메뉴 건너뛰기




Volumn 13, Issue 1, 2006, Pages 107-114

Stable inhibition of human thymidylate synthase expression following retroviral introduction of an siRNA gene

Author keywords

Cancer therapy; Retroviral gene therapy; RNA interference

Indexed keywords

RETROVIRUS VECTOR; SMALL INTERFERING RNA; THYMIDYLATE SYNTHASE;

EID: 29144530156     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700880     Document Type: Article
Times cited : (9)

References (32)
  • 1
    • 0029036377 scopus 로고
    • The catalytic mechanism and structure of thymidylate synthase
    • Carreras CW, Santi DV. The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 1995; 64: 721-762.
    • (1995) Annu Rev Biochem , vol.64 , pp. 721-762
    • Carreras, C.W.1    Santi, D.V.2
  • 2
    • 0017716458 scopus 로고
    • Thymidylate synthetase - A target enzyme in cancer chemotherapy
    • Danenberg PV. Thymidylate synthetase - a target enzyme in cancer chemotherapy. Biochim Biophys Acta 1977; 473: 73-92.
    • (1977) Biochim Biophys Acta , vol.473 , pp. 73-92
    • Danenberg, P.V.1
  • 3
    • 0029658045 scopus 로고    scopus 로고
    • Tomudex(TM) (ZD1694): From concept to care, a programme in rational drug discovery
    • Jackman AL, Boyle FT, Harrap KR. Tomudex(TM) (ZD1694): from concept to care, a programme in rational drug discovery. Invest New Drugs 1996; 14: 305-316.
    • (1996) Invest New Drugs , vol.14 , pp. 305-316
    • Jackman, A.L.1    Boyle, F.T.2    Harrap, K.R.3
  • 4
  • 5
    • 0027081148 scopus 로고
    • A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2′-deoxyuridine in mammalian and bacterial cells
    • Barbour KW, Hoganson DK, Berger SH, Berger FG. A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2′-deoxyuridine in mammalian and bacterial cells. Mol Pharmacol 1992; 42(2): 242-248.
    • (1992) Mol Pharmacol , vol.42 , Issue.2 , pp. 242-248
    • Barbour, K.W.1    Hoganson, D.K.2    Berger, S.H.3    Berger, F.G.4
  • 6
    • 0021335983 scopus 로고
    • Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil
    • Washtien WL. Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil. Mol Pharmacol 1984; 25: 171-177.
    • (1984) Mol Pharmacol , vol.25 , pp. 171-177
    • Washtien, W.L.1
  • 7
    • 0034124895 scopus 로고    scopus 로고
    • Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues
    • Welsh SJ, Titley J, Brunton L, Valenti M, Monaghan P, Jackman AL et al. Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues. Clin Cancer Res 2000; 6(6): 2538-2546.
    • (2000) Clin Cancer Res , vol.6 , Issue.6 , pp. 2538-2546
    • Welsh, S.J.1    Titley, J.2    Brunton, L.3    Valenti, M.4    Monaghan, P.5    Jackman, A.L.6
  • 9
    • 0033617219 scopus 로고    scopus 로고
    • Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization - Implications for autoregulation of translation
    • Kitchens ME, Forsthoefel AM, Rafique Z, Spencer HT, Berger FG. Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization - Implications for autoregulation of translation. J Biol Chem 1999; 274: 12544-12547.
    • (1999) J Biol Chem , vol.274 , pp. 12544-12547
    • Kitchens, M.E.1    Forsthoefel, A.M.2    Rafique, Z.3    Spencer, H.T.4    Berger, F.G.5
  • 11
    • 0030111238 scopus 로고    scopus 로고
    • The role of thymidylate synthase as an RNA binding protein
    • Chu E, Allegra CJ. The role of thymidylate synthase as an RNA binding protein. BioEssays 1996; 18: 191-198.
    • (1996) BioEssays , vol.18 , pp. 191-198
    • Chu, E.1    Allegra, C.J.2
  • 12
    • 0037130280 scopus 로고    scopus 로고
    • Thymidylate synthase as a translational regulator of cellular gene expression
    • Liu J, Schmitz JC, Lin X, Tai N, Yan W, Farrell M et al. Thymidylate synthase as a translational regulator of cellular gene expression. Biochim Biophys Acta 2002; 1587(2-3): 174-182.
    • (2002) Biochim Biophys Acta , vol.1587 , Issue.2-3 , pp. 174-182
    • Liu, J.1    Schmitz, J.C.2    Lin, X.3    Tai, N.4    Yan, W.5    Farrell, M.6
  • 13
    • 0020354139 scopus 로고
    • Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts
    • Rossana C, Rao LG, Johnson LF. Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts. Mol Cell Biol 1982; 2: 1118-1125.
    • (1982) Mol Cell Biol , vol.2 , pp. 1118-1125
    • Rossana, C.1    Rao, L.G.2    Johnson, L.F.3
  • 14
    • 0021808075 scopus 로고
    • Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines
    • Jenh C-H, Geyer PK, Baskin F, Johnson LF. Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines. Mol Pharmacol 1985; 28: 80-85.
    • (1985) Mol Pharmacol , vol.28 , pp. 80-85
    • Jenh, C.-H.1    Geyer, P.K.2    Baskin, F.3    Johnson, L.F.4
  • 15
    • 0022344622 scopus 로고
    • Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells
    • Berger SH, Jenh C-H, Johnson LF, Berger FG. Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells. Mol Pharmacol 1985; 28: 461-467.
    • (1985) Mol Pharmacol , vol.28 , pp. 461-467
    • Berger, S.H.1    Jenh, C.-H.2    Johnson, L.F.3    Berger, F.G.4
  • 16
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon GJ. RNA interference. Nature 2002; 418(6894): 244-251.
    • (2002) Nature , vol.418 , Issue.6894 , pp. 244-251
    • Hannon, G.J.1
  • 17
    • 0037686295 scopus 로고    scopus 로고
    • Killing the messenger: Short RNAs that silence gene expression
    • Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 2003; 4(6): 457-467.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.6 , pp. 457-467
    • Dykxhoorn, D.M.1    Novina, C.D.2    Sharp, P.A.3
  • 18
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus-mediated RNA interference
    • Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002; 2(3): 243-247.
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 20
    • 0037173613 scopus 로고    scopus 로고
    • Short interfering RNA confers intracellular antiviral immunity in human cells
    • Gitlin L, Karelsky S, Andino R. Short interfering RNA confers intracellular antiviral immunity in human cells. Nature 2002; 418(6896): 430-434.
    • (2002) Nature , vol.418 , Issue.6896 , pp. 430-434
    • Gitlin, L.1    Karelsky, S.2    Andino, R.3
  • 21
    • 0037173610 scopus 로고    scopus 로고
    • Modulation of HIV-1 replication by RNA interference
    • Jacque JM, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature 2002; 418(6896): 435-438.
    • (2002) Nature , vol.418 , Issue.6896 , pp. 435-438
    • Jacque, J.M.1    Triques, K.2    Stevenson, M.3
  • 22
    • 0022371692 scopus 로고
    • Thymidylate synthase-deficient Chinese hamster cells: A selection system for human chromosome 18 and experimental system for the study of thymidylate synthase regulation and fragile X expression
    • Nussbaum RL, Walmsley RM, Lesko JG, Airhart SD, Ledbetter DH. Thymidylate synthase-deficient Chinese hamster cells: a selection system for human chromosome 18 and experimental system for the study of thymidylate synthase regulation and fragile X expression. Am J Hum Genet 1985; 37: 1192-1205.
    • (1985) Am J Hum Genet , vol.37 , pp. 1192-1205
    • Nussbaum, R.L.1    Walmsley, R.M.2    Lesko, J.G.3    Airhart, S.D.4    Ledbetter, D.H.5
  • 23
    • 0031754609 scopus 로고    scopus 로고
    • Expression vectors and delivery systems
    • Nolan GP, Shatzman AR. Expression vectors and delivery systems. Curr Opin Biotechnol 1998; 9(5): 447-450.
    • (1998) Curr Opin Biotechnol , vol.9 , Issue.5 , pp. 447-450
    • Nolan, G.P.1    Shatzman, A.R.2
  • 24
    • 0037089589 scopus 로고    scopus 로고
    • Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
    • Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev 2002; 16(8): 948-958.
    • (2002) Genes Dev , vol.16 , Issue.8 , pp. 948-958
    • Paddison, P.J.1    Caudy, A.A.2    Bernstein, E.3    Hannon, G.J.4    Conklin, D.S.5
  • 25
    • 0000423899 scopus 로고
    • Thymidylate synthetase purified to homogeneity from human leukemic cells
    • Lockshin A, Moran RG, Danenberg PV. Thymidylate synthetase purified to homogeneity from human leukemic cells. Proc Natl Acad Sci USA 1979; 76: 750-754.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 750-754
    • Lockshin, A.1    Moran, R.G.2    Danenberg, P.V.3
  • 26
    • 0036499301 scopus 로고    scopus 로고
    • A new quantitative method of real-time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics
    • Liu W, Saint DA. A new quantitative method of real-time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics. Anal Biochem 2002; 302(1): 52-59.
    • (2002) Anal Biochem , vol.302 , Issue.1 , pp. 52-59
    • Liu, W.1    Saint, D.A.2
  • 27
    • 0033775615 scopus 로고    scopus 로고
    • Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays
    • Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 2000; 25(2): 169-193.
    • (2000) J Mol Endocrinol , vol.25 , Issue.2 , pp. 169-193
    • Bustin, S.A.1
  • 28
    • 0023705723 scopus 로고
    • Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells
    • Keyomarsi K, Moran RG. Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J Biol Chem 1988; 263(28): 14402-14409.
    • (1988) J Biol Chem , vol.263 , Issue.28 , pp. 14402-14409
    • Keyomarsi, K.1    Moran, R.G.2
  • 29
    • 1242316160 scopus 로고    scopus 로고
    • Small interfering double-stranded RNAs as therapeutic molecules to restore chemosensitivity to thymidylate synthase inhibitor compounds
    • Schmitz JC, Chen TM, Chu E. Small interfering double-stranded RNAs as therapeutic molecules to restore chemosensitivity to thymidylate synthase inhibitor compounds. Cancer Res 2004; 64(4): 1431-1435.
    • (2004) Cancer Res , vol.64 , Issue.4 , pp. 1431-1435
    • Schmitz, J.C.1    Chen, T.M.2    Chu, E.3
  • 30
    • 4944241573 scopus 로고    scopus 로고
    • Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition
    • Koehler SE, Ladner RD. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. Mol Pharmacol 2004; 66(3): 620-626.
    • (2004) Mol Pharmacol , vol.66 , Issue.3 , pp. 620-626
    • Koehler, S.E.1    Ladner, R.D.2
  • 31
    • 1842685083 scopus 로고    scopus 로고
    • Thymidylate synthase as an oncogene: A novel role for an essential DNA synthesis enzyme
    • Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC et al. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell 2004; 5(4): 341-351.
    • (2004) Cancer Cell , vol.5 , Issue.4 , pp. 341-351
    • Rahman, L.1    Voeller, D.2    Rahman, M.3    Lipkowitz, S.4    Allegra, C.5    Barrett, J.C.6
  • 32
    • 1842685096 scopus 로고    scopus 로고
    • Thymidylate synthase as an oncogene?
    • Bertino JR, Banerjee D. Thymidylate synthase as an oncogene? Cancer Cell 2004; 5(4): 301-302.
    • (2004) Cancer Cell , vol.5 , Issue.4 , pp. 301-302
    • Bertino, J.R.1    Banerjee, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.