Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification

Biotechnology Progress

Volumn 21, Issue 1, 2005, Pages 205-220

  Nellis, David F ^a   Ekstrom, Denise L ^a   Kirpotin, Dmitri B ^b,d   Zhu, Jianwei ^a   Andersson, Robert ^a   Broadt, Trevor L ^a   Ouellette, Timothy F ^a   Perkins, Shelley C ^a   Roach, John M ^a   Drummond, Daryl C ^b,d   Hong, Keelung ^b,d   Marks, James D ^c   Park, John W ^c   Giardina, Steven L ^a  

^a SAIC FREDERICK INC   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Hermes Biosciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADSORPTION; CELL CULTURE; CHROMATOGRAPHY; DNA; DRUG DOSAGE; ELECTROPHORESIS; ESCHERICHIA COLI; POLYPEPTIDES; QUENCHING; TUMORS;

IMMUNOLIPOSOMES-ENCAPSULATED THERAPEUTICS; LIPOSOMES; RESIDUAL ENDOTOXINS; TRISODIUM CITRATES;

LIPIDS;

EPIDERMAL GROWTH FACTOR RECEPTOR 2; IMMUNOGLOBULIN FRAGMENT; LIPOSOME; PHOSPHATE;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CHEMISTRY; CONFORMATION; CYTOLOGY; DRUG ANTAGONISM; ESCHERICHIA COLI; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MICELLE; MOLECULAR GENETICS; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; TIME;

AMINO ACID SEQUENCE; CELL DIVISION; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; IMMUNOGLOBULIN FRAGMENTS; LIPOSOMES; MICELLES; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PHOSPHATES; RECEPTOR, ERBB-2; TIME FACTORS;

ESCHERICHIA COLI;

EID: 13544268486     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp049840y     Document Type: Article

References (24)

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