Mature results from three large controlled studies with raltitrexed ('Tomudex')

British Journal of Cancer

Volumn 77, Issue SUPPL. 2, 1998, Pages 15-21

  Cunningham, D ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

Advanced colorectal cancer; Machover regimen; Mayo regimen; Phase III studies; Raltitrexed

Indexed keywords

AMINOTRANSFERASE; FLUOROURACIL; FOLINIC ACID; RALTITREXED;

ANEMIA; ASTHENIA; CANCER SURVIVAL; CLINICAL PROTOCOL; CLINICAL TRIAL; COLORECTAL CANCER; CONFERENCE PAPER; CONTINUOUS INFUSION; DIARRHEA; DRUG COST; DRUG EFFICACY; DRUG TOLERABILITY; DRUG TOXICITY; FOLLOW UP; HUMAN; INFECTION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; MAJOR CLINICAL STUDY; MEDICAL AUDIT; MUCOSA INFLAMMATION; NAUSEA; PAIN; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; THROMBOCYTOPENIA; VOMITING;

EID: 0031888857     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.421     Document Type: Article

References (24)

1. Assersohn L, Webb A, Cunningham D et al (1998) The effect of stomatitis on patients treated with adjuvant 5-fluorouracil and folinic acid for colorectal carcinoma. Br J Cancer (submitted)
2. Bleiberg H (1997) Colorectal cancer - is there an alternative to 5-FU? Eur J Cancer 33: 536-541
3. Buroker TR, O'Connell MJ, Wieand HS, Krook JE, Gerstner JB, Mailliard JA, Schaefer PL, Levitt R, Kardinal CG and Gesme DH Jr (1994) Randomized comparison of two schedules of fluorouracil and folinic acid in the treatment of advanced colorectal cancer. J Clin Oncol 12: 14-20
4. Clarke SJ, Hanwell J, de Boer M, Planting A, Verweij J, Walker M, Smith R, Jackman AL, Hughes LR, Harrap KR, Kennealey GT and Judson IR (1996) Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors. J Clin Oncol 14: 1495-1503
5. Cunningham D, Zalcberg JR, Rath U, Oliver I, van Cutsem E, Svensson C, Seitz JF, Harper P, Kerr D, Perez-Manga G and the Tomudex Colorectal Cancer Study Group (1996) Final results of a randomised trial comparing 'Tomudex'® (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. Ann Oncol 7: 961-965
6. de Gramont A, Bosset JF, Milan C, Rougier P, Bouché O, Etienne PL, Morvan F, Louvet C, Guillot T and Bedenne L (1995) A prospectively randomized trial comparing 5FU bolus with low-dose folinic acid (FUFOLld) and 5FU bolus plus continuous infusion with high-dose folinic acid (LV5FU2) for advanced colorectal cancer (abstract 455). Proc Am Soc Clin Oncol 14: 194
7. Harper P, Study Group (1997) Advanced colorectal cancer (ACC): results from the latest (raltitrexed) Tomudex comparative study (abstract). Proc Am Soc Clin Oncol 16: 228a
8. Hill M, Norman A, Cunningham D, Findlay M, Watson M, Nicolson V, Webb A, Middleton G, Ahmed F and Hickish T (1995a) The impact of protracted venous infusion 5FU with or without interferon alpha on tumour response, survival and quality of life in advanced colorectal cancer. J Clin Oncol 13: 2317-2323
9. Hill M, Norman A, Cunningham D, Findlay M, Nicolson V, Hill A, Iveson A, Evans C, Joffe J and Nicholson M (1995b) Royal Marsden phase III trial of fluorouracil with or without interferon-α-b in advanced colorectal cancer. J Clin Oncol 13: 1297-1302
10. Jackman AL and Judson IR (1996) The new generation of thymidylate synthase inhibitors in clinical study. Exp Opin Invest Drugs 5: 719-736
11. Lokich JJ, Ahlgren JD, Gullo JJ, Philips JA and Fryer JG (1989) A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus administration schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program study. J Clin Oncol 7: 425-432
12. Machover D, Goldsmith E, Chollet P, Metzger G, Zittoun J, Marquet J, Vandenbulcke J-M, Misset J-L, Schwarzenberg L, Fourtillan JB, Gaget H and Mathé G (1986) Treatment of advanced colorectal and gastric adenocarcinoma with 5-fluorouracil and high dose folinic acid. J Clin Oncol 4: 685-696
13. Minsky BD (1998) Multidisciplinary case teams: an approach to the future management of advanced colorectal cancer. Br J Cancer (this suppl.)
14. Pazdur R and Vincent M (1997) Raltitrexed (Tomudex) vs 5-fluorouracil + leucovorin (5-FU + LV) in patients with advanced colorectal cancer (ACC): results of a randomised multicenter North American trial (abstract). Proc Am Soc Clin Oncol 16: 228a
15. Poon MA, O'Connell MJ, Wieand HS, Cullinan SA, Everson LK, Krook JE, Mailliard JA, Laure JA, Tschetter LK and Wiesenfeld M (1989) Biochemical modulation of fluorouracil: evidence of significant improvements in survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 7: 1407-1418
16. Redmond K (1998) Assessing patients' needs and preferences in the management of advanced colorectal cancer. Br J Cancer (this suppl.)
17. Ross P, Webb A, Cunningham D, Norman A, Prendiville J, Watson M, Smith A and Hey L (1996a) Chemotherapy for colorectal cancer: relationship between toxicity and quality of life (abstract 1540). Ann Oncol 7 (suppl. 5): 34
18. Ross P, Heron J and Cunningham D (1996b) Cost of treating advanced colorectal cancer: a retrospective comparison of treatment regimens. Eur J Cancer 32A (suppl. 5): S13-S17
19. Rustum YM, Harstrick A, Cao S, Vanhoefer U, Yin M-B, Wilke H and Seeber S (1997) Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors. J Clin Oncol 15: 389-400
20. Seifert P, Baker LH, Reed ML and Vaitkevicius VK (1975) Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma. Cancer 36: 123-128
21. Sorensen JM, Jordan E, Grem JL, Arbuck SG, Chen AP, Hamilton JM, Johnston P, Kohler DR, Goldspiel BR and Allegra CJ (1994) Phase I trial of ZD1694 (Tomudex), a direct inhibitor of thymidylate synthase (abstract 241). Ann Oncol 5 (suppl. 1): 132
22. Touroutoglou N and Pazdur R (1996) Thymidylate synthase inhibitors. Clin Cancer Res 2: 227-243
23. Wils J (1998) The establishment of a large collaborative trial program in the adjuvant treatment of resectable colon cancer. Br J Cancer (this suppl.)
24. Zalcberg JR, Cunningham D, Van Cutsem E, Francois E, Schornagel J, Adenis A, Green M, Iveson A, Azab M and Seymour I for the Tomudex Colorectal Study Group (1996) ZD1694: a novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. J Clin Oncol 14: 716-721