Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 18, 2006, Pages 6841-6846

  Rossi, Edmund A ^a   Goldenberg, David M ^a,b,c   Cardillo, Thomas M ^b   McBride, William J ^b   Sharkey, Robert M ^c   Chang, Chien Hsing ^a  

^a IBC Pharmaceuticals Inc   (United States)

^b IMMUNOMEDICS INC   (United States)

^c CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY   (United States)

Author keywords

A kinase protein engineering; Bispecific antibody; Fusion proteins; Site specific conjugation

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HYBRID PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; TRACER;

ANALYTIC METHOD; ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; BINDING AFFINITY; CHEMICAL COMPOSITION; COMPLEX FORMATION; DOCK AND LOCK METHOD; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; VALIDATION PROCESS;

AMINO ACID SEQUENCE; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIAGNOSTIC IMAGING; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; NEOPLASM TRANSPLANTATION; NEOPLASMS; PROTEIN BINDING; PROTEIN SUBUNITS; REPRODUCIBILITY OF RESULTS; TRANSPLANTATION, HETEROLOGOUS;

RUMEX;

EID: 33646477258     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0600982103     Document Type: Article

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