-
1
-
-
0024347268
-
Biochemical modulation of fluorouracil with leucovorin. Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
-
Poon MA, O'Connel MJ, Moertel CG, et al. Biochemical modulation of fluorouracil with leucovorin. Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 1989, 7, 14071417.
-
(1989)
J Clin Oncol
, vol.7
, pp. 14071417
-
-
Poon, M.A.1
O'Connel, M.J.2
Moertel, C.G.3
-
2
-
-
0018696635
-
5-fluorouracil concentrations in human plasma following R, S-l-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) administration
-
Au JL, Sadee W. 5-fluorouracil concentrations in human plasma following R, S-l-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) administration. Cancer Res 1979, 42, 4289-4290.
-
(1979)
Cancer Res
, vol.42
, pp. 4289-4290
-
-
Au, J.L.1
Sadee, W.2
-
3
-
-
0024262909
-
Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule
-
Van Groeningen CJ, Pinedo HM, Heddes J, et al. Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule. Cancer Res 1988,48,6956-6961.
-
(1988)
Cancer Res
, vol.48
, pp. 6956-6961
-
-
Van Groeningen, C.J.1
Pinedo, H.M.2
Heddes, J.3
-
4
-
-
0025356873
-
Phase i trial of 5-fluorouracil and dipyridamole administered by seventy-two-hour concurrent continuous infusion
-
Remick SC, Grem JL, Fischer PH, et al. Phase I trial of 5-fluorouracil and dipyridamole administered by seventy-two-hour concurrent continuous infusion. Cancer Res 1990, SO, 2667-2672.
-
(1990)
Cancer Res
, vol.SO
, pp. 2667-2672
-
-
Remick, S.C.1
Grem, J.L.2
Fischer, P.H.3
-
5
-
-
0026079516
-
Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72-hour continuous infusion with and without dipyridamole
-
Trump DL, Egorin MJ, Forrest A, Willson JKV, Remick S, Tutsch KD. Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72-hour continuous infusion with and without dipyridamole. J Clin Oncol 1991, 9, 2027-2035.
-
(1991)
J Clin Oncol
, vol.9
, pp. 2027-2035
-
-
Trump, D.L.1
Egorin, M.J.2
Forrest, A.3
Willson, J.K.V.4
Remick, S.5
Tutsch, K.D.6
-
6
-
-
0022630996
-
Clinical pharmacokinetic study of 5-FU in continuous 5-day infusions for head and neck cancer
-
Thyss A, Milano G, Renée N, Vallicioni J, Schneider M, Demard F. Clinical pharmacokinetic study of 5-FU in continuous 5-day infusions for head and neck cancer. Cancer Chemother Pharmacol 1986, 16, 64-66.
-
(1986)
Cancer Chemother Pharmacol
, vol.16
, pp. 64-66
-
-
Thyss, A.1
Milano, G.2
Renée, N.3
Vallicioni, J.4
Schneider, M.5
Demard, F.6
-
7
-
-
0023904924
-
Dose versus pharmacokinetics for predicting tolerance to 5-day continuous infusion of 5-FU
-
Milano G, Roman P, Khater R, Frenay M, Renée N, Namer M. Dose versus pharmacokinetics for predicting tolerance to 5-day continuous infusion of 5-FU. IntJ Cancer 1988, 41, 537-541.
-
(1988)
IntJ Cancer
, vol.41
, pp. 537-541
-
-
Milano, G.1
Roman, P.2
Khater, R.3
Frenay, M.4
Renée, N.5
Namer, M.6
-
8
-
-
0018222094
-
Clinical response and plasma levels of 5-fluorouracil in patients with colonie cancer treated by drug infusion
-
Hillcoat BL, McCulloch PB, Figueredo AT, Ehsan MH, Rosenfeld JM. Clinical response and plasma levels of 5-fluorouracil in patients with colonie cancer treated by drug infusion. Br J Cancer 1978, 38, 719-724.
-
(1978)
Br J Cancer
, vol.38
, pp. 719-724
-
-
Hillcoat, B.L.1
McCulloch, P.B.2
Figueredo, A.T.3
Ehsan, M.H.4
Rosenfeld, J.M.5
-
9
-
-
0028357629
-
Relationship between fluorouracil systemic exposure and tumor response and patient survival
-
Milano G, Etienne MC, Renée N, et al. Relationship between fluorouracil systemic exposure and tumor response and patient survival. J Clin Oncol 1994, 12, 1291-1295.
-
(1994)
J Clin Oncol
, vol.12
, pp. 1291-1295
-
-
Milano, G.1
Etienne, M.C.2
Renée, N.3
-
10
-
-
0024512054
-
5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer
-
Santini J, Milano G, Thyss A, et al. 5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer. Br J Cancer 1989, 59, 287-290.
-
(1989)
Br J Cancer
, vol.59
, pp. 287-290
-
-
Santini, J.1
Milano, G.2
Thyss, A.3
-
11
-
-
0001119203
-
Feasibility of 5-FU therapeutic monitoring
-
Coudert B, De Gislain C, Beltramo R, et al. Feasibility of 5-FU therapeutic monitoring. Eur} Cancer 1995, 31A (Suppl. 5), 201.
-
(1995)
Eur} Cancer
, vol.31 A
, Issue.5 SUPPL.
, pp. 201
-
-
Coudert, B.1
De Gislain, C.2
Beltramo, R.3
-
13
-
-
0022448330
-
Distribution and inhibition of dihydrouracil dehydrogenase in human tissues using 5-fluorouracil as a substrate
-
Ho DH, Townsend L, Luma MA, Bodey GP. Distribution and inhibition of dihydrouracil dehydrogenase in human tissues using 5-fluorouracil as a substrate. Anticancer Res 1986, 6, 781-784.
-
(1986)
Anticancer Res
, vol.6
, pp. 781-784
-
-
Ho, D.H.1
Townsend, L.2
Luma, M.A.3
Bodey, G.P.4
-
14
-
-
0025058867
-
Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
-
Harris BE, Song R, Soong S, Diasio RB. Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 1990, SO, 197-201.
-
(1990)
Cancer Res
, vol.SO
, pp. 197-201
-
-
Harris, B.E.1
Song, R.2
Soong, S.3
Diasio, R.B.4
-
15
-
-
0026753035
-
Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients
-
Fleming RA, Milano G, Thyss A, et al. Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients. Cancer Res 1992, 52, 2899-2905.
-
(1992)
Cancer Res
, vol.52
, pp. 2899-2905
-
-
Fleming, R.A.1
Milano, G.2
Thyss, A.3
-
16
-
-
0030005786
-
Link between dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells and liver
-
Chazal M, Etienne MC, Renée N, Bourgeon A, Richelme H, Milano G. Link between dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells and liver. Clin Cancer Res 1996, 2, 507-510.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 507-510
-
-
Chazal, M.1
Etienne, M.C.2
Renée, N.3
Bourgeon, A.4
Richelme, H.5
Milano, G.6
-
17
-
-
0019993360
-
Clearance of continuously infused 5-fluorouracil in adults having lung or gastrointestinal carcinoma with or without hepatic métastases
-
Floyd RA, Hornbeck CL, Byfield JE. Clearance of continuously infused 5-fluorouracil in adults having lung or gastrointestinal carcinoma with or without hepatic métastases. Drug Intell Clin Pharm 1982, 16, 665-669.
-
(1982)
Drug Intell Clin Pharm
, vol.16
, pp. 665-669
-
-
Floyd, R.A.1
Hornbeck, C.L.2
Byfield, J.E.3
-
18
-
-
0025007904
-
Circadian rhythm of 5-fluorouracil pharmacokinetics and tolerance
-
Nowakowska-Dulawa E. Circadian rhythm of 5-fluorouracil pharmacokinetics and tolerance. Chronobiologia 1990, 17, 27-32.
-
(1990)
Chronobiologia
, vol.17
, pp. 27-32
-
-
Nowakowska-Dulawa, E.1
-
19
-
-
0021020960
-
Variability in human drug metabolism and its implication
-
Breimer DD. Variability in human drug metabolism and its implication. IntJ Clin Pharm Res 1983, 3, 399-13.
-
(1983)
IntJ Clin Pharm Res
, vol.3
, pp. 399
-
-
Breimer, D.D.1
-
20
-
-
0026636184
-
Influence of sex and age on fluorouracil clearance
-
Milano G, Etienne MC, Cassuto-Viguier E, et al. Influence of sex and age on fluorouracil clearance. J Clin Oncol 1992, 10, 1171-1175.
-
(1992)
J Clin Oncol
, vol.10
, pp. 1171-1175
-
-
Milano, G.1
Etienne, M.C.2
Cassuto-Viguier, E.3
-
21
-
-
0021271867
-
Experience with NONMEM: Analysis of routine phenytoin clinical pharmacokinetic data
-
Sheiner LB, Grasela TH. Experience with NONMEM: analysis of routine phenytoin clinical pharmacokinetic data. Drug Metab Rev 1984, IS, 293-303.
-
(1984)
Drug Metab Rev
, pp. 293-303
-
-
Sheiner, L.B.1
Grasela, T.H.2
-
22
-
-
0000083651
-
Methodology of population pharmacokinetics
-
Garrett ER, Hirtz J, eds. New York, Marcel Decker
-
Beal SL, Sheiner LB. Methodology of population pharmacokinetics. In Garrett ER, Hirtz J, eds. Drug Fate and Metabolism. New York, Marcel Decker, 1985, Vol. 5, 135-183.
-
(1985)
Drug Fate and Metabolism.
, vol.5
, pp. 135-183
-
-
Beal, S.L.1
Sheiner, L.B.2
-
23
-
-
0003747347
-
-
Technical Report of the Division of Clinical Pharmacology, University of California, San Francisco, University of California
-
Boekmann AJ, Sheiner LB, Beal SL. NONMEM User's Guide, Pan V: Introductory Guide. Technical Report of the Division of Clinical Pharmacology, University of California, San Francisco, University of California, 1992.
-
(1992)
NONMEM User's Guide, Pan V: Introductory Guide
-
-
Boekmann, A.J.1
Sheiner, L.B.2
Beal, S.L.3
-
24
-
-
0344761710
-
-
Technical Report of the Division of Clinical Pharmacology, University of California. San Francisco: University of California
-
Beal SL, Boekmann AJ, Sheiner LB. NONMEM User's Guide, Pan VI: PREDPP Guide. Technical Report of the Division of Clinical Pharmacology, University of California. San Francisco: University of California, 1992.
-
(1992)
NONMEM User's Guide, Pan VI: PREDPP Guide
-
-
Beal, S.L.1
Boekmann, A.J.2
Sheiner, L.B.3
-
25
-
-
0028936713
-
Prediction of carboplatin clearance from standard morphological and biological patient characteristics
-
Chatelut E, Canal P, Brunner V, et al. Prediction of carboplatin clearance from standard morphological and biological patient characteristics. J Nat! Cancer Inst 1995, 87, 573-580.
-
(1995)
J Nat! Cancer Inst
, vol.87
, pp. 573-580
-
-
Chatelut, E.1
Canal, P.2
Brunner, V.3
-
26
-
-
0029913104
-
Impact of different fluorouracil biochemical modulators on cellular dihydropyrimidine dehydrogenase
-
Haaz MC, Fischel JL, Formento P, et al. Impact of different fluorouracil biochemical modulators on cellular dihydropyrimidine dehydrogenase. Cancer Chemoiker Pharmacol 1996, 38, 52-58.
-
(1996)
Cancer Chemoiker Pharmacol
, vol.38
, pp. 52-58
-
-
Haaz, M.C.1
Fischel, J.L.2
Formento, P.3
-
27
-
-
0025974254
-
Close reduction without loss of efficacy for 5-fluorouracil and cisplatin combined with folinic acid. in vitro study on human head und neck carcinoma cell lines
-
Etienne MC, Bernard S, Fischel JL, et al. Close reduction without loss of efficacy for 5-fluorouracil and cisplatin combined with folinic acid. In vitro study on human head und neck carcinoma cell lines. Br J Cancer 1991, 63, 372-377.
-
(1991)
Br J Cancer
, vol.63
, pp. 372-377
-
-
Etienne, M.C.1
Bernard, S.2
Fischel, J.L.3
-
28
-
-
0022886092
-
Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells
-
Scanion KJ, Newman EM, Lu Y, et al. Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells. Proc NatlAcadSti USA 1986, 8:, 8923-8925.
-
(1986)
Proc NatlAcadSti USA
, vol.8
, pp. 8923-8925
-
-
Scanion, K.J.1
Newman, E.M.2
Lu, Y.3
-
29
-
-
0027285520
-
Metabolic basis of the synergistic antitumor activities of 5-1luorouracil and cisplatin in rodent tumor models in vivo
-
Shirasaka T, Shimamoto Y, Cheshimo H, et al. Metabolic basis of the synergistic antitumor activities of 5-1luorouracil and cisplatin in rodent tumor models in vivo. Career Chemother Pharmacol 1993, 32, 167-172.
-
(1993)
Career Chemother Pharmacol
, vol.32
, pp. 167-172
-
-
Shirasaka, T.1
Shimamoto, Y.2
Cheshimo, H.3
-
31
-
-
0028805308
-
Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy
-
Lu Z, Zhang R, Diasio RB. Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy. Clin Pharmacol Ther 1995, 58, 512-522.
-
(1995)
Clin Pharmacol Ther
, vol.58
, pp. 512-522
-
-
Lu, Z.1
Zhang, R.2
Diasio, R.B.3
-
32
-
-
0021846746
-
Continuous 5-day regional chemotherapy by 5-fluorouracil in colon carcinoma: Pharmacokinetic evaluation
-
Boublil JL, Milano G, Khater R, et al. Continuous 5-day regional chemotherapy by 5-fluorouracil in colon carcinoma: pharmacokinetic evaluation. Br J Cancer 1985, 52, 15-21.
-
(1985)
Br J Cancer
, vol.52
, pp. 15-21
-
-
Boublil, J.L.1
Milano, G.2
Khater, R.3
-
33
-
-
0027426408
-
Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver
-
Lu Z, Zhang R, Diasio RB. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver. Population characteristics, newly identified deficient patients and clinical implication in 5-fluorouracil chemotherapy. Cancer Res 1993, 53, 5433-5438.
-
(1993)
Population Characteristics, Newly Identified Deficient Patients and Clinical Implication in 5-fluorouracil Chemotherapy. Cancer Res
, vol.53
, pp. 5433-5438
-
-
Lu, Z.1
Zhang, R.2
Diasio, R.B.3
-
34
-
-
0028006858
-
Population study of dihydropyrimidine dehydrogenase in cancer patients
-
Etienne MC, Lagrange JL, Dassonville O, et al. Population study of dihydropyrimidine dehydrogenase in cancer patients. J Clin Oncol 1994, 12, 2248-2253.
-
(1994)
J Clin Oncol
, vol.12
, pp. 2248-2253
-
-
Etienne, M.C.1
Lagrange, J.L.2
Dassonville, O.3
-
35
-
-
9244255891
-
Pharmacodynamics of fluorouracil-based induction chemotherapy in advanced head and neck cancer
-
Yokes EE, Mick R, Kies MS, et al, Pharmacodynamics of fluorouracil-based induction chemotherapy in advanced head and neck cancer. J Clin Oncol 1996, 14, 1663-1671.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1663-1671
-
-
Yokes, E.E.1
Mick, R.2
Kies, M.S.3
-
36
-
-
0027496582
-
Severe fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency
-
Houyau P, Gay C, Chatelut E, et al. Severe fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency. J Nat! Cancer Inst 1993, 85, 1602-1603.
-
(1993)
J Nat! Cancer Inst
, vol.85
, pp. 1602-1603
-
-
Houyau, P.1
Gay, C.2
Chatelut, E.3
-
37
-
-
0028559551
-
Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy
-
Milano G, Etienne MC. Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy. Pharmacogenetics 1994, 4, 301-306.
-
(1994)
Pharmacogenetics
, vol.4
, pp. 301-306
-
-
Milano, G.1
Etienne, M.C.2
-
38
-
-
0029619542
-
Depressed hepatic dihydropyrimidine dehydrogenase activity and fluorouracil-related toxicities
-
Stephan F, Etienne MC, Wallays C, et al. Depressed hepatic dihydropyrimidine dehydrogenase activity and fluorouracil-related toxicities. AmJMed 1995, 99, 685-688.
-
(1995)
AmJMed
, vol.99
, pp. 685-688
-
-
Stephan, F.1
Etienne, M.C.2
Wallays, C.3
-
39
-
-
0026709718
-
No effect of dose, hepatic function, or nutritional status on 5-FU clearance following continuous (5-day), 5-FU infusion
-
Fleming RA, Milano G, Etienne MC, et al No effect of dose, hepatic function, or nutritional status on 5-FU clearance following continuous (5-day), 5-FU infusion, rjCancer 1992,66, 668-672.
-
(1992)
rjCancer
, vol.66
, pp. 668-672
-
-
Fleming, R.A.1
Milano, G.2
Etienne, M.C.3
-
40
-
-
0028568929
-
Clinical randomized study of 5FU monitoring versus standard dose in patients with head and neck cancer: Preliminary results
-
Fety R, Rolland F, Barbery-Heyob M, et al. Clinical randomized study of 5FU monitoring versus standard dose in patients with head and neck cancer: preliminary results. Anticancer Res 1994, 14, 2347.
-
(1994)
Anticancer Res
, vol.14
, pp. 2347
-
-
Fety, R.1
Rolland, F.2
Barbery-Heyob, M.3
-
41
-
-
0024440650
-
Carboplatin dosage: Prospective evaluation of a simple formula based on renal function
-
Calvert AH, Newell DR, Gumbrell LA, et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol 1989, 7, 1748-1756.
-
(1989)
J Clin Oncol
, vol.7
, pp. 1748-1756
-
-
Calvert, A.H.1
Newell, D.R.2
Gumbrell, L.A.3
-
42
-
-
0029743058
-
Dose calculation of anticancer drugs: A review of the current practice and introduction of an alternative
-
Gurney H. Dose calculation of anticancer drugs: a review of the current practice and introduction of an alternative. J Clin Oncol 1996, 14, 2990-2998.
-
(1996)
J Clin Oncol
, vol.14
, pp. 2990-2998
-
-
Gurney, H.1
|