Ly231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes

Cancer Research

Volumn 57, Issue 6, 1997, Pages 1116-1123

  Shin, Chuan ^a   Chen, Victor J ^a   Gossett, Lynn S ^a   Gates, Susan B ^a   MacKellar, Warren C ^a   Habeck, Lillian L ^a   Shackelford, Katherine A ^a   Mendelsohn, Lurane G ^a   Soose, Daniel J ^a   Patel, Vinod F ^a   Andis, Sherri L ^a   Bewley, Jesse R ^a   Rayl, Elizabeth A ^b   Moroson, Barbara A ^b   Peter Beardsley, G ^b   Kohler, William ^c   Ratnam, Manshan ^c   Schultz, Richard M ^a  

^a ELI LILLY AND COMPANY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; FORMATE TETRAHYDROFOLATE LIGASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; PEMETREXED; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; RALTITREXED; THYMIDYLATE SYNTHASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CLINICAL TRIAL; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NONHUMAN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACYLTRANSFERASES; AMINOHYDROLASES; ANTIMETABOLITES, ANTINEOPLASTIC; FOLIC ACID ANTAGONISTS; FORMATE-TETRAHYDROFOLATE LIGASE; GLUTAMATES; GUANINE; HUMANS; HYDROXYMETHYL AND FORMYL TRANSFERASES; METHOTREXATE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; POLYGLUTAMIC ACID; QUINAZOLINES; TETRAHYDROFOLATE DEHYDROGENASE; TETRAHYDROFOLATES; THIOPHENES; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0030891198     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

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