Human DNA polymerase λ diverged in evolution from DNA polymerase β toward specific Mn++ dependence: A kinetic and thermodynamic study

Biochemistry

Volumn 42, Issue 24, 2003, Pages 7467-7476

  Blanca, Giuseppina ^a   Shevelev, Igor ^b   Ramadan, Kristijan ^b   Villani, Giuseppe ^c   Spadari, Silvio ^a   Hübscher, Ulrich ^b   Maga, Giovanni ^a  

^a CNR   (Italy)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYME INHIBITION; ENZYME KINETICS; THERMODYNAMICS;

ALLOSTERIC SITES;

DNA;

DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE; DNA POLYMERASE LAMBDA; MAGNESIUM; MANGANESE; METAL ION; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL REACTION KINETICS; DNA SEQUENCE; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME MECHANISM; ESCHERICHIA COLI; PRIORITY JOURNAL; THERMODYNAMICS;

ALLOSTERIC SITE; BASE SEQUENCE; BINDING, COMPETITIVE; CATALYSIS; DIPHOSPHATES; DNA POLYMERASE BETA; ENZYME INHIBITORS; EVOLUTION, MOLECULAR; HUMANS; KINETICS; MAGNESIUM; MANGANESE; OLIGONUCLEOTIDES; RECOMBINANT PROTEINS; THERMODYNAMICS;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

EID: 0037732696     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034198m     Document Type: Article

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