Antitumor activity of 2′,3′-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase β

Molecular Pharmacology

Volumn 60, Issue 3, 2001, Pages 553-558

  Louat, Thierry ^a   Servant, Laurence ^a   Rols, Marie Pierre ^b   Bieth, Anne ^a   Teissie, Justin ^b   Hoffmann, Jean Sebastien ^a   Cazaux, Christophe ^a  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA; DOUBLE STRANDED DNA; NUCLEOSIDE ANALOG; ZALCITABINE;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL EXTRACTS; CELL SURVIVAL; DEOXYCYTOSINE NUCLEOTIDES; DNA; DNA POLYMERASE BETA; ENZYME ACTIVATION; MELANOMA, EXPERIMENTAL; MICE; NEOPLASM TRANSPLANTATION; SIMIAN VIRUS 40; TUMOR CELLS, CULTURED; UP-REGULATION; VIRUS REPLICATION; ZALCITABINE;

EID: 0034873055     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Progress in thetreatment of adults with acute leukemia
2. Overexpression of DNA polymerase β sensitizes mammalian cells to 2′,3′-dideoxycytidine and 3′-azido-3′-deoxythymidine
3. Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs
4. Overexpression of DNA polymerase β: A genomic instability enhancer process
5. Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: A potential source of genetic instability in cancer cells
6. Human DNA polymerases α and β are able to incorporate anti-HIV deoxynucleotides into DNA
7. Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea
8. Fork-like DNA templates support bypass replication of lesions that block DNA synthesis on single-stranded templates
9. Studies of the domain structure of mammalian DNA polymerase beta
10. The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations
11. Frameshift mutagenesis by eukaryotic DNA polymerases in vitro
12. Low fidelity DNA synthesis by human DNA polymerase-eta
13. Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa
14. The fidelity of DNA polymerase β during distributive and processive DNA synthesis
15. Mechanisms of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases α β, and by the 5′-triphosphates of carbovir, 3′-azido-3′-deoxythymidine, 2′,3′-dideoxyguanosine, and 3′-deoxythymidine
16. Enzymes of evolutionary change
17. Differential gene expression in human cancer cells resistant to cisplatin
18. Requirement of mammalian DNA polymerase-beta in base-excision repair
19. DNA polymerase beta expression differences in selected human tumors and cell lines
20. Poliota, a remarkably error-prone human DNA polymerase
21. Fidelity and processivity of Saccharomyces cerevisiae of DNA polymerase eta
22. A plethora of lesion-replicating DNA polymerases
23. Characterization of DNA polymerase beta mRNA: Cell-cycle and growth response in cultured human cells