Noninvasive localization of tumors by immunofluorescence imaging using a single chain Fv fragment of a human monoclonal antibody with broad cancer specificity

Cancer

Volumn 89, Issue 5, 2000, Pages 1134-1144

  Ramjiawan, Bram ^a   Maiti, Pradip ^b   Aftanas, Angela ^b   Kaplan, Howard ^b   Fast, Darren ^b   Mantsch, Henry H ^a   Jackson, Michael ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b Novopharm Biotech Inc   (Canada)

Author keywords

Cy5.5.; Imaging; Monoclonal antibody; Noninvasive; Nude mouse

Indexed keywords

HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN M; NOVOMAB G2 SCFV CY5 COMPLEX; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER GRAFT; CANCER SCREENING; CONJUGATION; CONTROLLED STUDY; COST BENEFIT ANALYSIS; HIGH RISK POPULATION; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR LOCALIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTIBODY SPECIFICITY; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; IMMUNOGLOBULIN FRAGMENTS; MICE; MICE, NUDE; NEOPLASMS;

EID: 0034283815     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20000901)89:5<1134::AID-CNCR23>3.0.CO;2-3     Document Type: Article

References (30)

1. Reduced immunogenicity and improved pharmacokinetics of humanized anti-Tac in cynomolgus monkeys
2. Human immune response to multiple injections of murine monoclonal IgG
3. Monoclonal antibodies in diagnosis and therapy
4. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
5. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
6. Development and characterization of pancarcinoma specific human monoclonal antibody H11 (NovoMAb-G2)
7. Clinical issues in antibody design
8. In vivo tumor targeting of a recombinant single-chain antigen-binding protein
9. Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49
10. Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library
11. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms
12. Updated results of the trials of screening mammography
13. Diagnostic and therapeutic applications of monoclonal antibodies in colorectal cancer
14. Experimental tumor targeting with radiolabeled ligands
15. Alpha v integrins as receptors for tumor targeting by circulating ligands
16. Technetium-99m labeled epidermal growth factor-tumor imaging in mice
17. Pretargeting: General principles; October 10-12, 1996
18. Delivery of molecular medicine to solid tumors
19. Systemic administration of recombinant interferon alfa in carcinoma patients upregulates the expression of the carcinoma-associated antigens tumor-associated glycoprotein-72 and carcinoembryonic antigen
20. Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice
21. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
22. Cyanine dye labeling reagents - Carboxymethylindocyanine succinimidyl esters
23. Tumor labeling in vivo using cyanine-conjugated monoclonal antibodies
24. Specificity and characteristics of NovoMAb G2 scFv in comparison with the parent human Mab (No-voMAbG2)
25. The physiological basis of glomerular ultrafiltration
26. Comparison of complete versus fragmented technetium-99m-labeled anti-CEA monoclonal antibodies for immunoscintigraphy in colorectal cancer
27. Renal filtration, transport, and metabolism of low-molecular-weight proteins: A review
28. Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives
29. Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine
30. Rapid imaging of human melanoma xenografts using a scFv fragment of the human monoclonal antibody NovoMab-G2 labeled with indium-111 and technetium-99