메뉴 건너뛰기




Volumn 22, Issue 3, 2004, Pages 529-536

Thymidylate-synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDYLATE SYNTHASE;

EID: 1442290323     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2004.05.064     Document Type: Review
Times cited : (410)

References (54)
  • 1
    • 0027173231 scopus 로고
    • Estimates of the worldwide incidence of eighteen major cancers in 1985
    • Parkin DM, Pisani P, Ferlay J: Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 54:594-606, 1993
    • (1993) Int J Cancer , vol.54 , pp. 594-606
    • Parkin, D.M.1    Pisani, P.2    Ferlay, J.3
  • 2
    • 0002056732 scopus 로고
    • Colorectal carcinoma
    • Lawson DH (ed), Ediburgh, Churchill Livingstone
    • Finlay IG, Pickford IR: Colorectal carcinoma, in Lawson DH (ed): Current Medicine 4th edition, Ediburgh, Churchill Livingstone, 1994, pp 51-64
    • (1994) Current Medicine 4th Edition , pp. 51-64
    • Finlay, I.G.1    Pickford, I.R.2
  • 3
    • 0025710611 scopus 로고
    • NIH consensus conference: Adjuvant therapy for patients with colon and rectal cancer
    • Anonymous: NIH consensus conference: Adjuvant therapy for patients with colon and rectal cancer. JAMA 264:1444-1450, 1990
    • (1990) JAMA , vol.264 , pp. 1444-1450
  • 4
    • 0028956045 scopus 로고
    • Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: A final report
    • Moertel CG, Fleming TR, Macdonald JS, et al: Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: A final report. Ann Intern Med 122: 321-326, 1995
    • (1995) Ann Intern Med , vol.122 , pp. 321-326
    • Moertel, C.G.1    Fleming, T.R.2    Macdonald, J.S.3
  • 5
    • 0032949446 scopus 로고    scopus 로고
    • Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
    • Mamounas E, Wieand S, Wolmark N, et al: Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J Clin Oncol 17: 1349-1355, 1999
    • (1999) J Clin Oncol , vol.17 , pp. 1349-1355
    • Mamounas, E.1    Wieand, S.2    Wolmark, N.3
  • 6
    • 0015993325 scopus 로고
    • Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides
    • Danenberg PV, Langenbach RJ, Heidelberger C: Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides. Biochemistry 13:926-933, 1974
    • (1974) Biochemistry , vol.13 , pp. 926-933
    • Danenberg, P.V.1    Langenbach, R.J.2    Heidelberger, C.3
  • 7
    • 0019813027 scopus 로고
    • 5-Fluoro-2′-deoxyuridine incorporation in L1210 DNA
    • Kufe DW, Major PP, Egan EM, et al: 5-Fluoro-2′-deoxyuridine incorporation in L1210 DNA. J Biol Chem 256:8885-8888, 1981
    • (1981) J Biol Chem , vol.256 , pp. 8885-8888
    • Kufe, D.W.1    Major, P.P.2    Egan, E.M.3
  • 8
    • 0019836941 scopus 로고
    • The incorporation of 5-fluoro-2′-deoxyuridine into DNA of mammalian tumor cells
    • Danenberg PV, Heidelberger C, Mulkins MA, et al: The incorporation of 5-fluoro-2′-deoxyuridine into DNA of mammalian tumor cells. Biochem Biophys Res Commun 102:654-658, 1931
    • (1931) Biochem Biophys Res Commun , vol.102 , pp. 654-658
    • Danenberg, P.V.1    Heidelberger, C.2    Mulkins, M.A.3
  • 9
    • 0015962412 scopus 로고
    • Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
    • Santi DV, McHenry CS, Sommer H: Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry 13:471-481, 1974
    • (1974) Biochemistry , vol.13 , pp. 471-481
    • Santi, D.V.1    McHenry, C.S.2    Sommer, H.3
  • 10
    • 0022344622 scopus 로고
    • Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells
    • Berger SH, Jenh CH, Johnson LF, et al: Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells. Mol Pharmacol 28:461-467, 1985
    • (1985) Mol Pharmacol , vol.28 , pp. 461-467
    • Berger, S.H.1    Jenh, C.H.2    Johnson, L.F.3
  • 11
    • 0026795489 scopus 로고
    • Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines
    • Johnston PG, Drake JC, Trepel J, et al: Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines. Cancer Res 52:4306-4312, 1992
    • (1992) Cancer Res , vol.52 , pp. 4306-4312
    • Johnston, P.G.1    Drake, J.C.2    Trepel, J.3
  • 13
    • 0030883708 scopus 로고    scopus 로고
    • Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
    • Leichman CG, Lenz HJ, Leichman L: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 15:3223-3229, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 3223-3229
    • Leichman, C.G.1    Lenz, H.J.2    Leichman, L.3
  • 14
    • 15444349773 scopus 로고    scopus 로고
    • p53 and thymidylate synthase expression in untreated stage II colon cancer: Associations with recurrence, survival, and site
    • Lenz HJ, Danenberg KD, Leichman CG, et al: p53 and thymidylate synthase expression in untreated stage II colon cancer: Associations with recurrence, survival, and site. Clin Cancer Res 4:1227-1234, 1998
    • (1998) Clin Cancer Res , vol.4 , pp. 1227-1234
    • Lenz, H.J.1    Danenberg, K.D.2    Leichman, C.G.3
  • 15
    • 14444285483 scopus 로고    scopus 로고
    • p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: An analysis of response and survival
    • Lenz HJ, Hayashi K, Salonga D, et al: p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: An analysis of response and survival. Clin Cancer Res 4:1243-1250, 1998
    • (1998) Clin Cancer Res , vol.4 , pp. 1243-1250
    • Lenz, H.J.1    Hayashi, K.2    Salonga, D.3
  • 16
    • 0033009501 scopus 로고    scopus 로고
    • Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine
    • Davies MM, Johnston PG, Kaur S, et al: Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine. Clin Cancer Res 5:325-328, 1999
    • (1999) Clin Cancer Res , vol.5 , pp. 325-328
    • Davies, M.M.1    Johnston, P.G.2    Kaur, S.3
  • 17
    • 0033050310 scopus 로고    scopus 로고
    • Increased thymidylate synthase gene expression in liver metastases from colorectal carcinoma: Implications for chemotherapeutic options and survival
    • Bathe OF, Franceschi D, Livingstone AS, et al: Increased thymidylate synthase gene expression in liver metastases from colorectal carcinoma: Implications for chemotherapeutic options and survival. Cancer J Sci Am 5:34-40, 1999
    • (1999) Cancer J Sci Am , vol.5 , pp. 34-40
    • Bathe, O.F.1    Franceschi, D.2    Livingstone, A.S.3
  • 18
    • 0033995850 scopus 로고    scopus 로고
    • Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method
    • Takenoue T, Nagawa H, Matsuda K, et al: Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method. Ann Surg Oncol 7:193-198, 2000
    • (2000) Ann Surg Oncol , vol.7 , pp. 193-198
    • Takenoue, T.1    Nagawa, H.2    Matsuda, K.3
  • 19
    • 0035209477 scopus 로고    scopus 로고
    • Thymidylate synthase expression in stage II and III colon cancer: A retrospective review
    • Tomiak A, Vincent M, Earle CC, et al: Thymidylate synthase expression in stage II and III colon cancer: A retrospective review. Am J Clin Oncol 24:597-602, 2001
    • (2001) Am J Clin Oncol , vol.24 , pp. 597-602
    • Tomiak, A.1    Vincent, M.2    Earle, C.C.3
  • 20
    • 0036534002 scopus 로고    scopus 로고
    • Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer
    • Allegra CJ, Parr AL, Wold LE, et al: Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer. J Clin Oncol 20:1735-1743, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 1735-1743
    • Allegra, C.J.1    Parr, A.L.2    Wold, L.E.3
  • 21
    • 18644383118 scopus 로고    scopus 로고
    • Role of biological markers in the clinical outcome of colon cancer
    • Nanni O, Volpi A, Frassineti GL, et al: Role of biological markers in the clinical outcome of colon cancer. Br J Cancer 87:868-875, 2002
    • (2002) Br J Cancer , vol.87 , pp. 868-875
    • Nanni, O.1    Volpi, A.2    Frassineti, G.L.3
  • 22
    • 0036875104 scopus 로고    scopus 로고
    • Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma
    • Berglund A, Edler D, Molin D, et al: Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma. Anticancer Res 22:3653-3659, 2002
    • (2002) Anticancer Res , vol.22 , pp. 3653-3659
    • Berglund, A.1    Edler, D.2    Molin, D.3
  • 23
    • 0037316169 scopus 로고    scopus 로고
    • Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer
    • Gonen M, Hummer A, Zervoudakis A, et al: Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer. J Clin Oncol 21:406-412, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 406-412
    • Gonen, M.1    Hummer, A.2    Zervoudakis, A.3
  • 24
    • 0037312517 scopus 로고    scopus 로고
    • Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
    • Ichikawa W, Uetake H, Shirota Y, et al: Combination of Dihydropyrimidine Dehydrogenase and Thymidylate Synthase Gene Expressions in Primary Tumors as Predictive Parameters for the Efficacy of Fluoropyrimidine-based Chemotherapy for Metastatic Colorectal Cancer. Clin Cancer Res 9:786-791, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 786-791
    • Ichikawa, W.1    Uetake, H.2    Shirota, Y.3
  • 25
    • 0037317004 scopus 로고    scopus 로고
    • Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed
    • Farrugia DC, Ford HE, Cunningham D, et al: Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed. Clin Cancer Res 9:792-801, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 792-801
    • Farrugia, D.C.1    Ford, H.E.2    Cunningham, D.3
  • 26
    • 0037364351 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in primary colorectal cancer: Lack of correlation with outcome and response to fluorouracil in metastatic disease sites
    • Johnston PG, Benson AB III, Catalano P, et al: Thymidylate synthase protein expression in primary colorectal cancer: Lack of correlation with outcome and response to fluorouracil in metastatic disease sites. J Clin Oncol 21:815-819, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 815-819
    • Johnston, P.G.1    Benson III, A.B.2    Catalano, P.3
  • 27
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analysis of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L: Extracting summary statistics to perform meta-analysis of the published literature for survival endpoints. Stat Med 17:2815-2834, 1998
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 28
    • 0033765491 scopus 로고    scopus 로고
    • Prognostic significance of p53 alterations in patients with non-small cell lung cancer: A meta-analysis
    • Mitsudomi T, Hamajima N, Ogawa M, et al: Prognostic significance of p53 alterations in patients with non-small cell lung cancer: A meta-analysis. Clin Cancer Res 6:4055-4063, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 4055-4063
    • Mitsudomi, T.1    Hamajima, N.2    Ogawa, M.3
  • 29
    • 0036534108 scopus 로고    scopus 로고
    • Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy
    • Edler D, Glimelius B, Hallstrom M, et al: Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. J Clin Oncol 20:1721-1728, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 1721-1728
    • Edler, D.1    Glimelius, B.2    Hallstrom, M.3
  • 30
    • 0032814777 scopus 로고    scopus 로고
    • Somatic mutations in the p53 gene and prognosis in breast cancer: A meta-analysis
    • Pharoah PD, Day NE, Caldas C: Somatic mutations in the p53 gene and prognosis in breast cancer: A meta-analysis. Br J Cancer 80:1968-1973, 1999
    • (1999) Br J Cancer , vol.80 , pp. 1968-1973
    • Pharoah, P.D.1    Day, N.E.2    Caldas, C.3
  • 32
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple graphical test
    • Egger M, Smith GD, Schneider M, et al: Bias in meta-analysis detected by a simple graphical test. BMJ 315:629-634, 1997
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3
  • 34
    • 0033981858 scopus 로고    scopus 로고
    • Immunohistochemically detected thymidylate synthase in colorectal cancer: An independent prognostic factor of survival
    • Edler D, Kressner U, Ragnhammar P, et al: Immunohistochemically detected thymidylate synthase in colorectal cancer: An independent prognostic factor of survival. Clin Cancer Res 6:488-492, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 488-492
    • Edler, D.1    Kressner, U.2    Ragnhammar, P.3
  • 35
    • 0033292028 scopus 로고    scopus 로고
    • Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors
    • Mini E, Biondi C, Morganti M, et al: Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors. Oncol Res 11:437-445, 1999
    • (1999) Oncol Res , vol.11 , pp. 437-445
    • Mini, E.1    Biondi, C.2    Morganti, M.3
  • 36
    • 0031053520 scopus 로고    scopus 로고
    • Lack of correlation between thymidylate synthase levels in primary colorectal tumors and subsequent response to chemotherapy
    • Findlay MP, Cunningham D, Morgan G, et al: Lack of correlation between thymidylate synthase levels in primary colorectal tumors and subsequent response to chemotherapy. Br J Cancer 75:903-909, 1997
    • (1997) Br J Cancer , vol.75 , pp. 903-909
    • Findlay, M.P.1    Cunningham, D.2    Morgan, G.3
  • 37
    • 0034661614 scopus 로고    scopus 로고
    • Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy
    • Link KH, Kornmann M, Butzer U, et al: Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy. Cancer 89:288-296, 2000
    • (2000) Cancer , vol.89 , pp. 288-296
    • Link, K.H.1    Kornmann, M.2    Butzer, U.3
  • 38
    • 12944293119 scopus 로고    scopus 로고
    • Prognostic role of thymidylate synthase, thymidine phosphorylase/ platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer
    • van Triest B, Pinedo HM, Blaauwgeers JL, et al: Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer. Clin Cancer Res 6:1063-1072, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 1063-1072
    • Van Triest, B.1    Pinedo, H.M.2    Blaauwgeers, J.L.3
  • 39
    • 0028151449 scopus 로고
    • The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
    • Johnston PG, Fisher ER, Rockette HE, et al: The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 12:2640-2647, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 2640-2647
    • Johnston, P.G.1    Fisher, E.R.2    Rockette, H.E.3
  • 40
    • 0031856639 scopus 로고    scopus 로고
    • The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer
    • Sanguedolce R, Vultaggio G, Sanguedolce F, et al: The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer. Anticancer Res 18:1515-1520, 1998
    • (1998) Anticancer Res , vol.18 , pp. 1515-1520
    • Sanguedolce, R.1    Vultaggio, G.2    Sanguedolce, F.3
  • 41
    • 0033637476 scopus 로고    scopus 로고
    • Immunohistochemical expression of thymidylate synthase as a prognostic factor and as a chemotherapeutic efficacy index in patients with colorectal carcinoma
    • Tachikawa D, Arima S, Futami K: Immunohistochemical expression of thymidylate synthase as a prognostic factor and as a chemotherapeutic efficacy index in patients with colorectal carcinoma. Anticancer Res 20:4103-4107, 2000
    • (2000) Anticancer Res , vol.20 , pp. 4103-4107
    • Tachikawa, D.1    Arima, S.2    Futami, K.3
  • 42
    • 0034087575 scopus 로고    scopus 로고
    • Thymidylate synthase expression: An independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer
    • Edler D, Hallstrom M, Johnston PG, et al: Thymidylate synthase expression: An independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer. Clin Cancer Res 6:1378-1384, 2000b
    • (2000) Clin Cancer Res , vol.6 , pp. 1378-1384
    • Edler, D.1    Hallstrom, M.2    Johnston, P.G.3
  • 43
    • 0031941249 scopus 로고    scopus 로고
    • A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance
    • Yamachika T, Nakanishi H, Inada K, et al: A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance. Cancer 82:70-77, 1998
    • (1998) Cancer , vol.82 , pp. 70-77
    • Yamachika, T.1    Nakanishi, H.2    Inada, K.3
  • 44
    • 0037440051 scopus 로고    scopus 로고
    • Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study
    • Allegra CJ, Paik S, Colangelo LH, et al: Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. J Clin Oncol 21:241-250, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 241-250
    • Allegra, C.J.1    Paik, S.2    Colangelo, L.H.3
  • 45
    • 0032997572 scopus 로고    scopus 로고
    • Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy
    • Aschele C, Debernardis D, Casazza S, et al: Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy. J Clin Oncol 17: 1760-1770, 1999
    • (1999) J Clin Oncol , vol.17 , pp. 1760-1770
    • Aschele, C.1    Debernardis, D.2    Casazza, S.3
  • 46
    • 0033975032 scopus 로고    scopus 로고
    • Thymidylate synthase and p53 primary tumor expression as predictive factors for advanced colorectal cancer patients
    • Paradiso A, Simone G, Petroni S, et al: Thymidylate synthase and p53 primary tumor expression as predictive factors for advanced colorectal cancer patients. Br J Cancer 82:560-567, 2000
    • (2000) Br J Cancer , vol.82 , pp. 560-567
    • Paradiso, A.1    Simone, G.2    Petroni, S.3
  • 47
    • 0035576102 scopus 로고    scopus 로고
    • ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy
    • Shirota Y, Stoehlmacher J, Brabender J, et al: ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J Clin Oncol 19:4298-4304, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 4298-4304
    • Shirota, Y.1    Stoehlmacher, J.2    Brabender, J.3
  • 48
    • 0037096901 scopus 로고    scopus 로고
    • Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: Phenotypic and genotypic analyses
    • Etienne MC, Chazal M, Laurent-Puig P, et al: Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: Phenotypic and genotypic analyses. J Clin Oncol 20:2832-2843, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 2832-2843
    • Etienne, M.C.1    Chazal, M.2    Laurent-Puig, P.3
  • 49
    • 15944396824 scopus 로고    scopus 로고
    • Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer
    • Kornmann M, Link KH, Galuba I, et al: Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer. J Gastrointest Surg 6:331-337, 2002
    • (2002) J Gastrointest Surg , vol.6 , pp. 331-337
    • Kornmann, M.1    Link, K.H.2    Galuba, I.3
  • 50
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga D, Danenberg KD, Johnson M, et al: Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 6:1322-1327, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 1322-1327
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3
  • 51
    • 0033427561 scopus 로고    scopus 로고
    • Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers
    • Kawakami K, Omura K, Kanehira E, et al: Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res 19:3249-3252, 1999
    • (1999) Anticancer Res , vol.19 , pp. 3249-3252
    • Kawakami, K.1    Omura, K.2    Kanehira, E.3
  • 52
    • 0034486207 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil
    • Aschele C, Debernardis D, Tunesi G, et al: Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil. Clin Cancer Res 6:4797-4802, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 4797-4802
    • Aschele, C.1    Debernardis, D.2    Tunesi, G.3
  • 53
    • 0023124103 scopus 로고
    • Meta-analyses of randomized controlled trials
    • Sacks HS, Berrier J, Reitman D, et al: Meta-analyses of randomized controlled trials. N Engl J Med 316:450-455, 1987
    • (1987) N Engl J Med , vol.316 , pp. 450-455
    • Sacks, H.S.1    Berrier, J.2    Reitman, D.3
  • 54
    • 0027064913 scopus 로고
    • Meta-analysis: State-of-the-science
    • Dickersin K, Berlin JA: Meta-analysis: State-of-the-science. Epidemiol Rev 14:154-176, 1992
    • (1992) Epidemiol Rev , vol.14 , pp. 154-176
    • Dickersin, K.1    Berlin, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.