M., Smith, J. R. & Darlingtong, G. J. CCAAT/enhancer-binding protein α (C/EBPα) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 10, 804-815 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 804-815
    • Timchenko, N.A.1    Wilde, M.2    Nakanishi, M.3    Smith, J.R.4    Darlingtong, G.J.5
  • 53
    • 0032588171 scopus 로고    scopus 로고
    • C/EBPα regulates formation of S-phase-specific E2F-107 complexes in livers of newborn mice
    • Timchenko, N. A., Wilde, M. & Darlington, G. J. C/EBPα regulates formation of S-phase-specific E2F-107 complexes in livers of newborn mice. Mol. Cell. Biol. 19, 2936-2945 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2936-2945
    • Timchenko, N.A.1    Wilde, M.2    Darlington, G.J.3
  • 54
    • 0038064220 scopus 로고    scopus 로고
    • Aging reduces proliferative capacities of liver by switching pathways of C/EBPα growth arrest
    • Iakova, P., Awad, S. S. & Timchenko, N. A. Aging reduces proliferative capacities of liver by switching pathways of C/EBPα growth arrest. Cell 113, 495-506 (2003).
    • (2003) Cell , vol.113 , pp. 495-506
    • Iakova, P.1    Awad, S.S.2    Timchenko, N.A.3
  • 55
    • 0033499747 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 is an insulin-regulated C/EBPα kinase
    • Ross, S. E., Erickson, R. L., Hemati, N. & MacDougald, O. A. Glycogen synthase kinase 3 is an insulin-regulated C/EBPα kinase. Mol. Cell. Biol. 19, 8433-8441 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8433-8441
    • Ross, S.E.1    Erickson, R.L.2    Hemati, N.3    MacDougald, O.A.4
  • 56
    • 16744363992 scopus 로고    scopus 로고
    • Ras signaling enhances the activity of C/EBPα to induce granulocytic differentiation by phosphorylation of serine 248
    • Behre, G. et al. Ras signaling enhances the activity of C/EBPα to induce granulocytic differentiation by phosphorylation of serine 248. J. Biol. Chem. 277, 26293-26299 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 26293-26299
    • Behre, G.1
  • 57
    • 3643121383 scopus 로고
    • (eds Handin, R. I., Lux, S. E. & Stossel, T. P.) (J.B. Lippincott Company, Philadelphia, USA)
    • Weinstein, H. & Griffin, J. D. in Blood, Principles and Practice of Hematology (eds Handin, R. I., Lux, S. E. & Stossel, T. P.) 543-574 (J.B. Lippincott Company, Philadelphia, USA, 1995).
    • (1995) Blood, Principles and Practice of Hematology , pp. 543-574
    • Weinstein, H.1    Griffin, J.D.2


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