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Volumn 18, Issue 19, 2000, Pages 3423-3434

Phase I assessment of the pharmacokinetics, metabolism, and safety of emitefur in patients with refractory solid tumors

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; EMITEFUR; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; INTERFERON; INTERLEUKIN 2; IRINOTECAN; LEDOXANTRONE; MELPHALAN; METHOTREXATE; MITOMYCIN; PACLITAXEL; TAMOXIFEN; TOPOTECAN; VINBLASTINE; VINCRISTINE;

EID: 0034306322     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2000.18.19.3423     Document Type: Article
Times cited : (21)

References (46)
  • 3
    • 0029965890 scopus 로고    scopus 로고
    • Leukopenia-induced effect of a combination of a new 5-fluorouracil (5-FU)-derived drug, BOF-A2 (emitefur), with other 5-FU-derived drugs or BV-araU (sorivudine) in rats
    • (1996) Jpn J Pharmacol , vol.70 , pp. 139-148
    • Miyauchi, S.1    Imaoka, T.2    Okada, T.3
  • 6
    • 0024833789 scopus 로고
    • Effects of the plasma concentration of 5-FU and the duration of continuous venous infusion of 5-FU with an inhibitor of 5-FU degradation on Yoshida sarcomas in rats
    • (1989) Jpn J Cancer Res , vol.80 , pp. 167-172
    • Fujii, S.1    Shimamoto, Y.2    Ohshimo, H.3
  • 8
    • 84871470308 scopus 로고    scopus 로고
    • Otsuka America Pharmaceutical, Inc.: BOF-A2: Investigator's Brochure. Rockville, MD, Otsuka America Pharmaceutical, Inc
    • (1997)
  • 12
    • 0000329023 scopus 로고    scopus 로고
    • Antimetabolites in cancer
    • De Vita VT, Hellman S, Rosenberg SA (eds): Principles and Practice of Oncology (ed 5). Philadelphia, PA, Lippincott-Raven
    • (1997) , pp. 432-452
    • Allegra, C.J.1    Grem, J.L.2
  • 14
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 15
    • 0345596364 scopus 로고    scopus 로고
    • Toxicity of fluorouracil in patients with advanced colorectal cancer: Effect of administration schedule and prognostic factors
    • (1998) J Clin Oncol , vol.16 , pp. 3537-3541
  • 16
    • 10344242912 scopus 로고    scopus 로고
    • Randomized phase II noncomparative trial of oral and intravenous doxifluridine plus levo-leucovorin in untreated patients with advanced colorectal carcinoma
    • (1996) Cancer , vol.78 , pp. 2087-2092
    • Bajetta, E.1    Di Bartolomeo, M.2    Somma, L.3
  • 19
    • 0027426408 scopus 로고
    • Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-FU chemotherapy
    • (1993) Cancer Res , vol.53 , pp. 5433-5438
    • Liu, Z.1    Zhang, R.2    Daisio, R.B.3
  • 20
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal cancer: A Mid-Atlantic Oncology Program Study
    • (1989) J Clin Oncol , vol.7 , pp. 425-432
    • Lokich, J.1    Ablgren, J.2    Guillo, J.3
  • 28
    • 0032520168 scopus 로고    scopus 로고
    • Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts
    • (1998) Cancer Res , vol.58 , pp. 685-690
    • Ishikawa, T.1    Sekiguchi, F.2    Fukase, Y.3
  • 29
    • 0031671094 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of intermittent twice daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer
    • (1998) J Clin Oncol , vol.16 , pp. 2977-2985
    • Mackean, M.1    Planting, A.2    Twelves, C.3
  • 31
    • 0026356409 scopus 로고
    • 5-Fluorouracil by protracted venous infusion: A review of recent clinical studies
    • (1991) Cancer Invest , vol.9 , pp. 637-642
    • Hansen, R.M.1
  • 33
    • 0028099423 scopus 로고
    • Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma
    • (1994) J Clin Oncol , vol.12 , pp. 2296-2300
    • Pazdur, R.1    Lassere, Y.2    Rhodes, V.3
  • 35
    • 0031910486 scopus 로고    scopus 로고
    • Randomized trial of adjuvant chemotherapy with mitomycin plus ftorafur versus mitomycin alone in resected locally advanced gastric cancer
    • (1998) J Clin Oncol , vol.16 , pp. 1036-1039
    • Grau, J.1    Estape, J.2    Fuster, J.3
  • 36
    • 0032127244 scopus 로고    scopus 로고
    • Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-FU selectively in tumors by enzymes concentrated in human liver and cancer tissue
    • (1998) Eur J Cancer , vol.34 , pp. 1274-1281
    • Miwa, M.1    Ura, M.2    Nishida, M.3
  • 37
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and 5-FU levels with evidence of circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-FU
    • (1990) Cancer Res , vol.50 , pp. 197-201
    • Harris, B.E.1    Song, R.2    Song, S.J.3
  • 38
    • 0002548405 scopus 로고    scopus 로고
    • 5-Fluoropyrimidines
    • Chabner BA, Longo DL (eds): Cancer Chemotherapy and Biotherapy (ed 2). Philadelphia, PA, Lippincott-Raven Publishers
    • (1996) , pp. 149-211
    • Grem, J.L.1
  • 44
    • 10544243363 scopus 로고    scopus 로고
    • Pharmacokinetics, oral bioavailability and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase
    • (1996) J Clin Oncol , vol.14 , pp. 3085-3096
    • Baker, S.1    Khor, S.2    Adjej, A.3
  • 46
    • 0000419698 scopus 로고    scopus 로고
    • A phase II open-lable study to evaluate a 28-day regimen of oral 5-FU plus 776C85 for the treatment of patients with previously untreated metastatic colorectal cancer
    • abstr 1083
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Mani, S.1    Beck, T.2    Chevlen, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.