DNA polymerases and diseases

Genome Dynamics and Stability

Volumn 1, Issue , 2007, Pages 69-102

  Ramadan, Kristijan ^a,c   Maga, Giovanni ^b   Hübscher, Ulrich ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b CNR   (Italy)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33750108921     PISSN: 18613373     EISSN: 18613381     Source Type: Book Series    
DOI: 10.1007/7050_005     Document Type: Review

References (169)

1. Aboussekhra A et al. (1995) Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell 80:859-868
2. Adams Martin A, Dionne I,Wellinger RJ, Holm C (2000) The function of DNA polymerase alpha at telomericGtails is important for telomere homeostasis.MolCell Biol 20:786-796
3. Albertella MR, Lau A, O'Connor MJ (2005) The overexpression of specialized DNA polymerases in cancer. DNA Repair (Amst) 4:583-593
4. Aoufouchi S et al. (2000) Two novel human and mouse DNA polymerases of the polX family. Nucleic Acids Res 28:3684-3693
5. Bavoux C et al. (2005) Up-regulation of the error-prone DNA polymerase {κ} promotes pleiotropic genetic alterations and tumorigenesis. Cancer Res 65:325-330
6. Bebenek K, Matsuda T, Masutani C, Hanaoka F, Kunkel TA (2001) Proofreading of DNA polymerase eta-dependent replication errors. J Biol Chem 276:2317-2320
7. Bergoglio V, Ferrari E, Hubscher U, Cazaux C, Hoffmann JS (2003) DNA Polymerase beta can Incorporate Ribonucleotides during DNA Synthesis of Undamaged, CPD-damaged DNA. Mol J Biol 331:1017-1023
8. Bergoglio V et al. (2004) Evidence of finely tuned expression of DNA polymerase beta in vivo using transgenic mice. FEBS Lett 566:147-150
9. Bertocci B, De Smet A, Berek C, Weill JC, Reynaud CA (2003) Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu. Immunity 19:203-211
10. Bertocci B et al. (2002) Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation. J Immunol 168:3702-3706
11. Blanca G et al. (2003) Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: A kinetic and thermodynamic study. Biochemistry 42:7467-7476
12. Boesen JJ et al. (1992) Stress response induced by DNA damage leads to specific, delayed and untargeted mutations. Mol Gen Genet 234:217-227
13. Bollum FJ, Chang LM, Tsiapalis CM, Dorson JW (1974) Nucleotide polymerizing enzymes from calf thymus gland. Methods Enzymol 29:70-81
14. Boule JB, Rougeon F, Papanicolaou C (2001) Terminal deoxynucleotidyl transferase indiscriminately incorporates ribonucleotides and deoxyribonucleotides. J Biol Chem 276:31388-31393
15. Boyd JB, Sakaguchi K, Harris PV (1990) mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease. Genetics 125:813-819
16. Brautigam CA, Steitz TA (1998) Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Curr Opin Struct Biol 8:54-63
17. Burgers PM (1998) Eukaryotic DNA polymerases in DNA replication, DNA repair. Chromosoma 107:218-227
18. Burgers PM et al. (2001) Eukaryotic DNA polymerases: Proposal for a revised nomenclature. J Biol Chem 276:43487-43490
19. Byrnes JJ, Downey KM, Black VL, So AG (1976) A new mammalian DNA polymerase with 3′ to 5′ exonuclease activity: DNA polymerase delta. Biochemistry 15:2817-2823
20. Carrodeguas JA, Theis K, Bogenhagen DF, Kisker C (2001) Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer. Mol Cell 7:43-54
21. Carson DR, Christman MF (2001) Evidence that replication fork components catalyze establishment of cohesion between sister chromatids. Proc Natl Acad Sci USA 98:8270-8275
22. Castano IB, Brzoska PM, Sadoff BU, Chen H, Christman MF (1996) Mitotic chromosome condensation in the rDNA requires TRF4, DNA topoisomerase I in Saccharomyces cerevisiae. Genes Dev 10:2564-2576
23. Castano IB, Heath-Pagliuso S, Sadoff BU, Fitzhugh DJ, Christman MF (1996) A novel family of TRF (DNA topoisomerase I-related function) genes required for proper nuclear segregation. Nucleic Acids Res 24:2404-2410
24. Chang S, DePinho RA (2002) Telomerase extracurricular activities. Proc Natl Acad Sci USA 99:12520-12522. Epub 12002 Sep 12523
25. Chang S et al. (2004) Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36:877-882. Epub 2004 Jul 2004
26. Chiu A et al. (2002) DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: An analysis utilizing in situ hybridization. Am J Pathol 161:1349-1355
27. Christmann M, Tomicic MT, Roos WP, Kaina B (2003) Mechanisms of human DNA repair: An update. Toxicology 193:3-34
28. Clark DR, Zacharias W, Panaitescu L, McGregor WG (2003) Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene. Nucleic Acids Res 31:4981-4988
29. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC (1992) Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age. Nat Genet 2:324-329
30. Cottrell DA, Blakely EL, Johnson MA, Ince PG, Borthwick GM, Turnbull DM (2001) Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age. Neurobiol Aging 22:265-272
31. Covo S, Blanco L, Livneh Z (2004) Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity. J Biol Chem 279:859-865
32. D'Urso G, Nurse P (1997) Schizosaccharomyces pombe cdc20+ encodes DNA polymerase epsilon and is required for chromosomal replication but not for the S phase checkpoint. Proc Natl Acad Sci USA 94:12491-12496
33. Dianov GL, Prasad R, Wilson SH, Bohr VA (1999) Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. J Biol Chem 274:13741-13743
34. Dominguez O et al. (2000) DNA polymerase mu (Pol mu), homologous to Td T, could act as a DNA mutator in eukaryotic cells. Embo J 19:1731-1742
35. Dunham MA, Neumann AA, Fasching CL, Reddel RR (2000) Telomere maintenance by recombination in human cells. Nat Genet 26:447-450
36. Duvauchelle JB, Blanco L, Fuchs RP, Cordonnier AM (2002) Human DNA polymerase mu (Pol mu) exhibits an unusual replication slippage ability at AAF lesion. Nucleic Acids Res 30:2061-2067
37. Edwards S, Li CM, Levy DL, Brown J, Snow PM, Campbell JL (2003) Saccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion. Mol Cell Biol 23:2733-2748
38. Efrati E, Tocco G, Eritja R, Wilson SH, Goodman MF (1997) Abasic translesion synthesis by DNA polymerase beta violates the A-rule. Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts. J Biol Chem 272:2559-2569
39. Esposito G, Godindagger I, Klein U, Yaspo ML, Cumano A, Rajewsky K (2000) Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality. Curr Biol 10:1221-1224
40. Ferrari G et al. (2005) Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gamma. Brain A 128:723-731
41. Foiani M, Lucchini G, Plevani P (1997) The DNA polymerase alpha-primase complex couples DNA replication, cell-cycle progression, DNA-damage response. Trends Biochem Sci 22:424-427
42. Francesconi S, Park H, Wang TS (1993) Fission yeast with DNA polymerase delta temperature-sensitive alleles exhibits cell division cycle phenotype. Nucleic Acids Res 21:3821-3828
43. Franklin A, Milburn PJ, Blanden RV, Steele EJ (2004) Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase. Immunol Cell Biol 82:219-225
44. Frechet M, Canitrot Y, Bieth A, Dogliotti E, Cazaux C, Hoffmann JS (2002) Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities. Oncogene 21:2320-2327
45. Frechet M, Canitrot Y, Cazaux C, Hoffmann JS (2001) DNA polymerase beta imbalance increases apoptosis and mutagenesis induced by oxidative stress. FEBS Lett 505:229- 232
46. Friedberg EC, Wagner R, Radman M (2002) Specialized DNA polymerases, cellular survival, and the genesis of mutations. Science 296:1627-1630
47. Garcia-Diaz M, Bebenek K, Kunkel TA, Blanco L (2001) Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: A possible role in base excision repair. J Biol Chem 276:34659-34663
48. Garcia-Diaz M et al. (2002) DNA polymerase lambda, a novel DNA repair enzyme in human cells. J Biol Chem 277:13184-13191
49. Garcia-Diaz M et al. (2000) DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis. J Mol Biol 301:851-867
50. Giot L, Chanet R, Simon M, Facca C, Faye G (1997) Involvement of the yeast DNA polymerase delta in DNA repair in vivo. Genetics 146:1239-1251
51. Goldsby RE et al. (2002) High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading. Proc Natl Acad Sci USA 99:15560-15565
52. Goldsby RE et al. (2001) Defective DNA polymerase-delta proofreading causes cancer susceptibility in mice. Nat Med 7:638-639
53. Goodman MF (2002) Error-prone repair DNA polymerases in prokaryotes and eukaryotes. Annu Rev Biochem 71:17-50
54. Graves SW, Johnson AA, Johnson KA (1998) Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase. Biochemistry 37:6050-6058
55. Graziewicz MA, Longley MJ, Bienstock RJ, Zeviani M, Copeland WC (2004) Structurefunction defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia. Nat Struct Mol Biol 11:770-776
56. Grey M, Dusterhoft A, Henriques JA, Brendel M (1996) Allelism of PSO4, PRP19 links premRNA processing with recombination and error-prone DNA repair in Saccharomyces cerevisiae. Nucleic Acids Res 24:4009-4014
57. Gu H,Marth JD, Orban PC,Mossmann H, Rajewsky K (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265:103-106
58. Guo C et al. (2003) Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. Embo J 22:6621-6630
59. Guo D, Wu X, Rajpal DK, Taylor JS, Wang Z (2001) Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene. Nucleic Acids Res 29:2875-2883
60. Haendeler J, Hoffmann J, Rahman S, Zeiher AM, Dimmeler S (2003) Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett 536:180-186
61. Haracska L et al. (2001a) Targeting of human DNA polymerase iota to the replication machinery via interaction with PCN. Proc Natl Acad Sci USA 98:14256-14261
62. Haracska L, Prakash S, Prakash L (2002) Yeast Rev1 protein is a G template-specific DNA polymerase. J Biol Chem 277:15546-15551
63. Haracska L et al. (2001b) Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Genes Dev 15:945-954
64. Harfe BD, Jinks-Robertson S (2000) DNA mismatch repair and genetic instability. Annu Rev Genet 34:359-399
65. Harris PV, Mazina OM, Leonhardt EA, Case RB, Boyd JB, Burtis KC (1996) Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes. Mol Cell Biol 16:5764-5771
66. Hoffmann JS, Pillaire MJ, Maga G, Podust V, Hubscher U, Villani G (1995) DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene. Proc Natl Acad Sci USA 92:5356-5360
67. Holm L, Sander C (1995) DNA polymerase beta belongs to an ancient nucleotidyltransferase superfamily. Trends Biochem Sci 20:345-347
68. Holmes AM, Haber JE (1999) Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases. Cell 96:415-424
69. Hubscher U, Maga G, Spadari S (2002) Eukaryotic DNA polymerases. Annu Rev Biochem 71:133-163
70. Hubscher U, Nasheuer HP, Syvaoja JE (2000) Eukaryotic DNA polymerases, a growing family. Trends Biochem Sci 25:143-147
71. Idriss HT, Al-Assar O, Wilson SH (2002) DNA polymerase beta. Int J Biochem Cell Biol 34:321-324
72. Jansen JG et al. (2005) The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis. Nucleic Acids Res 33:356-365. Print 2005
73. Jin YH et al. (2005) The multiple biological roles of the 3′-5′ exonuclease of Saccharomyces Cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. Mol Cell Biol 25:461-471
74. Johnson RE, Kondratick CM, Prakash S, Prakash L (1999) hRAD30 mutations in the variant form of xeroderma pigmentosum. Science 285:263-265
75. Johnson RE, Washington MT, Haracska L, Prakash S, Prakash L (2000) Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Nature 406:1015-1019
76. Joyce CM, Steitz TA (1994) Function and structure relationships in DNA polymerases. Annu Rev Biochem 63:777-822
77. Kaguni LS (2004) DNA polymerase gamma, the mitochondrial replicase. Annu Rev Biochem 73:293-320
78. Kannouche P et al. (2003) Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. Embo J 22:1223-1233
79. Kelman Z, O'Donnell M (1994) DNA replication: Enzymology and mechanisms. Curr Opin Genet Dev 4:185-195
80. Kesti T, Flick K, Keranen S, Syvaoja JE, Wittenberg C (1999) DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability. Mol Cell 3:679-685
81. Kobayashi Y et al. (2002) Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome. Mol Cell Biol 22:2769-2776
82. Kodama EN, McCaffrey RP, Yusa K, Mitsuya H (2000) Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem Pharmacol 59:273-281
83. Kokoska RJ, Stefanovic L, DeMai J, Petes TD (2000) Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta. Mol Cell Biol 20:7490-7504
84. Krayevsky AA, Victorova LS, Arzumanov AA, Jasko MV (2000) Terminal deoxynucleotidyl transferase. catalysis of DNA (oligodeoxynucleotide) phosphorylation. Pharmacol Ther 85:165-173
85. Kunkel TA, Pavlov YI, Bebenek K, Rogozin IB, Matsuda T (2003) Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. DNA Repair (Amst) 2:135-149
86. Lawrence CW (2002) Cellular roles of DNA polymerase zeta, Rev1 protein. DNA Repair (Amst) 1:425-435
87. Lawrence CW, Christensen R (1976) UV mutagenesis in radiation-sensitive strains of yeast. Genetics 82:207-232
88. Lawrence CW, Hinkle DC (1996) DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes. Cancer Surv 28:21-31
89. Lee GH, Nishimori H, Sasaki Y, Matsushita H, Kitagawa T, Tokino T (2003) Analysis of lung tumorigenesis in chimeric mice indicates the pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: Detection of polymorphisms in the Poli gene as a candidate for Par2. Oncogene 22:2374-2382
90. Lee JW et al. (2004) Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. J Biol Chem 279:805-811
91. Li L, Zou L (2005) Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells. J Cell Biochem 94:298-306
92. Lin W, Xin H, Zhang Y, Wu X, Yuan F, Wang Z (1999) The human REV1 gene codes for a DNA template-dependent dCMP transferase. Nucleic Acids Res 27:4468-4475
93. Loeb KR, Loeb LA (2000) Significance of multiple mutations in cancer. Carcinogenesis 21:379-385
94. Longley MJ, Pierce AJ, Modrich P (1997) DNA polymerase delta is required for human mismatch repair in vitro. J Biol Chem 272:10917-10921
95. Louat T et al. (2001) Antitumor activity of 2′,3′-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta. Mol Pharmacol 60:553-558
96. Luoma P et al. (2004) Parkinsonism, prematuremenopause, and mitochondrial DNA polymerase gammamutations: Clinical andmolecular genetic study. Lancet 364:875-882
97. Maga G, Shevelev I, Ramadan K, Spadari S, Hubscher U (2002) DNA polymerase theta purified from human cells is a high-fidelity enzyme. J Mol Biol 319:359-369
98. Maga G et al. (2002) Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. J Biol Chem 3:3
99. Mahajan KN et al. (1999) Association of terminal deoxynucleotidyl transferase with Ku. Proc Natl Acad Sci USA 96:13926-13931
100. Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA (2002) Association of DNA polymerase mu (pol mu) with Ku and ligase IV: Role for pol mu in end-joining double-strand break repair. Mol Cell Biol 22:5194-5202
101. Maloisel L, Bhargava J, Roeder GS (2004) A role for DNA polymerase delta in gene conversion and crossing over during meiosis in Saccharomyces cerevisiae. Genetics 167:1133-1142
102. Mancuso M, Filosto M, Oh SJ, DiMauro S (2004) A novel polymerase gamma mutation in a family with ophthalmoplegia, neuropathy, Parkinsonism. Arch Neurol 61:1777-1779
103. Marini F, Kim N, Schuffert A, Wood RD (2003) POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308. J Biol Chem 278:32014-32019
104. Marini F et al. (1997) A role for DNA primase in coupling DNA replication to DNA damage response. Embo J 16:639-650
105. Masuda Y, Kamiya K (2002) Biochemical properties of the human REV1 protein. FEBS Lett 520:88-92
106. Masutani C, Kusumoto R, Iwai S, Hanaoka F (2000) Mechanisms of accurate translesion synthesis by human DNA polymerase eta. Embo J 19:3100-3109
107. Masutani C et al. (1999) The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature 399:700-704
108. Masutomi K et al. (2003) Telomerase maintains telomere structure in normal human cells. Cell 114:241-253
109. Matsumoto Y, Kim K (1995) Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair. Science 269:699-702
110. McCulloch SD, Kokoska RJ, Masutani C, Iwai S, Hanaoka F, Kunkel TA (2004) Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Nature 428:97-100
111. McDonald JP et al. (1999) Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta. Genomics 60:20-30
112. Murakumo Y (2002) The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control. Mutat Res 510:37-44
113. Murakumo Y et al. (2001) Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem 276:35644-35651
114. Murakumo Y et al. (2000) A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J Biol Chem 275:4391-4397
115. O-Wang J et al. (2001) DNA polymerase kappa, implicated in spontaneous, DNA damageinduced mutagenesis, is overexpressed in lung cancer. Cancer Res 61:5366-5369
116. Ogi T, Mimura J, Hikida M, Fujimoto H, Fujii-Kuriyama Y, Ohmori H (2001) Expression of human and mouse genes encoding polkappa: Testis-specific developmental regulation, AhR-dependent inducible transcription. Genes Cells 6:943-953
117. Okochi E, Ichimura S, Sugimura T, Ushijima T (2002) The absence of Mth1 inactivation, DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions. Jpn J Cancer Res 93:501-506
118. Pan Q, Fang Y, Xu Y, ZhangK,Hu X (2005) Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers. Cancer Lett 217:139-147
119. Poltoratsky V, Woo CJ, Tippin B, Martin A, Goodman MF, Scharff MD (2001) Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proc Natl Acad Sci USA 98:7976-7981
120. Prakash S, Prakash L (2002) Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair. Genes Dev 16:1872-1883
121. Prasad R, Beard WA, Strauss PR, Wilson SH (1998) Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism. J Biol Chem 273:15263-15270
122. Qi H, Zakian VA (2000) The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes Dev 14:1777-1788
123. Radman M (2001) Fidelity and infidelity. Nature 413:115
124. Ramadan K, Maga G, Shevelev IV, Villani G, Blanco L, Hubscher U (2003) Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: Implications for novel functions. J Mol Biol 328:63-72
125. Ramadan K, Shevelev IV, Hubscher U (2004a) The DNA-polymerase-X family: controllers of DNA quality? Nat Rev Mol Cell Biol 5:1038-1043
126. Ramadan K, Shevelev IV, Maga G, Hubscher U (2002) DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. J Biol Chem 277:18454-18458
127. Ramadan K, Shevelev IV, Maga G, Hubscher U (2004b) De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase. J Mol Biol 339:395-404
128. Read RL, Martinho RG, Wang SW, Carr AM, Norbury CJ (2002) Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc Natl Acad Sci USA 99:12079-12084
129. Rechkoblit O et al. (2002) Trans-lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG, N6-dA lesions catalyzed by DNA bypass polymerases. J Biol Chem 277:30488-30494
130. Roychoudhury R (1972) Enzymic synthesis of polynucleotides. Oligodeoxynucleotides with one 3′-terminal ribonucleotide as primers for polydeoxynucleotide synthesis. J Biol Chem 247:3910-3917
131. Ruiz JF, Dominguez O, Lain de Lera T, Garcia-Diaz M, Bernad A, Blanco L (2001) DNA polymerase mu, a candidate hypermutase? Philos Trans R Soc Lond B Biol Sci 356:99-109
132. Ruiz JF et al. (2003) Lack of sugar discrimination by human Pol mu requires a single glycine residue. Nucleic Acids Res 31:4441-4449
133. Sadoff BU, Heath-Pagliuso S, Castano IB, Zhu Y, Kieff FS, Christman MF (1995) Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase. Genetics I 141:465-479
134. Saitoh S, Chabes A, McDonald WH, Thelander L, Yates JR, Russell P (2002) Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell 109:563-573
135. Sancar A, Lindsey-Boltz LA, Unsal-Kaccmaz K, Linn S (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.Annu Rev Biochem73:39-85
136. Seki M, Marini F, Wood RD (2003) POLQ (Pol theta), a DNA polymerase, DNA-dependent ATPase in human cells. Nucleic Acids Res 31:6117-6126
137. Seki M et al. (2004) High-efficiency bypass of DNA damage by human DNA polymerase Q. EMBO J 23:4484-4494. Epub 2004 Oct 4421
138. Semizarov DG et al. (1997) Stereoisomers of deoxynucleoside 5′-triphosphates as substrates for template-dependent and -independent DNA polymerases. J Biol Chem 272:9556-9560
139. Sharief FS, Vojta PJ, Ropp PA, Copeland WC (1999) Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase. Genomics 59:90-96
140. Shevelev IV, Hubscher U (2002) The 3′ 5′ exonucleases. Nat Rev Mol Cell Biol 3:364-376
141. Shima N, Hartford SA, Duffy T,Wilson LA, Schimenti KJ, Schimenti JC (2003) Phenotype-based identification of mouse chromosome instability mutants. Genetics 163:1031-1040
142. Shimazaki N, Yoshida K, Kobayashi T, Toji S, Tamai K, Koiwai O (2002) Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme. Genes Cells 7:639-651
143. Simpson LJ, Sale JE (2003) Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line. EMBO J 22:1654-1664
144. Sobol RW et al. (1996) Requirement of mammalian DNA polymerase-beta in baseexcision repair. Nature 379:183-186
145. Sonoda E et al. (2003) Multiple roles of Rev3, the catalytic subunit of pol zeta in maintaining genome stability in vertebrates. Embo J 22:3188-3197
146. Stucki M, Stagljar I, Jonsson ZO, Hubscher U (2001) A coordinated interplay: Proteins with multiple functions in DNA replication, DNA repair, cell cycle/checkpoint control, and transcription. Prog Nucleic Acid Res Mol Biol 65:261-298
147. Sugino A (1995) Yeast DNA polymerases and their role at the replication fork. Trends Biochem Sci 20:319-323
148. Suzuki N et al. (2002) Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). Biochemistry 41:6100-6106
149. Thai TH, Kearney JF (2004) Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants. J Immunol 173:4009-4019
150. Thai TH, Purugganan MM, Roth DB, Kearney JF (2002) Distinct and opposite diversifying activities of terminal transferase splice variants. Nat Immunol 3:457-462
151. Tissier A, Frank EG, McDonald JP, Iwai S, Hanaoka F,Woodgate R (2000) Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. Embo J 19:5259-5266
152. Tissier A, Kannouche P, Reck MP, Lehmann AR, Fuchs RP, Cordonnier A (2004) Colocalization in replication foci and interaction of human Y-family members, DNA polymerase pol eta, REVl protein. DNA Repair (Amst) 3:1503-1514
153. Tissier A, McDonald JP, Frank EG, Woodgate R (2000) poliota, a remarkably error-prone human DNA polymerase. Genes Dev 14:1642-1650
154. Trifunovic A et al. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417-423
155. Vaisman A, Chaney SG (2000) The efficiency and fidelity of translesion synthesis past cisplatin and oxaliplatin GpG adducts by human DNA polymerase beta. J Biol Chem 275:13017-13025
156. Velasco-Miguel S et al. (2003) Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa. DNA Repair (Amst) 2:91-106
157. Walowsky C, Fitzhugh DJ, Castano IB, Ju JY, Levin NA, Christman MF (1999) The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin. J Biol Chem 274:7302-7308
158. Wang Met al. (2004) Pol iota is a candidate for themouse pulmonary adenoma resistance 2 locus, amajormodifier of chemically induced lung neoplasia. Cancer Res 64:1924-1931
159. Wang Y et al. (2004) Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53. Int J Oncol 25:161-165
160. Wang Z, Castano IB, De Las Penas A, Adams C, Christman MF (2000) Pol kappa: A DNA polymerase required for sister chromatid cohesion. Science 289:774-779
161. Wang Z, Wu X, Friedberg EC (1993) DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae. Mol Cell Biol 13:1051-1058
162. Washington MT, Johnson RE, Prakash L, Prakash S (2004) Human DNA polymerase iota utilizes different nucleotide incorporation mechanisms dependent upon the template base. Mol Cell Biol 24:936-943
163. Yang J, Chen Z, Liu Y, Hickey RJ, Malkas LH (2004) Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesis. Cancer Res 64:5597-5607
164. Zeng X, Negrete GA, Kasmer C, Yang WW, Gearhart PJ (2004) Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J Exp Med 199:917-924. Epub 2004 Mar 2029
165. Zhang X, Yu Y, Chen X (1994) Evidence for nontargeted mutagenesis in a monkey kidney cell line and analysis of its sequence specificity using a shuttle-vector plasmid. Mutat Res 323:105-112
166. Zhang Y et al. (2002) Lesion bypass activities of human DNA polymerase mu. J Biol Chem 277:44582-44587
167. Zhang Y, Yuan F, Wu X, Wang Z (2000) Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota. Mol Cell Biol 20:7099-7108
168. Zhu F, Jin CX, Song T, Yang J, Guo L, Yu YN (2003) Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N′-nitro-N-nitrosoguanidine and its role in mutagenesis. World J Gastroenterol 9:888-893
169. Zhu F, Zhang M (2003) DNA polymerase zeta: New insight into eukaryotic mutagenesis and mammalian embryonic development. World J Gastroenterol 9:1165-1169