Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer

British Journal of Cancer

Volumn 89, Issue 8, 2003, Pages 1486-1492

  Ichikawa, W ^a   Uetake, H ^b   Shirota, Y ^b   Yamada, H ^b   Takahashi, T ^a   Nihei, Z ^a   Sugihara, K ^b   Sasaki, Y ^a   Hirayama, R ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b Tokyo Medical and Dental University ^*  (Japan)

Author keywords

Dihydropyrimidine dehydrogenase; Fluoropyrimidine based chemotherapy; Metastatic colorectal cancer; Orotate phosphoribosyl transferase

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FOLINIC ACID; OROTATE PHOSPHORIBOSYLTRANSFERASE; THYMIDINE PHOSPHORYLASE; UFT; URIDINE PHOSPHORYLASE;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; COLORECTAL CANCER; DRUG METABOLISM; GENE EXPRESSION; HUMAN; METASTASIS; PHOSPHORYLATION; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; SURVIVAL TIME;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; COLORECTAL NEOPLASMS; DIHYDROURACIL DEHYDROGENASE (NADP); DRUG COMBINATIONS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUCOVORIN; MALE; MIDDLE AGED; OROTATE PHOSPHORIBOSYLTRANSFERASE; PREDICTIVE VALUE OF TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL ANALYSIS; TEGAFUR; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; URACIL;

EID: 0242658929     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601335     Document Type: Article

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