PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch

Journal of Experimental Medicine

Volumn 202, Issue 10, 2005, Pages 1411-1422

  Ye, Min ^a   Ermakova, Olga ^a,b   Graf, Thomas ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD45 ANTIGEN; EARLY B CELL FACTOR; IMMUNOGLOBULIN M; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; FETUS; GENE EXPRESSION; LIVER CELL CULTURE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD45; B-LYMPHOCYTE SUBSETS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; DOWN-REGULATION; GENE REARRANGEMENT, B-LYMPHOCYTE; IMMUNOGLOBULIN M; IMMUNOPHENOTYPING; LIVER; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS; SPLEEN; STEM CELLS; TRANS-ACTIVATORS;

EID: 27944442060     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20051089     Document Type: Article

References (36)

1. Scott, E.W., M.C. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 265:1573-1577.
2. McKercher, S.R., B.E. Torbett, K.L. Anderson, G.W. Henkel, D.J. Vestal, H. Baribault, M. Klemsz, A.J. Feeney, G.E. Wu, C.J. Paige, and R.A. Maki. 1996. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15:5647-5658.
3. Scott, E.W., R.C. Fisher, M.C. Olson, E.W. Kehrli, M.C. Simon, and H. Singh. 1997. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity. 6:437-447.
4. DeKoter, R.P., J.C. Walsh, and H. Singh. 1998. PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 17:4456-4468.
5. DeKoter, R.P., H.J. Lee, and H. Singh. 2002. PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity. 16:297-309.
6. Schweitzer, B.L., and R.P. DeKoter. 2004. Analysis of gene expression and Ig transcription in PU.1/Spi-B-deficient progenitor B cell lines. J. Immunol. 172:144-154.
7. Medina, K.L., J.M. Pongubala, K.L. Reddy, D.W. Lancki, R. Dekoter, M. Kieslinger, R. Grosschedl, and H. Singh. 2004. Assembling a gene regulatory network for specification of the B cell fate. Dev. Cell. 7:607-617.
8. Kim, H.G., C.G. de Guzman, C.S. Swindle, C.V. Cotta, L. Gartland, E.W. Scott, and C.A. Klug. 2004. The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells. Blood. 104:3894-3900.
9. Nutt, S.L., D. Metcalf, A. D'Amico, M. Polli, and L. Wu. 2005. Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J. Exp. Med. 201:221-231.
10. Hardy, R.R., and K. Hayakawa. 2001. B cell development pathways. Annu. Rev. Immunol. 19:595-621.
11. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature. 381:751-758.
12. Cariappa, A., M. Tang, C. Parng, E. Nebelitskiy, M. Carroll, K. Georgopoulos, and S. Pillai. 2001. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity. 14:603-615.
13. Su, I., and A. Tarakhovsky. 2000. B-1 cells: orthodox or conformist? Curr. Opin. Immunol. 12:191-194.
14. Berland, R., and H.H. Wortis. 2002. Origins and functions of B-1 cells with notes on the role of CD5. Annu. Rev. Immunol. 20:253-300.
15. Casola, S., K.L. Otipoby, M. Alimzhanov, S. Humme, N. Uyttersprot, J.L. Kutok, M.C. Carroll, and K. Rajewsky. 2004. B cell receptor signal strength determines B cell fate. Nat. Immunol. 5:317-327.
16. Dal Porto, J.M., K. Burke, and J.C. Cambier. 2004. Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck. Immunity. 21:443-453.
17. ten Boekel, E., F. Melchers, and A. Rolink. 1995. The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7:1013-1019.
18. Fuxa, M., J. Skok, A. Souabni, G. Salvagiotto, E. Roldan, and M. Busslinger. 2004. Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes Dev. 18:411-422.
19. Rickert, R.C., J. Roes, and K. Rajewsky. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25:1317-1318.
20. Wadia, J.S., R.V. Stan, and S.F. Dowdy. 2004. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat. Med. 10:310-315.
21. Umar, A., and T.A. Kunkel. 1996. DNA-replication fidelity, mismatch repair and genome instability in cancer cells. Eur. J. Biochem. 238:297-307.
22. Spain, L.M., A. Guerriero, S. Kunjibettu, and E.W. Scott. 1999. T cell development in PU.1-deficient mice. J. Immunol. 163:2681-2687.
23. Dakic, A., D. Metcalf, L. Di Rago, S. Mifsud, L. Wu, and S.L. Nutt. 2005. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J. Exp. Med. 201:1487-1502.
24. Nutt, S.L., B. Heavey, A.G. Rolink, and M. Busslinger. 1999. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 401:556-562.
25. Ikawa, T.,H. Kawamoto, L.Y. Wright, and C. Murre. 2004. Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity. 20:349-360.
26. Lehar, S.M., and M.J. Bevan. 2002. T cell development in culture. Immunity. 17:689-692.
27. Chiorazzi, N., K.R. Rai, and M. Ferrarini. 2005. Chronic lymphocytic leukemia. N. Engl. J. Med. 352:804-815.
28. Quong, M.W., W.J. Romanow, and C. Murre. 2002. E protein function in lymphocyte development. Annu. Rev. Immunol. 20:301-322.
29. Anderson, K.L., S.L. Nelson, H.B. Perkin, K.A. Smith, M.J. Klemsz, and B.E. Torbett. 2001. PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45. J. Biol. Chem. 276:7637-7642.
30. Rothenberg, E.V., and T. Taghon. 2005. Molecular genetics of T cell development. Annu. Rev. Immunol. 23:601-649.
31. Johnson, P., L. Greenbaum, K. Bottomly, and I.S. Trowbridge. 1989. Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies. J. Exp. Med. 169:1179-1184.
32. Bleesing, J.J., M.R. Brown, J.K. Dale, S.E. Straus, M.J. Lenardo, J.M. Puck, T.P. Atkinson, and T.A. Fleisher. 2001. TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clin. Immunol. 100:314-324.
33. Iwasaki, H., C. Somoza, H. Shigematsu, E.A. Duprez, J. Iwasaki-Arai, S.I. Mizuno, Y. Arinobu, K. Geary, P. Zhang, T. Dayaram, et al. 2005. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 106:1590-1600.
34. Schwenk, F., U. Baron, and K. Rajewsky. 1995. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23:5080-5081.
35. Ye, M., H. Iwasaki, C.V. Laiosa, M. Stadtfeld, H. Xie, S. Heck, B. Clausen, K. Akashi, and T. Graf. 2003. Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity. 19:689-699.
36. Xie, H., M. Ye, R. Feng, and T. Graf. 2004. Stepwise reprogramming of B cells into macrophages. Cell. 117:663-676.