DNA mismatch repair and genetic instability

Annual Review of Genetics

Volumn 34, Issue , 2000, Pages 359-399

  Harfe, B D ^a   Jinks Robertson, S ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

Cancer; DNA damage; Mutation; Mutator; Recombination

Indexed keywords

BACTERIAL GENETICS; BASE MISPAIRING; DNA DAMAGE; DNA REPAIR; FUNGAL GENETICS; GENE MUTATION; GENETIC ANALYSIS; GENETIC RECOMBINATION; HUMAN; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

BASE PAIR MISMATCH; DNA DAMAGE; DNA REPAIR; MEIOSIS; MUTATION; RECOMBINATION, GENETIC;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA;

EID: 0034500024     PISSN: 00664197     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genet.34.1.359     Document Type: Review

References (242)

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14. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
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111. hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSα
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113. Homology search and choice of homologous partner during mitotic recombination
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119. Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability
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129. Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2 in transcription-coupled repair
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151. Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli
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153. The yeast HSM3 gene is not involved in DNA mismatch repair in rapidly dividing cells
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157. Influence of DNA sequence identity on efficiency of targeted gene replacement
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160. Multiple heterologies increase mitotic double-strand break-induced allelic gene conversion tract lengths in yeast
161. A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype
162. Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair
163. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection
164. hMUTSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
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166. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
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170. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
171. Conserved properties between functionally distinct MutS homologs in yeast
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173. Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene
174. Saccharomyces cerevisiae exonuclease1 plays a role in UV resistance that is distinct from nucleotide excision repair
175. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
176. Identification of hMutLβ, a heterodimer of hMLH1 and hPMS1
177. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants
178. Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: Evidence for separate mitochondrial and nuclear functions
179. Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction
180. The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization
181. Stabilization of the intermediate in frameshift mutation
182. DNA excision repair
183. Requirement of mismatch repair genes MSH2 and MSH3 in RAD1-RAD10 pathway of mitotic recombination in Saccharomyces cerevisiae
184. Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli
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188. Marker effects of G to C transversions on intragenic recombination and mismatch repair in Schizosaccharomyces pombe
189. Human exonuclease I interacts with the mismatch repair protein hMSH2
190. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
191. The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1
192. Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations
193. Effect of base pair mismatches on recombination via the RecBCD pathway
194. Functional analysis of human MLH1 mutations in Saccharomyces cerevisiae
195. Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae
196. Microsatellite instability in yeast: Dependence on repeat unit size and DNA mismatch repair genes
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202. Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination
203. Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair
204. Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination
205. +-ATPase isogenes PMA1 and PMA2: Insights into the mechanism of recombination initiated by a double-strand break
206. Mismatch repair mutants in yeast are not defective in transcription-coupled DNA repair of UV-induced DNA damage
207. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction
208. Heteroduplex repair in extracts of human HeLa cells
209. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
210. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair
211. Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting
212. The prevention of repeat-associated deletions in Saccharomyces cerevisiae by mismatch repair depends on size and origin of deletions
213. The 3′-5′ exonucleases of DNA polymerases δ and ε and the 5′-3′ exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae
214. Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants
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216. Functional overlap in mismatch repair by human MSH3 and MSH6
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218. Severe attenuation of the B cell immune response in Msh2-deficient mice
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227. Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
228. Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs
229. Role of MutS ATPase activity in MutL-dependent block of in vitro strand transfer
230. Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis
231. Dominant negative mutator mutations in the mutS gene of Escherichia coli
232. Deletion mutation analysis of the mutS gene in Escherichia coli
233. Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader
234. MutS and MutL activate DNA helicase II in a mismatch-dependent manner
235. Analysis of yeast pms1, msh2, and mlh1 mutators points to differences in mismatch correction efficiencies between prokaryotic and eukaryotic cells
236. Different mutator phenotypes in Mlh1-versus Pms2-deficient mice
237. Barriers to recombination between closely related bacteria: MutS and RecBCD inhibit recombination between Salmonella typhimurium and Salmonella typhi
238. Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast