-
1
-
-
0035073202
-
Therapeutic antibody production technologies: Molecules, applications, expression and purification
-
D.P. Humphreys, and D.J. Glover Therapeutic antibody production technologies: molecules, applications, expression and purification Curr Opin Drug Discov Dev 4 2001 172 185
-
(2001)
Curr Opin Drug Discov Dev
, vol.4
, pp. 172-185
-
-
Humphreys, D.P.1
Glover, D.J.2
-
2
-
-
0037344670
-
Production of antibodies and antibody fragments in Escherichia coli and a comparison of their functions, uses, modifications
-
D.P. Humphreys Production of antibodies and antibody fragments in Escherichia coli and a comparison of their functions, uses, modifications Curr Opin Drug Discov Dev 6 2003 188 196 A detailed overview of the different types of antibody fragments and their production in E. coli.
-
(2003)
Curr Opin Drug Discov Dev
, vol.6
, pp. 188-196
-
-
Humphreys, D.P.1
-
3
-
-
0036901079
-
Monoclonal antibody manufacturing in transgenic plants - Myths and realities
-
E.E. Hood, S.L. Woodard, and M.E. Horn Monoclonal antibody manufacturing in transgenic plants - myths and realities Curr Opin Biotechnol 13 2002 630 635
-
(2002)
Curr Opin Biotechnol
, vol.13
, pp. 630-635
-
-
Hood, E.E.1
Woodard, S.L.2
Horn, M.E.3
-
4
-
-
2942722679
-
Antibodies and genetically engineered related molecules: Production and purification
-
Roque ACA, C.R. Lowe, and M.A. Taipa Antibodies and genetically engineered related molecules: production and purification Biotechnol Prog 20 2004 639 654
-
(2004)
Biotechnol Prog
, vol.20
, pp. 639-654
-
-
Aca, R.1
Lowe, C.R.2
Taipa, M.A.3
-
5
-
-
1442352581
-
High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain
-
C. Chen, B. Snedecor, J.C. Nishihara, J.C. Joly, N. Mcfarland, D.C. Andersen, J.E. Battersby, and K.M. Champion High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain Biotechnol Bioeng 85 2004 463 474
-
(2004)
Biotechnol Bioeng
, vol.85
, pp. 463-474
-
-
Chen, C.1
Snedecor, B.2
Nishihara, J.C.3
Joly, J.C.4
McFarland, N.5
Andersen, D.C.6
Battersby, J.E.7
Champion, K.M.8
-
6
-
-
0036426427
-
A plasmid system for optimization of Fab′ production in Escherichia coli: Importance of balance of heavy chain and light chain synthesis
-
D.P. Humphreys, B. Carrington, L.C. Bowering, R. Ganesh, M. Sehdev, B.J. Smith, L.M. King, D.G. Reeks, A. Lawson, and A.G. Popplewell A plasmid system for optimization of Fab′ production in Escherichia coli: importance of balance of heavy chain and light chain synthesis Protein Expr Pur 26 2002 309 320
-
(2002)
Protein Expr Pur
, vol.26
, pp. 309-320
-
-
Humphreys, D.P.1
Carrington, B.2
Bowering, L.C.3
Ganesh, R.4
Sehdev, M.5
Smith, B.J.6
King, L.M.7
Reeks, D.G.8
Lawson, A.9
Popplewell, A.G.10
-
7
-
-
0038831330
-
The periplasmic Escherichia coli peptidylproyl cis, trans-isomerase FkpA
-
K. Ramm, and A. Plückthun The periplasmic Escherichia coli peptidylproyl cis, trans-isomerase FkpA J Biol Chem 275 2000 17106 17113
-
(2000)
J Biol Chem
, vol.275
, pp. 17106-17113
-
-
Ramm, K.1
Plückthun, A.2
-
8
-
-
0030041230
-
Co-expression of human protein disulphide isomerase (PDI) can increase the yield of an antibody Fab′ fragment expressed in Escherichia coli
-
D.P. Humphreys, N. Weir, A. Lawson, A. Mountain, and P.A. Lund Co-expression of human protein disulphide isomerase (PDI) can increase the yield of an antibody Fab′ fragment expressed in Escherichia coli FEBS Lett 380 1996 194 197
-
(1996)
FEBS Lett
, vol.380
, pp. 194-197
-
-
Humphreys, D.P.1
Weir, N.2
Lawson, A.3
Mountain, A.4
Lund, P.A.5
-
9
-
-
0032868653
-
Therapeutic antibody fragments with prolonged in vivo half-lives
-
A.P. Chapman, P. Antoniw, M. Spitali, S. West, S. Stephens, and D.J. King Therapeutic antibody fragments with prolonged in vivo half-lives Nat Biotechnol 17 1999 780 783
-
(1999)
Nat Biotechnol
, vol.17
, pp. 780-783
-
-
Chapman, A.P.1
Antoniw, P.2
Spitali, M.3
West, S.4
Stephens, S.5
King, D.J.6
-
10
-
-
0035824187
-
Adapting pharmacokinetic properties of a humanized anti-interleukin-8 antibody for therapeutic applications using site-specific pegylation
-
S.R. Leong, L. DeForge, L. Presta, T. Gonzalez, A. Fan, M. Reichert, A. Chuntharapai, K.J. Kim, D.B. Tumas, and W.P. Lee Adapting pharmacokinetic properties of a humanized anti-interleukin-8 antibody for therapeutic applications using site-specific pegylation Cytokine 16 2001 106 119
-
(2001)
Cytokine
, vol.16
, pp. 106-119
-
-
Leong, S.R.1
Deforge, L.2
Presta, L.3
Gonzalez, T.4
Fan, A.5
Reichert, M.6
Chuntharapai, A.7
Kim, K.J.8
Tumas, D.B.9
Lee, W.P.10
-
11
-
-
0037124466
-
PEGylated antibodies and antibody fragments for improved therapy: A review
-
A.P. Chapman PEGylated antibodies and antibody fragments for improved therapy: a review Adv Drug Deliv Rev 54 2002 531 545
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 531-545
-
-
Chapman, A.P.1
-
12
-
-
0037144397
-
Albumin binding as a general strategy for improving the pharmacokinetics of proteins
-
M.S. Dennis, M. Zhang, G. Meng, M. Kadkhodayan, D. Kirchhofer, D. Combs, and L.A. Damico Albumin binding as a general strategy for improving the pharmacokinetics of proteins J Biol Chem 277 2002 35035 35043 This report demonstrates the use of protein engineering to develop a novel peptide sequence that influences pharmacokinetics.
-
(2002)
J Biol Chem
, vol.277
, pp. 35035-35043
-
-
Dennis, M.S.1
Zhang, M.2
Meng, G.3
Kadkhodayan, M.4
Kirchhofer, D.5
Combs, D.6
Damico, L.A.7
-
13
-
-
18344372376
-
Expression of full-length immunoglobulins in Escherichia coli: Rapid and efficient production of aglycosylated antibodies
-
L.C. Simmons, D. Reilly, L. Klimowski, T.S. Raju, G. Meng, O. Sims, K. Hong, R.L. Shields, L.A. Damico, P. Rancatore, and D.G. Yansura Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies J Immunol Methods 263 2002 133 147 The first report of the production of functional full-length IgGs in E. coli.
-
(2002)
J Immunol Methods
, vol.263
, pp. 133-147
-
-
Simmons, L.C.1
Reilly, D.2
Klimowski, L.3
Raju, T.S.4
Meng, G.5
Sims, O.6
Hong, K.7
Shields, R.L.8
Damico, L.A.9
Rancatore, P.10
Yansura, D.G.11
-
14
-
-
0034879260
-
Factors affecting the production of a single-chain antibody fragment by Aspergillus awamori in a stirred tank reactor
-
A. Sotiriadis, T. Keshavarz, and E. Keshavarz-Moore Factors affecting the production of a single-chain antibody fragment by Aspergillus awamori in a stirred tank reactor Biotechnol Prog 17 2001 618 623
-
(2001)
Biotechnol Prog
, vol.17
, pp. 618-623
-
-
Sotiriadis, A.1
Keshavarz, T.2
Keshavarz-Moore, E.3
-
15
-
-
2442640723
-
Characterization of humanized antibodies secreted by Aspergillus niger
-
M. Ward, C. Lin, D.C. Victoria, B.P. Fox, J.A. Fox, D.L. Wong, H.J. Meerman, J.P. Pucci, R.B. Fong, and M.H. Heng Characterization of humanized antibodies secreted by Aspergillus niger Appl Environ Microbiol 70 2004 2567 2576 An interesting study on using A. niger for the production of antibodies and fragments.
-
(2004)
Appl Environ Microbiol
, vol.70
, pp. 2567-2576
-
-
Ward, M.1
Lin, C.2
Victoria, D.C.3
Fox, B.P.4
Fox, J.A.5
Wong, D.L.6
Meerman, H.J.7
Pucci, J.P.8
Fong, R.B.9
Heng, M.H.10
-
16
-
-
0042322600
-
Production of complex human glycoproteins in yeast
-
S.R. Hamilton, P. Bobrowicz, B. Bobrowicz, R.C. Davidson, H. Li, T. Mitchell, J.H. Nett, S. Rausch, T.A. Stadheim, and H. Wischnewski Production of complex human glycoproteins in yeast Science 301 2003 1244 1246 This approach represents a powerful technique for host cell engineering to alter glycosylation of recombinant proteins.
-
(2003)
Science
, vol.301
, pp. 1244-1246
-
-
Hamilton, S.R.1
Bobrowicz, P.2
Bobrowicz, B.3
Davidson, R.C.4
Li, H.5
Mitchell, T.6
Nett, J.H.7
Rausch, S.8
Stadheim, T.A.9
Wischnewski, H.10
-
17
-
-
0345633609
-
Very high expression of an anti-carcinoembryonic antigen single chain Fv antibody fragment in the yeast Pichia pastoris
-
F.M. Freyre, J.E. Vazquez, M. Ayala, L. Canaan-Haden, H. Bell, I. Rodriguez, A. Gonzalez, A. Cintado, and J.V. Gavilondo Very high expression of an anti-carcinoembryonic antigen single chain Fv antibody fragment in the yeast Pichia pastoris J Biotechnol 76 2000 157 163
-
(2000)
J Biotechnol
, vol.76
, pp. 157-163
-
-
Freyre, F.M.1
Vazquez, J.E.2
Ayala, M.3
Canaan-Haden, L.4
Bell, H.5
Rodriguez, I.6
Gonzalez, A.7
Cintado, A.8
Gavilondo, J.V.9
-
18
-
-
2442647904
-
Methanol induction optimization for scFv antibody fragment production in Pichia Pastoris
-
A.E. Cunha, J.J. Clemente, R. Gomes, F. Pinto, M. Thomaz, S. Miranda, R. Pinto, D. Moosmayer, P. Donner, and M.J.T. Carrondo Methanol induction optimization for scFv antibody fragment production in Pichia Pastoris Biotechnol Bioeng 86 2004 458 467
-
(2004)
Biotechnol Bioeng
, vol.86
, pp. 458-467
-
-
Cunha, A.E.1
Clemente, J.J.2
Gomes, R.3
Pinto, F.4
Thomaz, M.5
Miranda, S.6
Pinto, R.7
Moosmayer, D.8
Donner, P.9
Carrondo, M.J.T.10
-
19
-
-
0035956939
-
Galactose-extended glycans of antibodies produced by transgenic plants
-
H. Bakker, M. Bardor, J.W. Molthoff, V. Gomord, I. Elbers, L.H. Stevens, W. Jordi, A. Lommen, L. Faye, P. Lerouge, and D. Bosch Galactose-extended glycans of antibodies produced by transgenic plants Proc Natl Acad Sci USA 98 2001 2899 2904
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 2899-2904
-
-
Bakker, H.1
Bardor, M.2
Molthoff, J.W.3
Gomord, V.4
Elbers, I.5
Stevens, L.H.6
Jordi, W.7
Lommen, A.8
Faye, L.9
Lerouge, P.10
Bosch, D.11
-
20
-
-
0037027820
-
Serum-free suspension cultivation of PER.C6 cells and recombinant adenovirus production under different pH conditions
-
L. Xie, W. Pilbrough, C. Metallo, T. Zhong, L. Pikus, J. Leung, J. Aunins, and W. Zhou Serum-free suspension cultivation of PER.C6 cells and recombinant adenovirus production under different pH conditions Biotechnol Bioeng 80 2002 569 579
-
(2002)
Biotechnol Bioeng
, vol.80
, pp. 569-579
-
-
Xie, L.1
Pilbrough, W.2
Metallo, C.3
Zhong, T.4
Pikus, L.5
Leung, J.6
Aunins, J.7
Zhou, W.8
-
21
-
-
0037277684
-
High-level expression of recombinant IgG in the human cell line PER.C6
-
D. Jones, N. Kroos, R. Anema, B. van Montfort, A. Vooys, S. van der Kraats, E. van der Helm, S. Smits, J. Schouten, and K. Brouwer High-level expression of recombinant IgG in the human cell line PER.C6 Biotechnol Prog 19 2003 163 168
-
(2003)
Biotechnol Prog
, vol.19
, pp. 163-168
-
-
Jones, D.1
Kroos, N.2
Anema, R.3
Van Montfort, B.4
Vooys, A.5
Van Der Kraats, S.6
Van Der Helm, E.7
Smits, S.8
Schouten, J.9
Brouwer, K.10
-
22
-
-
0142073269
-
High-level expression of full-length antibodies using trans-complementing expression vectors
-
A.A. Bianchi, and J.T. McGrew High-level expression of full-length antibodies using trans-complementing expression vectors Biotechnol Bioeng 84 2003 439 444 An interesting approach to ensure co-amplification of heavy and light chains.
-
(2003)
Biotechnol Bioeng
, vol.84
, pp. 439-444
-
-
Bianchi, A.A.1
McGrew, J.T.2
-
23
-
-
0142118585
-
EASE vectors for rapid stable expression of recombinant antibodies
-
T.L. Aldrich, A. Viaje, and A.E. Morris EASE vectors for rapid stable expression of recombinant antibodies Biotechnol Prog 19 2003 1433 1438
-
(2003)
Biotechnol Prog
, vol.19
, pp. 1433-1438
-
-
Aldrich, T.L.1
Viaje, A.2
Morris, A.E.3
-
24
-
-
0036535753
-
Recombinant protein expression for therapeutic applications
-
D.C. Andersen, and L. Krummen Recombinant protein expression for therapeutic applications Curr Opin Biotechnol 13 2002 117 123
-
(2002)
Curr Opin Biotechnol
, vol.13
, pp. 117-123
-
-
Andersen, D.C.1
Krummen, L.2
-
25
-
-
0033038265
-
Genetic optimization of recombinant glycoprotein production by mammalian cells
-
M. Fussenegger, J.E. Bailey, H. Hauser, and P.P. Mueller Genetic optimization of recombinant glycoprotein production by mammalian cells Trends Biotechnol 17 1999 35 42
-
(1999)
Trends Biotechnol
, vol.17
, pp. 35-42
-
-
Fussenegger, M.1
Bailey, J.E.2
Hauser, H.3
Mueller, P.P.4
-
26
-
-
0037457338
-
Stability of protein production from recombinant mammalian cells
-
L.M. Barnes, C.M. Bentley, and A.J. Dickson Stability of protein production from recombinant mammalian cells Biotechnol Bioeng 81 2003 631 639
-
(2003)
Biotechnol Bioeng
, vol.81
, pp. 631-639
-
-
Barnes, L.M.1
Bentley, C.M.2
Dickson, A.J.3
-
27
-
-
0035128469
-
Key determinants in the occurrence of clonal variation in humanized antibody expression of CHO cells during dihydrofolate reductase mediated gene amplification
-
N.S. Kim, T.H. Byun, and G.M. Lee Key determinants in the occurrence of clonal variation in humanized antibody expression of CHO cells during dihydrofolate reductase mediated gene amplification Biotechnol Prog 17 2001 69 75
-
(2001)
Biotechnol Prog
, vol.17
, pp. 69-75
-
-
Kim, N.S.1
Byun, T.H.2
Lee, G.M.3
-
28
-
-
0038208103
-
A simple method for enriching populations of transfected CHO cells for cells of higher specific productivity
-
S.C. Brezinsky, G.G. Chiang, A. Szilvasi, S. Mohan, R.I. Shapiro, A. Maclean, W. Sisk, and G. Thill A simple method for enriching populations of transfected CHO cells for cells of higher specific productivity J Immunol Methods 277 2003 141 155
-
(2003)
J Immunol Methods
, vol.277
, pp. 141-155
-
-
Brezinsky, S.C.1
Chiang, G.G.2
Szilvasi, A.3
Mohan, S.4
Shapiro, R.I.5
MacLean, A.6
Sisk, W.7
Thill, G.8
-
29
-
-
0037146826
-
High-throughput clonal selection of recombinant CHO cells using a dominant selectable and amplifiable metallothionein-GFP fusion protein
-
C.G. Bailey, A.S. Tait, and N.-A. Sunstrom High-throughput clonal selection of recombinant CHO cells using a dominant selectable and amplifiable metallothionein-GFP fusion protein Biotechnol Bioeng 80 2002 670 676
-
(2002)
Biotechnol Bioeng
, vol.80
, pp. 670-676
-
-
Bailey, C.G.1
Tait, A.S.2
Sunstrom, N.-A.3
-
30
-
-
0034446598
-
Efficient selection of high-producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting
-
Borth N, Zeyda M, Katinger H: Efficient selection of high-producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting. Biotechnol Bioeng 2000-2001, 71:266-273.
-
(2000)
Biotechnol Bioeng
, vol.71
, pp. 266-273
-
-
Borth, N.1
Zeyda, M.2
Katinger, H.3
-
31
-
-
0037144084
-
P27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media
-
H. Meents, B. Enenkel, R.G. Werner, and M. Fussenegger p27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media Biotechnol Bioeng 79 2002 619 627
-
(2002)
Biotechnol Bioeng
, vol.79
, pp. 619-627
-
-
Meents, H.1
Enenkel, B.2
Werner, R.G.3
Fussenegger, M.4
-
33
-
-
1542410260
-
Uncoupling of cell growth and proliferation results in enhancement of productivity in p21cip1-arrested CHO cells
-
J.-X. Bi, J. Shuttleworth, and M. Al-Rubeai Uncoupling of cell growth and proliferation results in enhancement of productivity in p21cip1-arrested CHO cells Biotechnol Bioeng 85 2004 741 749
-
(2004)
Biotechnol Bioeng
, vol.85
, pp. 741-749
-
-
Bi, J.-X.1
Shuttleworth, J.2
Al-Rubeai, M.3
-
34
-
-
0035829827
-
Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control
-
C. Altamirano, J.J. Cairo, and F. Godia Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control Biotechnol Bioeng 76 2001 351 360
-
(2001)
Biotechnol Bioeng
, vol.76
, pp. 351-360
-
-
Altamirano, C.1
Cairo, J.J.2
Godia, F.3
-
35
-
-
0037279250
-
Cell growth arrest by nucleotides, nucleosides and bases as a tool for improved production or recombinant proteins
-
A.V. Carvahal, S. Sa Santos, J. Calado, M. Haury, and M.J.T. Carrondo Cell growth arrest by nucleotides, nucleosides and bases as a tool for improved production or recombinant proteins Biotechnol Prog 19 2003 69 83
-
(2003)
Biotechnol Prog
, vol.19
, pp. 69-83
-
-
Carvahal, A.V.1
Sa Santos, S.2
Calado, J.3
Haury, M.4
Carrondo, M.J.T.5
-
36
-
-
0037025151
-
A GFP-based screen for growth-arrested recombinant protein-producing cells
-
I.H.Y. Yuk, S. Wildt, M. Jolicoeur, D.I.C. Wang, and G. Stephanopoulos A GFP-based screen for growth-arrested recombinant protein-producing cells Biotechnol Bioeng 79 2002 74 82
-
(2002)
Biotechnol Bioeng
, vol.79
, pp. 74-82
-
-
Yuk, I.H.Y.1
Wildt, S.2
Jolicoeur, M.3
Wang, D.I.C.4
Stephanopoulos, G.5
-
37
-
-
0034607154
-
Part 2. Over-expression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults
-
A.J. Mastrangelo, J.M. Hardwick, S. Zou, and M.J. Betenbaugh Part 2. Over-expression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults Biotechnol Bioeng 67 2000 555 564
-
(2000)
Biotechnol Bioeng
, vol.67
, pp. 555-564
-
-
Mastrangelo, A.J.1
Hardwick, J.M.2
Zou, S.3
Betenbaugh, M.J.4
-
39
-
-
0037419710
-
Study of caspase inhibitors for limiting cell death in mammalian cell culture
-
T.M. Sauerwald, G.A. Oyler, and M.J. Betenbaugh Study of caspase inhibitors for limiting cell death in mammalian cell culture Biotechnol Bioeng 81 2003 329 340
-
(2003)
Biotechnol Bioeng
, vol.81
, pp. 329-340
-
-
Sauerwald, T.M.1
Oyler, G.A.2
Betenbaugh, M.J.3
-
40
-
-
0037140412
-
Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3
-
N.S. Kim, and G.M. Lee Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3 Biotechnol Bioeng 78 2002 217 228
-
(2002)
Biotechnol Bioeng
, vol.78
, pp. 217-228
-
-
Kim, N.S.1
Lee, G.M.2
-
41
-
-
0347297482
-
Transfection of NS0 myeloma fusion partner cells with hsp70 gene results in higher hybridoma yield by improving cellular resistance to apoptosis
-
E.B. Lasunskaia, I.I. Fridlianskaia, Z.A. Darieva, da Silva MSR, M.M. Kanashiro, and B.A. Margulis Transfection of NS0 myeloma fusion partner cells with hsp70 gene results in higher hybridoma yield by improving cellular resistance to apoptosis Biotechnol Bioeng 81 2003 496 504
-
(2003)
Biotechnol Bioeng
, vol.81
, pp. 496-504
-
-
Lasunskaia, E.B.1
Fridlianskaia, I.I.2
Darieva, Z.A.3
Da Silva, M.S.R.4
Kanashiro, M.M.5
Margulis, B.A.6
-
42
-
-
0038247891
-
Development of apoptosis-resistance dihydrofolate reductase-deficient Chinese hamster ovary cell line
-
S.K. Lee, and G.M. Lee Development of apoptosis-resistance dihydrofolate reductase-deficient Chinese hamster ovary cell line Biotechnol Bioeng 82 2003 872 876
-
(2003)
Biotechnol Bioeng
, vol.82
, pp. 872-876
-
-
Lee, S.K.1
Lee, G.M.2
-
43
-
-
0037146823
-
L on productivity, cell survival, and mitochondrial number in CHO-DG44 grown in suspension and serum-free media
-
L on productivity, cell survival, and mitochondrial number in CHO-DG44 grown in suspension and serum-free media Biotechnol Bioeng 80 2002 706 716
-
(2002)
Biotechnol Bioeng
, vol.80
, pp. 706-716
-
-
Meents, H.1
Enenkel, B.2
Eppenberger, H.M.3
Werner, R.G.4
Fussenegger, M.5
-
45
-
-
0037274318
-
Modulation of cell cycle for enhancement of antibody productivity in perfusion culture of NS0 cells
-
N. Ibarra, S. Watanabe, J-X. Bi, J. Shuttleworth, and M. Al-Rubeai Modulation of cell cycle for enhancement of antibody productivity in perfusion culture of NS0 cells Biotechnol Prog 19 2003 224 228 Combines growth control and anti-apoptosis engineering to enhance antibody productivity.
-
(2003)
Biotechnol Prog
, vol.19
, pp. 224-228
-
-
Ibarra, N.1
Watanabe, S.2
Bi, J.-X.3
Shuttleworth, J.4
Al-Rubeai, M.5
-
46
-
-
1842335676
-
Effect of serum-free and serum-containing medium on cellular levels of ER-based proteins in various mouse hybridoma cell lines
-
N. Lambert, and O.-W. Merten Effect of serum-free and serum-containing medium on cellular levels of ER-based proteins in various mouse hybridoma cell lines Biotechnol Bioeng 54 1997 165 180
-
(1997)
Biotechnol Bioeng
, vol.54
, pp. 165-180
-
-
Lambert, N.1
Merten, O.-W.2
-
47
-
-
1442352043
-
Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells
-
J.Y. Chung, S.W. Lim, Y.J. Hong, S.O. Hwang, and G.M. Lee Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells Biotechnol Bioeng 89 2004 539 546
-
(2004)
Biotechnol Bioeng
, vol.89
, pp. 539-546
-
-
Chung, J.Y.1
Lim, S.W.2
Hong, Y.J.3
Hwang, S.O.4
Lee, G.M.5
-
48
-
-
0031033895
-
Effect of glycosylation on antibody function: Implications for genetic engineering
-
A. Wright, and S.L. Morrison Effect of glycosylation on antibody function: implications for genetic engineering Trends Biotechnol 15 1997 26 32
-
(1997)
Trends Biotechnol
, vol.15
, pp. 26-32
-
-
Wright, A.1
Morrison, S.L.2
-
49
-
-
0034802701
-
Glycosylation of human IgG antibodies: Relevance to therapeutic applications
-
R. Jefferis Glycosylation of human IgG antibodies: relevance to therapeutic applications Biopharm 9 2001 19 27
-
(2001)
Biopharm
, vol.9
, pp. 19-27
-
-
Jefferis, R.1
-
50
-
-
0037178791
-
Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fc-γ RIII and antibody-dependent cellular toxicity
-
R.L. Shields, J. Lai, R. Keck, L.Y. O'Connell, K. Hong, Y.G. Meng, S.H. Weikert, and L.G. Presta Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fc-γ RIII and antibody-dependent cellular toxicity J Biol Chem 277 2002 26733 26740 Significant improvements in ADCC result from alteration of the oligosaccharides on Fc.
-
(2002)
J Biol Chem
, vol.277
, pp. 26733-26740
-
-
Shields, R.L.1
Lai, J.2
Keck, R.3
O'Connell, L.Y.4
Hong, K.5
Meng, Y.G.6
Weikert, S.H.7
Presta, L.G.8
-
51
-
-
0037474276
-
The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxity
-
T. Shinkawa, K. Nakamura, N. Yamane, E. Shoji-Hosaka, Y. Kanda, M. Sakurada, K. Uchida, H. Anazawa, M. Satoh, and M. Yamasaki The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxity J Biol Chem 278 2003 3466 3473
-
(2003)
J Biol Chem
, vol.278
, pp. 3466-3473
-
-
Shinkawa, T.1
Nakamura, K.2
Yamane, N.3
Shoji-Hosaka, E.4
Kanda, Y.5
Sakurada, M.6
Uchida, K.7
Anazawa, H.8
Satoh, M.9
Yamasaki, M.10
-
52
-
-
0036670565
-
Engineering therapeutic antibodies for improved function
-
L.G. Presta, R.L. Shields, A.K. Namenuk, K. Hong, and Y.G. Meng Engineering therapeutic antibodies for improved function Biochem Soc Trans 30 2002 487 490
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 487-490
-
-
Presta, L.G.1
Shields, R.L.2
Namenuk, A.K.3
Hong, K.4
Meng, Y.G.5
-
53
-
-
10744222698
-
Engineered human IgG antibodies with longer serum half-lives in primates
-
P.R. Hinton, M.G. Johlfs, J.M. Xiong, K. Hanestad, K.C. Ong, C. Bullock, S. Keller, M.T. Tang, J.Y. Tso, M. Vasquez, and N. Tsurushita Engineered human IgG antibodies with longer serum half-lives in primates J Biol Chem 279 2004 6213 6216
-
(2004)
J Biol Chem
, vol.279
, pp. 6213-6216
-
-
Hinton, P.R.1
Johlfs, M.G.2
Xiong, J.M.3
Hanestad, K.4
Ong, K.C.5
Bullock, C.6
Keller, S.7
Tang, M.T.8
Tso, J.Y.9
Vasquez, M.10
Tsurushita, N.11
-
54
-
-
0037143810
-
The response of GS-NS0 myeloma cells to single and multiple pH perturbations
-
J.J. Osman, J. Birch, and J. Varley The response of GS-NS0 myeloma cells to single and multiple pH perturbations Biotechnol Bioeng 79 2003 398 407
-
(2003)
Biotechnol Bioeng
, vol.79
, pp. 398-407
-
-
Osman, J.J.1
Birch, J.2
Varley, J.3
-
55
-
-
0037083193
-
2 and osmolality: Intracellular pH, cell size, apoptosis, and metabolism
-
2 and osmolality: intracellular pH, cell size, apoptosis, and metabolism Biotechnol Bioeng 77 2002 369 380
-
(2002)
Biotechnol Bioeng
, vol.77
, pp. 369-380
-
-
Dezengotita, V.M.1
Schmelzer, A.E.2
Miller, W.M.3
-
56
-
-
0036010290
-
2 alter monoclonal antibody charge distribution and monosaccharide content
-
2 alter monoclonal antibody charge distribution and monosaccharide content Biotechnol Prog 18 2002 346 353
-
(2002)
Biotechnol Prog
, vol.18
, pp. 346-353
-
-
Schmelzer, A.E.1
Miller, W.M.2
-
57
-
-
0037199148
-
Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality
-
V.M. DeZengotita, L.R. Abston, A.E. Schmelzer, S. Shaw, and W.M. Miller Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality Biotechnol Bioeng 78 2002 741 752
-
(2002)
Biotechnol Bioeng
, vol.78
, pp. 741-752
-
-
Dezengotita, V.M.1
Abston, L.R.2
Schmelzer, A.E.3
Shaw, S.4
Miller, W.M.5
-
58
-
-
1842814059
-
Hyperosmotic stress in murine hybridoma cells: Effects on antibody transcription, translation, posttranslational processing and the cell cycle
-
Z. Sun, R. Zhou, S. Liang, K.M. McNeeley, and S.T. Sharfstein Hyperosmotic stress in murine hybridoma cells: effects on antibody transcription, translation, posttranslational processing and the cell cycle Biotechnol Prog 20 2004 576 589
-
(2004)
Biotechnol Prog
, vol.20
, pp. 576-589
-
-
Sun, Z.1
Zhou, R.2
Liang, S.3
McNeeley, K.M.4
Sharfstein, S.T.5
-
59
-
-
17944387597
-
Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24
-
J. Muthing, S.E. Kemminer, H.S. Conradt, D. Sagi, M. Nimtz, U. Karst, and J. Peter-Katalinic Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24 Biotechnol Bioeng 83 2003 321 334
-
(2003)
Biotechnol Bioeng
, vol.83
, pp. 321-334
-
-
Muthing, J.1
Kemminer, S.E.2
Conradt, H.S.3
Sagi, D.4
Nimtz, M.5
Karst, U.6
Peter-Katalinic, J.7
-
60
-
-
0035543336
-
Effects of cloned gene dosage on the response of recombinant CHO cells to hyperosmotic pressure in regard to cell growth and antibody production
-
J.S. Ryu, M.S. Lee, and G.M. Lee Effects of cloned gene dosage on the response of recombinant CHO cells to hyperosmotic pressure in regard to cell growth and antibody production Biotechnol Prog 17 2001 993 999
-
(2001)
Biotechnol Prog
, vol.17
, pp. 993-999
-
-
Ryu, J.S.1
Lee, M.S.2
Lee, G.M.3
-
61
-
-
0348044478
-
Proteome analysis of antibody-expressing CHO cells in response to hyperosmotic pressure
-
M.S. Lee, K.W. Kim, Y.H. Kim, and G.M. Lee Proteome analysis of antibody-expressing CHO cells in response to hyperosmotic pressure Biotechnol Prog 19 2003 1734 1741
-
(2003)
Biotechnol Prog
, vol.19
, pp. 1734-1741
-
-
Lee, M.S.1
Kim, K.W.2
Kim, Y.H.3
Lee, G.M.4
-
62
-
-
0041476091
-
Effect of low temperature on specific productivity and transcription level of anti-4-BB antibody in recombinant Chinese hamster ovary cells
-
S.K. Yoon, S.H. Kim, and G.M. Lee Effect of low temperature on specific productivity and transcription level of anti-4-BB antibody in recombinant Chinese hamster ovary cells Biotechnol Prog 19 2003 1383 1386
-
(2003)
Biotechnol Prog
, vol.19
, pp. 1383-1386
-
-
Yoon, S.K.1
Kim, S.H.2
Lee, G.M.3
-
63
-
-
0037420754
-
Effect of low temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells
-
S.K. Yoon, J.Y. Song, and G.M. Lee Effect of low temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells Biotechnol Bioeng 82 2003 289 298
-
(2003)
Biotechnol Bioeng
, vol.82
, pp. 289-298
-
-
Yoon, S.K.1
Song, J.Y.2
Lee, G.M.3
-
64
-
-
0142104901
-
Higher expression of Fab antibody fragments in a CHO cell line at reduced temperature
-
S.M. Schatz, R.J. Kerschbaumer, G. Gerstenbauer, M. Kral, F. Dorner, and F. Scheiflinger Higher expression of Fab antibody fragments in a CHO cell line at reduced temperature Biotechnol Bioeng 84 2003 433 438
-
(2003)
Biotechnol Bioeng
, vol.84
, pp. 433-438
-
-
Schatz, S.M.1
Kerschbaumer, R.J.2
Gerstenbauer, G.3
Kral, M.4
Dorner, F.5
Scheiflinger, F.6
-
65
-
-
0942265268
-
Maximizing interferon-γ production by Chinese hamster ovary cells through temperature shift optimization: Experimental and modeling
-
S.R. Fox, U.A. Patel, M.G.S. Yap, and D.I.C. Wang Maximizing interferon-γ production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling Biotechnol Bioeng 85 2004 177 184
-
(2004)
Biotechnol Bioeng
, vol.85
, pp. 177-184
-
-
Fox, S.R.1
Patel, U.A.2
Yap, M.G.S.3
Wang, D.I.C.4
-
66
-
-
0037277639
-
Enhancement of monoclonal antibody production by lysine-containing peptides
-
F. Franek, T. Eckschlager, and H. Katinger Enhancement of monoclonal antibody production by lysine-containing peptides Biotechnol Prog 19 2003 169 174
-
(2003)
Biotechnol Prog
, vol.19
, pp. 169-174
-
-
Franek, F.1
Eckschlager, T.2
Katinger, H.3
-
67
-
-
0037026238
-
Antibody production by a hybridoma cell line at high cell density is limited by two independent mechanisms
-
M.J. Gramer, and T.L. Britton Antibody production by a hybridoma cell line at high cell density is limited by two independent mechanisms Biotechnol Bioeng 79 2002 277 283
-
(2002)
Biotechnol Bioeng
, vol.79
, pp. 277-283
-
-
Gramer, M.J.1
Britton, T.L.2
|