The property of DNA polymerase ζ: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 510, Issue 1-2, 2002, Pages 37-44

  Murakumo, Yoshiki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell cycle control; DNA polymerase ; Mutagenesis; REV7; Translesion DNA synthesis

Indexed keywords

DNA POLYMERASE; DNA POLYMERASE REV1; DNA POLYMERASE ZETA; PROTEIN REV3; PROTEIN REV7; PROTEIN SUBUNIT; REV PROTEIN; UNCLASSIFIED DRUG;

CELL CYCLE; DNA DAMAGE; DNA SYNTHESIS; GENE MUTATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; XENOPUS; YEAST;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037196067     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00250-6     Document Type: Review

References (66)

1. E.C. Friedberg, G.C. Walker, W. Siede, DNA Repair and Mutagenesis, ASM Press, Washington, DC, 1995.
2. Friedberg E.C., Gerlach V.L. Novel DNA polymerases offer clues to the molecular basis of mutagenesis. Cell. 98:1999;413-416.
3. Bridges B.A. DNA repair: polymerases for passing lesions. Curr. Biol. 9:1999;R475-R477.
4. Kunz B.A., Straffon A.F.L., Vonarx E.J. DNA damage-induced mutation: tolerance via translesion synthesis. Mutat. Res. 451:2000;169-185.
5. Friedberg E.C., Feaver W.J., Gerlach V.L. The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance. Proc. Natl. Acad. Sci. U.S.A. 97:2000;5681-5683.
6. Broomfield S., Hryciw T., Xiao W. DNA postreplication repair and metagenesis in Saccharomyces cerevisiae. Mutat. Res. 486:2001;167-184.
7. Lemontt J.F. Mutants of yeast defective in mutation induced by ultraviolet light. Genetics. 68:1971;21-33.
8. Lemontt J.F. Induction of forward mutations in mutationally defective yeast. Mol. Gen. Genet. 119:1972;27-42.
9. Lawrence C.W., Christensen R. UV mutagenesis in radiation-sensitive strains of yeast. Genetics. 82:1976;207-232.
10. Lawrence C.W., Christensen R.B. Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. Genetics. 92:1979;397-408.
11. Lawrence C.W., O'Brien T., Bond J. UV-induced reversion of his4 frameshift mutations in rad6, rev1, and rev3 mutants of yeast. Mol. Gen. Genet. 195:1984;487-490.
12. Lawrence C.W., Krauss B.R., Christensen R.B. New mutations affecting induced mutagenesis in yeast. Mutat. Res. 150:1985;211-216.
13. Lawrence C.W., Das G., Christensen R.B. REV7, a new gene concerned with UV mutagenesis in yeast. Mol. Gen. Genet. 200:1985;80-85.
14. Lawrence C.W., Nisson P.E., Christensen R.B. UV and chemical mutagenesis in rev7 mutants of yeast. Mol. Gen. Genet. 200:1985;86-91.
15. Nelson J.R., Lawrence C.W., Hinkle D.C. Thymine-thymine dimer bypass by yeast DNA polymerase ζ Science. 272:1996;1646-1649.
16. Nelson J.R., Lawrence C.W., Hinkle D.C. Deoxycytidyl transferase activity of yeast REV1 protein. Nature. 382:1996;729-731.
17. Haracska L., Prakash S., Prakash L. Yeast Rev1 protein is a G template specific DNA polymerase. J. Biol. Chem. 277:2002;15546-15551.
18. Xiao W., Lechler T., Chow B.L., Fontanie T., Agustus M., Carter K.C., Wei Y.-F. Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase ζ Carcinogenesis. 19:1998;945-949.
19. Gibbs P.E.M., Glenn McGregor W., Maher V.M., Nisson P., Lawrence C.W. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ Proc. Natl. Acad. Sci. U.S.A. 95:1998;6876-6880.
20. Morelli C., Mungall A.J., Negrini M., Barbanti-Brodano G., Croce C.M. Alternative splicing, genomic structure, and fine chromosome localization of REV3L. Cytogenet. Cell Genet. 83:1998;18-20.
21. Lin W., Wu X., Wang Z. A full-length cDNA of hREV3 is predicted to encode DNA polymerase ζ for damage-induced mutagenesis in humans. Mutat. Res. 433:1999;89-98.
22. Lin W., Xin H., Zhang Y., Wu X., Yuan F., Wang Z. The human REV1 gene codes for a DNA template-dependent dCMP transferase. Nucl. Acids Res. 27:1999;4468-4475.
23. Gibbs P.E.M., Wang X.-D., Li Z., McManus T.P., Glenn McGregor W., Lawrence C.W., Maher V.M. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. Proc. Natl. Acad. Sci. U.S.A. 97:2000;4186-4191.
24. Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce C.M., Fishel R. A human REV7 homolog that interacts with the polymerase ζ catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J. Biol. Chem. 275:2000;4391-4397.
25. Lawrence C.W., Hinkle D.C. DNA polymerase ζ and control of DNA damage induced mutagenesis in eukaryotes. Cancer Surv. 28:1996;21-31.
26. Lawrence C.W., Maher V.M. Eukaryotic mutagenesis and translesion replication dependent of DNA polymerase ζ and Rev1 protein. Biochem. Soc. Trans. 29:2001;187-191.
27. Pfleger C.M., Salic A., Lee E., Kirschner M.W. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes Dev. 15:2001;1759-1764.
28. Chen J., Fang G. MAD2B is an inhibitor of the anaphase-promoting complex. Genes Dev. 15:2001;1765-1770.
29. Murakumo Y., Ogura Y., Ishii H., Numata S., Ichihara M., Croce C.M., Fishel R., Takahashi M. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J. Biol. Chem. 276:2001;35644-35651.
30. Larimer F.W., Perry J.R., Hardigree A.A. The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis. J. Bacteriol. 171:1989;230-237.
31. Morrison A., Christensen R.B., Alley J., Beck A.K., Bernstine E.G., Lemontt J.F., Lawrence C.W. REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase. J. Bacteriol. 171:1989;5659-5667.
32. Torpey L.E., Gibbs P.E.M., Nelson J., Lawrence C.W. Cloning and sequence of REV7, a gene whose function is required for DNA damage-induced mutagenesis in Saccharomyces cerevisiae. Yeast. 10:1994;1503-1509.
33. Lawrence C. The RAD6 DNA repair pathway in Saccharomyces cerevisiae: what does it do, and how does it do it? BioEssays. 16:1994;253-258.
34. Burgers P.M.J., Koonin E.V., Bruford E., Blanco L., Burtis K.C., Christman M.F., Copeland W.C., Friedberg E.C., Hanaoka F., Hinkle D.C., Lawrence C.W., Nakanishi M., Ohmori H., Prakash L., Prakash S., Reynaud C.-A., Sugino A., Todo T., Wang Z., Weill J.-C., Woodgate R. Eukaryotic DNA polymerases: proposal for a revised nomenclature. J. Biol. Chem. 276:2001;43487-43490.
35. Tang M., Bruck I., Eritja R., Turner J., Frank E.G., Woodgate R., O'Donnell M., Goodman M.F. Biochemical. Proc. Natl. Acad. Sci. U.S.A. 95:1998;9755-9760.
36. 2′ C is an error-prone DNA polymerase, Escherichia coli pol V Proc. Natl. Acad. Sci. U.S.A. 96:1999;8919-8924.
37. Ohmori H., Hatada E., Qiao Y., Tsuji M., Fukuda R. dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues. Mutat. Res. 347:1995;1-7.
38. Wagner J., Gruz P., Kim S.-R., Yamada M., Matsui K., Fuchs R.P.P., Nohmi T. The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis. Mol. Cell. 4:1999;281-286.
39. McDonald J.P., Levine A.S., Woodgate R. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics. 147:1997;1557-1568.
40. Aravind L., Koonin E.V. The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. Trends Biochem. Sci. 23:1998;284-286.
41. Li R., Murray A.W. Feedback control of mitosis in Budding yeast. Cell. 66:1991;519-531.
42. Li Y., Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2. Science. 274:1996;246-248.
43. Schwacha A., Kleckner N. Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis. Cell. 76:1994;51-63.
44. Kironmai K.M., Muniyappa K., Friedman D.B., Hollingsworth N.M., Byers B. DNA-binding activities of Hop1 protein, a synaptonemal complex component from Saccharomyces cerevisiae. Mol. Cell. Biol. 18:1998;1424-1435.
45. Johnson R.E., Washington M.T., Haracska L., Prakash S., Prakash L. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions. Nature. 406:2000;1015-1019.
46. Haracska L., Unk I., Johnson R.E., Johansson E., Burgers P.M.J., Prakash S., Prakash L. Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sites. Genes Dev. 15:2001;945-954.
47. Guo D., Wu X., Rajpal D.K., Taylor J.-S., Wang Z. Translesion synthesis by yeast DNA polymerase ζ from templates containing lesions of ultraviolet radiation and acetylaminofluorene. Nucl. Acids Res. 29:2001;2875-2883.
48. Rajpal D.K., Wu X., Wang Z. Alteration of ultraviolet-induced mutagenesis in yeast through molecular modulation of the REV3 and REV7 gene expression. Mutat. Res. 461:2000;133-143.
49. Harfe B.D., Jinks-Robertson S. DNA polymerase ζ introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae. Mol. Cell. 6:2000;1491-1499.
50. Wang Z. Translesion synthesis by the UmuC family of DNA polymerases. Mutat. Res. 486:2001;59-70.
51. Masuda Y., Takahashi M., Tsunekuni N., Minami T., Sumii M., Miyagawa K., Kamiya K. Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain. J. Biol. Chem. 276:2001;15051-15058.
52. Zhang Y., Wu X., Rechkoblit O., Geacintov N.E., Taylor J.-S., Wang Z. Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucl. Acids Res. 30:2002;1630-1638.
53. Cahill D.P., da Costa L.T., Carson-Walter E.B., Kinzler K.W., Vogelstein B., Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics. 58:1999;181-6187.
54. Nelson K.K., Schlondorff J., Blobel C.P. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor α convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2β Biochem. J. 343:1999;673-680.
55. Bemark M., Khamlichi A.A., Davies S.L., Neuberger M.S. Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro. Curr. Biol. 10:2000;1213-1216.
56. Wittschieben J., Shivji M.K.K., Lalani E., Jacobs M.A., Marini F., Gearhart P.J., Rosewell I., Stamp G., Wood R.D. Disruption of the developmentally regulated Rev3l gene causes embryonic lethality. Curr. Biol. 10:2000;1217-1220.
57. Esposito G., Godin I., Klein U., Yaspo M.-L., Cumano A., Rajewsky K. Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality. Curr. Biol. 10:2000;1221-1224.
58. Kajiwara K., Wang J.O., Sakurai T., Yamashita S., Tanaka M., Sato M., Tagawa M., Sugaya E., Nakamura K., Nakao K., Katsuki M., Kimura M. Sez4 gene encoding an elongation subunit of DNA polymerase ζ is required for normal embryogenesis. Genes Cells. 6:2001;99-106.
59. Van Sloun P.P.H., Varlet I., Sonneveld E., Boei J.J.W.A., Romeijn R.J., Eeken J.C.J., De Wind N. Involvement of mouse REV3 in tolerance of endogenous and exogenous DNA damage. Mol. Cell. Biol. 22:2002;2159-2169.
60. Visintin R., Prinz S., Amon A. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science. 278:1997;460-463.
61. Amon A. The spindle checkpoint. Curr. Opin. Genet. Dev. 9:1999;69-75.
62. Zachariae W., Nasmyth K. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13:1999;2039-2058.
63. Holbeck S.L., Strathern J.N. A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae. Genetics. 147:1997;1017-1024.
64. Chan S.-H., Hung F.S.-J., Chan D.S.-B., Shaw P.-C. Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B. Eur. J. Biochem. 268:2001;2107-2112.
65. Weterman M.A.J., van Groningen J.J.M., Tertoolen L., van Kessel A.G. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. Proc. Natl. Acad. Sci. U.S.A. 98:2001;13808-13813.
66. Diaz M., Verkoczy L.K., Flajnik M.F., Klinman N.R. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ J. Immunol. 167:2001;327-335.