Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

Journal of Clinical Oncology

Volumn 19, Issue 6, 2001, Pages 1779-1786

  Villafranca, E ^a   Okruzhnov, Y ^a   Dominguez, M A ^a   Garcia Foncillas J ^a   Azinovic, I ^a   Martinez E ^a   Illarramendi, J J ^a   Arias, F ^a   Martinez Monge R ^a   Salgado, E ^a   Angeletti, S ^a   Brugarolas, A ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; FLUOROURACIL; FOLINATE CALCIUM; FOLINIC ACID; OXALIPLATIN; TEGAFUR; THYMIDYLATE SYNTHASE;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; ENHANCER REGION; FEMALE; GENE AMPLIFICATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECTUM CANCER;

EID: 0035868667     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2001.19.6.1779     Document Type: Article

References (35)

1. Modulation of iododeoxyuridine-mediated radiosensitization by 5-fluorouracil in human colon cancer cells
2. Chemotherapy for colorectal cancer
3. Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy
4. Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer
5. Rapid growth of microscopic rectal cancer as a determinant of response to preoperative radiation therapy
6. Preoperative radiotherapy (RT) for rectal cancer: Predictive factors of tumor downstaging and residual tumor cell density (RTCD): Prognostic implications
7. Prognostic implications of downstaging following preoperative radiation therapy for operable T3-T 4 rectal cancer
8. Radiotherapy in addition to radical surgery in rectal cancer: Evidence for a dose-response effect favoring preoperative treatment
9. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: The Lyon R90-01 randomized trial
10. p53 status: An indicator for the effect of preoperative radiotherapy of rectal cancer
11. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: An analysis of response and survival
12. Apoptosis, proliferation, bax, bc1- 2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer
13. The intratumoral levels of thymidylate synthetase and folate in gastric and colon cancer
14. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase
15. Role in translation of a triple tandemly repeated sequence in the 5′-untranslated region of human thymidylate synthase mRNA
16. Pre-mRNA processing enhancer (PPE) element increases the expression of an intronless thymidylate synthase gene but does not affect intron-dependent S phase regulation
17. Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers
18. Ethnic variation in the thymidylate synthase enhancer region
19. Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy
20. Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: The M. D. Anderson Cancer Center experience
21. Preoperative radiotherapy as adjuvant treatment in rectal cancer: Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC)
22. Preoperative radiotherapy in operable rectal cancer
23. Nonparametric estimation from incomplete observations
24. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma
25. TS gene structure and TS expression
26. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
27. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
28. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
29. Rapid detection of thymidylate synthase gene expression levels by semi-quantitative competitive reverse transcriptase polymerase chain reaction followed by quantitative digital image analysis
30. Preoperative infusional chemoradiation therapy for stage T3 rectal cancer
31. Preoperative chemotherapy and radiation therapy for locally advanced primary and recurrent rectal carcinoma: A report of surgical morbidity
32. Descenso de estadificación después de carboplatino y 5-fluoruracilo simultáneo durante la radioterapia preoperatoria en carcinoma de recto
33. Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, sphincter preservation
34. Analysis of thymidylate synthase gene polymorphisms in the Latino population