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Volumn 64, Issue 4, 2004, Pages 1431-1435

Small Interfering Double-Stranded RNAs as Therapeutic Molecules to Restore Chemosensitivity to Thymidylate Synthase Inhibitor Compounds

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; 5' FLUORO 2' DEOXYURIDINE; COMPLEMENTARY DNA; DOUBLE STRANDED RNA; DOXYCYCLINE; MONOCLONAL ANTIBODY; RALTITREXED; SMALL INTERFERING RNA; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 1242316160     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-1203     Document Type: Article
Times cited : (39)

References (34)
  • 1
  • 2
    • 0035281741 scopus 로고    scopus 로고
    • RNA interference - 2001
    • Sharp, P. A. RNA interference-2001. Genes Dev., 15: 485-490, 2001.
    • (2001) Genes Dev. , vol.15 , pp. 485-490
    • Sharp, P.A.1
  • 3
    • 0034877670 scopus 로고    scopus 로고
    • RNA interference: Listening to the sound of silence
    • Zamore, P. D. RNA interference: listening to the sound of silence. Nat. Struct. Biol., 8: 746-750, 2001.
    • (2001) Nat. Struct. Biol. , vol.8 , pp. 746-750
    • Zamore, P.D.1
  • 4
    • 0037422606 scopus 로고    scopus 로고
    • RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast
    • Hall, I. M., Noma, K., and Grewal, S. I. RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc. Natl. Acad. Sci. USA, 100: 193-198, 2003.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 193-198
    • Hall, I.M.1    Noma, K.2    Grewal, S.I.3
  • 5
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
    • Volpe, T. A., Kidner, C., Hall, I. M., Teng, G., Grewal, S. I., and Martienssen, R. A. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (Wash. DC), 297: 1833-1837, 2002.
    • (2002) Science (Wash. DC) , vol.297 , pp. 1833-1837
    • Volpe, T.A.1    Kidner, C.2    Hall, I.M.3    Teng, G.4    Grewal, S.I.5    Martienssen, R.A.6
  • 6
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy, A. A., Myers, M., Hannon, G. J., and Hammond, S. M. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev., 16: 2491-2496, 2002.
    • (2002) Genes Dev. , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 7
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., and Mello, C. C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (Lond.), 391: 806-811, 1998.
    • (1998) Nature (Lond.) , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 8
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense RNA in posttranscriptional gene silencing in plants
    • Hamilton, A. J., and Baulcombe, D. C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science (Wash. DC), 286: 950-952, 1999.
    • (1999) Science (Wash. DC) , vol.286 , pp. 950-952
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 9
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21-and 22-nucleotide RNAs
    • Elbashir, S. M., Lendeckel, W., and Tuschl, T. RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev., 15: 188-200, 2001.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 10
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore, P. D., Tuschl, T., Sharp, P. A., and Bartel, D. P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 101: 25-33, 2000.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 11
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond, S. M., Bernstein, E., Beach, D., and Hannon, G. J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (Lond.), 404: 293-296, 2000.
    • (2000) Nature (Lond.) , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 12
    • 0030996469 scopus 로고    scopus 로고
    • Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation
    • Williams, B. R. Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation. Biochem. Soc. Trans., 25: 509-513, 1997.
    • (1997) Biochem. Soc. Trans. , vol.25 , pp. 509-513
    • Williams, B.R.1
  • 13
    • 0020027615 scopus 로고
    • Heterogeneous nuclear RNA promotes synthesis of (2′, 5′)oligoadenylate and is cleaved by the (2′, 5′ )oligoadenylate-activated endoribonuclease
    • Nilsen, T. W., Maroney, P. A., Robertson, H. D., and Baglioni, C. Heterogeneous nuclear RNA promotes synthesis of (2′, 5′ )oligoadenylate and is cleaved by the (2′, 5′ )oligoadenylate-activated endoribonuclease. Mol. Cell Biol., 2: 154-160, 1982.
    • (1982) Mol. Cell Biol. , vol.2 , pp. 154-160
    • Nilsen, T.W.1    Maroney, P.A.2    Robertson, H.D.3    Baglioni, C.4
  • 14
    • 0032079356 scopus 로고    scopus 로고
    • The 2-5A system: Modulation of viral and cellular processes through acceleration of RNA degradation
    • Player, M. R., and Torrence, P. F. The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation. Pharmacol. Ther., 78: 55-113, 1998.
    • (1998) Pharmacol. Ther. , vol.78 , pp. 55-113
    • Player, M.R.1    Torrence, P.F.2
  • 15
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (Lond.), 411: 494-498, 2001.
    • (2001) Nature (Lond.) , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 16
    • 0029036377 scopus 로고
    • The catalytic mechanism and structure of thymidylate synthase
    • Carreras, C. W., and Santi, D. V. The catalytic mechanism and structure of thymidylate synthase. Annu. Rev. Biochem., 64: 721-762, 1995.
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 721-762
    • Carreras, C.W.1    Santi, D.V.2
  • 17
    • 0017716458 scopus 로고
    • Thymidylate synthetase-a target enzyme in cancer chemotherapy
    • Danenberg, P. V. Thymidylate synthetase-a target enzyme in cancer chemotherapy. Biochim. Biophys. Acta, 473: 73-92, 1977.
    • (1977) Biochim. Biophys. Acta , vol.473 , pp. 73-92
    • Danenberg, P.V.1
  • 21
    • 0030111238 scopus 로고    scopus 로고
    • The role of thymidylate synthase as an RNA binding protein
    • Chu, E., and Allegra, C. J. The role of thymidylate synthase as an RNA binding protein. Bioessays, 18: 191-198, 1996.
    • (1996) Bioessays , vol.18 , pp. 191-198
    • Chu, E.1    Allegra, C.J.2
  • 22
    • 0027816213 scopus 로고
    • Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-γ
    • Chu, E., and Allegra, C. J. Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-γ. Adv. Exp. Med. Biol., 339: 143-151, 1993.
    • (1993) Adv. Exp. Med. Biol. , vol.339 , pp. 143-151
    • Chu, E.1    Allegra, C.J.2
  • 23
    • 0027181763 scopus 로고
    • The thymidylate synthase inhibitor, IC1 D1694, overcomes translational detainment of the enzyme
    • Keyomarsi, K., Samet, J., Molnar, G., and Pardee, A. B. The thymidylate synthase inhibitor, IC1 D1694, overcomes translational detainment of the enzyme. J. Biol. Chem., 268: 15142-15149, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15142-15149
    • Keyomarsi, K.1    Samet, J.2    Molnar, G.3    Pardee, A.B.4
  • 24
    • 0026788343 scopus 로고
    • Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors
    • Van der Wilt, C. L., Pinedo, H. M., Smid, K., and Peters, G. J. Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. Cancer Res., 52: 4922-4928, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 4922-4928
    • Van Der Wilt, C.L.1    Pinedo, H.M.2    Smid, K.3    Peters, G.J.4
  • 25
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
    • (1970) Nature (Lond.) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 26
    • 0025043811 scopus 로고
    • Interaction of γ-interferon and 5-fluorouracil in the H630 human colon carcinoma cell line
    • Chu, E., Zinn, S., Boarman, D., and Allegra, C. J. Interaction of γ-interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer Res., 50: 5834-5840, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 5834-5840
    • Chu, E.1    Zinn, S.2    Boarman, D.3    Allegra, C.J.4
  • 28
    • 0023705723 scopus 로고
    • Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells
    • Keyomarsi, K., and Moran, R. G. Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J. Biol. Chem., 263: 14402-14409, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 14402-14409
    • Keyomarsi, K.1    Moran, R.G.2
  • 29
    • 0037386357 scopus 로고    scopus 로고
    • A "combination oligonucleotide" antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance
    • Berg, R. W., Ferguson, P. J., Vincent, M. D., and Koropatnick, D. J. A "combination oligonucleotide" antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance. Cancer Gene Ther., 10: 278-286, 2003.
    • (2003) Cancer Gene Ther. , vol.10 , pp. 278-286
    • Berg, R.W.1    Ferguson, P.J.2    Vincent, M.D.3    Koropatnick, D.J.4
  • 30
    • 0035862164 scopus 로고    scopus 로고
    • Effect of 2′-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells
    • Schmitz, J. C., Yu, D., Agrawal, S., and Chu, E. Effect of 2′-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells. Nucleic Acids Res., 29: 415-422, 2001.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 415-422
    • Schmitz, J.C.1    Yu, D.2    Agrawal, S.3    Chu, E.4
  • 31
    • 0024413739 scopus 로고
    • Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
    • Swain, S. M., Lippman, M. E., Egan, E. F., Drake, J. C., Steinberg, S. M., and Allegra, C. J. Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer. J. Clin. Oncol., 7: 890-899, 1989.
    • (1989) J. Clin. Oncol. , vol.7 , pp. 890-899
    • Swain, S.M.1    Lippman, M.E.2    Egan, E.F.3    Drake, J.C.4    Steinberg, S.M.5    Allegra, C.J.6
  • 32
    • 0033617219 scopus 로고    scopus 로고
    • Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation
    • Kitchens, M. E., Forsthoefel, A. M., Rafique, Z., Spencer, H. T., and Berger, F. G. Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation. J. Biol. Chem., 274: 12544-12547, 1999.
    • (1999) J. Biol. Chem. , vol.274 , pp. 12544-12547
    • Kitchens, M.E.1    Forsthoefel, A.M.2    Rafique, Z.3    Spencer, H.T.4    Berger, F.G.5
  • 33
    • 0029052988 scopus 로고
    • Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil
    • Copur, S., Aiba, K., Drake, J. C., Allegra, C. J., and Chu, E. Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. Biochem. Pharmacol., 49: 1419-1426, 1995.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 1419-1426
    • Copur, S.1    Aiba, K.2    Drake, J.C.3    Allegra, C.J.4    Chu, E.5


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