메뉴 건너뛰기




Volumn 1, Issue 4, 2006, Pages 403-427

Thymidylate synthase inhibitors

Author keywords

Capecitabine; Dihydropyrimidine dehydrogenase; Fluoropyrimidines; Pemetrexed; Thymidylate synthase

Indexed keywords

10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; 2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; 5 CHLORO 2,4 DIHYDROXYPYRIDINE; 5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; 5 ETHYNYLURACIL; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CISPLATIN; DOCETAXEL; EMITEFUR; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; LEVAMISOLE; MITOMYCIN C; NAVELBINE; NOLATREXED; OXALIPLATIN; PEMETREXED; PEPTIDE DERIVATIVE; PLEVITREXED; RALTITREXED; TAXANE DERIVATIVE; TEGAFUR; THYMIDYLATE SYNTHASE INHIBITOR; UFT; VACCINE;

EID: 33751252558     PISSN: 1872115X     EISSN: 1872115X     Source Type: Journal    
DOI: 10.1016/j.uct.2006.09.001     Document Type: Review
Times cited : (21)

References (225)
  • 1
    • 0035695106 scopus 로고    scopus 로고
    • Translational regulation as a novel mechanism for the development of cellular drug resistance
    • Schmitz J.C., Liu J., Lin X., Chen T.M., Yan W., Tai N., et al. Translational regulation as a novel mechanism for the development of cellular drug resistance. Cancer Metastasis Rev 20 1-2 (2001) 33-41
    • (2001) Cancer Metastasis Rev , vol.20 , Issue.1-2 , pp. 33-41
    • Schmitz, J.C.1    Liu, J.2    Lin, X.3    Chen, T.M.4    Yan, W.5    Tai, N.6
  • 3
    • 0033617219 scopus 로고    scopus 로고
    • Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation
    • Kitchens M.E., Forsthoefel A.M., Rafique Z., Spencer H.T., and Berger F.G. Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation. J Biol Chem 274 18 (1999) 12544-12547
    • (1999) J Biol Chem , vol.274 , Issue.18 , pp. 12544-12547
    • Kitchens, M.E.1    Forsthoefel, A.M.2    Rafique, Z.3    Spencer, H.T.4    Berger, F.G.5
  • 4
    • 32944460570 scopus 로고    scopus 로고
    • Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase
    • Pena M.M., Xing Y.Y., Koli S., and Berger F.G. Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase. Biochem J 394 Pt 1 (2006) 355-363
    • (2006) Biochem J , vol.394 , Issue.PART 1 , pp. 355-363
    • Pena, M.M.1    Xing, Y.Y.2    Koli, S.3    Berger, F.G.4
  • 5
    • 33646182010 scopus 로고    scopus 로고
    • Multi-level gene expression profiles affected by thymidylate synthase and 5-FU in colon cancer
    • Xi Y., Nakajima G., Schmitz J.C., Chu E., and Ju J. Multi-level gene expression profiles affected by thymidylate synthase and 5-FU in colon cancer. BMC Genom 7 1 (2006) 68
    • (2006) BMC Genom , vol.7 , Issue.1 , pp. 68
    • Xi, Y.1    Nakajima, G.2    Schmitz, J.C.3    Chu, E.4    Ju, J.5
  • 6
    • 1242316160 scopus 로고    scopus 로고
    • Small interfering double-stranded RNAs as therapeutic molecules to restore chemosensitivity to thymidylate synthase inhibitor compounds
    • Schmitz J.C., Chen T.M., and Chu E. Small interfering double-stranded RNAs as therapeutic molecules to restore chemosensitivity to thymidylate synthase inhibitor compounds. Cancer Res 64 4 (2004) 1431-1435
    • (2004) Cancer Res , vol.64 , Issue.4 , pp. 1431-1435
    • Schmitz, J.C.1    Chen, T.M.2    Chu, E.3
  • 7
    • 29144530156 scopus 로고    scopus 로고
    • Stable inhibition of human thymidylate synthase expression following retroviral introduction of an siRNA gene 12
    • Yang Z., Cloud A., Hughes D., and Johnson L.F. Stable inhibition of human thymidylate synthase expression following retroviral introduction of an siRNA gene 12. Cancer Gene Ther 13 1 (2006) 107-114
    • (2006) Cancer Gene Ther , vol.13 , Issue.1 , pp. 107-114
    • Yang, Z.1    Cloud, A.2    Hughes, D.3    Johnson, L.F.4
  • 8
    • 0037386357 scopus 로고    scopus 로고
    • A "combination oligonucleotide" antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance
    • Berg R.W., Ferguson P.J., Vincent M.D., and Koropatnick D.J. A "combination oligonucleotide" antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance. Cancer Gene Ther 10 4 (2003) 278-286
    • (2003) Cancer Gene Ther , vol.10 , Issue.4 , pp. 278-286
    • Berg, R.W.1    Ferguson, P.J.2    Vincent, M.D.3    Koropatnick, D.J.4
  • 9
    • 33748292931 scopus 로고    scopus 로고
    • Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil
    • Robinson H.M., Jones R., Walker M., Zachos G., Brown R., Cassidy J., et al. Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil. Oncogene (2006)
    • (2006) Oncogene
    • Robinson, H.M.1    Jones, R.2    Walker, M.3    Zachos, G.4    Brown, R.5    Cassidy, J.6
  • 10
    • 26944455210 scopus 로고    scopus 로고
    • 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine
    • Correale P., Del Vecchio M.T., Di Genova G., Savellini G.G., La Placa M., Terrosi C., et al. 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine. J Natl Cancer Inst 97 19 (2005) 1437-1445
    • (2005) J Natl Cancer Inst , vol.97 , Issue.19 , pp. 1437-1445
    • Correale, P.1    Del Vecchio, M.T.2    Di Genova, G.3    Savellini, G.G.4    La Placa, M.5    Terrosi, C.6
  • 11
    • 0034486207 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and the relationship with the clinical response to 5-fluorouracil
    • Aschele C., Debernardis D., Tunesi G., Maley F., and Sobrero A. Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and the relationship with the clinical response to 5-fluorouracil. Clin Cancer Res 6 (2000) 4797-4802
    • (2000) Clin Cancer Res , vol.6 , pp. 4797-4802
    • Aschele, C.1    Debernardis, D.2    Tunesi, G.3    Maley, F.4    Sobrero, A.5
  • 12
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston P.G., Lenz H.J., Leichman C.G., Danenberg K.D., Allegra C.J., Danenberg P.V., et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55 7 (1995) 1407-1412
    • (1995) Cancer Res , vol.55 , Issue.7 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3    Danenberg, K.D.4    Allegra, C.J.5    Danenberg, P.V.6
  • 13
    • 27344458501 scopus 로고    scopus 로고
    • The clinical significance of thymidylate synthase (TS) expression in primary colorectal cancer: an Intergroup combined analysis
    • [meeting abstracts]
    • Johnston P.G., Benson A., Catalano P., Eapen S., Wolmark N., Sargent D., et al. The clinical significance of thymidylate synthase (TS) expression in primary colorectal cancer: an Intergroup combined analysis. J Clin Oncol 23 16 Suppl. (2005) 3510 [meeting abstracts]
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL , pp. 3510
    • Johnston, P.G.1    Benson, A.2    Catalano, P.3    Eapen, S.4    Wolmark, N.5    Sargent, D.6
  • 14
    • 33745474963 scopus 로고    scopus 로고
    • 5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis
    • Kuramochi H., Hayashi K., Uchida K., Miyakura S., Shimizu D., Vallbohmer D., et al. 5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis. Int J Cancer (2006)
    • (2006) Int J Cancer
    • Kuramochi, H.1    Hayashi, K.2    Uchida, K.3    Miyakura, S.4    Shimizu, D.5    Vallbohmer, D.6
  • 15
    • 27144456276 scopus 로고    scopus 로고
    • Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients
    • Westra J.L., Hollema H., Schaapveld M., Platteel I., Oien K.A., Keith W.N., et al. Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients. Ann Oncol 16 10 (2005) 1646-1653
    • (2005) Ann Oncol , vol.16 , Issue.10 , pp. 1646-1653
    • Westra, J.L.1    Hollema, H.2    Schaapveld, M.3    Platteel, I.4    Oien, K.A.5    Keith, W.N.6
  • 16
    • 15444349773 scopus 로고    scopus 로고
    • p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site
    • Lenz H.J., Danenberg K.D., Leichman C.G., Florentine B., Johnston P.G., Groshen S., et al. p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site. Clin Cancer Res 4 5 (1998) 1227-1234
    • (1998) Clin Cancer Res , vol.4 , Issue.5 , pp. 1227-1234
    • Lenz, H.J.1    Danenberg, K.D.2    Leichman, C.G.3    Florentine, B.4    Johnston, P.G.5    Groshen, S.6
  • 17
    • 9044250848 scopus 로고    scopus 로고
    • Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival
    • Lenz H.J., Leichman C.G., Danenberg K.D., Danenberg P.V., Groshen S., Cohen H., et al. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol 14 1 (1996) 176-182
    • (1996) J Clin Oncol , vol.14 , Issue.1 , pp. 176-182
    • Lenz, H.J.1    Leichman, C.G.2    Danenberg, K.D.3    Danenberg, P.V.4    Groshen, S.5    Cohen, H.6
  • 18
    • 24944445619 scopus 로고    scopus 로고
    • Thymidylate synthase in nodal metastases: prognostic for chemosensitivity but not for adjuvant therapy?
    • Ahlgren J.D. Thymidylate synthase in nodal metastases: prognostic for chemosensitivity but not for adjuvant therapy?. J Clin Oncol 23 24 (2005) 5452-5454
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5452-5454
    • Ahlgren, J.D.1
  • 19
    • 24944441382 scopus 로고    scopus 로고
    • Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information
    • Ohrling K., Edler D., Hallstrom M., Ragnhammar P., and Blomgren H. Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information. J Clin Oncol 23 24 (2005) 5628-5634
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5628-5634
    • Ohrling, K.1    Edler, D.2    Hallstrom, M.3    Ragnhammar, P.4    Blomgren, H.5
  • 20
    • 1442290323 scopus 로고    scopus 로고
    • Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis
    • Popat S., Matakidou A., and Houlston R.S. Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 22 3 (2004) 529-536
    • (2004) J Clin Oncol , vol.22 , Issue.3 , pp. 529-536
    • Popat, S.1    Matakidou, A.2    Houlston, R.S.3
  • 21
    • 29844453626 scopus 로고    scopus 로고
    • Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase
    • Smorenburg C.H., Peters G.J., van Groeningen C.J., Noordhuis P., Smid K., van Riel A.M., et al. Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase. Ann Oncol 17 1 (2006) 35-42
    • (2006) Ann Oncol , vol.17 , Issue.1 , pp. 35-42
    • Smorenburg, C.H.1    Peters, G.J.2    van Groeningen, C.J.3    Noordhuis, P.4    Smid, K.5    van Riel, A.M.6
  • 22
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga D., Danenberg K.D., Johnson M., Metzger R., Groshen S., Tsao-Wei D.D., et al. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 6 4 (2000) 1322-1327
    • (2000) Clin Cancer Res , vol.6 , Issue.4 , pp. 1322-1327
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3    Metzger, R.4    Groshen, S.5    Tsao-Wei, D.D.6
  • 24
    • 0033975032 scopus 로고    scopus 로고
    • Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients
    • Paradiso A., Simone G., Petroni S., Leone B., Vallejo C., Lacava J., et al. Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients. Br J Cancer 82 3 (2000) 560-567
    • (2000) Br J Cancer , vol.82 , Issue.3 , pp. 560-567
    • Paradiso, A.1    Simone, G.2    Petroni, S.3    Leone, B.4    Vallejo, C.5    Lacava, J.6
  • 25
    • 0037364351 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites
    • Johnston P.G., Benson III A.B., Catalano P., Rao M.S., O'Dwyer P.J., and Allegra C.J. Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites. J Clin Oncol 21 5 (2003) 815-819
    • (2003) J Clin Oncol , vol.21 , Issue.5 , pp. 815-819
    • Johnston, P.G.1    Benson III, A.B.2    Catalano, P.3    Rao, M.S.4    O'Dwyer, P.J.5    Allegra, C.J.6
  • 26
    • 0037312517 scopus 로고    scopus 로고
    • Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
    • Ichikawa W., Uetake H., Shirota Y., Yamada H., Nishi N., Nihei Z., et al. Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin Cancer Res 9 2 (2003) 786-791
    • (2003) Clin Cancer Res , vol.9 , Issue.2 , pp. 786-791
    • Ichikawa, W.1    Uetake, H.2    Shirota, Y.3    Yamada, H.4    Nishi, N.5    Nihei, Z.6
  • 27
    • 0032520168 scopus 로고    scopus 로고
    • Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts
    • Ishikawa T., Sekiguchi F., Fukase Y., Sawada N., and Ishitsuka H. Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res 58 4 (1998) 685-690
    • (1998) Cancer Res , vol.58 , Issue.4 , pp. 685-690
    • Ishikawa, T.1    Sekiguchi, F.2    Fukase, Y.3    Sawada, N.4    Ishitsuka, H.5
  • 28
    • 31444431779 scopus 로고    scopus 로고
    • Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)-novel predictors for response and survival in gastric cancer patients
    • Goekkurt E., Hoehn S., Wolschke C., Wittmer C., Stueber C., Hossfeld D.K., et al. Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)-novel predictors for response and survival in gastric cancer patients. Br J Cancer 94 2 (2006) 281-286
    • (2006) Br J Cancer , vol.94 , Issue.2 , pp. 281-286
    • Goekkurt, E.1    Hoehn, S.2    Wolschke, C.3    Wittmer, C.4    Stueber, C.5    Hossfeld, D.K.6
  • 29
    • 33745076752 scopus 로고    scopus 로고
    • Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response
    • Matsuyama R., Togo S., Shimizu D., Momiyama N., Ishikawa T., Ichikawa Y., et al. Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. Int J Cancer (2006)
    • (2006) Int J Cancer
    • Matsuyama, R.1    Togo, S.2    Shimizu, D.3    Momiyama, N.4    Ishikawa, T.5    Ichikawa, Y.6
  • 30
    • 33646389260 scopus 로고    scopus 로고
    • Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy
    • Ochiai T., Nishimura K., Noguchi H., Kitajima M., Tsukada A., Watanabe E., et al. Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy. Int J Cancer 118 12 (2006) 3084-3088
    • (2006) Int J Cancer , vol.118 , Issue.12 , pp. 3084-3088
    • Ochiai, T.1    Nishimura, K.2    Noguchi, H.3    Kitajima, M.4    Tsukada, A.5    Watanabe, E.6
  • 32
    • 4444339951 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
    • Lecomte T., Ferraz J.M., Zinzindohoue F., Loriot M.A., Tregouet D.A., Landi B., et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res 10 17 (2004) 5880-5888
    • (2004) Clin Cancer Res , vol.10 , Issue.17 , pp. 5880-5888
    • Lecomte, T.1    Ferraz, J.M.2    Zinzindohoue, F.3    Loriot, M.A.4    Tregouet, D.A.5    Landi, B.6
  • 33
    • 0037567591 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
    • Mandola M.V., Stoehlmacher J., Muller-Weeks S., Cesarone G., Yu M.C., Lenz H.J., et al. A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 63 11 (2003) 2898-2904
    • (2003) Cancer Res , vol.63 , Issue.11 , pp. 2898-2904
    • Mandola, M.V.1    Stoehlmacher, J.2    Muller-Weeks, S.3    Cesarone, G.4    Yu, M.C.5    Lenz, H.J.6
  • 34
    • 0141507954 scopus 로고    scopus 로고
    • Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene
    • Kawakami K., and Watanabe G. Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 63 18 (2003) 6004-6007
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 6004-6007
    • Kawakami, K.1    Watanabe, G.2
  • 35
    • 7244258790 scopus 로고    scopus 로고
    • Single nucleotide polymorphism in the 5′ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients
    • Marcuello E., Altes A., del Rio E., Cesar A., Menoyo A., and Baiget M. Single nucleotide polymorphism in the 5′ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. Int J Cancer 112 5 (2004) 733-737
    • (2004) Int J Cancer , vol.112 , Issue.5 , pp. 733-737
    • Marcuello, E.1    Altes, A.2    del Rio, E.3    Cesar, A.4    Menoyo, A.5    Baiget, M.6
  • 36
    • 0034518362 scopus 로고    scopus 로고
    • Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene
    • Ulrich C.M., Bigler J., Velicer C.M., Greene E.A., Farin F.M., and Potter J.D. Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev 9 12 (2000) 1381-1385
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , Issue.12 , pp. 1381-1385
    • Ulrich, C.M.1    Bigler, J.2    Velicer, C.M.3    Greene, E.A.4    Farin, F.M.5    Potter, J.D.6
  • 37
    • 2442480694 scopus 로고    scopus 로고
    • A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
    • Mandola M.V., Stoehlmacher J., Zhang W., Groshen S., Yu M.C., Iqbal S., et al. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 14 5 (2004) 319-327
    • (2004) Pharmacogenetics , vol.14 , Issue.5 , pp. 319-327
    • Mandola, M.V.1    Stoehlmacher, J.2    Zhang, W.3    Groshen, S.4    Yu, M.C.5    Iqbal, S.6
  • 38
    • 0842306407 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of systemic toxicity and response after 5-fluorouracil (5-FU)/CPT-11, 5-FU/oxaliplatin (oxal), or CPT-11/oxal therapy for advanced colorectal cancer
    • McLeod H.L., Sargent D., Marsh S., Fuchs C.S., Ramanathan R.K., Williamson S.K., et al. Pharmacogenetic analysis of systemic toxicity and response after 5-fluorouracil (5-FU)/CPT-11, 5-FU/oxaliplatin (oxal), or CPT-11/oxal therapy for advanced colorectal cancer. Proc Am Soc Clin Oncol 22 (2003) 52
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 52
    • McLeod, H.L.1    Sargent, D.2    Marsh, S.3    Fuchs, C.S.4    Ramanathan, R.K.5    Williamson, S.K.6
  • 39
    • 25144481273 scopus 로고    scopus 로고
    • Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil
    • Hitre E., Budai B., Adleff V., Czegledi F., Horvath Z., Gyergyay F., et al. Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil. Pharmacogenet Genom 15 10 (2005) 723-730
    • (2005) Pharmacogenet Genom , vol.15 , Issue.10 , pp. 723-730
    • Hitre, E.1    Budai, B.2    Adleff, V.3    Czegledi, F.4    Horvath, Z.5    Gyergyay, F.6
  • 40
    • 33751239379 scopus 로고    scopus 로고
    • Pharmacogenetic study in patients (pts) with metastatic breast (MBC) and colorectal cancer (MCRC) treated with capecitabine (C)
    • Alba E., Ribelles N., Sanchez A., Lopez Siles J., Sanchez M.J., Gonzalez E., et al. Pharmacogenetic study in patients (pts) with metastatic breast (MBC) and colorectal cancer (MCRC) treated with capecitabine (C). Eur J Cancer 3 2 (2005) 66
    • (2005) Eur J Cancer , vol.3 , Issue.2 , pp. 66
    • Alba, E.1    Ribelles, N.2    Sanchez, A.3    Lopez Siles, J.4    Sanchez, M.J.5    Gonzalez, E.6
  • 41
    • 0242658929 scopus 로고    scopus 로고
    • Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
    • Ichikawa W., Uetake H., Shirota Y., Yamada H., Takahashi T., Nihei Z., et al. Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Br J Cancer 89 8 (2003) 1486-1492
    • (2003) Br J Cancer , vol.89 , Issue.8 , pp. 1486-1492
    • Ichikawa, W.1    Uetake, H.2    Shirota, Y.3    Yamada, H.4    Takahashi, T.5    Nihei, Z.6
  • 42
    • 0035430619 scopus 로고    scopus 로고
    • Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion
    • Uchida K., Hayashi K., Kuramochi H., and Takasaki K. Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion. Int J Oncol 19 2 (2001) 341-346
    • (2001) Int J Oncol , vol.19 , Issue.2 , pp. 341-346
    • Uchida, K.1    Hayashi, K.2    Kuramochi, H.3    Takasaki, K.4
  • 43
    • 0141455146 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil
    • Kornmann M., Schwabe W., Sander S., Kron M., Strater J., Polat S., et al. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. Clin Cancer Res 9 11 (2003) 4116-4124
    • (2003) Clin Cancer Res , vol.9 , Issue.11 , pp. 4116-4124
    • Kornmann, M.1    Schwabe, W.2    Sander, S.3    Kron, M.4    Strater, J.5    Polat, S.6
  • 44
    • 0037096901 scopus 로고    scopus 로고
    • Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses
    • Etienne M.C., Chazal M., Laurent-Puig P., Magne N., Rosty C., Formento J.L., et al. Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses. J Clin Oncol 20 12 (2002) 2832-2843
    • (2002) J Clin Oncol , vol.20 , Issue.12 , pp. 2832-2843
    • Etienne, M.C.1    Chazal, M.2    Laurent-Puig, P.3    Magne, N.4    Rosty, C.5    Formento, J.L.6
  • 45
    • 0031890613 scopus 로고    scopus 로고
    • Co-variables influencing 5-fluorouracil clearance during continuous venous infusion. A NONMEM analysis
    • Etienne M.C., Chatelut E., Pivot X., Lavit M., Pujol A., Canal P., et al. Co-variables influencing 5-fluorouracil clearance during continuous venous infusion. A NONMEM analysis. Eur J Cancer 34 1 (1998) 92-97
    • (1998) Eur J Cancer , vol.34 , Issue.1 , pp. 92-97
    • Etienne, M.C.1    Chatelut, E.2    Pivot, X.3    Lavit, M.4    Pujol, A.5    Canal, P.6
  • 46
    • 0028006858 scopus 로고
    • Population study of dihydropyrimidine dehydrogenase in cancer patients
    • Etienne M.-C., Lagrange J.L., Dassonville O., et al. Population study of dihydropyrimidine dehydrogenase in cancer patients. J Clin Oncol 12 (1994) 2248-2253
    • (1994) J Clin Oncol , vol.12 , pp. 2248-2253
    • Etienne, M.-C.1    Lagrange, J.L.2    Dassonville, O.3
  • 47
    • 0034782963 scopus 로고    scopus 로고
    • Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients
    • Di Paolo A., Danesi R., Falcone A., Cionini L., Vannozzi F., Masi G., et al. Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients. Ann Oncol 12 9 (2001) 1301-1306
    • (2001) Ann Oncol , vol.12 , Issue.9 , pp. 1301-1306
    • Di Paolo, A.1    Danesi, R.2    Falcone, A.3    Cionini, L.4    Vannozzi, F.5    Masi, G.6
  • 48
    • 6344247602 scopus 로고    scopus 로고
    • Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics
    • Jiang H., Lu J., Jiang J., and Hu P. Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics. J Clin Pharmacol 44 11 (2004) 1260-1272
    • (2004) J Clin Pharmacol , vol.44 , Issue.11 , pp. 1260-1272
    • Jiang, H.1    Lu, J.2    Jiang, J.3    Hu, P.4
  • 49
    • 1942502420 scopus 로고    scopus 로고
    • Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test
    • Mattison L.K., Ezzeldin H., Carpenter M., Modak A., Johnson M.R., and Diasio R.B. Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test. Clin Cancer Res 10 8 (2004) 2652-2658
    • (2004) Clin Cancer Res , vol.10 , Issue.8 , pp. 2652-2658
    • Mattison, L.K.1    Ezzeldin, H.2    Carpenter, M.3    Modak, A.4    Johnson, M.R.5    Diasio, R.B.6
  • 50
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
    • Van Kuilenburg A.B. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 40 7 (2004) 939-950
    • (2004) Eur J Cancer , vol.40 , Issue.7 , pp. 939-950
    • Van Kuilenburg, A.B.1
  • 51
    • 0034808681 scopus 로고    scopus 로고
    • Prevalence of a common point mutation in the Dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls
    • Raida M., Schwabe W., Hausler P., Van Kuilenburg A.B.P., Van Gennip A.H., Behnke D., et al. Prevalence of a common point mutation in the Dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls. Clin Cancer Res 7 9 (2001) 2832-2839
    • (2001) Clin Cancer Res , vol.7 , Issue.9 , pp. 2832-2839
    • Raida, M.1    Schwabe, W.2    Hausler, P.3    Van Kuilenburg, A.B.P.4    Van Gennip, A.H.5    Behnke, D.6
  • 52
    • 0037041639 scopus 로고    scopus 로고
    • Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene
    • Maring J.G., Van Kuilenburg A.B.P., Haasjes J., Piersma H., Groen H.J.M., Uges D.R.A., et al. Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene. Br J Cancer 86 7 (2002) 1028-1033
    • (2002) Br J Cancer , vol.86 , Issue.7 , pp. 1028-1033
    • Maring, J.G.1    Van Kuilenburg, A.B.P.2    Haasjes, J.3    Piersma, H.4    Groen, H.J.M.5    Uges, D.R.A.6
  • 53
    • 0036798968 scopus 로고    scopus 로고
    • High prevalence of the IVS14 + 1G > A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity
    • Van Kuilenburg A.B.P., Meinsma R., Zoetekouw L., and Van Gennip A.H. High prevalence of the IVS14 + 1G > A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity. Pharmacogenetics 12 7 (2002) 555-558
    • (2002) Pharmacogenetics , vol.12 , Issue.7 , pp. 555-558
    • Van Kuilenburg, A.B.P.1    Meinsma, R.2    Zoetekouw, L.3    Van Gennip, A.H.4
  • 54
    • 0034488052 scopus 로고    scopus 로고
    • Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene
    • Van Kuilenburg A.B.P., Haasjes J., Richel D.J., Zoetekouw L., Van Lenthe H., De Abreu R.A., et al. Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. Clin Cancer Res 6 12 (2000) 4705-4712
    • (2000) Clin Cancer Res , vol.6 , Issue.12 , pp. 4705-4712
    • Van Kuilenburg, A.B.P.1    Haasjes, J.2    Richel, D.J.3    Zoetekouw, L.4    Van Lenthe, H.5    De Abreu, R.A.6
  • 55
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10 1 (1995) 111-113
    • (1995) Nat Genet , vol.10 , Issue.1 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 56
    • 1342301546 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity
    • Etienne M.C., Ilc K., Formento J.L., Laurent-Puig P., Formento P., Cheradame S., et al. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity. Br J Cancer 90 2 (2004) 526-534
    • (2004) Br J Cancer , vol.90 , Issue.2 , pp. 526-534
    • Etienne, M.C.1    Ilc, K.2    Formento, J.L.3    Laurent-Puig, P.4    Formento, P.5    Cheradame, S.6
  • 57
    • 1042292043 scopus 로고    scopus 로고
    • Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate
    • Sohn K.J., Croxford R., Yates Z., Lucock M., and Kim Y.I. Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J Natl Cancer Inst 96 2 (2004) 134-144
    • (2004) J Natl Cancer Inst , vol.96 , Issue.2 , pp. 134-144
    • Sohn, K.J.1    Croxford, R.2    Yates, Z.3    Lucock, M.4    Kim, Y.I.5
  • 58
    • 0037990003 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy
    • Cohen V., Panet-Raymond V., Sabbaghian N., Morin I., Batist G., and Rozen R. Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. Clin Cancer Res 9 5 (2003) 1611-1615
    • (2003) Clin Cancer Res , vol.9 , Issue.5 , pp. 1611-1615
    • Cohen, V.1    Panet-Raymond, V.2    Sabbaghian, N.3    Morin, I.4    Batist, G.5    Rozen, R.6
  • 59
    • 14944380124 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity
    • Jakobsen A., Nielsen J.N., Gyldenkerne N., and Lindeberg J. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol 23 7 (2005) 1365-1369
    • (2005) J Clin Oncol , vol.23 , Issue.7 , pp. 1365-1369
    • Jakobsen, A.1    Nielsen, J.N.2    Gyldenkerne, N.3    Lindeberg, J.4
  • 60
    • 19944428095 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients
    • Etienne M.C., Formento J.L., Chazal M., Francoual M., Magne N., Formento P., et al. Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients. Pharmacogenetics 14 12 (2004) 785-792
    • (2004) Pharmacogenetics , vol.14 , Issue.12 , pp. 785-792
    • Etienne, M.C.1    Formento, J.L.2    Chazal, M.3    Francoual, M.4    Magne, N.5    Formento, P.6
  • 61
    • 31444452927 scopus 로고    scopus 로고
    • The prognostic significance of genetic polymorphisms (methylenetetrahydrofolate reductase C677T, methionine synthase A2756G, thymidilate synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma
    • Sarbia M., Stahl M., von Weyhern C., Weirich G., and Puhringer-Oppermann F. The prognostic significance of genetic polymorphisms (methylenetetrahydrofolate reductase C677T, methionine synthase A2756G, thymidilate synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma. Br J Cancer 94 2 (2006) 203-207
    • (2006) Br J Cancer , vol.94 , Issue.2 , pp. 203-207
    • Sarbia, M.1    Stahl, M.2    von Weyhern, C.3    Weirich, G.4    Puhringer-Oppermann, F.5
  • 62
    • 0034114654 scopus 로고    scopus 로고
    • Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors
    • van Triest B., Pinedo H.M., Giaccone G., and Peters G.J. Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors. Ann Oncol 11 4 (2000) 385-391
    • (2000) Ann Oncol , vol.11 , Issue.4 , pp. 385-391
    • van Triest, B.1    Pinedo, H.M.2    Giaccone, G.3    Peters, G.J.4
  • 63
    • 4143083857 scopus 로고    scopus 로고
    • 5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers
    • Noordhuis P., Holwerda U., van der Wilt C.L., van Groeningen C.J., Smid K., Meijer S., et al. 5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers. Ann Oncol 15 7 (2004) 1025-1032
    • (2004) Ann Oncol , vol.15 , Issue.7 , pp. 1025-1032
    • Noordhuis, P.1    Holwerda, U.2    van der Wilt, C.L.3    van Groeningen, C.J.4    Smid, K.5    Meijer, S.6
  • 64
    • 0033178019 scopus 로고    scopus 로고
    • Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs
    • Ackland S.P., and Peters G.J. Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs. Drug Resist Updat 2 4 (1999) 205-214
    • (1999) Drug Resist Updat , vol.2 , Issue.4 , pp. 205-214
    • Ackland, S.P.1    Peters, G.J.2
  • 65
    • 0037436280 scopus 로고    scopus 로고
    • Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells
    • de Bruin M., Smid K., Laan A.C., Noordhuis P., Fukushima M., Hoekman K., et al. Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells. Biochem Biophys Res Commun 301 3 (2003) 675-679
    • (2003) Biochem Biophys Res Commun , vol.301 , Issue.3 , pp. 675-679
    • de Bruin, M.1    Smid, K.2    Laan, A.C.3    Noordhuis, P.4    Fukushima, M.5    Hoekman, K.6
  • 66
    • 10344262925 scopus 로고    scopus 로고
    • Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate
    • de Bruin M., van Capel T., Smid K., van der B.K., Fukushima M., Hoekman K., et al. Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate. Nucleosides Nucleotides Nucleic Acids 23 8-9 (2004) 1485-1490
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , Issue.8-9 , pp. 1485-1490
    • de Bruin, M.1    van Capel, T.2    Smid, K.3    van der, B.K.4    Fukushima, M.5    Hoekman, K.6
  • 67
    • 29244451374 scopus 로고    scopus 로고
    • Development of stealth liposome formulation of 2′-deoxyinosine as 5-fluorouracil modulator: in vitro and in vivo study
    • Fanciullino R., Giacometti S., Aubert C., Fina F., Martin P.M., Piccerelle P., et al. Development of stealth liposome formulation of 2′-deoxyinosine as 5-fluorouracil modulator: in vitro and in vivo study. Pharm Res 22 12 (2005) 2051-2057
    • (2005) Pharm Res , vol.22 , Issue.12 , pp. 2051-2057
    • Fanciullino, R.1    Giacometti, S.2    Aubert, C.3    Fina, F.4    Martin, P.M.5    Piccerelle, P.6
  • 68
    • 0038575246 scopus 로고    scopus 로고
    • Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer
    • Saini A., Norman A.R., Cunningham D., Chau I., Hill M., Tait D., et al. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer. Br J Cancer 88 12 (2003) 1859-1865
    • (2003) Br J Cancer , vol.88 , Issue.12 , pp. 1859-1865
    • Saini, A.1    Norman, A.R.2    Cunningham, D.3    Chau, I.4    Hill, M.5    Tait, D.6
  • 69
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg R.M., Sargent D.J., Morton R.F., Fuchs C.S., Ramanathan R.K., Williamson S.K., et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22 1 (2004) 23-30
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3    Fuchs, C.S.4    Ramanathan, R.K.5    Williamson, S.K.6
  • 70
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • Andre T., Boni C., Mounedji-Boudiaf L., Navarro M., Tabernero J., Hickish T., et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350 23 (2004) 2343-2351
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2343-2351
    • Andre, T.1    Boni, C.2    Mounedji-Boudiaf, L.3    Navarro, M.4    Tabernero, J.5    Hickish, T.6
  • 71
    • 24344476396 scopus 로고    scopus 로고
    • A phase III trial comparing FULV to FULV + oxaliplatin in stage II or III carcinoma of the colon: results of NSABP Protocol C-07
    • [meeting abstracts]
    • Wolmark N., Wieand S., Kuebler J.P., Colangelo L., and Smith R.E. A phase III trial comparing FULV to FULV + oxaliplatin in stage II or III carcinoma of the colon: results of NSABP Protocol C-07. J Clin Oncol 23 16 Suppl. (2005) LBA3500 [meeting abstracts]
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL
    • Wolmark, N.1    Wieand, S.2    Kuebler, J.P.3    Colangelo, L.4    Smith, R.E.5
  • 72
    • 2542563257 scopus 로고    scopus 로고
    • Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much?
    • Gill S., Loprinzi C.L., Sargent D.J., Thome S.D., Alberts S.R., Haller D.G., et al. Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much?. J Clin Oncol 22 10 (2004) 1797-1806
    • (2004) J Clin Oncol , vol.22 , Issue.10 , pp. 1797-1806
    • Gill, S.1    Loprinzi, C.L.2    Sargent, D.J.3    Thome, S.D.4    Alberts, S.R.5    Haller, D.G.6
  • 73
    • 3242657624 scopus 로고    scopus 로고
    • QUASAR: a randomized study of adjuvant chemotherapy (CT) vs observation including 3238 colorectal cancer patients
    • Gray R.G., Barnwell J., Hills R., McConkey C., Williams N., Kerr D., et al. QUASAR: a randomized study of adjuvant chemotherapy (CT) vs observation including 3238 colorectal cancer patients. J Clin Oncol 22 14s (2004) 3501
    • (2004) J Clin Oncol , vol.22 , Issue.14 s , pp. 3501
    • Gray, R.G.1    Barnwell, J.2    Hills, R.3    McConkey, C.4    Williams, N.5    Kerr, D.6
  • 74
    • 0035076059 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of capecitabine
    • Reigner B., Blesch K., and Weidekamm E. Clinical pharmacokinetics of capecitabine. Clin Pharmacokinet 40 2 (2001) 85-104
    • (2001) Clin Pharmacokinet , vol.40 , Issue.2 , pp. 85-104
    • Reigner, B.1    Blesch, K.2    Weidekamm, E.3
  • 75
    • 0037430035 scopus 로고    scopus 로고
    • Penetration of capecitabine and its metabolites into malignant and healthy tissues of patients with advanced breast cancer
    • Mader R.M., Schrolnberger C., Rizovski B., Brunner M., Wenzel C., Locker G., et al. Penetration of capecitabine and its metabolites into malignant and healthy tissues of patients with advanced breast cancer. Br J Cancer 88 5 (2003) 782-787
    • (2003) Br J Cancer , vol.88 , Issue.5 , pp. 782-787
    • Mader, R.M.1    Schrolnberger, C.2    Rizovski, B.3    Brunner, M.4    Wenzel, C.5    Locker, G.6
  • 76
    • 14444280873 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients
    • Reigner B., Verweij J., Dirix L., Cassidy J., Twelves C., Allman D., et al. Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients. Clin Cancer Res 4 4 (1998) 941-948
    • (1998) Clin Cancer Res , vol.4 , Issue.4 , pp. 941-948
    • Reigner, B.1    Verweij, J.2    Dirix, L.3    Cassidy, J.4    Twelves, C.5    Allman, D.6
  • 77
    • 0034895187 scopus 로고    scopus 로고
    • Effect of food on the oral bioavailability of UFT and leucovorin in cancer patients
    • Damle B., Ravandi F., Kaul S., Sonnichsen D., Ferreira I., Brooks D., et al. Effect of food on the oral bioavailability of UFT and leucovorin in cancer patients. Clin Cancer Res 7 3 (2001) 517-523
    • (2001) Clin Cancer Res , vol.7 , Issue.3 , pp. 517-523
    • Damle, B.1    Ravandi, F.2    Kaul, S.3    Sonnichsen, D.4    Ferreira, I.5    Brooks, D.6
  • 78
    • 32944475687 scopus 로고    scopus 로고
    • An adverse interaction between warfarin and fluoropyrimidines revisited
    • Saif M.W. An adverse interaction between warfarin and fluoropyrimidines revisited. Clin Colorectal Cancer 5 3 (2005) 175-180
    • (2005) Clin Colorectal Cancer , vol.5 , Issue.3 , pp. 175-180
    • Saif, M.W.1
  • 79
    • 23044454675 scopus 로고    scopus 로고
    • Significant effect of capecitabine on the pharmacokinetics and pharmacodynamics of warfarin in patients with cancer
    • Camidge R., Reigner B., Cassidy J., Grange S., Abt M., Weidekamm E., et al. Significant effect of capecitabine on the pharmacokinetics and pharmacodynamics of warfarin in patients with cancer. J Clin Oncol 23 21 (2005) 4719-4725
    • (2005) J Clin Oncol , vol.23 , Issue.21 , pp. 4719-4725
    • Camidge, R.1    Reigner, B.2    Cassidy, J.3    Grange, S.4    Abt, M.5    Weidekamm, E.6
  • 80
    • 33244481095 scopus 로고    scopus 로고
    • A retrospective study of coagulation abnormalities in patients receiving concomitant capecitabine and warfarin
    • Shah H.R., Ledbetter L., Diasio R., and Saif M.W. A retrospective study of coagulation abnormalities in patients receiving concomitant capecitabine and warfarin. Clin Colorectal Cancer 5 5 (2006) 354-358
    • (2006) Clin Colorectal Cancer , vol.5 , Issue.5 , pp. 354-358
    • Shah, H.R.1    Ledbetter, L.2    Diasio, R.3    Saif, M.W.4
  • 81
    • 20144386870 scopus 로고    scopus 로고
    • A phase I clinical and pharmacokinetic study of capecitabine (Xeloda((R))) and irinotecan combination therapy (XELIRI) in patients with metastatic gastrointestinal tumours
    • Delord J.P., Pierga J.Y., Dieras V., Bertheault-Cvitkovic F., Turpin F.L., Lokiec F., et al. A phase I clinical and pharmacokinetic study of capecitabine (Xeloda((R))) and irinotecan combination therapy (XELIRI) in patients with metastatic gastrointestinal tumours. Br J Cancer 92 5 (2005) 820-826
    • (2005) Br J Cancer , vol.92 , Issue.5 , pp. 820-826
    • Delord, J.P.1    Pierga, J.Y.2    Dieras, V.3    Bertheault-Cvitkovic, F.4    Turpin, F.L.5    Lokiec, F.6
  • 82
    • 18244414936 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors
    • van Groeningen C.J., Peters G.J., Schornagel J.H., Gall H., Noordhuis P., de Vries M.J., et al. Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors. J Clin Oncol 18 14 (2000) 2772-2779
    • (2000) J Clin Oncol , vol.18 , Issue.14 , pp. 2772-2779
    • van Groeningen, C.J.1    Peters, G.J.2    Schornagel, J.H.3    Gall, H.4    Noordhuis, P.5    de Vries, M.J.6
  • 83
    • 0041903833 scopus 로고    scopus 로고
    • Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors
    • Peters G.J., Noordhuis P., Van Kuilenburg A.B.P., Schornagel J.H., Gall H., Turner S.L., et al. Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors. Cancer Chemother Pharmacol 52 1 (2003) 1-12
    • (2003) Cancer Chemother Pharmacol , vol.52 , Issue.1 , pp. 1-12
    • Peters, G.J.1    Noordhuis, P.2    Van Kuilenburg, A.B.P.3    Schornagel, J.H.4    Gall, H.5    Turner, S.L.6
  • 84
    • 9344240455 scopus 로고    scopus 로고
    • Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5′-deoxy-5-fluorouridine on human keratinocytes
    • Fischel J.L., Formento P., Ciccolini J., Etienne-Grimaldi M.C., and Milano G. Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5′-deoxy-5-fluorouridine on human keratinocytes. Anticancer Drugs 15 10 (2004) 969-974
    • (2004) Anticancer Drugs , vol.15 , Issue.10 , pp. 969-974
    • Fischel, J.L.1    Formento, P.2    Ciccolini, J.3    Etienne-Grimaldi, M.C.4    Milano, G.5
  • 85
    • 22144479717 scopus 로고    scopus 로고
    • The frequency and pattern of cardiotoxicity observed with capecitabine used in conjunction with oxaliplatin in patients treated for advanced colorectal cancer (CRC)
    • Ng M., Cunningham D., and Norman A.R. The frequency and pattern of cardiotoxicity observed with capecitabine used in conjunction with oxaliplatin in patients treated for advanced colorectal cancer (CRC). Eur J Cancer 41 11 (2005) 1542-1546
    • (2005) Eur J Cancer , vol.41 , Issue.11 , pp. 1542-1546
    • Ng, M.1    Cunningham, D.2    Norman, A.R.3
  • 86
    • 11144354462 scopus 로고    scopus 로고
    • Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials
    • van Cutsem E., Hoff P.M., Harper P., Bukowski R.M., Cunningham D., Dufour P., et al. Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials. Br J Cancer 90 6 (2004) 1190-1197
    • (2004) Br J Cancer , vol.90 , Issue.6 , pp. 1190-1197
    • van Cutsem, E.1    Hoff, P.M.2    Harper, P.3    Bukowski, R.M.4    Cunningham, D.5    Dufour, P.6
  • 87
    • 31544437749 scopus 로고    scopus 로고
    • A randomised cross-over trial comparing patient preference for oral capecitabine and 5-fluorouracil/leucovorin regimens in patients with advanced colorectal cancer
    • Twelves C., Gollins S., Grieve R., and Samuel L. A randomised cross-over trial comparing patient preference for oral capecitabine and 5-fluorouracil/leucovorin regimens in patients with advanced colorectal cancer. Ann Oncol 17 2 (2006) 239-245
    • (2006) Ann Oncol , vol.17 , Issue.2 , pp. 239-245
    • Twelves, C.1    Gollins, S.2    Grieve, R.3    Samuel, L.4
  • 89
    • 33646142547 scopus 로고    scopus 로고
    • Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial
    • Cassidy J., Douillard J.Y., Twelves C., McKendrick J.J., Scheithauer W., Bustova I., et al. Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial. Br J Cancer 94 8 (2006) 1122-1129
    • (2006) Br J Cancer , vol.94 , Issue.8 , pp. 1122-1129
    • Cassidy, J.1    Douillard, J.Y.2    Twelves, C.3    McKendrick, J.J.4    Scheithauer, W.5    Bustova, I.6
  • 90
    • 2942638081 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer
    • Cassidy J., Tabernero J., Twelves C., Brunet R., Butts C., Conroy T., et al. XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol 22 11 (2004) 2084-2091
    • (2004) J Clin Oncol , vol.22 , Issue.11 , pp. 2084-2091
    • Cassidy, J.1    Tabernero, J.2    Twelves, C.3    Brunet, R.4    Butts, C.5    Conroy, T.6
  • 91
    • 9144255466 scopus 로고    scopus 로고
    • Randomized multicenter Phase II trial of two different schedules of irinotecan combined with capecitabine as first-line treatment in metastatic colorectal carcinoma
    • Bajetta E., Di Bartolomeo M., Mariani L., Cassata A., Artale S., Frustaci S., et al. Randomized multicenter Phase II trial of two different schedules of irinotecan combined with capecitabine as first-line treatment in metastatic colorectal carcinoma. Cancer 100 2 (2004) 279-287
    • (2004) Cancer , vol.100 , Issue.2 , pp. 279-287
    • Bajetta, E.1    Di Bartolomeo, M.2    Mariani, L.3    Cassata, A.4    Artale, S.5    Frustaci, S.6
  • 92
    • 20044384354 scopus 로고    scopus 로고
    • A randomized phase II trial of capecitabine and two different schedules of irinotecan in first-line treatment of metastatic colorectal cancer: efficacy, quality-of-life and toxicity
    • Borner M.M., Bernhard J., Dietrich D., Popescu R., Wernli M., Saletti P., et al. A randomized phase II trial of capecitabine and two different schedules of irinotecan in first-line treatment of metastatic colorectal cancer: efficacy, quality-of-life and toxicity. Ann Oncol 16 2 (2005) 282-288
    • (2005) Ann Oncol , vol.16 , Issue.2 , pp. 282-288
    • Borner, M.M.1    Bernhard, J.2    Dietrich, D.3    Popescu, R.4    Wernli, M.5    Saletti, P.6
  • 93
    • 21344457969 scopus 로고    scopus 로고
    • A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer
    • Rea D.W., Nortier J.W., Bokkel Huinink W.W., Falk S., Richel D.J., Maughan T., et al. A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer. Ann Oncol 16 7 (2005) 1123-1132
    • (2005) Ann Oncol , vol.16 , Issue.7 , pp. 1123-1132
    • Rea, D.W.1    Nortier, J.W.2    Bokkel Huinink, W.W.3    Falk, S.4    Richel, D.J.5    Maughan, T.6
  • 94
    • 21844472538 scopus 로고    scopus 로고
    • Results of a phase II open-label study of capecitabine in combination with irinotecan as first-line treatment for metastatic colorectal cancer
    • Cartwright T., Lopez T., Vukelja S.J., Encarnacion C., Boehm K.A., and Asmar L. Results of a phase II open-label study of capecitabine in combination with irinotecan as first-line treatment for metastatic colorectal cancer. Clin Colorectal Cancer 5 1 (2005) 50-56
    • (2005) Clin Colorectal Cancer , vol.5 , Issue.1 , pp. 50-56
    • Cartwright, T.1    Lopez, T.2    Vukelja, S.J.3    Encarnacion, C.4    Boehm, K.A.5    Asmar, L.6
  • 95
    • 33751227751 scopus 로고    scopus 로고
    • Initial safety findings from a phase III study of capecitabine (X) plus oxaliplatin (XELOX) vs. infusional 5-FU/LV plus oxaliplatin (FOLFOX-6) in first-line treatment of patients (pts) with metastatic colorectal cancer (MCRC)
    • Bennouna J., Lledo G., Ychou M., Conroy T., Hebbar M., Adenis A., et al. Initial safety findings from a phase III study of capecitabine (X) plus oxaliplatin (XELOX) vs. infusional 5-FU/LV plus oxaliplatin (FOLFOX-6) in first-line treatment of patients (pts) with metastatic colorectal cancer (MCRC). Eur J Cancer 3 Suppl. 2 (2005) 179
    • (2005) Eur J Cancer , vol.3 , Issue.SUPPL. 2 , pp. 179
    • Bennouna, J.1    Lledo, G.2    Ychou, M.3    Conroy, T.4    Hebbar, M.5    Adenis, A.6
  • 96
    • 33645731984 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer
    • Feliu J., Salud A., Escudero P., Lopez-Gomez L., Bolanos M., Galan A., et al. XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer. Br J Cancer 94 7 (2006) 969-975
    • (2006) Br J Cancer , vol.94 , Issue.7 , pp. 969-975
    • Feliu, J.1    Salud, A.2    Escudero, P.3    Lopez-Gomez, L.4    Bolanos, M.5    Galan, A.6
  • 97
    • 33644987078 scopus 로고    scopus 로고
    • Infusional 5-fluorouracil/folinic acid plus oxaliplatin (FUFOX) versus Capecitabine plus oxaliplatin (CAPOX) as first line treatment of metaststic colorectal carcinoma (MCRC): results of the safety and efficacy analysis
    • Arkenau H.T., Kubicka S., Greil R., Schmoll H., Seufferlein T., Greaven U., et al. Infusional 5-fluorouracil/folinic acid plus oxaliplatin (FUFOX) versus Capecitabine plus oxaliplatin (CAPOX) as first line treatment of metaststic colorectal carcinoma (MCRC): results of the safety and efficacy analysis. Eur J Cancer 3 Suppl. 2 (2005) 168
    • (2005) Eur J Cancer , vol.3 , Issue.SUPPL. 2 , pp. 168
    • Arkenau, H.T.1    Kubicka, S.2    Greil, R.3    Schmoll, H.4    Seufferlein, T.5    Greaven, U.6
  • 98
    • 33644664586 scopus 로고    scopus 로고
    • The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been?
    • Glynne-Jones R., Dunst J., and Sebag-Montefiore D. The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been?. Ann Oncol 17 3 (2006) 361-371
    • (2006) Ann Oncol , vol.17 , Issue.3 , pp. 361-371
    • Glynne-Jones, R.1    Dunst, J.2    Sebag-Montefiore, D.3
  • 99
    • 29844435015 scopus 로고    scopus 로고
    • A phase I dose escalation study of continuous oral capecitabine in combination with oxaliplatin and pelvic radiation (XELOX-RT) in patients with locally advanced rectal cancer
    • Glynne-Jones R., Sebag-Montefiore D., Maughan T.S., Falk S.J., and McDonald A.C. A phase I dose escalation study of continuous oral capecitabine in combination with oxaliplatin and pelvic radiation (XELOX-RT) in patients with locally advanced rectal cancer. Ann Oncol 17 1 (2006) 50-56
    • (2006) Ann Oncol , vol.17 , Issue.1 , pp. 50-56
    • Glynne-Jones, R.1    Sebag-Montefiore, D.2    Maughan, T.S.3    Falk, S.J.4    McDonald, A.C.5
  • 100
    • 31544461568 scopus 로고    scopus 로고
    • Capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: a multicentric phase II study
    • De Paoli A., Chiara S., Luppi G., Friso M.L., Beretta G.D., Del Prete S., et al. Capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: a multicentric phase II study. Ann Oncol 17 2 (2006) 246-251
    • (2006) Ann Oncol , vol.17 , Issue.2 , pp. 246-251
    • De Paoli, A.1    Chiara, S.2    Luppi, G.3    Friso, M.L.4    Beretta, G.D.5    Del Prete, S.6
  • 101
    • 33644846344 scopus 로고    scopus 로고
    • Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer
    • Chau I., Brown G., Cunningham D., Tait D., Wotherspoon A., Norman A.R., et al. Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol 24 4 (2006) 668-674
    • (2006) J Clin Oncol , vol.24 , Issue.4 , pp. 668-674
    • Chau, I.1    Brown, G.2    Cunningham, D.3    Tait, D.4    Wotherspoon, A.5    Norman, A.R.6
  • 102
    • 33144459846 scopus 로고    scopus 로고
    • Comparison of the efficacy of oral capecitabine versus bolus 5-FU in preoperative radiotherapy of locally advanced rectal cancer
    • Kim J.S., Kim J.S., Cho M.J., Yoon W.H., and Song K.S. Comparison of the efficacy of oral capecitabine versus bolus 5-FU in preoperative radiotherapy of locally advanced rectal cancer. J Korean Med Sci 21 1 (2006) 52-57
    • (2006) J Korean Med Sci , vol.21 , Issue.1 , pp. 52-57
    • Kim, J.S.1    Kim, J.S.2    Cho, M.J.3    Yoon, W.H.4    Song, K.S.5
  • 103
    • 27944449720 scopus 로고    scopus 로고
    • Phase II study of concurrent chemoradiotherapy with capecitabine and cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck
    • Kim J.G., Sohn S.K., Kim D.H., Baek J.H., Jeon S.B., Chae Y.S., et al. Phase II study of concurrent chemoradiotherapy with capecitabine and cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck. Br J Cancer 93 10 (2005) 1117-1121
    • (2005) Br J Cancer , vol.93 , Issue.10 , pp. 1117-1121
    • Kim, J.G.1    Sohn, S.K.2    Kim, D.H.3    Baek, J.H.4    Jeon, S.B.5    Chae, Y.S.6
  • 104
    • 11144354852 scopus 로고    scopus 로고
    • Phase III study of mitomycin-C with protracted venous infusion or circadian-timed infusion of 5-fluorouracil in advanced colorectal carcinoma
    • Price T.J., Ross P.J., Hickish T., Tait D., Norman A.R., Ford H.E., et al. Phase III study of mitomycin-C with protracted venous infusion or circadian-timed infusion of 5-fluorouracil in advanced colorectal carcinoma. Clin Colorectal Cancer 3 4 (2004) 235-242
    • (2004) Clin Colorectal Cancer , vol.3 , Issue.4 , pp. 235-242
    • Price, T.J.1    Ross, P.J.2    Hickish, T.3    Tait, D.4    Norman, A.R.5    Ford, H.E.6
  • 105
    • 26944454064 scopus 로고    scopus 로고
    • Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan
    • Chong G., Dickson J.L., Cunningham D., Norman A.R., Rao S., Hill M.E., et al. Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan. Br J Cancer 93 5 (2005) 510-514
    • (2005) Br J Cancer , vol.93 , Issue.5 , pp. 510-514
    • Chong, G.1    Dickson, J.L.2    Cunningham, D.3    Norman, A.R.4    Rao, S.5    Hill, M.E.6
  • 106
    • 4644240651 scopus 로고    scopus 로고
    • Phase II study of capecitabine and mitomycin C as first-line treatment in patients with advanced colorectal cancer
    • Rao S., Cunningham D., Price T., Hill M.E., Ross P.J., Tebbutt N., et al. Phase II study of capecitabine and mitomycin C as first-line treatment in patients with advanced colorectal cancer. Br J Cancer 91 5 (2004) 839-843
    • (2004) Br J Cancer , vol.91 , Issue.5 , pp. 839-843
    • Rao, S.1    Cunningham, D.2    Price, T.3    Hill, M.E.4    Ross, P.J.5    Tebbutt, N.6
  • 107
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar F.F., Hambleton J., Mass R.D., Hurwitz H.I., Bergsland E., and Sarkar S. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 23 16 (2005) 3706-3712
    • (2005) J Clin Oncol , vol.23 , Issue.16 , pp. 3706-3712
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3    Hurwitz, H.I.4    Bergsland, E.5    Sarkar, S.6
  • 108
    • 27944483577 scopus 로고    scopus 로고
    • A phase II study of oxaliplatin, capecitabine and bevacizumab in the treatment of metastatic colorectal cancer
    • Fernando N., Yu D., Morse M., Bolbe G., Odogwu L., Cruse J., et al. A phase II study of oxaliplatin, capecitabine and bevacizumab in the treatment of metastatic colorectal cancer. J Clin Oncol 23 16S (2005) 3556
    • (2005) J Clin Oncol , vol.23 , Issue.16 S , pp. 3556
    • Fernando, N.1    Yu, D.2    Morse, M.3    Bolbe, G.4    Odogwu, L.5    Cruse, J.6
  • 109
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., Cartwright T., Hainsworth J., Heim W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 23 (2004) 2335-2342
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 110
    • 33751224096 scopus 로고    scopus 로고
    • Safety, tolerability and efficacy of the addition of bevacizumab to oxaliplatin/fluoropyrimidine regimens as first-line treatment of metastatic colorectal cancer (mCRC): results of TREE 2 cohort of the TREE study
    • Hochster H., Hart R.K., Ramanathan R.K., Hainsworth J., Griffing S., Mass R.D., et al. Safety, tolerability and efficacy of the addition of bevacizumab to oxaliplatin/fluoropyrimidine regimens as first-line treatment of metastatic colorectal cancer (mCRC): results of TREE 2 cohort of the TREE study. Eur J Cancer 3 2 (2005) 173
    • (2005) Eur J Cancer , vol.3 , Issue.2 , pp. 173
    • Hochster, H.1    Hart, R.K.2    Ramanathan, R.K.3    Hainsworth, J.4    Griffing, S.5    Mass, R.D.6
  • 111
    • 0037265616 scopus 로고    scopus 로고
    • A pilot phase II study of capecitabine in advanced or recurrent gastric cancer
    • Koizumi W., Saigenji K., Ujiie S., Terashima M., Sakata Y., and Taguchi T. A pilot phase II study of capecitabine in advanced or recurrent gastric cancer. Oncology 64 3 (2003) 232-236
    • (2003) Oncology , vol.64 , Issue.3 , pp. 232-236
    • Koizumi, W.1    Saigenji, K.2    Ujiie, S.3    Terashima, M.4    Sakata, Y.5    Taguchi, T.6
  • 112
    • 2342459741 scopus 로고    scopus 로고
    • A phase II study of capecitabine and docetaxel combination chemotherapy in patients with advanced gastric cancer
    • Park Y.H., Ryoo B.Y., Choi S.J., and Kim H.T. A phase II study of capecitabine and docetaxel combination chemotherapy in patients with advanced gastric cancer. Br J Cancer 90 7 (2004) 1329-1333
    • (2004) Br J Cancer , vol.90 , Issue.7 , pp. 1329-1333
    • Park, Y.H.1    Ryoo, B.Y.2    Choi, S.J.3    Kim, H.T.4
  • 113
    • 33645315211 scopus 로고    scopus 로고
    • Docetaxel and capecitabine in patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction: a phase II study from the North Central Cancer Treatment Group
    • Giordano K.F., Jatoi A., Stella P.J., Foster N., Tschetter L.K., Alberts S.R., et al. Docetaxel and capecitabine in patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction: a phase II study from the North Central Cancer Treatment Group. Ann Oncol 17 4 (2006) 652-656
    • (2006) Ann Oncol , vol.17 , Issue.4 , pp. 652-656
    • Giordano, K.F.1    Jatoi, A.2    Stella, P.J.3    Foster, N.4    Tschetter, L.K.5    Alberts, S.R.6
  • 114
    • 33645732748 scopus 로고    scopus 로고
    • A phase II study of capecitabine plus 3-weekly oxaliplatin as first-line therapy for patients with advanced gastric cancer
    • Park Y.H., Kim B.S., Ryoo B.Y., and Yang S.H. A phase II study of capecitabine plus 3-weekly oxaliplatin as first-line therapy for patients with advanced gastric cancer. Br J Cancer 94 7 (2006) 959-963
    • (2006) Br J Cancer , vol.94 , Issue.7 , pp. 959-963
    • Park, Y.H.1    Kim, B.S.2    Ryoo, B.Y.3    Yang, S.H.4
  • 115
    • 2342522698 scopus 로고    scopus 로고
    • Capecitabine in hormone-resistant metastatic prostatic carcinoma-a phase II trial
    • Morant R., Bernhard J., Dietrich D., Gillessen S., Bonomo M., Borner M., et al. Capecitabine in hormone-resistant metastatic prostatic carcinoma-a phase II trial. Br J Cancer 90 7 (2004) 1312-1317
    • (2004) Br J Cancer , vol.90 , Issue.7 , pp. 1312-1317
    • Morant, R.1    Bernhard, J.2    Dietrich, D.3    Gillessen, S.4    Bonomo, M.5    Borner, M.6
  • 116
    • 33646373451 scopus 로고    scopus 로고
    • Phase II study of capecitabine combined with gemcitabine in the treatment of androgen-independent prostate cancer previously treated with taxanes
    • Rodney A., Dieringer P., Mathew P., Jonasch E., Tannir N., and Pagliaro L.C. Phase II study of capecitabine combined with gemcitabine in the treatment of androgen-independent prostate cancer previously treated with taxanes. Cancer 106 10 (2006) 2143-2147
    • (2006) Cancer , vol.106 , Issue.10 , pp. 2143-2147
    • Rodney, A.1    Dieringer, P.2    Mathew, P.3    Jonasch, E.4    Tannir, N.5    Pagliaro, L.C.6
  • 117
    • 33751248166 scopus 로고    scopus 로고
    • Vinorelbine (N)-capecitabine (C) combination in advanced breast cancer (ABC): long-term results of two multicentric phase II trials
    • [meeting abstracts]
    • Ghosn M., Chahine G., Kattan J., Farhat F., Nasr F., Moukadem W., et al. Vinorelbine (N)-capecitabine (C) combination in advanced breast cancer (ABC): long-term results of two multicentric phase II trials. J Clin Oncol 23 16 Suppl. (2005) 673 [meeting abstracts]
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL , pp. 673
    • Ghosn, M.1    Chahine, G.2    Kattan, J.3    Farhat, F.4    Nasr, F.5    Moukadem, W.6
  • 118
    • 31544475481 scopus 로고    scopus 로고
    • Dose-finding and pharmacokinetic study of an all-oral combination regimen of oral vinorelbine and capecitabine for patients with metastatic breast cancer
    • Nole F., Catania C., Sanna G., Imadalou K., Munzone E., Adamoli L., et al. Dose-finding and pharmacokinetic study of an all-oral combination regimen of oral vinorelbine and capecitabine for patients with metastatic breast cancer. Ann Oncol 17 2 (2006) 322-329
    • (2006) Ann Oncol , vol.17 , Issue.2 , pp. 322-329
    • Nole, F.1    Catania, C.2    Sanna, G.3    Imadalou, K.4    Munzone, E.5    Adamoli, L.6
  • 119
    • 33751244186 scopus 로고    scopus 로고
    • A phase II multicentre study of combination chemotherapy with capecitabine (C) and intravenous (Iv) vinorelbine (V) in patients (Pts) with pretreated metastatic breast cancer (Mbc)
    • Davis A.J., Lewis C., Moylan E., Parnis F.X., and Ackland S.P. A phase II multicentre study of combination chemotherapy with capecitabine (C) and intravenous (Iv) vinorelbine (V) in patients (Pts) with pretreated metastatic breast cancer (Mbc). Asia Pacific J Clin Oncol 1 S1 (2005) A18
    • (2005) Asia Pacific J Clin Oncol , vol.1 , Issue.SUPPL.1
    • Davis, A.J.1    Lewis, C.2    Moylan, E.3    Parnis, F.X.4    Ackland, S.P.5
  • 120
    • 33751251641 scopus 로고    scopus 로고
    • A phase I/II study of capecitabine (X) combined with oral vinorelbine (N) as first- or second-line chemotherapy in patients (pts) with locally advanced or metastatic breast cancer (MBC)
    • Delcambre C., Veyret C., Levy C., Switsers O., and Allouache D. A phase I/II study of capecitabine (X) combined with oral vinorelbine (N) as first- or second-line chemotherapy in patients (pts) with locally advanced or metastatic breast cancer (MBC). Eur J Cancer 3 Suppl. 2 (2005) 118
    • (2005) Eur J Cancer , vol.3 , Issue.SUPPL. 2 , pp. 118
    • Delcambre, C.1    Veyret, C.2    Levy, C.3    Switsers, O.4    Allouache D5
  • 121
    • 0035038134 scopus 로고    scopus 로고
    • A pharmacological study of the weekday-on/weekend-off oral UFT schedule in colorectal cancer patients
    • Sadahiro S., Suzuki T., Kameya T., Iwase H., Tajima T., and Makuuchi H. A pharmacological study of the weekday-on/weekend-off oral UFT schedule in colorectal cancer patients. Cancer Chemother Pharmacol 47 5 (2001) 457-460
    • (2001) Cancer Chemother Pharmacol , vol.47 , Issue.5 , pp. 457-460
    • Sadahiro, S.1    Suzuki, T.2    Kameya, T.3    Iwase, H.4    Tajima, T.5    Makuuchi, H.6
  • 122
    • 0029762711 scopus 로고    scopus 로고
    • Thymidylate synthase inhibition by an oral regimen consisting of tegafur-uracil (UFT) and low-dose leucovorin for patients with gastric cancer
    • Ichikura T., Tomimatsu S., Okusa Y., Yahara T., Uefuji K., and Tamakuma S. Thymidylate synthase inhibition by an oral regimen consisting of tegafur-uracil (UFT) and low-dose leucovorin for patients with gastric cancer. Cancer Chemother Pharmacol 38 5 (1996) 401-405
    • (1996) Cancer Chemother Pharmacol , vol.38 , Issue.5 , pp. 401-405
    • Ichikura, T.1    Tomimatsu, S.2    Okusa, Y.3    Yahara, T.4    Uefuji, K.5    Tamakuma, S.6
  • 123
    • 0034016343 scopus 로고    scopus 로고
    • Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II study
    • van Cutsem E., Findlay M., Osterwalder B., Kocha W., Dalley D., Pazdur R., et al. Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II study. J Clin Oncol 18 6 (2000) 1337-1345
    • (2000) J Clin Oncol , vol.18 , Issue.6 , pp. 1337-1345
    • van Cutsem, E.1    Findlay, M.2    Osterwalder, B.3    Kocha, W.4    Dalley, D.5    Pazdur, R.6
  • 124
    • 26244451545 scopus 로고    scopus 로고
    • Randomised study of tegafur and oral leucovorin versus intravenous 5-fluorouracil and leucovorin in patients with advanced colorectal cancer
    • Nogue M., Salud A., Batiste-Alentorn E., Saigi E., Losa F., Cirera L., et al. Randomised study of tegafur and oral leucovorin versus intravenous 5-fluorouracil and leucovorin in patients with advanced colorectal cancer. Eur J Cancer 41 15 (2005) 2241-2249
    • (2005) Eur J Cancer , vol.41 , Issue.15 , pp. 2241-2249
    • Nogue, M.1    Salud, A.2    Batiste-Alentorn, E.3    Saigi, E.4    Losa, F.5    Cirera, L.6
  • 125
    • 33646443236 scopus 로고    scopus 로고
    • Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06
    • Lembersky B.C., Wieand H.S., Petrelli N.J., O'Connell M.J., Colangelo L.H., Smith R.E., et al. Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06. J Clin Oncol 24 13 (2006) 2059-2064
    • (2006) J Clin Oncol , vol.24 , Issue.13 , pp. 2059-2064
    • Lembersky, B.C.1    Wieand, H.S.2    Petrelli, N.J.3    O'Connell, M.J.4    Colangelo, L.H.5    Smith, R.E.6
  • 126
    • 6544263262 scopus 로고    scopus 로고
    • Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug
    • Hirata K., Horikoshi N., Aiba K., Okazaki M., Denno R., Sasaki K., et al. Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug. Clin Cancer Res 5 8 (1999) 2000-2005
    • (1999) Clin Cancer Res , vol.5 , Issue.8 , pp. 2000-2005
    • Hirata, K.1    Horikoshi, N.2    Aiba, K.3    Okazaki, M.4    Denno, R.5    Sasaki, K.6
  • 127
    • 0033729224 scopus 로고    scopus 로고
    • Oral uracil and Ftorafur plus leucovorin: pharmacokinetics and toxicity in patients with metastatic cancer
    • Ho D.H., Covington W., Brown N., Lin S.N., Pazdur R., Huo Y.Y., et al. Oral uracil and Ftorafur plus leucovorin: pharmacokinetics and toxicity in patients with metastatic cancer. Cancer Chemother Pharmacol 46 5 (2000) 351-356
    • (2000) Cancer Chemother Pharmacol , vol.46 , Issue.5 , pp. 351-356
    • Ho, D.H.1    Covington, W.2    Brown, N.3    Lin, S.N.4    Pazdur, R.5    Huo, Y.Y.6
  • 128
    • 6944226476 scopus 로고    scopus 로고
    • Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer
    • Ichikawa W., Takahashi T., Suto K., Yamashita T., Nihei Z., Shirota Y., et al. Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer. Br J Cancer 91 7 (2004) 1245-1250
    • (2004) Br J Cancer , vol.91 , Issue.7 , pp. 1245-1250
    • Ichikawa, W.1    Takahashi, T.2    Suto, K.3    Yamashita, T.4    Nihei, Z.5    Shirota, Y.6
  • 129
    • 0036275282 scopus 로고    scopus 로고
    • Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells
    • Takechi T., Fujioka A., Matsushima E., and Fukushima M. Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer 38 9 (2002) 1271-1277
    • (2002) Eur J Cancer , vol.38 , Issue.9 , pp. 1271-1277
    • Takechi, T.1    Fujioka, A.2    Matsushima, E.3    Fukushima, M.4
  • 130
    • 0141706566 scopus 로고    scopus 로고
    • Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity
    • Fujiwara H., Terashima M., Irinoda T., Takagane A., Abe K., Nakaya T., et al. Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity. Eur J Cancer 39 16 (2003) 2387-2394
    • (2003) Eur J Cancer , vol.39 , Issue.16 , pp. 2387-2394
    • Fujiwara, H.1    Terashima, M.2    Irinoda, T.3    Takagane, A.4    Abe, K.5    Nakaya, T.6
  • 131
    • 26244450871 scopus 로고    scopus 로고
    • Level of 5-fluorodeoxyuridine 5′-monophosphate in cancerous tissue in patients with gastric cancer under preoperative administration of TS-1, A preliminary study
    • Yamamoto S., and Kubota K. Level of 5-fluorodeoxyuridine 5′-monophosphate in cancerous tissue in patients with gastric cancer under preoperative administration of TS-1, A preliminary study. J Exp Clin Cancer Res 24 3 (2005) 457-462
    • (2005) J Exp Clin Cancer Res , vol.24 , Issue.3 , pp. 457-462
    • Yamamoto, S.1    Kubota, K.2
  • 132
    • 27644586802 scopus 로고    scopus 로고
    • Enhancement of the anti-tumor activity of S-1 by low-dose cisplatin in mice bearing the sarcoma-180 model
    • Yurimoto S., Miyakawa A., Okuzawa A., Sakamoto S., Sakamoto K., Hosoda S., et al. Enhancement of the anti-tumor activity of S-1 by low-dose cisplatin in mice bearing the sarcoma-180 model. Anticancer Drugs 16 10 (2005) 1109-1114
    • (2005) Anticancer Drugs , vol.16 , Issue.10 , pp. 1109-1114
    • Yurimoto, S.1    Miyakawa, A.2    Okuzawa, A.3    Sakamoto, S.4    Sakamoto, K.5    Hosoda, S.6
  • 133
    • 23744515641 scopus 로고    scopus 로고
    • Canalicular and nasolacrimal duct blockage: an ocular side effect associated with the antineoplastic drug S-1
    • Esmaeli B., Golio D., Lubecki L., and Ajani J. Canalicular and nasolacrimal duct blockage: an ocular side effect associated with the antineoplastic drug S-1. Am J Ophthalmol 140 2 (2005) 325-327
    • (2005) Am J Ophthalmol , vol.140 , Issue.2 , pp. 325-327
    • Esmaeli, B.1    Golio, D.2    Lubecki, L.3    Ajani, J.4
  • 134
    • 4143123301 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the oral fluoropyrimidine S-1 on a once-daily-for-28-day schedule in patients with advanced malignancies
    • Chu Q.S., Hammond L.A., Schwartz G., Ochoa L., Rha S.Y., Denis L., et al. Phase I and pharmacokinetic study of the oral fluoropyrimidine S-1 on a once-daily-for-28-day schedule in patients with advanced malignancies. Clin Cancer Res 10 15 (2004) 4913-4921
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 4913-4921
    • Chu, Q.S.1    Hammond, L.A.2    Schwartz, G.3    Ochoa, L.4    Rha, S.Y.5    Denis, L.6
  • 135
    • 0032189218 scopus 로고    scopus 로고
    • Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients
    • Sakata Y., Ohtsu A., Horikoshi N., Sugimachi K., Mitachi Y., and Taguchi T. Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients. Eur J Cancer 34 11 (1998) 1715-1720
    • (1998) Eur J Cancer , vol.34 , Issue.11 , pp. 1715-1720
    • Sakata, Y.1    Ohtsu, A.2    Horikoshi, N.3    Sugimachi, K.4    Mitachi, Y.5    Taguchi, T.6
  • 137
    • 0034029776 scopus 로고    scopus 로고
    • Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer
    • For the S-1 Cooperative Gastric Cancer Study Group
    • Koizumi W., Kurihara M., Nakano S., Hasegawa K., and For the S-1 Cooperative Gastric Cancer Study Group. Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. Oncology 58 3 (2000) 191-197
    • (2000) Oncology , vol.58 , Issue.3 , pp. 191-197
    • Koizumi, W.1    Kurihara, M.2    Nakano, S.3    Hasegawa, K.4
  • 138
    • 0842330394 scopus 로고    scopus 로고
    • Phase I/II study of S-1 combined with cisplatin in patients with advanced gastric cancer
    • Koizumi W., Tanabe S., Saigenji K., Ohtsu A., Boku N., Nagashima F., et al. Phase I/II study of S-1 combined with cisplatin in patients with advanced gastric cancer. Br J Cancer 89 12 (2003) 2207-2212
    • (2003) Br J Cancer , vol.89 , Issue.12 , pp. 2207-2212
    • Koizumi, W.1    Tanabe, S.2    Saigenji, K.3    Ohtsu, A.4    Boku, N.5    Nagashima, F.6
  • 139
    • 33644833992 scopus 로고    scopus 로고
    • Multicenter phase II trial of S-1 plus cisplatin in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma
    • Ajani J.A., Lee F.C., Singh D.A., Haller D.G., Lenz H.J., Benson III A.B., et al. Multicenter phase II trial of S-1 plus cisplatin in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma. J Clin Oncol 24 4 (2006) 663-667
    • (2006) J Clin Oncol , vol.24 , Issue.4 , pp. 663-667
    • Ajani, J.A.1    Lee, F.C.2    Singh, D.A.3    Haller, D.G.4    Lenz, H.J.5    Benson III, A.B.6
  • 140
    • 0027787998 scopus 로고
    • 3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase
    • Tatsumi K., Yamauchi T., Kiyono K., Kishi K., Yanagihara Y., Imaoka T., et al. 3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase. J Biochem (Tokyo) 114 6 (1993) 912-918
    • (1993) J Biochem (Tokyo) , vol.114 , Issue.6 , pp. 912-918
    • Tatsumi, K.1    Yamauchi, T.2    Kiyono, K.3    Kishi, K.4    Yanagihara, Y.5    Imaoka, T.6
  • 141
    • 0034490187 scopus 로고    scopus 로고
    • A phase II trial of a new 5-fluorouracil derivative, BOF-A2 (Emitefur), for patients with advanced gastric cancer
    • Sugimachi K., and Maehara Y. A phase II trial of a new 5-fluorouracil derivative, BOF-A2 (Emitefur), for patients with advanced gastric cancer. Surg Today 30 12 (2000) 1067-1072
    • (2000) Surg Today , vol.30 , Issue.12 , pp. 1067-1072
    • Sugimachi, K.1    Maehara, Y.2
  • 142
    • 0034306322 scopus 로고    scopus 로고
    • Phase I assessment of the pharmacokinetics, metabolism, and safety of emitefur in patients with refractory solid tumors
    • Nemunaitis J., Eager R., Twaddell T., Corey A., Sekar K., Tkaczuk K., et al. Phase I assessment of the pharmacokinetics, metabolism, and safety of emitefur in patients with refractory solid tumors. J Clin Oncol 18 19 (2000) 3423-3434
    • (2000) J Clin Oncol , vol.18 , Issue.19 , pp. 3423-3434
    • Nemunaitis, J.1    Eager, R.2    Twaddell, T.3    Corey, A.4    Sekar, K.5    Tkaczuk, K.6
  • 143
    • 1942439032 scopus 로고    scopus 로고
    • Antifolates targeted specifically to the folate receptor
    • Jackman A.L., Theti D.S., and Gibbs D.D. Antifolates targeted specifically to the folate receptor. Adv Drug Deliv Rev 56 8 (2004) 1111-1125
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.8 , pp. 1111-1125
    • Jackman, A.L.1    Theti, D.S.2    Gibbs, D.D.3
  • 144
    • 29244449017 scopus 로고    scopus 로고
    • BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors
    • Gibbs D.D., Theti D.S., Wood N., Green M., Raynaud F., Valenti M., et al. BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors. Cancer Res 65 24 (2005) 11721-11728
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11721-11728
    • Gibbs, D.D.1    Theti, D.S.2    Wood, N.3    Green, M.4    Raynaud, F.5    Valenti, M.6
  • 145
    • 33645976121 scopus 로고    scopus 로고
    • Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment
    • Hooijberg J.H., de Vries N.A., Kaspers G.J., Pieters R., Jansen G., and Peters G.J. Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment. Cancer Chemother Pharmacol 58 1 (2005) 1-12
    • (2005) Cancer Chemother Pharmacol , vol.58 , Issue.1 , pp. 1-12
    • Hooijberg, J.H.1    de Vries, N.A.2    Kaspers, G.J.3    Pieters, R.4    Jansen, G.5    Peters, G.J.6
  • 146
    • 0033152212 scopus 로고    scopus 로고
    • Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
    • Hooijberg J.H., Broxterman H.J., Kool M., Assaraf Y.G., Peters G.J., Noordhuis P., et al. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res 59 11 (1999) 2532-2535
    • (1999) Cancer Res , vol.59 , Issue.11 , pp. 2532-2535
    • Hooijberg, J.H.1    Broxterman, H.J.2    Kool, M.3    Assaraf, Y.G.4    Peters, G.J.5    Noordhuis, P.6
  • 148
    • 20144382254 scopus 로고    scopus 로고
    • The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates
    • Wielinga P., Hooijberg J.H., Gunnarsdottir S., Kathmann I., Reid G., Zelcer N., et al. The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res 65 10 (2005) 4425-4430
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 4425-4430
    • Wielinga, P.1    Hooijberg, J.H.2    Gunnarsdottir, S.3    Kathmann, I.4    Reid, G.5    Zelcer, N.6
  • 149
    • 24944556055 scopus 로고    scopus 로고
    • ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates
    • Shafran A., Ifergan I., Bram E., Jansen G., Kathmann I., Peters G.J., et al. ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates. Cancer Res 65 18 (2005) 8414-8422
    • (2005) Cancer Res , vol.65 , Issue.18 , pp. 8414-8422
    • Shafran, A.1    Ifergan, I.2    Bram, E.3    Jansen, G.4    Kathmann, I.5    Peters, G.J.6
  • 150
    • 9944248649 scopus 로고    scopus 로고
    • Lack of an effect of breast cancer resistance protein (BCRP/ABCG2) overexpression on methotrexate polyglutamate export and folate accumulation in a human breast cancer cell line
    • Rhee M.S., and Schneider E. Lack of an effect of breast cancer resistance protein (BCRP/ABCG2) overexpression on methotrexate polyglutamate export and folate accumulation in a human breast cancer cell line. Biochem Pharmacol 69 1 (2005) 123-132
    • (2005) Biochem Pharmacol , vol.69 , Issue.1 , pp. 123-132
    • Rhee, M.S.1    Schneider, E.2
  • 152
    • 0027889184 scopus 로고
    • The history of the development and clinical use of CB 3717 and ICI D1694
    • Clarke S.J., Jackman A.L., and Judson I.R. The history of the development and clinical use of CB 3717 and ICI D1694. Adv Exp Med Biol 339 (1993) 277-287
    • (1993) Adv Exp Med Biol , vol.339 , pp. 277-287
    • Clarke, S.J.1    Jackman, A.L.2    Judson, I.R.3
  • 153
    • 0025925284 scopus 로고
    • The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice
    • Jodrell D.I., Newell D.R., Morgan S.E., Clinton S., Bensted J.P., Hughes L.R., et al. The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice. Br J Cancer 64 5 (1991) 833-838
    • (1991) Br J Cancer , vol.64 , Issue.5 , pp. 833-838
    • Jodrell, D.I.1    Newell, D.R.2    Morgan, S.E.3    Clinton, S.4    Bensted, J.P.5    Hughes, L.R.6
  • 154
    • 0027811090 scopus 로고
    • The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694
    • [review, 12 refs.]
    • Jackman A.L., Gibson W., Brown M., Kimbell R., and Boyle F.T. The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694. Adv Exp Med Biol 339 (1993) 265-276 [review, 12 refs.]
    • (1993) Adv Exp Med Biol , vol.339 , pp. 265-276
    • Jackman, A.L.1    Gibson, W.2    Brown, M.3    Kimbell, R.4    Boyle, F.T.5
  • 156
    • 0029658045 scopus 로고    scopus 로고
    • Tomudex (ZD1694): from concept to care, a programme in rational drug discovery
    • Jackman A.L., Boyle F.T., and Harrap K.R. Tomudex (ZD1694): from concept to care, a programme in rational drug discovery. Invest New Drugs 14 3 (1996) 305-316
    • (1996) Invest New Drugs , vol.14 , Issue.3 , pp. 305-316
    • Jackman, A.L.1    Boyle, F.T.2    Harrap, K.R.3
  • 157
    • 9244240774 scopus 로고    scopus 로고
    • Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors
    • Clarke S.J., Hanwell J., de Boer M., Planting A., Verweij J., Walker M., et al. Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors. J Clin Oncol 14 5 (1996) 1495-1503
    • (1996) J Clin Oncol , vol.14 , Issue.5 , pp. 1495-1503
    • Clarke, S.J.1    Hanwell, J.2    de Boer, M.3    Planting, A.4    Verweij, J.5    Walker, M.6
  • 158
    • 0032834995 scopus 로고    scopus 로고
    • A Phase I study of raltitrexed, an antifolate thymidylate synthase inhibitor, in adult patients with advanced solid tumors
    • Grem J.L., Sorensen J.M., Cullen E., Takimoto C.H., Steinberg S.M., Chen A.P., et al. A Phase I study of raltitrexed, an antifolate thymidylate synthase inhibitor, in adult patients with advanced solid tumors. Clin Cancer Res 5 9 (1999) 2381-2391
    • (1999) Clin Cancer Res , vol.5 , Issue.9 , pp. 2381-2391
    • Grem, J.L.1    Sorensen, J.M.2    Cullen, E.3    Takimoto, C.H.4    Steinberg, S.M.5    Chen, A.P.6
  • 159
    • 0036186018 scopus 로고    scopus 로고
    • Efficacy, tolerability and management of raltitrexed (Tomudex) monotherapy in patients with advanced colorectal cancer. A review of phase II/III trials
    • Cunningham D., Zalcberg J., Maroun J., James R., Clarke S., Maughan T.S., et al. Efficacy, tolerability and management of raltitrexed (Tomudex) monotherapy in patients with advanced colorectal cancer. A review of phase II/III trials. Eur J Cancer 38 4 (2002) 478-486
    • (2002) Eur J Cancer , vol.38 , Issue.4 , pp. 478-486
    • Cunningham, D.1    Zalcberg, J.2    Maroun, J.3    James, R.4    Clarke, S.5    Maughan, T.S.6
  • 160
    • 0033818004 scopus 로고    scopus 로고
    • Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies
    • Farrugia D.C., Aherne G.W., Brunton L., Clarke S.J., and Jackman A.L. Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies. Clin Cancer Res 6 9 (2000) 3646-3656
    • (2000) Clin Cancer Res , vol.6 , Issue.9 , pp. 3646-3656
    • Farrugia, D.C.1    Aherne, G.W.2    Brunton, L.3    Clarke, S.J.4    Jackman, A.L.5
  • 161
    • 0031888857 scopus 로고    scopus 로고
    • Mature results from three large controlled studies with raltitrexed (Tomudex)
    • Cunningham D. Mature results from three large controlled studies with raltitrexed (Tomudex). Br J Cancer 77 2 (1998) 15-21
    • (1998) Br J Cancer , vol.77 , Issue.2 , pp. 15-21
    • Cunningham, D.1
  • 162
    • 0037018765 scopus 로고    scopus 로고
    • Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial
    • Maughan T.S., James R.D., Kerr D.J., Ledermann J.A., McArdle C., Seymour M.T., et al. Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial. Lancet 359 9317 (2002) 1555-1563
    • (2002) Lancet , vol.359 , Issue.9317 , pp. 1555-1563
    • Maughan, T.S.1    James, R.D.2    Kerr, D.J.3    Ledermann, J.A.4    McArdle, C.5    Seymour, M.T.6
  • 163
    • 0035985287 scopus 로고    scopus 로고
    • Raltitrexed plus oxaliplatin (TOMOX) as first-line chemotherapy for metastatic colorectal cancer. A phase II study of the Italian Group for the Study of Gastrointestinal Tract Carcinomas (GISCAD)
    • Cascinu S., Graziano F., Ferrau F., Catalano V., Massacesi C., Santini D., et al. Raltitrexed plus oxaliplatin (TOMOX) as first-line chemotherapy for metastatic colorectal cancer. A phase II study of the Italian Group for the Study of Gastrointestinal Tract Carcinomas (GISCAD). Ann Oncol 13 5 (2002) 716-720
    • (2002) Ann Oncol , vol.13 , Issue.5 , pp. 716-720
    • Cascinu, S.1    Graziano, F.2    Ferrau, F.3    Catalano, V.4    Massacesi, C.5    Santini, D.6
  • 164
    • 0036928276 scopus 로고    scopus 로고
    • Oxaliplatin plus irinotecan and leucovorin-modulated 5-fluorouracil triplet regimen every other week: a dose-finding study in patients with advanced gastrointestinal malignancies
    • Comella P., Casaretti R., De R., Avallone V., Izzo A., Fiore F., et al. Oxaliplatin plus irinotecan and leucovorin-modulated 5-fluorouracil triplet regimen every other week: a dose-finding study in patients with advanced gastrointestinal malignancies. Ann Oncol 13 12 (2002) 1874-1881
    • (2002) Ann Oncol , vol.13 , Issue.12 , pp. 1874-1881
    • Comella, P.1    Casaretti, R.2    De, R.3    Avallone, V.4    Izzo, A.5    Fiore, F.6
  • 165
    • 2442604628 scopus 로고    scopus 로고
    • Activity and toxicity of oxaliplatin plus raltitrexed in 5-fluorouracil refractory metastatic colorectal adeno-carcinoma
    • Laudani A., Gebbia V., Leonardi V., Savio G., Borsellino N., Cusimano M.P., et al. Activity and toxicity of oxaliplatin plus raltitrexed in 5-fluorouracil refractory metastatic colorectal adeno-carcinoma. Anticancer Res 24 2C (2004) 1139-1142
    • (2004) Anticancer Res , vol.24 , Issue.2 C , pp. 1139-1142
    • Laudani, A.1    Gebbia, V.2    Leonardi, V.3    Savio, G.4    Borsellino, N.5    Cusimano, M.P.6
  • 166
    • 0037236085 scopus 로고    scopus 로고
    • Oxaliplatin plus raltitrexed in the treatment of patients with advanced colorectal cancer: a phase II study
    • Martoni A., Mini E., Pinto C., Gentile A.L., Nobili S., Dentico P., et al. Oxaliplatin plus raltitrexed in the treatment of patients with advanced colorectal cancer: a phase II study. Anticancer Res 23 1B (2003) 687-691
    • (2003) Anticancer Res , vol.23 , Issue.1 B , pp. 687-691
    • Martoni, A.1    Mini, E.2    Pinto, C.3    Gentile, A.L.4    Nobili, S.5    Dentico, P.6
  • 167
    • 0036667943 scopus 로고    scopus 로고
    • Raltitrexed plus oxaliplatin as first-line chemotherapy in metastatic colorectal carcinoma: a multicentric phase II trial
    • Neri B., Doni L., Fulignati C., Perfetto F., Turrini M., Andreoli F., et al. Raltitrexed plus oxaliplatin as first-line chemotherapy in metastatic colorectal carcinoma: a multicentric phase II trial. Anticancer Drugs 13 7 (2002) 719-724
    • (2002) Anticancer Drugs , vol.13 , Issue.7 , pp. 719-724
    • Neri, B.1    Doni, L.2    Fulignati, C.3    Perfetto, F.4    Turrini, M.5    Andreoli, F.6
  • 168
    • 0035990835 scopus 로고    scopus 로고
    • Multicenter non-randomized phase II study of raltitrexed (Tomudex) and oxaliplatin in non-pretreated metastatic colorectal cancer patients
    • Seitz J.F., Bennouna J., Paillot B., Gamelin E., Francois E., Conroy T., et al. Multicenter non-randomized phase II study of raltitrexed (Tomudex) and oxaliplatin in non-pretreated metastatic colorectal cancer patients. Ann Oncol 13 7 (2002) 1072-1079
    • (2002) Ann Oncol , vol.13 , Issue.7 , pp. 1072-1079
    • Seitz, J.F.1    Bennouna, J.2    Paillot, B.3    Gamelin, E.4    Francois, E.5    Conroy, T.6
  • 169
    • 2942624024 scopus 로고    scopus 로고
    • Raltitrexed plus oxaliplatin in the treatment of metastatic colorectal cancer
    • Cortinovis D., Bajetta E., Di B.M., Dognini G., Beretta E., Ferrario E., et al. Raltitrexed plus oxaliplatin in the treatment of metastatic colorectal cancer. Tumori 90 2 (2004) 186-191
    • (2004) Tumori , vol.90 , Issue.2 , pp. 186-191
    • Cortinovis, D.1    Bajetta, E.2    Di, B.M.3    Dognini, G.4    Beretta, E.5    Ferrario, E.6
  • 170
    • 11144353909 scopus 로고    scopus 로고
    • Raltitrexed plus weekly oxaliplatin as first-line chemotherapy in metastatic colorectal cancer: a multicenter non-randomized phase ii study
    • Santini D., Massacesi C., D'Angelillo R.M., Marcucci F., Campisi C., Vincenzi B., et al. Raltitrexed plus weekly oxaliplatin as first-line chemotherapy in metastatic colorectal cancer: a multicenter non-randomized phase ii study. Med Oncol 21 1 (2004) 59-66
    • (2004) Med Oncol , vol.21 , Issue.1 , pp. 59-66
    • Santini, D.1    Massacesi, C.2    D'Angelillo, R.M.3    Marcucci, F.4    Campisi, C.5    Vincenzi, B.6
  • 171
    • 20944442973 scopus 로고    scopus 로고
    • First-line treatment with irinotecan and raltitrexed in metastatic colorectal cancer. Mature results of a multicenter phase II study
    • Aparicio J., Vicent J.M., Maestu I., Bosch C., Galan A., Busquier I., et al. First-line treatment with irinotecan and raltitrexed in metastatic colorectal cancer. Mature results of a multicenter phase II study. Oncology 68 1 (2005) 58-63
    • (2005) Oncology , vol.68 , Issue.1 , pp. 58-63
    • Aparicio, J.1    Vicent, J.M.2    Maestu, I.3    Bosch, C.4    Galan, A.5    Busquier, I.6
  • 172
    • 0042701930 scopus 로고    scopus 로고
    • Multicenter phase II trial evaluating a three-weekly schedule of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer
    • Aparicio J., Vicent J.M., Maestu I., Garcera S., Busquier I., Bosch C., et al. Multicenter phase II trial evaluating a three-weekly schedule of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer. Ann Oncol 14 7 (2003) 1121-1125
    • (2003) Ann Oncol , vol.14 , Issue.7 , pp. 1121-1125
    • Aparicio, J.1    Vicent, J.M.2    Maestu, I.3    Garcera, S.4    Busquier, I.5    Bosch, C.6
  • 173
    • 0036739135 scopus 로고    scopus 로고
    • Irinotecan and raltitrexed: an active combination in advanced colorectal cancer
    • Carnaghi C., Rimassa L., Garassino I., Zucali P.A., Masci G., Fallini M., et al. Irinotecan and raltitrexed: an active combination in advanced colorectal cancer. Ann Oncol 13 9 (2002) 1424-1429
    • (2002) Ann Oncol , vol.13 , Issue.9 , pp. 1424-1429
    • Carnaghi, C.1    Rimassa, L.2    Garassino, I.3    Zucali, P.A.4    Masci, G.5    Fallini, M.6
  • 174
    • 2442456768 scopus 로고    scopus 로고
    • Irinotecan plus raltitrexed as first-line treatment in advanced colorectal cancer: a phase II study
    • Feliu J., Salud A., Escudero P., Lopez-Gomez L., Pericay C., Castanon C., et al. Irinotecan plus raltitrexed as first-line treatment in advanced colorectal cancer: a phase II study. Br J Cancer 90 8 (2004) 1502-1507
    • (2004) Br J Cancer , vol.90 , Issue.8 , pp. 1502-1507
    • Feliu, J.1    Salud, A.2    Escudero, P.3    Lopez-Gomez, L.4    Pericay, C.5    Castanon, C.6
  • 175
    • 27944435401 scopus 로고    scopus 로고
    • Phase II randomised trial of raltitrexed-oxaliplatin vs raltitrexed-irinotecan as first-line treatment in advanced colorectal cancer
    • Feliu J., Castanon C., Salud A., Mel J.R., Escudero P., Pelegrin A., et al. Phase II randomised trial of raltitrexed-oxaliplatin vs raltitrexed-irinotecan as first-line treatment in advanced colorectal cancer. Br J Cancer 93 11 (2005) 1230-1235
    • (2005) Br J Cancer , vol.93 , Issue.11 , pp. 1230-1235
    • Feliu, J.1    Castanon, C.2    Salud, A.3    Mel, J.R.4    Escudero, P.5    Pelegrin, A.6
  • 176
    • 15244356686 scopus 로고    scopus 로고
    • A phase II study of raltitrexed and gemcitabine in patients with advanced pancreatic carcinoma
    • Arends J.J., Sleeboom H.P., Leys M.B., Ten Bokkel H.D., de Jong R.S., Smit J.M., et al. A phase II study of raltitrexed and gemcitabine in patients with advanced pancreatic carcinoma. Br J Cancer 92 3 (2005) 445-448
    • (2005) Br J Cancer , vol.92 , Issue.3 , pp. 445-448
    • Arends, J.J.1    Sleeboom, H.P.2    Leys, M.B.3    Ten Bokkel, H.D.4    de Jong, R.S.5    Smit, J.M.6
  • 177
    • 0037481752 scopus 로고    scopus 로고
    • Activity of raltitrexed and gemcitabine in advanced pancreatic cancer
    • Kralidis E., Aebi S., Friess H., Buchler M.W., and Borner M.M. Activity of raltitrexed and gemcitabine in advanced pancreatic cancer. Ann Oncol 14 4 (2003) 574-579
    • (2003) Ann Oncol , vol.14 , Issue.4 , pp. 574-579
    • Kralidis, E.1    Aebi, S.2    Friess, H.3    Buchler, M.W.4    Borner, M.M.5
  • 178
    • 13844307892 scopus 로고    scopus 로고
    • Raltitrexed plus gemcitabine (TOMGEM) in advanced pancreatic cancer. Results of a Belgian multicentre phase II study
    • Van Laethem J.L., Van M.P., Verslype C., Polus M., Demols A., Houbiers G., et al. Raltitrexed plus gemcitabine (TOMGEM) in advanced pancreatic cancer. Results of a Belgian multicentre phase II study. Oncology 67 5-6 (2004) 338-343
    • (2004) Oncology , vol.67 , Issue.5-6 , pp. 338-343
    • Van Laethem, J.L.1    Van, M.P.2    Verslype, C.3    Polus, M.4    Demols, A.5    Houbiers, G.6
  • 179
    • 0037304998 scopus 로고    scopus 로고
    • The activity of raltitrexed (Tomudex(R)) in malignant pleural mesothelioma. an EORTC phase II study (08992)
    • Baas P., Ardizzoni A., Grossi F., Nackaerts K., Numico G., Van Marck E., et al. The activity of raltitrexed (Tomudex(R)) in malignant pleural mesothelioma. an EORTC phase II study (08992). Eur J Cancer 39 3 (2003) 353-357
    • (2003) Eur J Cancer , vol.39 , Issue.3 , pp. 353-357
    • Baas, P.1    Ardizzoni, A.2    Grossi, F.3    Nackaerts, K.4    Numico, G.5    Van Marck, E.6
  • 180
    • 0037440073 scopus 로고    scopus 로고
    • Combination of raltitrexed and oxaliplatin is an active regimen in malignant mesothelioma: results of a phase II study
    • Fizazi K., Doubre H., Le Chevalier T., Riviere A., Viala J., Daniel C., et al. Combination of raltitrexed and oxaliplatin is an active regimen in malignant mesothelioma: results of a phase II study. J Clin Oncol 21 2 (2003) 349-354
    • (2003) J Clin Oncol , vol.21 , Issue.2 , pp. 349-354
    • Fizazi, K.1    Doubre, H.2    Le Chevalier, T.3    Riviere, A.4    Viala, J.5    Daniel, C.6
  • 181
    • 18844403354 scopus 로고    scopus 로고
    • Raltitrexed-Oxaliplatin combination chemotherapy is inactive as second-line treatment for malignant pleural mesothelioma patients
    • Porta C., Zimatore M., Bonomi L., Imarisio I., Paglino C., Sartore-Bianchi A., et al. Raltitrexed-Oxaliplatin combination chemotherapy is inactive as second-line treatment for malignant pleural mesothelioma patients. Lung Cancer 48 3 (2005) 429-434
    • (2005) Lung Cancer , vol.48 , Issue.3 , pp. 429-434
    • Porta, C.1    Zimatore, M.2    Bonomi, L.3    Imarisio, I.4    Paglino, C.5    Sartore-Bianchi, A.6
  • 182
    • 33645944379 scopus 로고    scopus 로고
    • Adding raltitrexed to cisplatin improves overall survival in people with malignant pleural mesothelioma
    • Porta C. Adding raltitrexed to cisplatin improves overall survival in people with malignant pleural mesothelioma. Cancer Treat Rev 32 3 (2006) 229-233
    • (2006) Cancer Treat Rev , vol.32 , Issue.3 , pp. 229-233
    • Porta, C.1
  • 183
    • 27244447448 scopus 로고    scopus 로고
    • Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada
    • van Meerbeeck J.P., Gaafar R., Manegold C., Van Klaveren R.J., Van Marck E.A., Vincent M., et al. Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. J Clin Oncol 23 28 (2005) 6881-6889
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6881-6889
    • van Meerbeeck, J.P.1    Gaafar, R.2    Manegold, C.3    Van Klaveren, R.J.4    Van Marck, E.A.5    Vincent, M.6
  • 184
    • 0030891198 scopus 로고    scopus 로고
    • LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    • Shih C., Chen V.J., Gossett L.S., Gates S.B., MacKellar W.C., Habeck L.L., et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 57 6 (1997) 1116-1123
    • (1997) Cancer Res , vol.57 , Issue.6 , pp. 1116-1123
    • Shih, C.1    Chen, V.J.2    Gossett, L.S.3    Gates, S.B.4    MacKellar, W.C.5    Habeck, L.L.6
  • 185
    • 0036562507 scopus 로고    scopus 로고
    • Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy
    • Niyikiza C., Baker S.D., Seitz D.E., Walling J.M., Nelson K., Rusthoven J.J., et al. Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol Cancer Ther 1 7 (2002) 545-552
    • (2002) Mol Cancer Ther , vol.1 , Issue.7 , pp. 545-552
    • Niyikiza, C.1    Baker, S.D.2    Seitz, D.E.3    Walling, J.M.4    Nelson, K.5    Rusthoven, J.J.6
  • 187
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • Vogelzang N.J., Rusthoven J.J., Symanowski J., Denham C., Kaukel E., Ruffie P., et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 21 14 (2003) 2636-2644
    • (2003) J Clin Oncol , vol.21 , Issue.14 , pp. 2636-2644
    • Vogelzang, N.J.1    Rusthoven, J.J.2    Symanowski, J.3    Denham, C.4    Kaukel, E.5    Ruffie, P.6
  • 188
    • 33645449947 scopus 로고    scopus 로고
    • Phase II study of pemetrexed plus carboplatin in malignant pleural mesothelioma
    • Ceresoli G.L., Zucali P.A., Favaretto A.G., Grossi F., Bidoli P., Del C.G., et al. Phase II study of pemetrexed plus carboplatin in malignant pleural mesothelioma. J Clin Oncol 24 9 (2006) 1443-1448
    • (2006) J Clin Oncol , vol.24 , Issue.9 , pp. 1443-1448
    • Ceresoli, G.L.1    Zucali, P.A.2    Favaretto, A.G.3    Grossi, F.4    Bidoli, P.5    Del, C.G.6
  • 189
    • 20244374653 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma
    • Hughes A., Calvert P., Azzabi A., Plummer R., Johnson R., Rusthoven J., et al. Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma. J Clin Oncol 20 16 (2002) 3533-3544
    • (2002) J Clin Oncol , vol.20 , Issue.16 , pp. 3533-3544
    • Hughes, A.1    Calvert, P.2    Azzabi, A.3    Plummer, R.4    Johnson, R.5    Rusthoven, J.6
  • 190
    • 0037352426 scopus 로고    scopus 로고
    • ALIMTA (pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: a phase II study
    • Smit E.F., Mattson K., von P.J., Manegold C., Clarke S., and Postmus P.E. ALIMTA (pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: a phase II study. Ann Oncol 14 3 (2003) 455-460
    • (2003) Ann Oncol , vol.14 , Issue.3 , pp. 455-460
    • Smit, E.F.1    Mattson, K.2    von, P.J.3    Manegold, C.4    Clarke, S.5    Postmus, P.E.6
  • 191
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N., Shepherd F.A., Fossella F.V., Pereira J.R., de M.F., von P.J., et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 22 9 (2004) 1589-1597
    • (2004) J Clin Oncol , vol.22 , Issue.9 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3    Pereira, J.R.4    de, M.F.5    von, P.J.6
  • 192
    • 0035985288 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer
    • Clarke S.J., Abratt R., Goedhals L., Boyer M.J., Millward M.J., and Ackland S.P. Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer. Ann Oncol 13 5 (2002) 737-741
    • (2002) Ann Oncol , vol.13 , Issue.5 , pp. 737-741
    • Clarke, S.J.1    Abratt, R.2    Goedhals, L.3    Boyer, M.J.4    Millward, M.J.5    Ackland, S.P.6
  • 193
    • 0032908148 scopus 로고    scopus 로고
    • Multitargeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: a phase II study
    • Rusthoven J.J., Eisenhauer E., Butts C., Gregg R., Dancey J., Fisher B., et al. Multitargeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: a phase II study. J Clin Oncol 17 4 (1999) 1194
    • (1999) J Clin Oncol , vol.17 , Issue.4 , pp. 1194
    • Rusthoven, J.J.1    Eisenhauer, E.2    Butts, C.3    Gregg, R.4    Dancey, J.5    Fisher, B.6
  • 194
    • 16244378895 scopus 로고    scopus 로고
    • Pemetrexed plus carboplatin or oxaliplatin in advanced non-small cell lung cancer
    • Scagliotti G.V. Pemetrexed plus carboplatin or oxaliplatin in advanced non-small cell lung cancer. Semin Oncol 32 2 Suppl. 2 (2005) S5-S8
    • (2005) Semin Oncol , vol.32 , Issue.2 SUPPL. 2
    • Scagliotti, G.V.1
  • 195
    • 19944426696 scopus 로고    scopus 로고
    • Pemetrexed combined with oxaliplatin or carboplatin as first-line treatment in advanced non-small cell lung cancer: a multicenter, randomized, phase II trial
    • Scagliotti G.V., Kortsik C., Dark G.G., Price A., Manegold C., Rosell R., et al. Pemetrexed combined with oxaliplatin or carboplatin as first-line treatment in advanced non-small cell lung cancer: a multicenter, randomized, phase II trial. Clin Cancer Res 11 2 Pt 1 (2005) 690-696
    • (2005) Clin Cancer Res , vol.11 , Issue.2 PART 1 , pp. 690-696
    • Scagliotti, G.V.1    Kortsik, C.2    Dark, G.G.3    Price, A.4    Manegold, C.5    Rosell, R.6
  • 196
    • 23744482948 scopus 로고    scopus 로고
    • A phase I/II study of pemetrexed and vinorelbine in patients with non-small cell lung cancer
    • Clarke S.J., Boyer M.J., Millward M., Underhill C., Moylan E., Yip D., et al. A phase I/II study of pemetrexed and vinorelbine in patients with non-small cell lung cancer. Lung Cancer 49 3 (2005) 401-412
    • (2005) Lung Cancer , vol.49 , Issue.3 , pp. 401-412
    • Clarke, S.J.1    Boyer, M.J.2    Millward, M.3    Underhill, C.4    Moylan, E.5    Yip, D.6
  • 197
    • 24944485165 scopus 로고    scopus 로고
    • Randomized phase II trial of three schedules of pemetrexed and gemcitabine as front-line therapy for advanced non-small-cell lung cancer
    • Ma C.X., Nair S., Thomas S., Mandrekar S.J., Nikcevich D.A., Rowland K.M., et al. Randomized phase II trial of three schedules of pemetrexed and gemcitabine as front-line therapy for advanced non-small-cell lung cancer. J Clin Oncol 23 25 (2005) 5929-5937
    • (2005) J Clin Oncol , vol.23 , Issue.25 , pp. 5929-5937
    • Ma, C.X.1    Nair, S.2    Thomas, S.3    Mandrekar, S.J.4    Nikcevich, D.A.5    Rowland, K.M.6
  • 198
    • 16244401470 scopus 로고    scopus 로고
    • Pemetrexed (Alimta) in small cell lung cancer
    • Socinski M.A. Pemetrexed (Alimta) in small cell lung cancer. Semin Oncol 32 2 Suppl. 2 (2005) S1-S4
    • (2005) Semin Oncol , vol.32 , Issue.2 SUPPL. 2
    • Socinski, M.A.1
  • 199
    • 27144530079 scopus 로고    scopus 로고
    • A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
    • Oettle H., Richards D., Ramanathan R.K., Van Laethem J.L., Peeters M., Fuchs M., et al. A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol 16 10 (2005) 1639-1645
    • (2005) Ann Oncol , vol.16 , Issue.10 , pp. 1639-1645
    • Oettle, H.1    Richards, D.2    Ramanathan, R.K.3    Van Laethem, J.L.4    Peeters, M.5    Fuchs, M.6
  • 200
    • 0035446433 scopus 로고    scopus 로고
    • Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck
    • Pivot X., Raymond E., Laguerre B., Degardin M., Cals L., Armand J.P., et al. Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck. Br J Cancer 85 5 (2001) 649-655
    • (2001) Br J Cancer , vol.85 , Issue.5 , pp. 649-655
    • Pivot, X.1    Raymond, E.2    Laguerre, B.3    Degardin, M.4    Cals, L.5    Armand, J.P.6
  • 202
    • 0032693973 scopus 로고    scopus 로고
    • Phase II study of first-line LY231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: an NCIC Clinical Trials Group Study
    • Cripps C., Burnell M., Jolivet J., Batist G., Lofters W., Dancey J., et al. Phase II study of first-line LY231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: an NCIC Clinical Trials Group Study. Ann Oncol 10 10 (1999) 1175-1179
    • (1999) Ann Oncol , vol.10 , Issue.10 , pp. 1175-1179
    • Cripps, C.1    Burnell, M.2    Jolivet, J.3    Batist, G.4    Lofters, W.5    Dancey, J.6
  • 203
    • 32944481077 scopus 로고    scopus 로고
    • Pemetrexed/oxaliplatin for first-line treatment of patients with advanced colorectal cancer: a phase II trial of the National Surgical Adjuvant Breast and Bowel Project Foundation Research Program
    • Atkins J.N., Jacobs S.A., Wieand H.S., Smith R.E., John W.J., Colangelo L.H., et al. Pemetrexed/oxaliplatin for first-line treatment of patients with advanced colorectal cancer: a phase II trial of the National Surgical Adjuvant Breast and Bowel Project Foundation Research Program. Clin Colorectal Cancer 5 3 (2005) 181-187
    • (2005) Clin Colorectal Cancer , vol.5 , Issue.3 , pp. 181-187
    • Atkins, J.N.1    Jacobs, S.A.2    Wieand, H.S.3    Smith, R.E.4    John, W.J.5    Colangelo, L.H.6
  • 204
    • 33644840299 scopus 로고    scopus 로고
    • Phase I/II dose-escalation study of pemetrexed plus irinotecan in patients with advanced colorectal cancer
    • Hochster H., Kettner E., Kroning H., Becker K., Lordick F., Ramanathan R.K., et al. Phase I/II dose-escalation study of pemetrexed plus irinotecan in patients with advanced colorectal cancer. Clin Colorectal Cancer 5 4 (2005) 257-262
    • (2005) Clin Colorectal Cancer , vol.5 , Issue.4 , pp. 257-262
    • Hochster, H.1    Kettner, E.2    Kroning, H.3    Becker, K.4    Lordick, F.5    Ramanathan, R.K.6
  • 205
    • 22144437340 scopus 로고    scopus 로고
    • Phase II study of pemetrexed in patients pretreated with an anthracycline, a taxane, and capecitabine for advanced breast cancer
    • O'Shaughnessy J.A., Clark R.S., Blum J.L., Mennel R.G., Snyder D., Ye Z., et al. Phase II study of pemetrexed in patients pretreated with an anthracycline, a taxane, and capecitabine for advanced breast cancer. Clin Breast Cancer 6 2 (2005) 143-149
    • (2005) Clin Breast Cancer , vol.6 , Issue.2 , pp. 143-149
    • O'Shaughnessy, J.A.1    Clark, R.S.2    Blum, J.L.3    Mennel, R.G.4    Snyder, D.5    Ye, Z.6
  • 206
    • 13744252159 scopus 로고    scopus 로고
    • Phase II studies of pemetrexed in metastatic breast and gynecologic cancers
    • Smith I. Phase II studies of pemetrexed in metastatic breast and gynecologic cancers. Oncology (Williston, Park) 18 13 Suppl. 8 (2004) 63-65
    • (2004) Oncology (Williston, Park) , vol.18 , Issue.13 SUPPL. 8 , pp. 63-65
    • Smith, I.1
  • 207
    • 0036355046 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer
    • Park D.J., Stoehlmacher J., Zhang W., Tsao-Wei D., Groshen S., and Lenz H.J. Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer. Int J Colorectal Dis 17 1 (2002) 46-49
    • (2002) Int J Colorectal Dis , vol.17 , Issue.1 , pp. 46-49
    • Park, D.J.1    Stoehlmacher, J.2    Zhang, W.3    Tsao-Wei, D.4    Groshen, S.5    Lenz, H.J.6
  • 208
    • 0035430487 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
    • Marsh S., McKay J.A., Cassidy J., and McLeod H.L. Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int J Oncol 19 2 (2001) 383-386
    • (2001) Int J Oncol , vol.19 , Issue.2 , pp. 383-386
    • Marsh, S.1    McKay, J.A.2    Cassidy, J.3    McLeod, H.L.4
  • 209
    • 25144517063 scopus 로고    scopus 로고
    • Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers
    • Morganti M., Ciantelli M., Giglioni B., Putignano A.L., Nobili S., Papi L., et al. Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers. Eur J Cancer 41 14 (2005) 2176-2183
    • (2005) Eur J Cancer , vol.41 , Issue.14 , pp. 2176-2183
    • Morganti, M.1    Ciantelli, M.2    Giglioni, B.3    Putignano, A.L.4    Nobili, S.5    Papi, L.6
  • 210
    • 0035860142 scopus 로고    scopus 로고
    • A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil
    • Iacopetta B., Grieu F., Joseph D., and Elsaleh H. A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. Br J Cancer 85 6 (2001) 827-831
    • (2001) Br J Cancer , vol.85 , Issue.6 , pp. 827-831
    • Iacopetta, B.1    Grieu, F.2    Joseph, D.3    Elsaleh, H.4
  • 211
    • 0035868667 scopus 로고    scopus 로고
    • Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
    • Villafranca E., Okruzhnov Y., Dominguez M.A., Garcia-Foncillas J., Azinovic I., Martinez E., et al. Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 19 6 (2001) 1779-1786
    • (2001) J Clin Oncol , vol.19 , Issue.6 , pp. 1779-1786
    • Villafranca, E.1    Okruzhnov, Y.2    Dominguez, M.A.3    Garcia-Foncillas, J.4    Azinovic, I.5    Martinez, E.6
  • 212
    • 0036765664 scopus 로고    scopus 로고
    • Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer
    • Ishida Y., Kawakami K., Tanaka Y., Kanehira E., Omura K., and Watanabe G. Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer. Anticancer Res 20 5 (2002) 2805-2809
    • (2002) Anticancer Res , vol.20 , Issue.5 , pp. 2805-2809
    • Ishida, Y.1    Kawakami, K.2    Tanaka, Y.3    Kanehira, E.4    Omura, K.5    Watanabe, G.6
  • 213
    • 12444302837 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region is not an efficacious marker for tumor sensitivity to 5-fluorouracil-based oral adjuvant chemotherapy in colorectal cancer
    • Tsuji T., Hidaka S., Sawai T., Nakagoe T., Yano H., Haseba M., et al. Polymorphism in the thymidylate synthase promoter enhancer region is not an efficacious marker for tumor sensitivity to 5-fluorouracil-based oral adjuvant chemotherapy in colorectal cancer. Clin Cancer Res 9 10 (2003) 3700-3704
    • (2003) Clin Cancer Res , vol.9 , Issue.10 , pp. 3700-3704
    • Tsuji, T.1    Hidaka, S.2    Sawai, T.3    Nakagoe, T.4    Yano, H.5    Haseba, M.6
  • 214
    • 33646838450 scopus 로고    scopus 로고
    • Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil
    • Fernandez-Contreras M.E., Sanchez-Prudencio S., Sanchez-Hernandez J.J., Garcia de Paredes M.L., Gisbert J.P., Roda-Navarro P., et al. Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil. Int J Oncol 28 5 (2006) 1303-1310
    • (2006) Int J Oncol , vol.28 , Issue.5 , pp. 1303-1310
    • Fernandez-Contreras, M.E.1    Sanchez-Prudencio, S.2    Sanchez-Hernandez, J.J.3    Garcia de Paredes, M.L.4    Gisbert, J.P.5    Roda-Navarro, P.6
  • 215
    • 33645750172 scopus 로고    scopus 로고
    • Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment
    • Dotor E., Cuatrecases M., Martinez-Iniesta M., Navarro M., Vilardell F., Guino E., et al. Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment. J Clin Oncol 24 10 (2006) 1603-1611
    • (2006) J Clin Oncol , vol.24 , Issue.10 , pp. 1603-1611
    • Dotor, E.1    Cuatrecases, M.2    Martinez-Iniesta, M.3    Navarro, M.4    Vilardell, F.5    Guino, E.6
  • 216
    • 6344265942 scopus 로고    scopus 로고
    • Scheduling of fluorouracil: a forget-me-not in the jungle of doublets
    • Sobrero A.F. Scheduling of fluorouracil: a forget-me-not in the jungle of doublets. J Clin Oncol 22 1 (2004) 4-6
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 4-6
    • Sobrero, A.F.1
  • 217
    • 15744377355 scopus 로고    scopus 로고
    • Phase III Southwest Oncology Group 9415/Intergroup 0153 randomized trial of fluorouracil, leucovorin, and levamisole versus fluorouracil continuous infusion and levamisole for adjuvant treatment of stage III and high-risk stage II colon cancer
    • Poplin E.A., Benedetti J.K., Estes N., Haller D.G., Mayer R.J., Goldberg R.M., et al. Phase III Southwest Oncology Group 9415/Intergroup 0153 randomized trial of fluorouracil, leucovorin, and levamisole versus fluorouracil continuous infusion and levamisole for adjuvant treatment of stage III and high-risk stage II colon cancer. J Clin Oncol 23 9 (2005) 1819-1825
    • (2005) J Clin Oncol , vol.23 , Issue.9 , pp. 1819-1825
    • Poplin, E.A.1    Benedetti, J.K.2    Estes, N.3    Haller, D.G.4    Mayer, R.J.5    Goldberg, R.M.6
  • 218
    • 33751228651 scopus 로고    scopus 로고
    • van Cutsem E, Labianca R, Hossfeld D, Bodoky G, Roth A, Aranda E, et al. Randomized phase III trial comparing infused irinotecan/5-fluorouracil (5-FU)/folinic acid (IF) versus 5-FU/FA (F) in stage III colon cancer patients (pts). (PETACC 3). J Clin Oncol (Meeting Abstracts) 2005, Jun 01, LBA8.
  • 219
    • 33751224095 scopus 로고    scopus 로고
    • Saltz LB, Niedzwiecki D, Hollis D, Goldberg RM, Hantel A, Thomas JP, et al. Irinotecan plus fluorouracil/leucovorin (IFL) versus fluorouracil/leucovorin alone (FL) in stage III colon cancer (intergroup trial CALGB C89803). J Clin Oncol (Meeting Abstracts) 2004, Jul 15, p. 1264.
  • 220
    • 0036731818 scopus 로고    scopus 로고
    • Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Douillard J.Y., Hoff P.M., Skillings J.R., Eisenberg P., Davidson N., Harper P., et al. Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 20 17 (2002) 3605-3616
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3605-3616
    • Douillard, J.Y.1    Hoff, P.M.2    Skillings, J.R.3    Eisenberg, P.4    Davidson, N.5    Harper, P.6
  • 221
    • 0036727089 scopus 로고    scopus 로고
    • Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Carmichael J., Popiela T., Radstone D., Falk S., Borner M., Oza A., et al. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 20 17 (2002) 3617-3627
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3617-3627
    • Carmichael, J.1    Popiela, T.2    Radstone, D.3    Falk, S.4    Borner, M.5    Oza, A.6
  • 222
    • 27744568670 scopus 로고    scopus 로고
    • An investigation of TS-1 single-agent therapy administered as first-line therapy for unresectable advanced gastric cancer
    • Nukaya H., Hirashima N., Tanaka Y., Endo M., Matsunaga S., Hasegawa I., et al. An investigation of TS-1 single-agent therapy administered as first-line therapy for unresectable advanced gastric cancer. Gan To Kagaku Ryoho 32 10 (2005) 1421-1426
    • (2005) Gan To Kagaku Ryoho , vol.32 , Issue.10 , pp. 1421-1426
    • Nukaya, H.1    Hirashima, N.2    Tanaka, Y.3    Endo, M.4    Matsunaga, S.5    Hasegawa, I.6
  • 223
    • 1942503303 scopus 로고    scopus 로고
    • Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy
    • Elnakat H., and Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev 56 (2004) 1067-1084
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1067-1084
    • Elnakat, H.1    Ratnam, M.2
  • 224
    • 1942439032 scopus 로고    scopus 로고
    • Antifolates targeted specifically to the folate receptor
    • Jackman A.L., Theti D.S., and Gibbs D.D. Antifolates targeted specifically to the folate receptor. Adv Drug Deliv Rev 56 (2004) 1111-1125
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1111-1125
    • Jackman, A.L.1    Theti, D.S.2    Gibbs, D.D.3
  • 225
    • 3042668095 scopus 로고    scopus 로고
    • The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors
    • Peters G.J., Noordhuis P., van Groeningen C.J., Giaccone G., Holwerda U., Voorn D., et al. The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors. Clin Cancer Res 10 12 (2004) 4072-4076
    • (2004) Clin Cancer Res , vol.10 , Issue.12 , pp. 4072-4076
    • Peters, G.J.1    Noordhuis, P.2    van Groeningen, C.J.3    Giaccone, G.4    Holwerda, U.5    Voorn, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.