Significance of multiple mutations in cancer

Carcinogenesis

Volumn 21, Issue 3, 2000, Pages 379-385

  Loeb, Keith R ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; DNA; DNA POLYMERASE;

ANEUPLOIDY; BASE MISPAIRING; CANCER; CANCER GENETICS; CARCINOGENESIS; CHROMOSOME ABERRATION; DNA DAMAGE; DNA REPAIR; GENE AMPLIFICATION; GENE MUTATION; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; REVIEW;

ANIMALS; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA-DIRECTED DNA POLYMERASE; GENETIC HETEROGENEITY; HUMANS; MUTATION; NEOPLASMS; PHENOTYPE;

EID: 0034011427     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.3.379     Document Type: Review

References (71)

1. Ames, B.N., Gold, L.S. and Willet, W.C. (1995) The causes and prevention of cancer. Proc. Natl Acad. Science USA, 92, 5258-5265
2. Ames, B.N., Profet, M. and Gold, L.S. (1990) Nature's chemicals and synthetic chemicals: comparative toxicology. Proc. Natl Acad. Science USA, 87, 7782-7786
3. Loeb, L.A. (1989) Endogenous carcinogenesis: molecular oncology into the twenty-first century-presidential address. Cancer Res., 49, 5489-5496
4. Lindahl, T. and Nyberg, B. (1972) Rate of depurination of native deoxyribonucleic acid. Biochemistry, 11, 3610-3618
5. Cathcart, R., Scheiers, E., Saul, R.L. and Ames, B.N. (1984) Thymine glycol and thymidine glycol in human and rat urine: A possible assay for oxidative DNA damage. Proc. Natl Acad. Science USA, 81, 5633-5637
6. Shigenaga, M.K., Cimeno, C.J. and Ames, B.N. (1989) Urinary 8-hydroxy-2′ deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc. Natl Acad. Science USA, 86, 9697-9701
7. 4-ethenocytosine and 4-amino-5-(imidazol-2-yl)imidazole. Biochemistry, 32, 12793-12801
8. Cheng, K.C., Cahill, D.S., Kasai, H., Nishimura, S. and Loeb, L.A. (1992) 8-hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions. J. Biol. Chem., 267, 166-172
9. Shibutani, S., Takeshita, M. and Grollman, A.O. (1991) Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxo-dG. Nature, 349, 431-434
10. Lindahl, T. and Nyberg, B. (1974) Heat-induced deamination of cytosine residues in deoxyribonucleic acid. Biochemistry, 13, 3405-3410
11. Loeb, L.A. and Cheng, K.C. (1990) Errors in DNA synthesis: a source of spontaneous mutations. Mutat. Res., 238, 297-304
12. Murli, S. and Walker, G.C. (1993) SOS mutagenesis. Curr. Opin. Genet. Dev., 3, 719-725
13. Umar, A. and Kunkel, T.A. (1996) DNA-replication fidelity, mismatch repair and genomic instability in cancer cells. Eur. J. Biochem., 238, 297-307
14. Hindges, R. and Hubscher, U. (1995) Production of active mouse DNA polymerase delta in bacteria. Gene, 158, 241-246
15. Syvaoja, J., Suomensaari, S., Nishida, C., Goldsmith, J.S., Chui, G.S.J., Jain, S. and Linn, S. (1990) DNA polymerases α, δ and ε: three distinct enzymes from HeLa cells. Proc. Natl Acad. Science USA, 87, 6664-6668
16. Kunkel, T.A. and Alexander, P.S. (1986) The base substitution fidelity of eucaryotic DNA polymerases. J. Biol. Chem., 261, 160-166
17. Fry, M. and Loeb, L.A. (1992) A DNA polymerase α pause site is a hot spot for nucleotide misinsertion. Proc. Natl Acad. Science USA, 89, 763-767
18. Modrich, P. (1987) DNA mismatch correction. Annu. Rev. Biochem., 56, 435-466
19. Wang, H., Lawrence, C.W., Li, G.-M. and Hays, J.B. (1999) Specific binding of human MSH2-MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine-or uracil-containing UV light photoproducts opposite mismatched bases. J. Biol. Chem., 274, 16894-16900
20. Sweasy, J.B. and Loeb, L.A. (1992) Mammalian DNA polymerase β can substitute for DNA polymerase I during DNA replication in Escherichia coli. J. Biol. Chem., 267, 1407-1410
21. Srivastava, D.K., Husain, I., Arteaga, C.L. and Wilson, S.H. (1999) DNA polymerase beta expression differences in selected human tumors and cell lines. Carcinogenesis, 20, 1049-1054
22. Clairmont, C.A. and Sweasy, J.B. (1996) Dominant negative rat DNA polymerase β mutants interfere with base excision repair in Saccharomyces cerevisiae. J. Bacteriol., 178, 656-661
23. Canitrot, Y., Frechet, M., Servant, L., Cazaux, C. and Hoffmann, J.-S. (1999) Overexpression of DNA polymerase β: a genomic instability enhancer process. FASEB J., 13, 1107-1111
24. Witkin, E.M. (1976) Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. Bacteriol. Rev., 40, 869-907
25. 2C mutagenic complex and RecA protein. Proc. Natl Acad. Science USA, 95, 9755-9760
26. 2C is an error-prone DNA polymerase, Escherichia coli pol V. Proc. Natl Acad. Science USA, 96, 8919-8924
27. Johnson, R.E., Prakash, S. and Prakash, L. (1999) Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function. J. Biol. Chem., 274, 15975-15977
28. Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S. and Hanaoka, F. (1999) Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J., 18, 3491-3501
29. Johnson, R.E., Kondratick, C.M., Prakash, S. and Prakash, L. (1999) hRAD30 mutations in the variant form of xeroderma pigmentosum. Science, 285, 263-265
30. Hartwell, L.H. and Kastan, M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1827
31. Crook, T., Marston, N.J., Sara, E.A. and Vousden, K.H. (1994) Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell, 79, 814-827
32. Orr-Weaver, T.L. and Weinberg, R.A. (1998) A checkpoint on the road to cancer. Nature, 392, 223-224
33. Loeb, L.A., Springgate, C.F. and Battula, N. (1974) Errors in DNA replication as a basis of malignant change. Cancer Res., 34, 2311-2321
34. Nowell, P.C. (1976) The clonal evolution of tumor cell populations. Science, 194, 23-28
35. Tlsty, T.D., Margolin, B.H. and Lum, K. (1989) Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis. Proc. Natl Acad. Science USA, 86, 9441-9445
36. Peinado, M.A., Malkhosyan, S., Velazquez, A. and Perucho, M. (1992) Isolation and characterization of allelic loss and gains in colorectal tumors by arbitrarily primed polymerase chain reaction. Proc. Natl Acad. Science USA, 89, 10065-10069
37. Ionov, Y., Peinado, M.A., Malkhosyan, S., Shibata, S. and Perucho, M. (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature, 363, 558-561
38. Perucho, M. (1996) Cancer of the microsatellite mutator phenotype. Biol. Chem., 377, 675-684
39. Rampino, N., Yamamoto, H., Ionov, Y., Li, Y., Sawai, H., Reed, J.C. and Perucho, M. (1997) Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science, 275, 967-969
40. Markowitz, S., Wang, J., Myeroff, L. et al. (1995) Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science, 268, 1336-1338
41. Fishel, R., Lescoe, M.K., Rao, M.R.S., Copeland, N.G., Jenkins, N.A., Garber, J., Kane, M. and Kolodner, R. (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell, 75, 1027-1038
42. Herman, J.G., Umar, A., Polyak, K. et al. (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl Acad. Science USA, 95, 6870-6875
43. Leung, S.Y., Yuen, S.T. Chung, L.P., Chu, K.M., Chan, A.S.Y. and Ho, J.C.I. (1999) hMLH1 promoter methylation and lack of hMLH expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res., 59, 159-164
44. Jackson, A.L., Chen, R. and Loeb, L.A. (1998) Induction of microsatellite instability by oxidative DNA damage. Proc. Natl Acad. Science USA, 95, 12468-12473
45. Richards, B., Zhang, H., Phear, G. and Meuth, M. (1997) Conditional mutator phenotypes in hMSH2 deficient tumor cell lines. Science, 277, 1523-1526
46. Kallioniemi, A., Kallioniemi, O.-P., Piper, J., Tanner, M., Stokke, T., Chen, L., Smith, H.S., Pinkel, D., Gray, J.W. and Waldman, F.M. (1994) Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc. Natl Acad. Science USA, 91, 2156-2160
47. Iwabuchi, H., Sakamoto, M., Sakunaga, H. and Ma, Y.Y. (1995) Genetic analysis of benign, low-grade and high-grade ovarian tumors. Cancer Res., 55, 6172-6180
48. Kerangueven, F., Noguchi, T., Coulier, F., Allione, F., Wargniez, V., Simony-Lafontaine, J., Longy, M., Jacquemier, J., Sobol, H., Eisinger, F. and Birnbaum, D. (1997) Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas. Cancer Res., 57, 5469-5474
49. Jackson, A.L. and Loeb, L.A. (1998) The mutation rate and cancer. Genetics, 148, 1483-1490
50. Kuerbitz, S.J., Plunkett, B.S., Walsh, W.V. and Kastan, M.B. (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl Acad. Science USA, 89, 7491-7495
51. LaCasse, E.C., Baird, S., Korneluk, R.G. and MacKenzie, A.E. (1998) The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene, 17, 3247-3259
52. Duesberg, P., Rausch, C., Rasnick, D. and Hehlmann, R. (1998) Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc. Natl Acad. Science USA, 95, 13692-13697
53. Andreassen, P.R., Martineau, S.N. and Margolis, R.L. (1996) Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state. Mutat. Res., 372, 181-194
54. Lengauer, C., Kinzler, K.W. and Vogelstein, B. (1997) Genetic instability in colorectal cancers. Nature, 386, 623-627
55. Cahill, D., Lengauer, C., Yu, J., Riggins, G.J., Willson, J.K., Markowitz, S.D., Kinzler, K.W. and Vogelstein, B. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature, 392, 300-303
56. Hoyt, M.A., Totis, L. and Roberts, B.T. (1991) S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell, 66, 507-517
57. Liehr, J.G. (1997) Androgen-induced redox changes in prostate cancer cells: what are causes and effects? J. Natl Cancer Inst., 89, 3-4
58. Taylor, S.S. and McKeon, F. (1997) Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell, 89, 727-735
59. L and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev., 10, 2621-2631
60. Basu, J., Bousbaa, H., Logarinho, E., Li, Z., Williams, B.C., Lopes, C., Sunkel, C.E. and Goldberg, M.L. (1999) Mutations in the essential spindle checkpoint gene bubI cause chromosome missegregation and fail to block apoptosis in Drosophila. J. Cell Biol., 146, 13-28
61. Lanni, J.S. and Jacks, T. (1998) Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell Biol., 18, 1055-1064
62. 1 arrest. Cancer Res., 58, 396-401
63. Stewart, Z.A., Leach, S.D. and Pietenpol, J.A. (1999) p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol. Cell Biol., 19, 205-215
64. Li, X. and Nicklas, R.B. (1995) Mitotic forces control a cell-cycle checkpoint. Nature, 373, 630-632
65. Cahill, D.P., da Costa, L.T., Carson-Walter, E.B., Kinzler, K.W., Vogelstein, B. and Lengauer, C. (1999) Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics, 58, 181-187
66. Yamaguchi, K., Okami, K., Hibi, K., Wehage, S.L., Jen, J. and Sidransky, D. (1999) Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines. Cancer Lett., 139, 183-187
67. Lee, H., Trainer, A.H., Friedman, L.S., Thistlethwaite, F.C., Evans, M.J., Ponder, B.A. and Venkitaraman, A.R. (1999) Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene. Brca2. Mol. Cell, 4, 1-10
68. Mao, E.F., Lane, L., Lee, J. and Miller, J.H. (1997) Proliferation of mutators in a cell population. J. Bacteriol., 179, 417-422
69. Taddei, F., Radman, M., Maynard-Smith, J., Toupance, B., Gouyon, P.H. and Godelle, B. (1997) Role of mutator alleles in adaptive evolution. Nature, 387, 700-702
70. Loeb, L.A. (1996) Genetic instability in cancer. In Lindahl, T. (ed.) Genetic Instability in Cancer. Cold Spring Harbor Press, Plainview, NY, pp. 329-342
71. Sekowski, J.W., Malkas, L.H., Schnaper, L., Bechtel, P.E., Long, B.J. and Hickey, R.J. (1998) Human breast cancer cells contain an error-prone DNA replication apparatus. Cancer Res., 58, 3259-3263