Single nucleotide polymorphism in the 5′ tandem repeat sequences of Thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients

International Journal of Cancer

Volumn 112, Issue 5, 2004, Pages 733-737

  Marcuello, Eugenio ^a   Altés, Albert ^b   Del Rio, Elisabeth ^a   César, Angeles ^a   Menoyo, Anna ^a   Baiget, Montserrat ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b HOSPITAL DE L ESPERIT SANT   (Spain)

Author keywords

5 FU resistance; Colorectal cancer; Fluoropyrimidine chemotherapy; TS polymorphism

Indexed keywords

FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; THYMIDYLATE SYNTHASE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER GROWTH; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; METASTASIS; PATIENT SELECTION; PHARMACOGENETICS; PREDICTION; PRIORITY JOURNAL; REGRESSION ANALYSIS; SIDE EFFECT; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; TREATMENT OUTCOME; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; REGRESSION ANALYSIS; SURVIVAL ANALYSIS; TANDEM REPEAT SEQUENCES; THYMIDYLATE SYNTHASE; TREATMENT OUTCOME;

EID: 7244258790     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20487     Document Type: Article

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