-
1
-
-
0016756272
-
Continuous culture of fused cells secreting antibody of predefined specificity
-
Kohler G, Milstein C. Continuous culture of fused cells secreting antibody of predefined specificity. Nature 1975;256:495.
-
(1975)
Nature
, vol.256
, pp. 495
-
-
Kohler, G.1
Milstein, C.2
-
2
-
-
0028878938
-
Problems of delivery, of monoclonal antibodies. Pharmaceutical and pharmacokinetic solutions
-
Reilly RM, J Sandhu, TM Alvarez-Diez, et al. Problems of delivery, of monoclonal antibodies. Pharmaceutical and pharmacokinetic solutions. Clin Pharmacokinet 1995;28:126.
-
(1995)
Clin Pharmacokinet
, vol.28
, pp. 126
-
-
Reilly, R.M.1
Sandhu, J.2
Alvarez-Diez, T.M.3
-
3
-
-
11144334098
-
Recombinant protein therapeutics-success rates, market trends, and values to 2010
-
Pavlou AK, and Reichert JM. Recombinant protein therapeutics-success rates, market trends, and values to 2010. Nat Biotech 2004;22:1513.
-
(2004)
Nat Biotech
, vol.22
, pp. 1513
-
-
Pavlou, A.K.1
Reichert, J.M.2
-
4
-
-
0028289241
-
Anatomy of the antibody molecule
-
Padlan EA. Anatomy of the antibody molecule. Mol Immunol 1994;31:169.
-
(1994)
Mol Immunol
, vol.31
, pp. 169
-
-
Padlan, E.A.1
-
5
-
-
0021716682
-
Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains
-
Morrison SL, Johnson MJ, Herzenberg LA, et al. Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains. Proc Natl Acad Sci USA 1984;81:6851.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 6851
-
-
Morrison, S.L.1
Johnson, M.J.2
Herzenberg, L.A.3
-
6
-
-
0021713342
-
Production of functional chimaeric mouse/human antibody
-
Boulianne GL, Hozumi N, Shulman MJ. Production of functional chimaeric mouse/human antibody. Nature 1984;312:643.
-
(1984)
Nature
, vol.312
, pp. 643
-
-
Boulianne, G.L.1
Hozumi, N.2
Shulman, M.J.3
-
7
-
-
17644386490
-
Development of humanized antibodies as cancer therapeutics
-
Qu Z, Griffiths GL, Wegener WA, et al. Development of humanized antibodies as cancer therapeutics. Methods 2005;36:84.
-
(2005)
Methods
, vol.36
, pp. 84
-
-
Qu, Z.1
Griffiths, G.L.2
Wegener, W.A.3
-
8
-
-
0024292736
-
Assembly of a functional immunoglobulin Fv fragment in Escherichia coli
-
Skerra A, Pluckthun A. Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. Science 1988;240:1038.
-
(1988)
Science
, vol.240
, pp. 1038
-
-
Skerra, A.1
Pluckthun, A.2
-
9
-
-
0004198722
-
Protein engineering of antibody binding sites: Recovery of specific activity in an antidigoxin single-chain Fv analogue produced in Escherichia coli
-
Huston JS, Levinson D, Mudgett-Hunter M, et al. Protein engineering of antibody binding sites: Recovery of specific activity in an antidigoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 1988;85:5879.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 5879
-
-
Huston, J.S.1
Levinson, D.2
Mudgett-Hunter, M.3
-
10
-
-
0025162270
-
A comparison of strategies to stabilize immunoglobulin Fv-fragments
-
Glockshuber R, Malia M, Pfitzinger I, et al. A comparison of strategies to stabilize immunoglobulin Fv-fragments. Biochemistry 1990;29:1362.
-
(1990)
Biochemistry
, vol.29
, pp. 1362
-
-
Glockshuber, R.1
Malia, M.2
Pfitzinger, I.3
-
11
-
-
1542698957
-
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction
-
Orlandi R, Gussow DH, Jones PT, et al. Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc Natl Acad Sci USA 1989;86:3833.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 3833
-
-
Orlandi, R.1
Gussow, D.H.2
Jones, P.T.3
-
12
-
-
0024461313
-
Binding activities of a repertoire of single immunglobulin variable domains secreted from Escherichia coli
-
Ward ES, Gussow D, Griffiths AD, et al. Binding activities of a repertoire of single immunglobulin variable domains secreted from Escherichia coli, Nature 1989;341:544.
-
(1989)
Nature
, vol.341
, pp. 544
-
-
Ward, E.S.1
Gussow, D.2
Griffiths, A.D.3
-
13
-
-
0035793208
-
Stability engineering of antibody single-chain Fv fragments
-
Worn A, Pluckthun A. Stability engineering of antibody single-chain Fv fragments. J Mol Biol 2001; 989.
-
(2001)
J Mol Biol
, vol.989
-
-
Worn, A.1
Pluckthun, A.2
-
14
-
-
27144432842
-
Engineered antibody fragments and the rise of single domains
-
Holliger P, Hudson PJ. Engineered antibody fragments and the rise of single domains. Nat Biotech 2005;23:1126.
-
(2005)
Nat Biotech
, vol.23
, pp. 1126
-
-
Holliger, P.1
Hudson, P.J.2
-
16
-
-
0028962371
-
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
-
Greenberg AS, Avila D, Hughes M, et al. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks. Nature 1995;374:168.
-
(1995)
Nature
, vol.374
, pp. 168
-
-
Greenberg, A.S.1
Avila, D.2
Hughes, M.3
-
17
-
-
0034830063
-
Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries
-
Nuttall SD, Krishnan UV, Hattarki M, et al. Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries. Mol Immunol 2001;38:313.
-
(2001)
Mol Immunol
, vol.38
, pp. 313
-
-
Nuttall, S.D.1
Krishnan, U.V.2
Hattarki, M.3
-
18
-
-
10644228142
-
Efficient cancer therapy with a nanobody-based conjugate
-
Cortez-Retamozo V, Backmann N, Senter PD, et al. Efficient cancer therapy with a nanobody-based conjugate. Cancer Res 2004;64:2853.
-
(2004)
Cancer Res
, vol.64
, pp. 2853
-
-
Cortez-Retamozo, V.1
Backmann, N.2
Senter, P.D.3
-
19
-
-
0030738617
-
New protein engineering approches to multivalent and bispecific antibody fragments
-
Pluckthun A, Pack P. New protein engineering approches to multivalent and bispecific antibody fragments. Immunotechnology 1997;3:83.
-
(1997)
Immunotechnology
, vol.3
, pp. 83
-
-
Pluckthun, A.1
Pack, P.2
-
20
-
-
0034882279
-
Bispecific and bifunctional single chain recombinant antibodies
-
Kriangkum J, Xu B, Nagata LP, et al. Bispecific and bifunctional single chain recombinant antibodies. Biomol Eng 2001;18:31.
-
(2001)
Biomol Eng
, vol.18
, pp. 31
-
-
Kriangkum, J.1
Xu, B.2
Nagata, L.P.3
-
21
-
-
0035251453
-
Bispecific human IgG by design
-
Carter P. Bispecific human IgG by design. J Immunol Meth 2001;248:7.
-
(2001)
J Immunol Meth
, vol.248
, pp. 7
-
-
Carter, P.1
-
22
-
-
0035251638
-
Design and application of diabodies, triabodies, and tetrabodies for cancer targeting
-
Todorovska A, Roovers RC, Dolezal O, et al. Design and application of diabodies, triabodies, and tetrabodies for cancer targeting. J Immunol Meth 2001;248:47.
-
(2001)
J Immunol Meth
, vol.248
, pp. 47
-
-
Todorovska, A.1
Roovers, R.C.2
Dolezal, O.3
-
23
-
-
0027197493
-
"Diabodies": Small bivalent and bispecific antibody fragments
-
Holliger P, Prospero T, Winter G. "Diabodies": Small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 1993;90:6444.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 6444
-
-
Holliger, P.1
Prospero, T.2
Winter, G.3
-
24
-
-
33646477258
-
Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting
-
Rossi EA, Goldenberg DM, Cardillo TM, et al. Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting. Proc Natl Acad Sci USA 2006;103:6841.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6841
-
-
Rossi, E.A.1
Goldenberg, D.M.2
Cardillo, T.M.3
-
25
-
-
0036900286
-
Antibody discovery: The use of transgenic mice to generate human monoclonal antibodies for therapeutics
-
Kellermann SA, Green LL. Antibody discovery: The use of transgenic mice to generate human monoclonal antibodies for therapeutics. Curr Opin Biotech 2002;13:593.
-
(2002)
Curr Opin Biotech
, vol.13
, pp. 593
-
-
Kellermann, S.A.1
Green, L.L.2
-
26
-
-
0026317443
-
By-passing immunization. Human antibodies from V-gene libraries displayed on phage
-
Marks JD, Hoogenboom HR, Bonnert TP, et al. By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol 1991;222:581.
-
(1991)
J Mol Biol
, vol.222
, pp. 581
-
-
Marks, J.D.1
Hoogenboom, H.R.2
Bonnert, T.P.3
-
27
-
-
0034635335
-
Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides
-
Knappik A, Ge L, Honegger A, et al. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. J Mol Biol 2000;296:57.
-
(2000)
J Mol Biol
, vol.296
, pp. 57
-
-
Knappik, A.1
Ge, L.2
Honegger, A.3
-
28
-
-
0025226085
-
Phage antibodies: Filamentous phage displaying antibody variable domains
-
McCafferty J, Griffiths AD, Winter G, et al. Phage antibodies: Filamentous phage displaying antibody variable domains. Nature 1990;348:552.
-
(1990)
Nature
, vol.348
, pp. 552
-
-
McCafferty, J.1
Griffiths, A.D.2
Winter, G.3
-
29
-
-
33645024046
-
Exploiting directed evolution for the discovery of biologicals
-
Douthwaite J, Jermutus L. Exploiting directed evolution for the discovery of biologicals. Curr Opin Drug Discov Devel 2006;9:269.
-
(2006)
Curr Opin Drug Discov Devel
, vol.9
, pp. 269
-
-
Douthwaite, J.1
Jermutus, L.2
-
30
-
-
3142685154
-
In vitro protein evolution by ribosome display and mRNA display
-
Lipovsek D, Pluckthun A. In vitro protein evolution by ribosome display and mRNA display. J Immunol Meth 2004;290:51.
-
(2004)
J Immunol Meth
, vol.290
, pp. 51
-
-
Lipovsek, D.1
Pluckthun, A.2
-
31
-
-
0030994634
-
Yeast surface display for screening combinatorial polypeptide libraries
-
Boder ET, Wittrup KD. Yeast surface display for screening combinatorial polypeptide libraries. Nat Biotech 1997;15:553.
-
(1997)
Nat Biotech
, vol.15
, pp. 553
-
-
Boder, E.T.1
Wittrup, K.D.2
-
32
-
-
0035957521
-
Fast selection of antibodies without antigen purification: Adaptation of the protein fragment complementation assay to select antigen-antibody pairs
-
Mossner E, Koch H, Pluckthun A. Fast selection of antibodies without antigen purification: Adaptation of the protein fragment complementation assay to select antigen-antibody pairs. J Mol Biol 2001;308:115.
-
(2001)
J Mol Biol
, vol.308
, pp. 115
-
-
Mossner, E.1
Koch, H.2
Pluckthun, A.3
-
33
-
-
4644309963
-
Production technologies for monoclonal antibodies and their fragments
-
Andersen DC, Reilly DE. Production technologies for monoclonal antibodies and their fragments. Curr Opin Biotech 2004;15:456.
-
(2004)
Curr Opin Biotech
, vol.15
, pp. 456
-
-
Andersen, D.C.1
Reilly, D.E.2
-
34
-
-
0036425175
-
Rapid refolding and polishing of single-chain antibodies from Escherichia coli inclusion bodies
-
Sinacola JR, Robinson AS. Rapid refolding and polishing of single-chain antibodies from Escherichia coli inclusion bodies. Prot Expr Purif 2002;26:301.
-
(2002)
Prot Expr Purif
, vol.26
, pp. 301
-
-
Sinacola, J.R.1
Robinson, A.S.2
-
35
-
-
0035937505
-
Intracellular functions of N-linked glycans
-
Helenius A, Aebi M. Intracellular functions of N-linked glycans. Science 2001;291:2364.
-
(2001)
Science
, vol.291
, pp. 2364
-
-
Helenius, A.1
Aebi, M.2
-
36
-
-
0036535753
-
Recombinant protein expression for therapeutic applications
-
Andersen DC, Krummen L. Recombinant protein expression for therapeutic applications. Curr Opin Biotech 2002;13:117.
-
(2002)
Curr Opin Biotech
, vol.13
, pp. 117
-
-
Andersen, D.C.1
Krummen, L.2
-
37
-
-
20444377682
-
Developments in transgenic technology: Applications for medicine
-
Hunter CV, Tiley LS, Sang HM. Developments in transgenic technology: Applications for medicine. Trends Mol Med 2005;1:293.
-
(2005)
Trends Mol Med
, vol.1
, pp. 293
-
-
Hunter, C.V.1
Tiley, L.S.2
Sang, H.M.3
-
38
-
-
0035212386
-
Medical molecular farming: Production of antibodies, biopharmaceuticals, and edible vaccines in plants
-
Daniell H, Streatfield SJ, Wycoff K. Medical molecular farming: Production of antibodies, biopharmaceuticals, and edible vaccines in plants. Trends Plant Sci 2001;6:219.
-
(2001)
Trends Plant Sci
, vol.6
, pp. 219
-
-
Daniell, H.1
Streatfield, S.J.2
Wycoff, K.3
-
39
-
-
0034050074
-
Species-specific variation in glycosylation of IgG: Evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics
-
Raju TS, Briggs JB, Borge SM, et al. Species-specific variation in glycosylation of IgG: Evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics. Glycobiology 2000;10:477.
-
(2000)
Glycobiology
, vol.10
, pp. 477
-
-
Raju, T.S.1
Briggs, J.B.2
Borge, S.M.3
-
40
-
-
33644552393
-
Competitive bioreactor hens on the horizon
-
Ivarie R. Competitive bioreactor hens on the horizon. Trends Biotech 2006;24:99.
-
(2006)
Trends Biotech
, vol.24
, pp. 99
-
-
Ivarie, R.1
-
41
-
-
0042322600
-
Production of complex human glycoproteins in yeast
-
Hamilton SR, Bobrowicz P, Bobrowicz B, et al. Production of complex human glycoproteins in yeast. Science 2003;301:1244.
-
(2003)
Science
, vol.301
, pp. 1244
-
-
Hamilton, S.R.1
Bobrowicz, P.2
Bobrowicz, B.3
-
42
-
-
0035073202
-
Therapeutic antibody production technologies: Molecules, applications, expression, and purification
-
Humphreys DP, Glover DJ. Therapeutic antibody production technologies: Molecules, applications, expression, and purification. Curr Opin Drug Discov Devel 2001;4:172.
-
(2001)
Curr Opin Drug Discov Devel
, vol.4
, pp. 172
-
-
Humphreys, D.P.1
Glover, D.J.2
-
43
-
-
17044454065
-
Radioimmunoguided surgery in colorectal cancer using a genetically engineered anti-CEA, single-chain Fv antibody
-
Mayer A, Tsiompanou E, O'Malley D, et al. Radioimmunoguided surgery in colorectal cancer using a genetically engineered anti-CEA, single-chain Fv antibody. Clin Cancer Res 2000;6:1711.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1711
-
-
Mayer, A.1
Tsiompanou, E.2
O'Malley, D.3
-
44
-
-
0034074997
-
Divalent forms of CC49 single-chain antibody constructs in Pichia pastoris: Expression, purification, and characterization
-
Goel A, Beresford GW, Colcher D, et al. Divalent forms of CC49 single-chain antibody constructs in Pichia pastoris: Expression, purification, and characterization. J Biochem (Tokyo) 2000;127:829.
-
(2000)
J Biochem (Tokyo)
, vol.127
, pp. 829
-
-
Goel, A.1
Beresford, G.W.2
Colcher, D.3
-
45
-
-
3042784498
-
Modifying an immunogenic epitope on a therapeutic protein: A step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT)
-
Mayer A, Sharma SK, Tolner B, et al. Modifying an immunogenic epitope on a therapeutic protein: A step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT). Br J Cancer 2004;90:2402.
-
(2004)
Br J Cancer
, vol.90
, pp. 2402
-
-
Mayer, A.1
Sharma, S.K.2
Tolner, B.3
-
46
-
-
13544268486
-
Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification
-
Nellis DF, Ekstrom DL, Kirpotin DB, et al. Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification. Biotech Prog 2005;21:205.
-
(2005)
Biotech Prog
, vol.21
, pp. 205
-
-
Nellis, D.F.1
Ekstrom, D.L.2
Kirpotin, D.B.3
-
47
-
-
0023683508
-
Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers
-
Knauf MJ, Bell DP, Hirtzer P, et al. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers. J Biol Chem 1988;263:15064.
-
(1988)
J Biol Chem
, vol.263
, pp. 15064
-
-
Knauf, M.J.1
Bell, D.P.2
Hirtzer, P.3
-
48
-
-
10744227326
-
Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation
-
Yang K, Basu A, Wang M, et al. Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation. Prot Eng 2003;16:761.
-
(2003)
Prot Eng
, vol.16
, pp. 761
-
-
Yang, K.1
Basu, A.2
Wang, M.3
-
49
-
-
27544496736
-
Protein PEGylation decreases observed target association rates via a dual blocking mechanism
-
Kubetzko S, Sarkar CA, Pluckthun A. Protein PEGylation decreases observed target association rates via a dual blocking mechanism. Mol Pharmacol 2005;68:1439.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1439
-
-
Kubetzko, S.1
Sarkar, C.A.2
Pluckthun, A.3
-
50
-
-
0035210960
-
Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies
-
Ober RJ, Radu CG, Ghetie V, et al. Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies. Int Immunol 2001;13:1551.
-
(2001)
Int Immunol
, vol.13
, pp. 1551
-
-
Ober, R.J.1
Radu, C.G.2
Ghetie, V.3
-
51
-
-
19944430279
-
Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments
-
Kenanova V, Olafsen T, Crow DM, et al. Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments. Cancer Res 2005;65:622.
-
(2005)
Cancer Res
, vol.65
, pp. 622
-
-
Kenanova, V.1
Olafsen, T.2
Crow, D.M.3
-
53
-
-
0742324507
-
Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein
-
Medzihradszky KF, Spencer DI, Sharma SK, et al. Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein. Glycobiology 2004;14:27.
-
(2004)
Glycobiology
, vol.14
, pp. 27
-
-
Medzihradszky, K.F.1
Spencer, D.I.2
Sharma, S.K.3
-
54
-
-
0033963824
-
Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer
-
Knox SJ, Goris ML, Tempero M, et al. Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer. Clin Cancer Res 2000;6:406.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 406
-
-
Knox, S.J.1
Goris, M.L.2
Tempero, M.3
-
55
-
-
33645071568
-
Avidity-mediated enhancement of in vivo tumor targeting by single-chain Fv dimers
-
Adams GP, Tai MS, McCartney JE, et al. Avidity-mediated enhancement of in vivo tumor targeting by single-chain Fv dimers. Clin Cancer Res 2006;12:1599.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1599
-
-
Adams, G.P.1
Tai, M.S.2
McCartney, J.E.3
-
56
-
-
0031942906
-
Prolonged in vivo tumor retention of a human diabody targeting the extracellular domain of human HER2/neu
-
Adams GP, Schier R, McCall AM, et al. Prolonged in vivo tumor retention of a human diabody targeting the extracellular domain of human HER2/neu. Br J Cancer 1998;77:1405.
-
(1998)
Br J Cancer
, vol.77
, pp. 1405
-
-
Adams, G.P.1
Schier, R.2
McCall, A.M.3
-
57
-
-
0035874887
-
High-affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules
-
Adams GP, Schier R, McCall AM, et al. High-affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules. Cancer Res 2001;61:4750.
-
(2001)
Cancer Res
, vol.61
, pp. 4750
-
-
Adams, G.P.1
Schier, R.2
McCall, A.M.3
-
58
-
-
0025334830
-
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy
-
Boucher Y, Baxter LT, Jain RK. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy. Cancer Res 1990;50:4478.
-
(1990)
Cancer Res
, vol.50
, pp. 4478
-
-
Boucher, Y.1
Baxter, L.T.2
Jain, R.K.3
-
59
-
-
24744450185
-
Penetratin improves tumor retention of single-chain antibodies: A novel step toward optimization of radioimmunotherapy of solid tumors
-
Jain M, Chauhan SC, Singh AP, et al, Penetratin improves tumor retention of single-chain antibodies: A novel step toward optimization of radioimmunotherapy of solid tumors. Cancer Res 2005;65:7840.
-
(2005)
Cancer Res
, vol.65
, pp. 7840
-
-
Jain, M.1
Chauhan, S.C.2
Singh, A.P.3
-
62
-
-
0029143994
-
Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives
-
Behr TM, Sharkey RM, Juweid ME, et al. Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives. Cancer Res 1995;55:3825.
-
(1995)
Cancer Res
, vol.55
, pp. 3825
-
-
Behr, T.M.1
Sharkey, R.M.2
Juweid, M.E.3
-
63
-
-
0035661063
-
Cleavable linkers to enhance selectivity of antibody-targeted therapy of cancer
-
Kukis DL, Novak-Hofer I, DeNardo SJ. Cleavable linkers to enhance selectivity of antibody-targeted therapy of cancer. Cancer Biother Radiopharm 2001;16:457.
-
(2001)
Cancer Biother Radiopharm
, vol.16
, pp. 457
-
-
Kukis, D.L.1
Novak-Hofer, I.2
Denardo, S.J.3
-
64
-
-
0034787123
-
Advances in pretargeting biotechnology
-
Goodwin DA, Meares CF. Advances in pretargeting biotechnology. Biotech Adv 2001;19:435.
-
(2001)
Biotech Adv
, vol.19
, pp. 435
-
-
Goodwin, D.A.1
Meares, C.F.2
-
65
-
-
0036560016
-
Molecular advances in pretargeting radioimmunotherapy with bispecific antibodies
-
Chang CH, Sharkey RM, Rossi EA, et al. Molecular advances in pretargeting radioimmunotherapy with bispecific antibodies. Mol Cancer Ther 2002;1:553.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 553
-
-
Chang, C.H.1
Sharkey, R.M.2
Rossi, E.A.3
-
66
-
-
0035214047
-
Toxin-labeled monoclonal antibodies
-
Kreitman RJ. Toxin-labeled monoclonal antibodies. Curr Pharm Biotech 2001;2:313.
-
(2001)
Curr Pharm Biotech
, vol.2
, pp. 313
-
-
Kreitman, R.J.1
-
67
-
-
0013673142
-
Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria, and Pseudomonas toxin and immunotoxins
-
Brinkmann U, Mansfield E, Pastan I. Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria, and Pseudomonas toxin and immunotoxins. Apoptosis 1997;2:192.
-
(1997)
Apoptosis
, vol.2
, pp. 192
-
-
Brinkmann, U.1
Mansfield, E.2
Pastan, I.3
-
68
-
-
0034682480
-
Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-TAC(FV)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenecity
-
Tsutsumi Y, Onda M, Nagata S, et al. Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-TAC(FV)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenecity. Proc Natl Acad Sci USA 2000;97:8548.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8548
-
-
Tsutsumi, Y.1
Onda, M.2
Nagata, S.3
-
69
-
-
0036137925
-
Phase II trial of a single weekly intravenous dose of ranpirnase in patients with unresectable malignant mesothelioma
-
Mikulski SM, Costanzi JJ, Vogelzang NJ, et al. Phase II trial of a single weekly intravenous dose of ranpirnase in patients with unresectable malignant mesothelioma. J Clin Oncol 2002;20:274.
-
(2002)
J Clin Oncol
, vol.20
, pp. 274
-
-
Mikulski, S.M.1
Costanzi, J.J.2
Vogelzang, N.J.3
-
70
-
-
0035863726
-
Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin's lymphoma
-
Newton DL, Hansen HJ, Mikulski SM, et al. Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin's lymphoma. Blood 2001;97:528.
-
(2001)
Blood
, vol.97
, pp. 528
-
-
Newton, D.L.1
Hansen, H.J.2
Mikulski, S.M.3
-
71
-
-
0024246527
-
A cytotoxic agent can be generated selectively at cancer sites
-
Bagshawe KD, Springer CJ, Searle F, et al. A cytotoxic agent can be generated selectively at cancer sites. Br J Cancer 1988;58:700.
-
(1988)
Br J Cancer
, vol.58
, pp. 700
-
-
Bagshawe, K.D.1
Springer, C.J.2
Searle, F.3
-
73
-
-
33644917163
-
Construction and optimization of a CC49-based scFv-beta-lactamase fusion protein for ADEPT
-
Roberge M, Estabrook M, Basler J, et al. Construction and optimization of a CC49-based scFv-beta-lactamase fusion protein for ADEPT. Prot Eng Des Sel 2006;19:141.
-
(2006)
Prot Eng des Sel
, vol.19
, pp. 141
-
-
Roberge, M.1
Estabrook, M.2
Basler, J.3
-
74
-
-
33644781456
-
Multifunctional polymeric nanoparticles for tumour-targeted drug delivery
-
van Vlerken LE, Amiji MM. Multifunctional polymeric nanoparticles for tumour-targeted drug delivery. Exp Opin Drug Deliv 2006;3:205.
-
(2006)
Exp Opin Drug Deliv
, vol.3
, pp. 205
-
-
Van Vlerken, L.E.1
Amiji, M.M.2
-
75
-
-
0034000453
-
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
-
Maeda H, Wu J, Sawa T, et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. J Cont Rel 2000;65:271.
-
(2000)
J Cont Rel
, vol.65
, pp. 271
-
-
Maeda, H.1
Wu, J.2
Sawa, T.3
-
76
-
-
0842263617
-
Production of soluble ScFvs with C-terminal-free thiol for site-specific conjugation or stable dimeric ScFvs on demand
-
Albrecht H, Burke PA, Natarajan A, et al. Production of soluble ScFvs with C-terminal-free thiol for site-specific conjugation or stable dimeric ScFvs on demand. Bioconj Chem 2004;15:16.
-
(2004)
Bioconj Chem
, vol.15
, pp. 16
-
-
Albrecht, H.1
Burke, P.A.2
Natarajan, A.3
-
77
-
-
3142773316
-
Multiplexed sandwich assays in microarray format
-
Nielsen TJB, Geierstanger BH. Multiplexed sandwich assays in microarray format. J Immunol Meth 2004;290:107.
-
(2004)
J Immunol Meth
, vol.290
, pp. 107
-
-
Nielsen, T.J.B.1
Geierstanger, B.H.2
-
78
-
-
28944448654
-
Cancer diagnostics: Decision criteria for marker utilization in the clinic
-
Taube SE, Jacobson JW, Lively TG. Cancer diagnostics: Decision criteria for marker utilization in the clinic. Am J Pharmacogenom 2005;5:357.
-
(2005)
Am J Pharmacogenom
, vol.5
, pp. 357
-
-
Taube, S.E.1
Jacobson, J.W.2
Lively, T.G.3
-
79
-
-
17144453160
-
Advances in imaging in the postoperative patient with a rising prostate-specific antigen level
-
Hricak H, Schoder H, Pucar D, et al. Advances in imaging in the postoperative patient with a rising prostate-specific antigen level. Semin Oncol 2003;30:616.
-
(2003)
Semin Oncol
, vol.30
, pp. 616
-
-
Hricak, H.1
Schoder, H.2
Pucar, D.3
-
80
-
-
0033770046
-
99mTc-labeled antibody fragments for detection of the recurrence of colorectal carcinoma
-
99mTc-labeled antibody fragments for detection of the recurrence of colorectal carcinoma. J Nucl Med 2000;41:1657.
-
(2000)
J Nucl Med
, vol.41
, pp. 1657
-
-
Willkomm, P.1
Bender, H.2
Bangard, M.3
-
82
-
-
0029918942
-
Tumor localization of anti-CEA single-chain Fvs: Improved targeting by noncovalent dimers
-
Wu AM, Chen W, Raubitschek A, et al. Tumor localization of anti-CEA single-chain Fvs: Improved targeting by noncovalent dimers. Immunotech 1996;2:21.
-
(1996)
Immunotech
, vol.2
, pp. 21
-
-
Wu, A.M.1
Chen, W.2
Raubitschek, A.3
-
84
-
-
0033046339
-
Binding characteristics and tumor targeting of a covalently linked divalent CC49 single-chain antibody
-
Beresford GW, Pavlinkova G, Booth BJM, et al. Binding characteristics and tumor targeting of a covalently linked divalent CC49 single-chain antibody. Int J Cancer 1999;81:911.
-
(1999)
Int J Cancer
, vol.81
, pp. 911
-
-
Beresford, G.W.1
Pavlinkova, G.2
Booth, B.J.M.3
-
85
-
-
0242353714
-
High-resolution microPET imaging of carcino-embryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment
-
Wu AM, Yasaki PJ, Tsai SW, et al. High-resolution microPET imaging of carcino-embryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment. Proc Natl Acad Sci USA 2000;97:8495.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8495
-
-
Wu, A.M.1
Yasaki, P.J.2
Tsai, S.W.3
-
86
-
-
4143080306
-
123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer
-
123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer. Clin Cancer Res 2004;10:5014.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5014
-
-
Wong, J.Y.C.1
Chu, D.Z.2
Williams, L.E.3
-
87
-
-
30744455270
-
Signal amplification in molecular imaging by pretargeting a multivalent, bispecific antibody
-
Sharkey RM, Cardillo TM, Rossi EA, et al. Signal amplification in molecular imaging by pretargeting a multivalent, bispecific antibody. Nat Med 2005;1:1250.
-
(2005)
Nat Med
, vol.1
, pp. 1250
-
-
Sharkey, R.M.1
Cardillo, T.M.2
Rossi, E.A.3
-
88
-
-
33645149227
-
A membrane antibody receptor for noninvasive imaging of gene expression
-
Roffler SR, Wang HE, Yu HM, et al. A membrane antibody receptor for noninvasive imaging of gene expression. Gene Ther 2006;13:412.
-
(2006)
Gene Ther
, vol.13
, pp. 412
-
-
Roffler, S.R.1
Wang, H.E.2
Yu, H.M.3
-
89
-
-
28144449723
-
The progress and promise of molecular imaging probes in oncologic drug development
-
Kelloff GJ, Krohn KA, Larson SM, et al. The progress and promise of molecular imaging probes in oncologic drug development. Clin Cancer Res 2005;11:7967.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7967
-
-
Kelloff, G.J.1
Krohn, K.A.2
Larson, S.M.3
-
90
-
-
0034283815
-
Noninvasive localization of tumors by immunofluorescence imaging using a single-chain Fv fragment of a human monoclonal antibody with broad cancer specificity
-
Ramjiawan B, Maiti P, Aftanas A, et al. Noninvasive localization of tumors by immunofluorescence imaging using a single-chain Fv fragment of a human monoclonal antibody with broad cancer specificity. Cancer 2000;89:1134.
-
(2000)
Cancer
, vol.89
, pp. 1134
-
-
Ramjiawan, B.1
Maiti, P.2
Aftanas, A.3
-
91
-
-
3543022686
-
In vivo cancer targeting and imaging with semiconductor quantum dots
-
Gao X, Cui Y, Levenson RM, et al. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotech 2004;22:969.
-
(2004)
Nat Biotech
, vol.22
, pp. 969
-
-
Gao, X.1
Cui, Y.2
Levenson, R.M.3
-
92
-
-
24644434876
-
In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals
-
Huh YM, Jun YW, Song HT, et al. In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J Am Chem Soc 2005;127:12387.
-
(2005)
J Am Chem Soc
, vol.127
, pp. 12387
-
-
Huh, Y.M.1
Jun, Y.W.2
Song, H.T.3
-
94
-
-
4143149984
-
Recent advances in the generation of bispecific antibodies for tumor immunotherapy
-
Kipriyanov SM, Le GF. Recent advances in the generation of bispecific antibodies for tumor immunotherapy. Curr Opin Drug Discov Devel 2004;7:233.
-
(2004)
Curr Opin Drug Discov Devel
, vol.7
, pp. 233
-
-
Kipriyanov, S.M.1
Le, G.F.2
-
95
-
-
0029041003
-
Prevention of breast tumour development in vivo by down-regulation of the p185neu receptor
-
Katsumata M, Okudaira T, Samanta A, et al. Prevention of breast tumour development in vivo by down-regulation of the p185neu receptor. Nat Med 1995;1:644.
-
(1995)
Nat Med
, vol.1
, pp. 644
-
-
Katsumata, M.1
Okudaira, T.2
Samanta, A.3
-
97
-
-
0037297117
-
The mechanisms of action of rituximab in the elimination of tumor cells
-
Johnson P, Glennie P. The mechanisms of action of rituximab in the elimination of tumor cells. Semin Oncol 2003;30:3.
-
(2003)
Semin Oncol
, vol.30
, pp. 3
-
-
Johnson, P.1
Glennie, P.2
-
98
-
-
0345337254
-
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
-
McLaughlin P, Grillo-Lopez AJ, Link BK, et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program. J Clin Oncol 1998;16:2825.
-
(1998)
J Clin Oncol
, vol.16
, pp. 2825
-
-
McLaughlin, P.1
Grillo-Lopez, A.J.2
Link, B.K.3
-
99
-
-
23744493939
-
Treatment of non-Hodgkin's lymphoma (NHL) with radiolabeled antibodies (mAbs)
-
DeNardo GL. Treatment of non-Hodgkin's lymphoma (NHL) with radiolabeled antibodies (mAbs). Semin Nucl Med 2005;35:202.
-
(2005)
Semin Nucl Med
, vol.35
, pp. 202
-
-
DeNardo, G.L.1
-
100
-
-
12944275472
-
131I-Tositumomab therapy as initial treatment for follicular lymphoma
-
131I-Tositumomab therapy as initial treatment for follicular lymphoma. N Engl J Med 2005;352:441.
-
(2005)
N Engl J Med
, vol.352
, pp. 441
-
-
Kaminski, M.S.1
Tuck, M.2
Estes, J.3
-
101
-
-
0042787657
-
Progress in immunoconjugate cancer therapeutics
-
Payne G. Progress in immunoconjugate cancer therapeutics. Cancer Cell 2003;3:207.
-
(2003)
Cancer Cell
, vol.3
, pp. 207
-
-
Payne, G.1
-
102
-
-
0036683449
-
Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
-
Lundin J, Kimby E, Bjorkholm M, et al. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 2002;100:768.
-
(2002)
Blood
, vol.100
, pp. 768
-
-
Lundin, J.1
Kimby, E.2
Bjorkholm, M.3
-
105
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353:1659.
-
(2005)
N Engl J Med
, vol.353
, pp. 1659
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
106
-
-
33645651433
-
A phase II trial with trastuzumab and pertuzumab in patients with HER2-overexpressed locally advanced and metastatic breast cancer
-
Walshe JM, Denduluri N, Berman AW, et al. A phase II trial with trastuzumab and pertuzumab in patients with HER2-overexpressed locally advanced and metastatic breast cancer. Clin Breast Cancer 2006;6:535.
-
(2006)
Clin Breast Cancer
, vol.6
, pp. 535
-
-
Walshe, J.M.1
Denduluri, N.2
Berman, A.W.3
-
107
-
-
33644600485
-
Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
-
Adams CW, Allison DE, Flagella K, et al. Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab. Cancer Immunol Immunother 2006;55:717.
-
(2006)
Cancer Immunol Immunother
, vol.55
, pp. 717
-
-
Adams, C.W.1
Allison, D.E.2
Flagella, K.3
-
108
-
-
30544439661
-
The role of bevacizumab as first-line therapy for colon cancer
-
Marshall J. The role of bevacizumab as first-line therapy for colon cancer. Semin Oncol 2005;32:S43.
-
(2005)
Semin Oncol
, vol.32
-
-
Marshall, J.1
-
109
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
110
-
-
33750630547
-
Panitumumab improves progression-free survival in metastatic colorectal cancer
-
Amgen and Abgenix Inc.
-
Amgen and Abgenix Inc. Panitumumab improves progression-free survival in metastatic colorectal cancer. Oncology 2005;19:1800.
-
(2005)
Oncology
, vol.19
, pp. 1800
-
-
-
111
-
-
27244458791
-
131I-labetuzumab after salvage resection of colorectal matastases in the liver: Five-year safety and efficacy results
-
131I-labetuzumab after salvage resection of colorectal matastases in the liver: Five-year safety and efficacy results. J Clin Oncol 2005;23:6763.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6763
-
-
Liersch, T.1
Meller, J.2
Kulle, B.3
-
112
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
-
Xiong HQ, Rosenberg A, LoBuglio A, et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial. J Clin Oncol 2004;22:2610.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2610
-
-
Xiong, H.Q.1
Rosenberg, A.2
LoBuglio, A.3
-
113
-
-
25844483748
-
In focus: Advanced pancreatic cancer
-
Kindler HL. In focus: Advanced pancreatic cancer. Clin Adv Hematol Oncol 2005;3:420.
-
(2005)
Clin Adv Hematol Oncol
, vol.3
, pp. 420
-
-
Kindler, H.L.1
-
114
-
-
33744754420
-
Locoregional therapies for glioma
-
Mamelak AN. Locoregional therapies for glioma. Oncology (Williston Park) 2005;19:1803.
-
(2005)
Oncology (Williston Park)
, vol.19
, pp. 1803
-
-
Mamelak, A.N.1
-
115
-
-
20044374196
-
Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: Initial experience in 51 patients
-
Patel SJ, Shapiro WR, Laske DW, et al. Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: Initial experience in 51 patients. Neurosurgery 2005;56:1243.
-
(2005)
Neurosurgery
, vol.56
, pp. 1243
-
-
Patel, S.J.1
Shapiro, W.R.2
Laske, D.W.3
-
116
-
-
0242692683
-
Clinical use of monoclonal antibody HuJ591 therapy: Targeting prostate specific membrane antigen
-
Nanus DM, Milowsky MI, Kostakoglu L, et al. Clinical use of monoclonal antibody HuJ591 therapy: Targeting prostate specific membrane antigen. J Urol 2003;170:S84.
-
(2003)
J Urol
, vol.170
-
-
Nanus, D.M.1
Milowsky, M.I.2
Kostakoglu, L.3
-
117
-
-
30944446883
-
Lessons from phase III clinical trials on anti-VEGF therapy for cancer
-
Jain RK, Duda DG, Clark JW, et al. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006;3:24.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 24
-
-
Jain, R.K.1
Duda, D.G.2
Clark, J.W.3
-
118
-
-
13844310366
-
The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs
-
Wittel UA, Jain M, Goel A, et al. The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs. Nucl Med Biol 2005;32:157.
-
(2005)
Nucl Med Biol
, vol.32
, pp. 157
-
-
Wittel, U.A.1
Jain, M.2
Goel, A.3
-
119
-
-
33644869654
-
Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy
-
Goldenberg DM, Sharkey RM, Paganelli G, et al. Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy. J Clin Oncol 2006;24:823.
-
(2006)
J Clin Oncol
, vol.24
, pp. 823
-
-
Goldenberg, D.M.1
Sharkey, R.M.2
Paganelli, G.3
-
120
-
-
26444530095
-
Pretargeting of carcinoembryonic antigen-expressing cancers with a trivalent bispecific fusion protein produced in myeloma cells
-
Rossi EA, Chang CH, Losman MJ, et al. Pretargeting of carcinoembryonic antigen-expressing cancers with a trivalent bispecific fusion protein produced in myeloma cells. Clin Cancer Res 2005;11:7122s.
-
(2005)
Clin Cancer Res
, vol.11
-
-
Rossi, E.A.1
Chang, C.H.2
Losman, M.J.3
-
121
-
-
33645729095
-
Comparison of a tetravalent single-chain antibody-streptavidin fusion protein and an antibody-streptavidin chemical conjugate for pretargeted anti-CD20 radioimmunotherapy of B-cell lymphomas
-
Pagel JM, Lin Y, Hedin N, et al. Comparison of a tetravalent single-chain antibody-streptavidin fusion protein and an antibody-streptavidin chemical conjugate for pretargeted anti-CD20 radioimmunotherapy of B-cell lymphomas. Blood 2006;108:328.
-
(2006)
Blood
, vol.108
, pp. 328
-
-
Pagel, J.M.1
Lin, Y.2
Hedin, N.3
-
122
-
-
26444574248
-
Enhancement of the therapeutic index: From nonmyeloablative and myeloablative toward pretargeted radioimmunotherapy for metastatic prostate cancer
-
DeNardo SJ, Richman CM, Albrecht H, et al. Enhancement of the therapeutic index: From nonmyeloablative and myeloablative toward pretargeted radioimmunotherapy for metastatic prostate cancer. Clin Cancer Res 2005;11:7187s.
-
(2005)
Clin Cancer Res
, vol.11
-
-
DeNardo, S.J.1
Richman, C.M.2
Albrecht, H.3
-
123
-
-
14644395560
-
In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter
-
Dwyer RM, Bergert ER, O'Connor MK, et al. In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter. Clin Cancer Res 2005;11:1483.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1483
-
-
Dwyer, R.M.1
Bergert, E.R.2
O'Connor, M.K.3
-
124
-
-
13844281694
-
Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of the monoclonal antibody CC49
-
Wittel UA, Jain M, Goel A, et al. Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of the monoclonal antibody CC49. Biochem Biophys Res Commun 2005;329:168.
-
(2005)
Biochem Biophys Res Commun
, vol.329
, pp. 168
-
-
Wittel, U.A.1
Jain, M.2
Goel, A.3
-
125
-
-
22044456976
-
Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy
-
Ebbinghaus C, Ronca R, Kaspar M, et al. Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy. Int J Cancer 2005;116:304.
-
(2005)
Int J Cancer
, vol.116
, pp. 304
-
-
Ebbinghaus, C.1
Ronca, R.2
Kaspar, M.3
-
126
-
-
33744537358
-
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates
-
Sutherland MS, Sanderson RJ, Gordon KA, et al. Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates. J Biol Chem 2006;281:10540.
-
(2006)
J Biol Chem
, vol.281
, pp. 10540
-
-
Sutherland, M.S.1
Sanderson, R.J.2
Gordon, K.A.3
-
127
-
-
31544455876
-
Antitumor efficacy of a combination of CMC-544 (inotuzumab ozogamicin), a CD22-targeted cytotoxic immunoconjugate of calicheamicin, and rituximab against non-Hodgkin's B-cell lymphoma
-
Dijoseph JF, Dougher MM, Kalyandrug LB, et al. Antitumor efficacy of a combination of CMC-544 (inotuzumab ozogamicin), a CD22-targeted cytotoxic immunoconjugate of calicheamicin, and rituximab against non-Hodgkin's B-cell lymphoma. Clin Cancer Res 2006;12:242.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 242
-
-
Dijoseph, J.F.1
Dougher, M.M.2
Kalyandrug, L.B.3
-
128
-
-
14644426573
-
HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity
-
Bang S, Nagata S, Onda M, et al. HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity. Clin Cancer Res 2005;11:1545.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1545
-
-
Bang, S.1
Nagata, S.2
Onda, M.3
-
129
-
-
33645467075
-
Characterization of a CC49-based single-chain fragment-beta-lactamase fusion protein for antibody-directed enzyme pro-drug therapy (ADEPT)
-
Alderson RF, Toki BE, Roberge M, et al. Characterization of a CC49-based single-chain fragment-beta-lactamase fusion protein for antibody-directed enzyme pro-drug therapy (ADEPT). Bioconj Chem 2006;17:410.
-
(2006)
Bioconj Chem
, vol.17
, pp. 410
-
-
Alderson, R.F.1
Toki, B.E.2
Roberge, M.3
-
130
-
-
33750622122
-
Genospheres: Self-assembling nucleic acid-lipid nanoparticles suitable for targeted gene delivery
-
Hay es ME, Drummond DC, Kirpotin DB, et al. Genospheres: Self-assembling nucleic acid-lipid nanoparticles suitable for targeted gene delivery. Gene Ther 2005;1.
-
(2005)
Gene Ther
, pp. 1
-
-
Hay Es, M.E.1
Drummond, D.C.2
Kirpotin, D.B.3
-
131
-
-
26444620215
-
111In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy
-
111In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy. Clin Cancer Res 2005;11:7087s.
-
(2005)
Clin Cancer Res
, vol.11
-
-
DeNardo, S.J.1
DeNardo, G.L.2
Miers, L.A.3
-
132
-
-
27944494819
-
Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26
-
Aktas Y, Yemisci M, Andrieux K, et al. Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26. Bioconj Chem 2005;16:1503.
-
(2005)
Bioconj Chem
, vol.16
, pp. 1503
-
-
Aktas, Y.1
Yemisci, M.2
Andrieux, K.3
-
133
-
-
0141681221
-
Intracellular antibodies and challenges facing their use as therapeutic agents
-
Lobato MN, Rabbitts TH. Intracellular antibodies and challenges facing their use as therapeutic agents. Trends Mol Med 2003;9:390.
-
(2003)
Trends Mol Med
, vol.9
, pp. 390
-
-
Lobato, M.N.1
Rabbitts, T.H.2
-
134
-
-
4143110187
-
Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering
-
Ewert S, Honegger A, Pluckthun A. Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering. Methods 2004;34:184.
-
(2004)
Methods
, vol.34
, pp. 184
-
-
Ewert, S.1
Honegger, A.2
Pluckthun, A.3
-
136
-
-
33747829837
-
Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: Enhanced effects in vitro and dose-dependent growth delay in vivo
-
in press
-
Marini P, Denzinger S, Schiller D, et al. Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: Enhanced effects in vitro and dose-dependent growth delay in vivo. Oncogene 2006;in press.
-
(2006)
Oncogene
-
-
Marini, P.1
Denzinger, S.2
Schiller, D.3
-
137
-
-
29044435837
-
Multitargeted therapy in estrogen receptor-positive, human epidermal growth factor receptor-2-positive breast cancer
-
Nahleh ZA, Jazieh AR. Multitargeted therapy in estrogen receptor-positive, human epidermal growth factor receptor-2-positive breast cancer. Am J Clin Oncol 2005;28:631.
-
(2005)
Am J Clin Oncol
, vol.28
, pp. 631
-
-
Nahleh, Z.A.1
Jazieh, A.R.2
-
138
-
-
0026889151
-
Synthesis of novel 1,4,7-triazacyclononane-N,N′,N″-triacetic acid derivatives suitable for protein labeling
-
Studer M, Meares CF. Synthesis of novel 1,4,7-triazacyclononane-N, N′,N″-triacetic acid derivatives suitable for protein labeling. Bioconj Chem 1992;3:337.
-
(1992)
Bioconj Chem
, vol.3
, pp. 337
-
-
Studer, M.1
Meares, C.F.2
-
139
-
-
33748756029
-
VEGF regulates the mobilisation of VEGFR-2/KDR from an intracellular endothelial storage compartment
-
in press
-
Gampel A, Moss L, Jones MC, et al. VEGF regulates the mobilisation of VEGFR-2/KDR from an intracellular endothelial storage compartment. Blood 2006;in press.
-
(2006)
Blood
-
-
Gampel, A.1
Moss, L.2
Jones, M.C.3
|