Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 15, 2000, Pages 8548-8553

  Tsutsumi, Yasuo ^a   Onda, Masanori ^a   Nagata, Satoshi ^a   Lee, Byungkook ^a   Kreitman, Robert J ^a   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer therapy; Immunotherapy pharmacokinetics; Liver toxicity; Pseudomonas exotoxin

Indexed keywords

IMMUNOTOXIN; IMMUNOTOXIN LMB2; INTERLEUKIN 2 RECEPTOR ANTIBODY; MACROGOL; MONOCLONAL ANTIBODY; PSEUDOMONAS EXOTOXIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HALF LIFE TIME; IMMUNOGENICITY; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY;

ANIMALS; ANTIBODIES; ANTINEOPLASTIC AGENTS; CELL LINE; FEMALE; HUMANS; IMMUNOTOXINS; MICE; MICE, INBRED BALB C; MICE, NUDE; MUTAGENESIS, SITE-DIRECTED; NEOPLASMS, EXPERIMENTAL; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS;

EID: 0034682480     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.140210597     Document Type: Article

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