Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor GFi1

Nature Genetics

Volumn 30, Issue 3, 2002, Pages 295-300

  Karsunky, Holger ^a   Zeng, Hui ^a   Schmidt, Thorsten ^a,c   Zevnik, Branko ^a,d   Kluge, Reinhart ^b   Schmid, Kurt Werner ^a   Dührsen, Ulrich ^a   Möröy, Tarik ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c BAYER AG   (Germany)

^d Artemis Pharmaceuticals GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; ENDOTOXIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GFI1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; GRANULOCYTE; IMMUNE RESPONSE; IMMUNITY; INFLAMMATION; LYMPHOMA; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; CYTOKINES; DNA-BINDING PROTEINS; INFLAMMATION MEDIATORS; MACROPHAGES; MICE; MICE, INBRED C57BL; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0036510161     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng831     Document Type: Article

References (12)

1. Progression of interleukin-2 (11-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi1) encoding a novel zinc finger protein
2. Gfi1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor
3. Evidence implicating Gfi1 and Pim-1 in pre-T-cell differentiation steps associated with β selection
4. The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3
5. Characterization of Pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-Myc and Pim-1 transgenic mice
6. Zinc finger protein GFI1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis
7. Zinc finger protein GFI1 cooperates with Myc and Pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2
8. Flow cytometric identification of murine neutrophils and monocytes
9. RAG1-deficient mice have no mature B and T lymphocytes
10. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
11. Enhanced TH1 activity and development of chronic enterocolitis in mice devoid of STAT3 in macrophages and neutrophils
12. Features of systemic lupus erythematosus in DNase 1-deficient mice