De Novo DNA synthesis by human DNA polymerase λ, DNA polymerase μ and terminal deoxyribonucleotidyl transferase

Journal of Molecular Biology

Volumn 339, Issue 2, 2004, Pages 395-404

  Ramadan, Kristijan ^a   Shevelev, Igor V ^a   Maga, Giovanni ^b   Hübscher, Ulrich ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b CNR   (Italy)

Author keywords

de novo DNA synthesis; DNA polymerase ; DNA polymerase ; DNA repair; pol, polymerase; ss, single stranded; TdT, terminal deoxyribonucleotidyl transferase; terminal deoxyribonucleotidyl transferase; WCE, whole calf thymus extract

Indexed keywords

AMINO ACID; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE LAMBDA; DNA DIRECTED DNA POLYMERASE MU; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA POLYMERASE; PRIMER DNA; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DNA RECOMBINATION; DNA REPAIR; DNA SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURAL GENE;

EID: 2342568939     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.03.056     Document Type: Article

References (29)

1. Hubscher U., Maga G., Spadari S. Eukaryotic DNA polymerases. Annu. Rev. Biochem. 71:2002;133-163
2. Aoufouchi S., Flatter E., Dahan A., Faili A., Bertocci B., Storck S., et al. Two novel human and mouse DNA polymerases of the polX family. Nucl. Acids Res. 28:2000;3684-3693
3. Garcia-Diaz M., Dominguez O., Lopez-Fernandez L.A., de Lera L.T., Saniger M.L., Ruiz J.F., et al. DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis. J. Mol. Biol. 301:2000;851-867
4. Garcia-Diaz M., Bebenek K., Kunkel T.A., Blanco L. Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. J. Biol. Chem. 276:2001;34659-34663
5. Ramadan K., Shevelev I.V., Maga G., Hubscher U. DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. J. Biol. Chem. 277:2002;18454-18458
6. Maga G., Villani G., Ramadan K., Shevelev I., Tanguy Le Gac N., Blanco L., et al. Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. J. Biol. Chem. 277:2002;48434-48440
7. Garcia-Diaz M., Bebenek K., Sabariegos R., Dominguez O., Rodriguez J., Kirchhoff T., et al. DNA polymerase lambda, a novel DNA repair enzyme in human cells. J. Biol. Chem. 277:2002;13184-13191
8. Chang L.M., Cassani G.R., Bollum F.J. Deoxynucleotide-polymerizing enzymes of calf thymus gland. VII. Replication of homopolymers. J. Biol. Chem. 247:1972;7718-7723
9. Benedict C.L., Gilfillan S., Thai T.H., Kearney J.F. Terminal deoxynucleotidyl transferase and repertoire development. Immunol. Rev. 175:2000;150-157
10. Dominguez O., Ruiz J.F., Lain de Lera T., Garcia-Diaz M., Gonzalez M.A., Kirchhoff T., et al. DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. EMBO J. 19:2000;1731-1742
11. Ramadan K., Maga G., Shevelev I.V., Villani G., Blanco L., Hubscher U. Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions. J. Mol. Biol. 328:2003;63-72
12. McElhinny N., Ramsden S.A. Polymerase DNA mu is a DNA-directed DNA/RNA polymerase. Mol. Cell Biol. 23:2003;2309-2315
13. Ruiz J.F., Juarez R., Garcia-Diaz M., Terrados G., Picher A.J., Gonzalez-Barrera S. Lack of sugar discrimination by human Pol mu requires a single glycine residue. Nucl. Acids Res. 31:2003;4441-4449
14. Shevelev I., Blanca G., Villani G., Ramadan K., Spadari S., Hubscher U., Maga G. Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Nucl. Acids Res. 31:2003;6916-6925
15. Wilson S.H., Sobol R.W., Beard W.A., Horton J.K., Prasad R., Vande Berg B.J. DNA polymerase beta and mammalian base excision repair. Cold Spring Harbor Symp. Quant. Biol. 65:2000;143-155
16. Idriss H.T., Al-Assar O., Wilson S.H. DNA polymerase beta. Int. J. Biochem. Cell Biol. 34:2002;321-324
17. Gilfillan S., Benoist C., Mathis D. Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoire. Immunol. Rev. 148:1995;201-219
18. Thai T.H., Purugganan M.M., Roth D.B., Kearney J.F. Distinct and opposite diversifying activities of terminal transferase splice variants. Nature Immunol. 3:2002;457-462
19. Mahajan K.N., Nick McElhinny S.A., Mitchell B.S., Ramsden D.A. Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol. Cell Biol. 22:2002;5194-5202
20. Bergoglio V., Ferrari E., Hubscher U., Cazaux C., Hoffmann J.S. DNA Polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA. J. Mol. Biol. 331:2003;1017-1023
21. Bertocci B., De Smet A., Flatter E., Dahan A., Bories J.C., Landreau C., et al. Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation. J. Immunol. 168:2002;3702-3706
22. Schachman H.K., Adler J., Radding C.M., Lehman I.R., Kornberg A. Enzymatic synthesis of deoxyribonucleic acid. J. Biol. Chem. 235:1960;3242-3249
23. Okazaki T., Kornberg A. Enzymatic synthesis of deoxyribonucleic acid. J. Biol. Chem. 239:1964;259-268
24. Ogata N., Miura T. Creation of genetic information by DNA polymerase of the archaeon Thermococcus litoralis: influences of temperature and ionic strength. Nucl. Acids Res. 26:1998;4652-4656
25. Ogata N., Miura T. Creation of genetic information by DNA polymerase of the thermophilic bacterium Thermus thermophilus. Nucl. Acids Res. 26:1998;4657-4661
26. Ogata N., Miura T. Elongation of tandem repetitive DNA by the DNA polymerase of the hyperthermophilic archaeon Thermococcus litoralis at a hairpin-coil transitional state: a model of amplification of a primordial simple DNA sequence. Biochemistry. 39:2000;13993-14001
27. McKenzie G.J., Rosenberg S.M. Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens. Curr. Opin. Microbiol. 4:2001;586-594
28. Shevelev I.V., Ramadan K., Hubscher U. The TREX2 exonuclease physically interacts with DNA polymerase δ and increases its accuracy. Sci. World J. 2:2002;275-281
29. Weiser T., Gassmann M., Thommes P., Ferrari E., Hafkemeyer P., Hubscher U. Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus. J. Biol. Chem. 266:1991;10420-10428