Transcriptional regulation of the stem cell leukemia gene (SCL) - Comparative analysis of five vertebrate SCL loci

Genome Research

Volumn 12, Issue 5, 2002, Pages 749-759

  Göttgens, Berthold ^a,b,c   Barton, Linda M ^a,b,c   Chapman, Michael A ^a,b,c   Sinclair, Angus M ^a,b,c   Knudsen, Bjarne ^a,b,c   Grafham, Darren ^a,b,c   Gilbert, James G R ^a,b,c   Rogers, Jane ^a,b,c   Bentley, David R ^a,b,c   Green, Anthony R ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b AARHUS UNIVERSITY   (Denmark)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HELIX LOOP HELIX PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CHICKEN; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FOOTPRINTING; EMBRYO; ENHANCER REGION; EXON; FETUS; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE ISOLATION; GENE LOCUS; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; GENETIC CONSERVATION; GENOME SIZE; HEMATOPOIESIS; LEUKEMIA; MAMMAL; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; SYNTENY; TRANSCRIPTION REGULATION; ZEBRA FISH;

5' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; CHICKENS; CHROMOSOMES, ARTIFICIAL, P1 BACTERIOPHAGE; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; EXONS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC MARKERS; HUMANS; LEUKEMIA, T-CELL, ACUTE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; POLY A; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RATS; SEQUENCE HOMOLOGY, NUCLEIC ACID; TETRAODONTIFORMES; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; GALLUS GALLUS; MAMMALIA; TETRAODONTIDAE; VERTEBRATA;

EID: 0036110293     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.45502     Document Type: Article

References (66)

1. Localized XId3 mRNA activation in Xenopus embryos by cytoplasmic polyadenylation
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Dissecting hematopoiesis and disease using the zebrafish
4. An AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: Binding of Apobec-1 to this motif in the 3′ untranslated region of c- stability
5. Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes
6. Regulation of the stem cell leukemia (SCL) gene: A tale of two fishes
7. Identification of NFI-binding sites and cloning of NFI-cDNAs suggest a regulatory role for NFI transcription factors in olfactory neuron gene expression
8. Transgenic analysis of a potential Hoxd-11 limb regulatory element present in tetrapods and fish
9. The SCL gene: From case report to critical hematopoietic regulator
10. Lineage-restricted regulation of the murine SCL/TAL-1 promoter
11. Distinct mechanisms direct SCL/tal-1 expression in erythroid cells and CD34 positive primitive myeloid cells
12. Transcriptional regulation of the stem cell leukemia gene by PU.1 and Elf-1
13. Vasculogenesis in the day 6.5 to 9.5 mouse embryo
14. Zebrafish: Genetic tools for studying vertebrate development
15. Strong conservation of non-coding sequences during vertebrates evolution: Potential involvement in post-transcriptional regulation of gene expression
16. Fish x 3
17. ACeDB and macace
18. The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins
19. SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues
20. Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the α globin cluster
21. Analysis of 148 kb of genomic DNA around the wnt1 locus of Fugu rubripes
22. The SCL gene specifies haemangioblast development from early mesoderm
23. Transcription of the SCL gene in erythroid and CD34 positive primitive myeloid cells is controlled by a complex network of lineage-restricted chromatin-dependent and chromatin-independent regulatory elements
24. The pufferfish SLP-1 gene, a new member of the SCL/TAL-1 family of transcription factors
25. Analysis of vertebrate SCL loci identifies conserved enhancers
26. Long-range comparison of human and mouse SCL loci: Localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences
27. SCL is co-expressed with GATA-1 in haemopoietic cells but is also expressed in developing brain
28. Transient translational silencing by reversible mRNA deadenylation
29. DNA binding sites for the transcriptional activator/repressor YY1
30. RNA secondary structure prediction based on free energy and phylogenetic analysis
31. The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis
32. RNA secondary structure prediction using stochastic context-free grammars and evolutionary history
33. Identification and partial characterization of a novel membrane-associated protein (MAP17) up-regulated in human carcinomas and modulating cell replication and tumor growth
34. Hox genes in vertebrate development
35. GATA- and SP1-binding sites are required for the full activity of the tissue-specific promoter of the tal-1 gene
36. Definition of an efficient synthetic poly(A) site
37. SCL/Tal-1 transcription factor acts downstrem of cloche to specify hematopoietic and vascular progenitors in zebrafish
38. The specificity of homeotic gene function
39. VISTA: Visualizing global DNA sequence alignments of arbitrary length
40. SCL specifies hematopoietic mesoderm in Xenopus embryos
41. DIALIGN: Finding local similarities by multiple sequence alignment
42. Discordant regulation of SCL/TAL-1 mRNA and protein during erythroid differentiation
43. Primitive synteny of vertebrate major histocompatibility complex class I and class II genes
44. Intersections between blood cell development and leukemia genes
45. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
46. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
47. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
48. Zebrafish comparative genomics and the origins of vertebrate chromosomes
49. Erythropoietin stimulates transcription of the TAL1/SCL gene and phosphorylation of its protein products
50. The SCL gene product is required for the generation of all hematopoietic lineages in the adult mouse
51. A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1
52. Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis
53. Identification of an evolutionary conserved 110 base-pair cis-acting regulatory sequence that governs wnt-1 expressino in the murine neural plate
54. An SCL 3′ enhancer targets developing endothelium together with embryonic and adult hematopoietic progenitors
55. Aberrant processing of the Fugu HD (FrHD) mRNA in mouse cells and in transgenic mice
56. PipMaker-A web server for aligning two genomic DNA sequences
57. Distinct 5′ SCL enhancers direct transcription to developing brain, spinal chord and endothelium; Conserved neural expression is GATA factor dependant
58. A dot-matrix program with dynamic threshold control suited for genomic DNA and protein sequence analysis
59. Highly conserved RNA sequences that are sensors of environmental stress
60. Unlocking the mechanisms of transcription factor YY1: Are chromatin modifying enzymes the key?
61. Cloning and characterization of MUPP1, a novel PDZ domain protein
62. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
63. Ier5, a novel member of the slow-kinetics immediate-early genes
64. Genomic cis-regulatory logic: Experimental and computational analysis of a sea urchin gene
65. A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
66. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter