Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARα

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 35, 2005, Pages 12513-12518

  Walter, Matthew J ^a   Park, John S ^a   Ries, Rhonda E ^a   Lau, Steven K M ^a   McLellan, Michael ^a   Jaeger, Sara ^a   Wilson, Richard K ^a   Mardis, Elaine R ^a   Ley, Timothy J ^a,b,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b USA   (United States)

^c Section of Stem Cell Biology   (United States)

Author keywords

Acute promyelocytic leukemia; Chromosome 2; Mouse model; Transcription factor

Indexed keywords

PROMYELOCYTIC LEUKEMIA PROTEIN; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR PU 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CANCER GROWTH; CELL FATE; CELL LINEAGE; CELL STRAIN U937; CELL TRANSFORMATION; CHROMOSOME 2; CHROMOSOME DELETION; CONTROLLED STUDY; EXON; FEMALE; GENE EXPRESSION; GENE MUTATION; HEMATOPOIESIS; LEUKEMIA; MALE; MOUSE; MYELOID PROGENITOR CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN FAMILY; SPLEEN; SPLENOMEGALY; TRANSGENIC MOUSE;

ANIMALS; CHROMOSOME DELETION; DOWN-REGULATION; GENE EXPRESSION; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELOID PROGENITOR CELLS; NEOPLASM PROTEINS; ONCOGENE PROTEINS, FUSION; PHENOTYPE; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; SPLENOMEGALY; TRANS-ACTIVATORS; U937 CELLS;

MURINAE; MUS MUSCULUS;

EID: 24644482422     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0504247102     Document Type: Article

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