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Volumn 19, Issue 6, 2006, Pages 555-563

Of mice and men: More neurobiology in dementia

Author keywords

Alzheimer disease; apoE; APP; Tau; Transgenic mice

Indexed keywords

AMYLOID; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; PRESENILIN 1; TAU PROTEIN;

EID: 33749463108     PISSN: 09517367     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.yco.0000245757.06374.6a     Document Type: Review
Times cited : (23)

References (130)
  • 1
    • 0027282035 scopus 로고
    • Apolipoprotein E polymorphism and Alzheimer disease
    • Poirier J, Davignon J, Bouthillier D, et al. Apolipoprotein E polymorphism and Alzheimer disease. Lancet 1993; 342:697-699.
    • (1993) Lancet , vol.342 , pp. 697-699
    • Poirier, J.1    Davignon, J.2    Bouthillier, D.3
  • 2
    • 0027327267 scopus 로고
    • Association of apoliprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders A, Strittmatter W, Schmechel D, et al. Association of apoliprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993; 43:1467-1472.
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.1    Strittmatter, W.2    Schmechel, D.3
  • 3
    • 0030005627 scopus 로고    scopus 로고
    • Apolipoprotein E alleles as risk factors in Alzheimer's disease
    • Roses A. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu Rev Med 1996; 47:387-400.
    • (1996) Annu Rev Med , vol.47 , pp. 387-400
    • Roses, A.1
  • 4
    • 17344362232 scopus 로고    scopus 로고
    • Alpha-2 macroglobulin is genetically associated with Alzheimer disease
    • Blacker D, Wilcox M, Laird N, et al. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet 1998; 19:357-360.
    • (1998) Nat Genet , vol.19 , pp. 357-360
    • Blacker, D.1    Wilcox, M.2    Laird, N.3
  • 5
    • 0034711619 scopus 로고    scopus 로고
    • Alpha-2 macroglobulin and the risk of Alzheimer's disease
    • Dodel R, Du Y, Bales K, et al. Alpha-2 macroglobulin and the risk of Alzheimer's disease. Neurology 2000; 54:438-442.
    • (2000) Neurology , vol.54 , pp. 438-442
    • Dodel, R.1    Du, Y.2    Bales, K.3
  • 6
    • 23944438473 scopus 로고    scopus 로고
    • Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease
    • Lehmann DJ, Cortina-Borja M, Warden DR, et al. Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. Am J Epidemiol 2005; 162:305-317. After analysing data from 6037 patients with Alzheimer disease and 12 099 controls, the authors conclude that angiotensin I-converting enzyme (ACE) indel is a marker for the risk of Alzheimer disease, probably in linkage disequilibrium with the true risk polymorphism.
    • (2005) Am J Epidemiol , vol.162 , pp. 305-317
    • Lehmann, D.J.1    Cortina-Borja, M.2    Warden, D.R.3
  • 7
    • 0033358671 scopus 로고    scopus 로고
    • Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity and mutation spectrum
    • Campion D, Dumanchin C, Hannequin D, et al. Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity and mutation spectrum. Am J Hum Genet 1999; 65:664-670.
    • (1999) Am J Hum Genet , vol.65 , pp. 664-670
    • Campion, D.1    Dumanchin, C.2    Hannequin, D.3
  • 8
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin M, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor gene with familial Alzheimer's disease. Nature 1991; 349:704-706.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.2    Mullan, M.3
  • 9
    • 0029004341 scopus 로고
    • Cloning a gene bearing missense mutations in early-onset familial Alzheimer disease
    • Sherrington R, Rogaev E, Liang Y, et al. Cloning a gene bearing missense mutations in early-onset familial Alzheimer disease. Nature 1995; 375:754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.2    Liang, Y.3
  • 10
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer disease locus. Science 1995; 269:973-977.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 11
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • (Berl)
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 1991; 82:239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 12
    • 0025992295 scopus 로고
    • A topographical pathway by which histopathological lesions disseminate through the brain of patients with Alzheimer disease
    • Fewster P, Griffin-Brooks S, MacGregor J, et al. A topographical pathway by which histopathological lesions disseminate through the brain of patients with Alzheimer disease. Dementia 1991; 2:121-132.
    • (1991) Dementia , vol.2 , pp. 121-132
    • Fewster, P.1    Griffin-Brooks, S.2    MacGregor, J.3
  • 13
    • 0032191016 scopus 로고    scopus 로고
    • Selective vulnerability of neocortical association areas in Alzheimer's disease
    • Giannakopoulos P, Hof P, Bouras C. Selective vulnerability of neocortical association areas in Alzheimer's disease. Microsc Res Tech 1998; 43:16-23.
    • (1998) Microsc Res Tech , vol.43 , pp. 16-23
    • Giannakopoulos, P.1    Hof, P.2    Bouras, C.3
  • 14
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer disease
    • Davies P, Maloney J. Selective loss of central cholinergic neurons in Alzheimer disease. Lancet 1976; 2:1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, J.2
  • 15
    • 0030963566 scopus 로고    scopus 로고
    • Acetylcholine, aging, and Alzheimer disease
    • Muir J. Acetylcholine, aging, and Alzheimer disease. Pharmacol Biochem Behav 1997; 56:687-696.
    • (1997) Pharmacol Biochem Behav , vol.56 , pp. 687-696
    • Muir, J.1
  • 16
    • 0034612148 scopus 로고    scopus 로고
    • Inflamatory hypotheses: Novel mechanisms of Alzheimer's neurodegeneration and new therapeutic targets?
    • Pratico D, Trojanowski J. Inflamatory hypotheses: novel mechanisms of Alzheimer's neurodegeneration and new therapeutic targets? Neurobiol Aging 2000; 21:441-445.
    • (2000) Neurobiol Aging , vol.21 , pp. 441-445
    • Pratico, D.1    Trojanowski, J.2
  • 17
    • 26244437738 scopus 로고    scopus 로고
    • Basal forebrain cholinergic dysfunction in Alzheimer's disease interrelationship with beta-amyloid, inflammation and neurotrophin signaling
    • Schliebs R. Basal forebrain cholinergic dysfunction in Alzheimer's disease interrelationship with beta-amyloid, inflammation and neurotrophin signaling. Neurochem Res 2005; 30:895-908. The author reviews the complex interrelationship between cholinergic neurotransmission, APP metabolism and -amyloid-induced production of proinflammatory cytokines hypothesizing that an age-related disturbance of the homeostatic interaction between cholinergic function and APP metabolism plays a major role in the genesis of SAD.
    • (2005) Neurochem Res , vol.30 , pp. 895-908
    • Schliebs, R.1
  • 18
    • 0032997546 scopus 로고    scopus 로고
    • Critical threshold cerebral hypoperfusion causes Alzheimer disease?
    • (Berl)
    • de la Torre J. Critical threshold cerebral hypoperfusion causes Alzheimer disease? Acta Neuropathol (Berl) 1999; 98:1-8.
    • (1999) Acta Neuropathol , vol.98 , pp. 1-8
    • De La Torre, J.1
  • 19
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • Farkas E, Luiten P. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol 2001; 64:575-611.
    • (2001) Prog Neurobiol , vol.64 , pp. 575-611
    • Farkas, E.1    Luiten, P.2
  • 20
    • 0029006492 scopus 로고
    • Synapse loss and gliosis in the molecular layer of the cerebral cortex in Alzheimer's disease and frontal lobe degeneration
    • Brun A, Liu X, Erikson C. Synapse loss and gliosis in the molecular layer of the cerebral cortex in Alzheimer's disease and frontal lobe degeneration. Neurodegeneration 1995; 4:171-177.
    • (1995) Neurodegeneration , vol.4 , pp. 171-177
    • Brun, A.1    Liu, X.2    Erikson, C.3
  • 21
    • 0344653664 scopus 로고    scopus 로고
    • Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    • Gomez-Isla T, Hollister R, West H, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997; 41:17-24.
    • (1997) Ann Neurol , vol.41 , pp. 17-24
    • Gomez-Isla, T.1    Hollister, R.2    West, H.3
  • 22
    • 0035077448 scopus 로고    scopus 로고
    • Problems of cell death in neurodegeneration and Alzheimer's disease
    • Jellinger K, Stadelmann C. Problems of cell death in neurodegeneration and Alzheimer's disease. J Alzheimers Dis 2001; 3:31-40.
    • (2001) J Alzheimers Dis , vol.3 , pp. 31-40
    • Jellinger, K.1    Stadelmann, C.2
  • 23
    • 0033945494 scopus 로고    scopus 로고
    • Presenilin-1 regulates neuronal differentiation during neurogenesis
    • Handler M, Yang X, Shen J. Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 2000; 127:2593-2606.
    • (2000) Development , vol.127 , pp. 2593-2606
    • Handler, M.1    Yang, X.2    Shen, J.3
  • 24
    • 0041355557 scopus 로고    scopus 로고
    • Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
    • Selkoe D, Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci 2003; 26:565-597.
    • (2003) Annu Rev Neurosci , vol.26 , pp. 565-597
    • Selkoe, D.1    Kopan, R.2
  • 25
    • 0346458659 scopus 로고    scopus 로고
    • Increased hippocampal neurogenesis in Alzheimer's disease
    • Jin K, Peel A, Mao X, et al. Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci USA 2004; 101:343-347.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 343-347
    • Jin, K.1    Peel, A.2    Mao, X.3
  • 26
    • 0026075602 scopus 로고
    • Early-onset Alzheimer disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
    • Chartier-Harlin M, Crawford F, Houlden H, et al. Early-onset Alzheimer disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 1991; 353:844-846.
    • (1991) Nature , vol.353 , pp. 844-846
    • Chartier-Harlin, M.1    Crawford, F.2    Houlden, H.3
  • 27
    • 0028866435 scopus 로고
    • The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
    • Haass C, Lemere C, Capell A, et al. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med 1995; 1:1291-1296.
    • (1995) Nat Med , vol.1 , pp. 1291-1296
    • Haass, C.1    Lemere, C.2    Capell, A.3
  • 28
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
    • Citron M, Westaway D, Xia W, et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 1997; 3:67-72.
    • (1997) Nat Med , vol.3 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3
  • 29
    • 26444463825 scopus 로고    scopus 로고
    • Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    • Kivipelto M, Ngandu T, Fratiglioni L, et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol 2005; 62:1556-1560. The authors investigated how the clustering of vascular risk factors affects the risk of developing Alzheimer disease.
    • (2005) Arch Neurol , vol.62 , pp. 1556-1560
    • Kivipelto, M.1    Ngandu, T.2    Fratiglioni, L.3
  • 30
    • 0027365822 scopus 로고
    • Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
    • Schmechel D, Saunders A, Strittmatter W, et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993; 90:9649-9653.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9649-9653
    • Schmechel, D.1    Saunders, A.2    Strittmatter, W.3
  • 31
    • 0037047008 scopus 로고    scopus 로고
    • Contribution of APOE promoter polymorphysms to Alzheimer's disease risk
    • Lambert J, Araria-Goumidi L, Myllykangas L, et al. Contribution of APOE promoter polymorphysms to Alzheimer's disease risk. Neurology 2002; 59:59-66.
    • (2002) Neurology , vol.59 , pp. 59-66
    • Lambert, J.1    Araria-Goumidi, L.2    Myllykangas, L.3
  • 32
    • 10744226703 scopus 로고    scopus 로고
    • Genetic association of Alzheimer disease with multiple polymorphisms in alpha-2-macroglobulin
    • Saunders A, Bertram L, Mullin K, et al. Genetic association of Alzheimer disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet 2003; 12:2765-2776.
    • (2003) Hum Mol Genet , vol.12 , pp. 2765-2776
    • Saunders, A.1    Bertram, L.2    Mullin, K.3
  • 33
    • 0033848463 scopus 로고    scopus 로고
    • Gene polymorphism affecting alpha 1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk
    • Licastro F, Pedrini S, Ferri C, et al. Gene polymorphism affecting alpha 1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk. Ann Neurol 2000; 48:388-391.
    • (2000) Ann Neurol , vol.48 , pp. 388-391
    • Licastro, F.1    Pedrini, S.2    Ferri, C.3
  • 34
    • 0043092123 scopus 로고    scopus 로고
    • Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain
    • Licastro F, Grimaldi LM, Bonafe M, et al. Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol Aging 2003; 24:921-926.
    • (2003) Neurobiol Aging , vol.24 , pp. 921-926
    • Licastro, F.1    Grimaldi, L.M.2    Bonafe, M.3
  • 35
    • 2942531060 scopus 로고    scopus 로고
    • Interleukin-6 promoter polymorphism: Risk and pathology of Alzheimer's disease
    • Zhang Y, Hayes A, Pritchard A, et al. Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease. Neurosci Lett 2004; 362:99-102.
    • (2004) Neurosci Lett , vol.362 , pp. 99-102
    • Zhang, Y.1    Hayes, A.2    Pritchard, A.3
  • 36
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy J, Higgins G. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992; 256:184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.1    Higgins, G.2
  • 37
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe D. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297:353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.2
  • 38
    • 0038652102 scopus 로고    scopus 로고
    • Gamma secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1 and Pen-2
    • Kimberly W, LaVoie M, Ostaszewski B, et al. Gamma secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1 and Pen-2. Proc Natl Acad Sci USA 2003; 100:6382-6387.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6382-6387
    • Kimberly, W.1    LaVoie, M.2    Ostaszewski, B.3
  • 39
    • 0037468759 scopus 로고    scopus 로고
    • The role of presenilin cofactors in the gamma-secretase complex
    • Takasugi N, Tomita T, Hayashi I, et al. The role of presenilin cofactors in the gamma-secretase complex. Nature 2003; 422:438-441.
    • (2003) Nature , vol.422 , pp. 438-441
    • Takasugi, N.1    Tomita, T.2    Hayashi, I.3
  • 40
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein, presenilins and alpha synuclein: Molecular pathogenesis and pharmacological applications in Alzheimer disease
    • Suh Y, Checler F. Amyloid precursor protein, presenilins and alpha synuclein: molecular pathogenesis and pharmacological applications in Alzheimer disease. Pharmacol Rev 2002; 54:469-525.
    • (2002) Pharmacol Rev , vol.54 , pp. 469-525
    • Suh, Y.1    Checler, F.2
  • 41
    • 0022435132 scopus 로고
    • Image reconstruction of the Alzheimer paired helical filament
    • Crowther R, Wischik C. Image reconstruction of the Alzheimer paired helical filament. Embo J 1985; 4:3661-3665.
    • (1985) Embo J , vol.4 , pp. 3661-3665
    • Crowther, R.1    Wischik, C.2
  • 42
    • 0002792366 scopus 로고
    • Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau
    • Goedert M, Wischik CM, Crowther RA, et al. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci USA 1988; 85:4051-4055.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4051-4055
    • Goedert, M.1    Wischik, C.M.2    Crowther, R.A.3
  • 43
    • 4744370969 scopus 로고    scopus 로고
    • Amyloid induced neurofibrillary tangle formation in Alzheimer's disease: Insight from transgenic mouse and tissue culture models
    • Gotz J, Schild A, Hoerndli F, Pennanen L. Amyloid induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue culture models. Int J Dev Neurosci 2004; 22:453-465.
    • (2004) Int J Dev Neurosci , vol.22 , pp. 453-465
    • Gotz, J.1    Schild, A.2    Hoerndli, F.3    Pennanen, L.4
  • 44
    • 28944431913 scopus 로고    scopus 로고
    • Animal models of Alzheimer's disease: A road full of pitfalls
    • Delacourte A, Buee L. Animal models of Alzheimer's disease: a road full of pitfalls. Psychol Neuropsychiatr Vieil 2005; 3:261-270.
    • (2005) Psychol Neuropsychiatr Vieil , vol.3 , pp. 261-270
    • Delacourte, A.1    Buee, L.2
  • 45
    • 0031424883 scopus 로고    scopus 로고
    • Animal models of aging
    • (Milano)
    • Richardson A. Animal models of aging. Aging (Milano) 1997; 9:439-441.
    • (1997) Aging , vol.9 , pp. 439-441
    • Richardson, A.1
  • 46
    • 0028243033 scopus 로고
    • Cellular and molecular biology of Alzheimer's disease and animal models
    • Price D, Sisodia S. Cellular and molecular biology of Alzheimer's disease and animal models. Annu Rev Med 1994; 45:435-446.
    • (1994) Annu Rev Med , vol.45 , pp. 435-446
    • Price, D.1    Sisodia, S.2
  • 47
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
    • Hutton M, Lendon C, Rizzu P, et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 1998; 393:702-705.
    • (1998) Nature , vol.393 , pp. 702-705
    • Hutton, M.1    Lendon, C.2    Rizzu, P.3
  • 48
    • 14444284106 scopus 로고    scopus 로고
    • Tau is a candidate gene for chromosome 17 frontotemporal dementia
    • Poorkaj P, Bird T, Wijsman E, et al. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol 1998; 43:815-825.
    • (1998) Ann Neurol , vol.43 , pp. 815-825
    • Poorkaj, P.1    Bird, T.2    Wijsman, E.3
  • 49
    • 0032560487 scopus 로고    scopus 로고
    • Mutation in tau gene in familial multiple system tauopathy with presenile dementia
    • Spillantini M, Murrell J, Goedert M, et al. Mutation in tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci USA 1998; 95:7737-7741.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7737-7741
    • Spillantini, M.1    Murrell, J.2    Goedert, M.3
  • 50
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717 beta-amyloid precursor protein
    • Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717 beta-amyloid precursor protein. Nature 1995; 373:523-527.
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1    Adams, D.2    Alessandrini, R.3
  • 51
    • 0037417899 scopus 로고    scopus 로고
    • Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis
    • Redwine J, Kosofsky B, Jacobs R, et al. Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci USA 2003; 100:1381-1386.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1381-1386
    • Redwine, J.1    Kosofsky, B.2    Jacobs, R.3
  • 52
    • 2342486529 scopus 로고    scopus 로고
    • Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: Digital morphometric analyses
    • Wu CC, Chawla F, Games D, et al. Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses. Proc Natl Acad Sci USA 2004; 101:7141-7146.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7141-7146
    • Wu, C.C.1    Chawla, F.2    Games, D.3
  • 53
    • 0030611097 scopus 로고    scopus 로고
    • Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mice
    • Irizarry M, Soriano F, McNamara M, et al. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mice. J Neurosci 1997; 17:7053-7059.
    • (1997) J Neurosci , vol.17 , pp. 7053-7059
    • Irizarry, M.1    Soriano, F.2    McNamara, M.3
  • 54
    • 0035057591 scopus 로고    scopus 로고
    • Neurofibrillary pathology induced in transgenic mice overexpressing V717F beta-amyloid precursor protein
    • Masliah E, Sisk A, Mallory M, Games D. Neurofibrillary pathology induced in transgenic mice overexpressing V717F beta-amyloid precursor protein. J Neuropathol Exp Neurol 2001; 60:357-368.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 357-368
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Games, D.4
  • 55
    • 0034648738 scopus 로고    scopus 로고
    • Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein-initial observations
    • Diez M, Koistinaho J, Kahn K, et al. Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein-initial observations. Neuroscience 2000; 100:259-286.
    • (2000) Neuroscience , vol.100 , pp. 259-286
    • Diez, M.1    Koistinaho, J.2    Kahn, K.3
  • 56
    • 32544460592 scopus 로고    scopus 로고
    • Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
    • Donovan M, Yazdani U, Norris R, et al. Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease. J Comp Neurol 2006; 495:70-83. While some studies link Alzheimer disease to increased neurogenesis, in the PDAPP the primary characteristic is decreased neurogenesis. This feature might contribute to the cognitive decline and thus could be used as a supplementary means to evaluate Alzheimer disease therapies.
    • (2006) J Comp Neurol , vol.495 , pp. 70-83
    • Donovan, M.1    Yazdani, U.2    Norris, R.3
  • 57
    • 0033523480 scopus 로고    scopus 로고
    • Alterations in synaptic transmission and long-term potentiation in hippocampal slice from young and aged PDAPP mice
    • Larson J, Lynch G, Games D, Seubert P. Alterations in synaptic transmission and long-term potentiation in hippocampal slice from young and aged PDAPP mice. Brain Res 1999; 840:23-35.
    • (1999) Brain Res , vol.840 , pp. 23-35
    • Larson, J.1    Lynch, G.2    Games, D.3    Seubert, P.4
  • 58
    • 0037154764 scopus 로고    scopus 로고
    • Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in the PDAPP mice
    • Huitron-Resendiz S, Sanchez-Alavez M, Gallegos R, et al. Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in the PDAPP mice. Brain Res 2002; 928:126-137.
    • (2002) Brain Res , vol.928 , pp. 126-137
    • Huitron-Resendiz, S.1    Sanchez-Alavez, M.2    Gallegos, R.3
  • 59
    • 0034700480 scopus 로고    scopus 로고
    • A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
    • Chen G, Chen K, Knox J, et al. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature 2000; 408:975-979.
    • (2000) Nature , vol.408 , pp. 975-979
    • Chen, G.1    Chen, K.2    Knox, J.3
  • 60
    • 21544468846 scopus 로고    scopus 로고
    • Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits and hippocampal long-term potentiation in a mouse model of Alzheimer's disease
    • Hartman R, Izumi Y, Bales K, et al. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J Neurosci 2005; 25:6213-6220. PDAPP mice, on a pure C57BL/6 background, tested on a 5-week water maze protocol, have early learning impairments and exhibit greater cognitive deterioration with age than their WT littermates. The authors also show that after systemic treatment for several weeks with an anti-Abeta antibody, the performance of animals with high Abeta burden is improved.
    • (2005) J Neurosci , vol.25 , pp. 6213-6220
    • Hartman, R.1    Izumi, Y.2    Bales, K.3
  • 62
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996; 274:99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3
  • 63
    • 0031981072 scopus 로고    scopus 로고
    • Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
    • Smith MA, Hirai K, Hsiao K, et al. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem 1998; 70:2212-2215.
    • (1998) J Neurochem , vol.70 , pp. 2212-2215
    • Smith, M.A.1    Hirai, K.2    Hsiao, K.3
  • 64
    • 18044392303 scopus 로고    scopus 로고
    • Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis
    • doi: 10.1186/1742-2094-1-21
    • Yao Y, Chinnici C, Tang H, et al. Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis. J Neuroinflammation 2004; 1:21, doi: 10.1186/1742-2094-1-21.
    • (2004) J Neuroinflammation , vol.1 , pp. 21
    • Yao, Y.1    Chinnici, C.2    Tang, H.3
  • 65
    • 3242667174 scopus 로고    scopus 로고
    • Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis
    • Paris D, Patel N, DelleDonne A, et al. Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis. Neurosci Lett 2004; 366:80-85.
    • (2004) Neurosci Lett , vol.366 , pp. 80-85
    • Paris, D.1    Patel, N.2    DelleDonne, A.3
  • 66
    • 33645520634 scopus 로고    scopus 로고
    • Early-onset behavioural and synaptic deficits in a mouse model of Alzheimer disease
    • Jacobsen J, Wu C, Redwine J, et al. Early-onset behavioural and synaptic deficits in a mouse model of Alzheimer disease. Proc Natl Acad Sci USA 2006; 103:5161-5166. Morphological, functional and behavioural changes in the Tg 2576 line are consistent with a compromised perforant path input from the enthorhinal cortex to the dentate gyrus.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5161-5166
    • Jacobsen, J.1    Wu, C.2    Redwine, J.3
  • 67
    • 4043052478 scopus 로고    scopus 로고
    • Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPSwe
    • Middei S, Geracitano R, Caprioli A, et al. Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPSwe. Learn Mem 2004; 11:447-452.
    • (2004) Learn Mem , vol.11 , pp. 447-452
    • Middei, S.1    Geracitano, R.2    Caprioli, A.3
  • 68
    • 0011444914 scopus 로고    scopus 로고
    • Two amyloid precursor protein transgenic mouse models with Alzheimer-like pathology
    • Sturchler-Pierrat C, Abramowski D, Duke M, et al. Two amyloid precursor protein transgenic mouse models with Alzheimer-like pathology. Proc Natl Acad Sci USA 1997; 94:13287-13292.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13287-13292
    • Sturchler-Pierrat, C.1    Abramowski, D.2    Duke, M.3
  • 69
    • 0033525520 scopus 로고    scopus 로고
    • Early phenotipic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
    • Moechars D, Dewachter I, Lorent K, et al. Early phenotipic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 1999; 274:6483-6492.
    • (1999) J Biol Chem , vol.274 , pp. 6483-6492
    • Moechars, D.1    Dewachter, I.2    Lorent, K.3
  • 70
    • 10744233782 scopus 로고    scopus 로고
    • Aberrant expressions of pathogenic phenotype in Alzheimer's disease transgenic mice carrying NSE-controlled APPSwe
    • Hwang D, Cho J, Lee S, et al. Aberrant expressions of pathogenic phenotype in Alzheimer's disease transgenic mice carrying NSE-controlled APPSwe. Exp Neurol 2004; 186:20-32.
    • (2004) Exp Neurol , vol.186 , pp. 20-32
    • Hwang, D.1    Cho, J.2    Lee, S.3
  • 71
    • 16844382906 scopus 로고    scopus 로고
    • APP 23 mice as a model of Alzheimer's disease example of transgenic approach to modeling a CNS disorder
    • Van Dam D, Vloeberghs E, Abramowski D, et al. APP 23 mice as a model of Alzheimer's disease example of transgenic approach to modeling a CNS disorder. CNS Spectr 2005; 10:207-222.
    • (2005) CNS Spectr , vol.10 , pp. 207-222
    • Van Dam, D.1    Vloeberghs, E.2    Abramowski, D.3
  • 72
    • 0032558784 scopus 로고    scopus 로고
    • Neuron loss in APP transgenic mice
    • Calhoun M, Wiederhold K, Abramowski D, et al. Neuron loss in APP transgenic mice. Nature 1998; 395:755-756.
    • (1998) Nature , vol.395 , pp. 755-756
    • Calhoun, M.1    Wiederhold, K.2    Abramowski, D.3
  • 73
    • 0035282982 scopus 로고    scopus 로고
    • Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy
    • Winkler D, Bondolfi L, Herzig M, et al. Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy. J Neurosci 2001; 21:1619-1627.
    • (2001) J Neurosci , vol.21 , pp. 1619-1627
    • Winkler, D.1    Bondolfi, L.2    Herzig, M.3
  • 74
    • 26944436685 scopus 로고    scopus 로고
    • Characterization of two APP gene promoter polymorphisms that appear to influence the risk of late on-set Alzheimer disease
    • Lahiri D, Ge Y, Maloney B, et al. Characterization of two APP gene promoter polymorphisms that appear to influence the risk of late on-set Alzheimer disease. Neurobiol Aging 2005; 26:1329-1341. Further characterization of regulatory mechanisms of Alzheimer disease-related genes, like the APP gene promoter investigated by the authors, could lead to deciphering the mechanisms underlying SAD cases.
    • (2005) Neurobiol Aging , vol.26 , pp. 1329-1341
    • Lahiri, D.1    Ge, Y.2    Maloney, B.3
  • 75
    • 0032877158 scopus 로고    scopus 로고
    • Exotic mice as models for aging research: Polemic and prospectus
    • Miller R, Austad S, Burke D, et al. Exotic mice as models for aging research: polemic and prospectus. Neurobiol aging 1999; 20:217-231.
    • (1999) Neurobiol Aging , vol.20 , pp. 217-231
    • Miller, R.1    Austad, S.2    Burke, D.3
  • 76
    • 0032417251 scopus 로고    scopus 로고
    • Transgenic mice expressing Alzheimer amyloid precursor proteins
    • Hsiao K. Transgenic mice expressing Alzheimer amyloid precursor proteins. Exp Gerontol 1998; 33:883-889.
    • (1998) Exp Gerontol , vol.33 , pp. 883-889
    • Hsiao, K.1
  • 77
    • 0033675163 scopus 로고    scopus 로고
    • Dissecting the behaviour of transgenic mice: Is it the mutation the genetic background, or the environment?
    • Wolfer DP, Lipp HP. Dissecting the behaviour of transgenic mice: is it the mutation the genetic background, or the environment? Exp Physiol 2000; 85:627-634.
    • (2000) Exp Physiol , vol.85 , pp. 627-634
    • Wolfer, D.P.1    Lipp, H.P.2
  • 78
    • 0034700471 scopus 로고    scopus 로고
    • A beta peptide immunisation reduces behavioural impairment and plaques in a model of Alzheimer disease
    • Janus C, Pearson J, McLaurin J, et al. A beta peptide immunisation reduces behavioural impairment and plaques in a model of Alzheimer disease. Nature 2000; 408:979-982.
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3
  • 79
    • 0035877756 scopus 로고    scopus 로고
    • Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
    • Chishti M, Yang D, Janus C, et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 2001; 276:21562-21570.
    • (2001) J Biol Chem , vol.276 , pp. 21562-21570
    • Chishti, M.1    Yang, D.2    Janus, C.3
  • 80
    • 0034213718 scopus 로고    scopus 로고
    • High-level neuronal expression of Abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
    • Mucke L, Masliah E, Yu G, et al. High-level neuronal expression of Abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 2000; 20:4050-4058.
    • (2000) J Neurosci , vol.20 , pp. 4050-4058
    • Mucke, L.1    Masliah, E.2    Yu, G.3
  • 81
    • 13044287361 scopus 로고    scopus 로고
    • Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
    • Hsia A, Masliah E, McConlogue L, et al. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 1999; 96:3228-3233.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3228-3233
    • Hsia, A.1    Masliah, E.2    McConlogue, L.3
  • 82
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer disease
    • McLean C, Cherny R, Fraser F, et al. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer disease. Ann Neurol 1999; 46:860-866.
    • (1999) Ann Neurol , vol.46 , pp. 860-866
    • McLean, C.1    Cherny, R.2    Fraser, F.3
  • 83
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Naslund J, Haroutunian V, Mohs R, et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. Jama 2000; 283:1571-1577.
    • (2000) Jama , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mohs, R.3
  • 84
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh D, Klyubin I, Fadeeva J, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416:535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.1    Klyubin, I.2    Fadeeva, J.3
  • 85
    • 33745268224 scopus 로고    scopus 로고
    • Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons
    • Deshpande A, Mina E, Glabe C, Busciglio J. Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci 2006; 26:6011-6018. Aβ oligomers, Aβ-derived diffusible ligands and fibrillar Ab are shown to act in a different temporal manner and by activating distinct pathways in human cortical neurons.
    • (2006) J Neurosci , vol.26 , pp. 6011-6018
    • Deshpande, A.1    Mina, E.2    Glabe, C.3    Busciglio, J.4
  • 86
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • Lesne S, Koh M, Kotilinek L, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006; 440:352-357. A specific soluble amyloid beta assembly of 56-kDa, purified from the brains of impaired Tg 2576 and demonstrated to cause memory deficits in young rats is proposed as a determinant of cognitive deficits in Alzheimer disease.
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesne, S.1    Koh, M.2    Kotilinek, L.3
  • 87
    • 27744512118 scopus 로고    scopus 로고
    • The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
    • Lord A, Kalimo H, Eckman C, et al. The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice. Neurobiol Aging 2006; 27:67-77. This is an interesting new model for Abeta aggregation. Further studies using the tg-APPArc/Swe mice could result in linking intraneuronal Abeta and tau pathology and increase the understanding of early stages of Alzheimer disease.
    • (2006) Neurobiol Aging , vol.27 , pp. 67-77
    • Lord, A.1    Kalimo, H.2    Eckman, C.3
  • 88
    • 17944368176 scopus 로고    scopus 로고
    • The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
    • Nilsberth C, Westlind-Danielsson A, Eckman C, et al. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci 2001; 4:887-893.
    • (2001) Nat Neurosci , vol.4 , pp. 887-893
    • Nilsberth, C.1    Westlind-Danielsson, A.2    Eckman, C.3
  • 89
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1
    • Duff K, Eckman C, Zehr C, et al. Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1. Nature 1996; 383:710-713.
    • (1996) Nature , vol.383 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3
  • 90
    • 0032032847 scopus 로고    scopus 로고
    • Mutant human presenilin 1 protects presenilin null mouse against embryonic lethality and elevates Abeta 1-42/43 expression
    • Qian S, Jiang P, Guan X, et al. Mutant human presenilin 1 protects presenilin null mouse against embryonic lethality and elevates Abeta 1-42/43 expression. Neuron 1998; 20:611-617.
    • (1998) Neuron , vol.20 , pp. 611-617
    • Qian, S.1    Jiang, P.2    Guan, X.3
  • 91
    • 0034058834 scopus 로고    scopus 로고
    • Functional phenotype in transgenic mice expressing mutant presenilin-1
    • Barrow P, Empson R, Gladwell S, et al. Functional phenotype in transgenic mice expressing mutant presenilin-1. Neurobiol Dis 2000; 7:119-126.
    • (2000) Neurobiol Dis , vol.7 , pp. 119-126
    • Barrow, P.1    Empson, R.2    Gladwell, S.3
  • 92
    • 20444474852 scopus 로고    scopus 로고
    • PS1 knockin mice with the Japanese I213T mutation: Effects on exploratory activity, motor coordination, and spatial learning
    • Lalonde R, Strazielle C. PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learning. Behav Brain Res 2005; 162:182-190. SHIRPA primary screen and a large battery of elaborated tests were used in the presented study in order to characterize the exploratory behaviour, motor coordination and spatial learning of the PS1/I213T KI mice.
    • (2005) Behav Brain Res , vol.162 , pp. 182-190
    • Lalonde, R.1    Strazielle, C.2
  • 93
    • 0036275638 scopus 로고    scopus 로고
    • Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease
    • Hwang DY, Chae KR, Kang TS, et al. Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. FASEB J 2002; 16:805-813.
    • (2002) FASEB J , vol.16 , pp. 805-813
    • Hwang, D.Y.1    Chae, K.R.2    Kang, T.S.3
  • 94
    • 0036019155 scopus 로고    scopus 로고
    • Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor and presenilin 1 transgenic mice
    • Wirths O, Multhaup G, Czech C, et al. Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor and presenilin 1 transgenic mice. Brain Pathol 2002; 12:275-286.
    • (2002) Brain Pathol , vol.12 , pp. 275-286
    • Wirths, O.1    Multhaup, G.2    Czech, C.3
  • 95
    • 0344826476 scopus 로고    scopus 로고
    • Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice
    • Blanchard V, Moussaoui S, Czech C, et al. Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice. Exp Neurol 2003; 184:247-263.
    • (2003) Exp Neurol , vol.184 , pp. 247-263
    • Blanchard, V.1    Moussaoui, S.2    Czech, C.3
  • 96
    • 4644276796 scopus 로고    scopus 로고
    • Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta 42 accumulation in a novel Alzheimer transgenic model
    • Casas C, Sergeant N, Itier J, et al. Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta 42 accumulation in a novel Alzheimer transgenic model. Am J Pathol 2004; 165:1289-1300.
    • (2004) Am J Pathol , vol.165 , pp. 1289-1300
    • Casas, C.1    Sergeant, N.2    Itier, J.3
  • 97
    • 1642368934 scopus 로고    scopus 로고
    • Building a more perfect beast: APP transgenic mice with neuronal loss
    • Dickson D. Building a more perfect beast: APP transgenic mice with neuronal loss. Am J Pathol 2004; 164:1143-1146.
    • (2004) Am J Pathol , vol.164 , pp. 1143-1146
    • Dickson, D.1
  • 98
    • 0029788661 scopus 로고    scopus 로고
    • Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a 'humanized' Abeta sequence
    • Reaume A, Howland D, Trusko S, et al. Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a 'humanized' Abeta sequence. J Biol Chem 1996; 271:23380-23388.
    • (1996) J Biol Chem , vol.271 , pp. 23380-23388
    • Reaume, A.1    Howland, D.2    Trusko, S.3
  • 99
    • 26944435186 scopus 로고    scopus 로고
    • Alzheimer's disease-like neuropathology of gene targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels
    • Kohler C, Ebert U, Baumann K, Schroder H. Alzheimer's disease-like neuropathology of gene targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels. Neurobiol Dis 2005; 20:528-540.
    • (2005) Neurobiol Dis , vol.20 , pp. 528-540
    • Kohler, C.1    Ebert, U.2    Baumann, K.3    Schroder, H.4
  • 100
    • 0028965635 scopus 로고
    • Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human tau
    • Gotz J, Probst A, Spillantini MG, et al. Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human tau. EMBO J 1995; 14:1304-1313.
    • (1995) EMBO J , vol.14 , pp. 1304-1313
    • Gotz, J.1    Probst, A.2    Spillantini, M.G.3
  • 101
    • 0034426011 scopus 로고    scopus 로고
    • Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
    • Lewis J, McGowan E, Rockwood J, et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 2000; 25:402-405.
    • (2000) Nat Genet , vol.25 , pp. 402-405
    • Lewis, J.1    McGowan, E.2    Rockwood, J.3
  • 102
    • 0035808361 scopus 로고    scopus 로고
    • Tau filament formation in transgenic mice expressing P301L tau
    • Gotz J, Chen F, Barmettler R, Nitsch R. Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem 2001; 276:529-534.
    • (2001) J Biol Chem , vol.276 , pp. 529-534
    • Gotz, J.1    Chen, F.2    Barmettler, R.3    Nitsch, R.4
  • 103
    • 0036685608 scopus 로고    scopus 로고
    • Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration
    • Higuchi M, Ishihara T, Zhang B, et al. Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron 2002; 35:433-446.
    • (2002) Neuron , vol.35 , pp. 433-446
    • Higuchi, M.1    Ishihara, T.2    Zhang, B.3
  • 104
    • 0036850725 scopus 로고    scopus 로고
    • Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
    • Allen B, Ingram E, Takao M, et al. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci 2002; 22:9340-9351.
    • (2002) J Neurosci , vol.22 , pp. 9340-9351
    • Allen, B.1    Ingram, E.2    Takao, M.3
  • 105
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301L transgenic mice induced by Abeta 42 fibrils
    • Gotz J, Chen F, van Dorpe. Nitsch RM. Formation of neurofibrillary tangles in P301L transgenic mice induced by Abeta 42 fibrils. Science 2001; 293:1491-1495.
    • (2001) Science , vol.293 , pp. 1491-1495
    • Gotz, J.1    Chen, F.2    Van Dorpe Nitsch, R.M.3
  • 106
    • 3142655729 scopus 로고    scopus 로고
    • Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behaviour and therapy
    • Gotz J, Streffer J, David D, et al. Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behaviour and therapy. Mol Psychiatry 2004; 9:664-683.
    • (2004) Mol Psychiatry , vol.9 , pp. 664-683
    • Gotz, J.1    Streffer, J.2    David, D.3
  • 107
    • 33645764470 scopus 로고    scopus 로고
    • Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer disease
    • (Berl)
    • Wirths O, Weis J, Szczygielski J, et al. Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer disease. Acta Neuropathol (Berl) 2006; 111:312-319. The study demonstrates that high Ab intracellular levels lead to the formation of axonal spheroids and myelin ovoids, affecting both descending and ascending axonal tracts, in the white matter of an APP/PS1 tg mouse model of Alzheimer disease.
    • (2006) Acta Neuropathol , vol.111 , pp. 312-319
    • Wirths, O.1    Weis, J.2    Szczygielski, J.3
  • 108
    • 33746411112 scopus 로고    scopus 로고
    • Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease
    • Gotz J, Ittner L, Kins S. Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease. J Neurochem 2006; 98:993-1006. The authors review the evidence attesting the important and early role of impaired axonal transport in Alzheimer disease.
    • (2006) J Neurochem , vol.98 , pp. 993-1006
    • Gotz, J.1    Ittner, L.2    Kins, S.3
  • 109
    • 0042697305 scopus 로고    scopus 로고
    • Triple transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo S, Caccamo A, Shepherd J, et al. Triple transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003; 39:409-421.
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.3
  • 110
    • 33144487701 scopus 로고    scopus 로고
    • Temporal profile of amyloid beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology
    • ••].
    • (2006) J Biol Chem , vol.281 , pp. 1599-1604
    • Oddo, S.1    Caccamo, A.2    Tran, L.3
  • 111
    • 30344448543 scopus 로고    scopus 로고
    • A dynamic relationship between intracellular and extracellular pools of Abeta
    • ••], constitutes a step forward in clarifying the relationship between different Abeta pools and their relation to tau pathology.
    • (2006) Am J Pathol , vol.168 , pp. 184-194
    • Oddo, S.1    Caccamo, A.2    Smith, I.3
  • 112
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late hyperphosphorylated tau aggregates via proteasome
    • Oddo S, Billings L, Kesslak J, et al. Abeta immunotherapy leads to clearance of early, but not late hyperphosphorylated tau aggregates via proteasome. Neuron 2004; 43:321-332.
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.3
  • 113
    • 26844580461 scopus 로고    scopus 로고
    • A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wildtype siblings
    • Nagasaka Y, Dillner K, Ebise H, et al. A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wildtype siblings. Proc Natl Acad Sci USA 2005; 102:14854-14859. The authors provide evidence for significantly different gene expression levels in FAD mutation carriers and their wild-type siblings, which are present before the onset of clinical symptoms and can be detected in fibroblasts, a seemingly disease-unrelated tissue.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14854-14859
    • Nagasaka, Y.1    Dillner, K.2    Ebise, H.3
  • 114
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder E, Saunders A, Strittmatter W, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.1    Saunders, A.2    Strittmatter, W.3
  • 115
    • 0345072821 scopus 로고    scopus 로고
    • Apolipoprotein E, amyloid and Alzheimer disease
    • 339
    • Bales K, Dodart J, DeMattos R, et al. Apolipoprotein E, amyloid and Alzheimer disease. Mol Interv 2002; 2:363-375; 339.
    • (2002) Mol Interv , vol.2 , pp. 363-375
    • Bales, K.1    Dodart, J.2    Demattos, R.3
  • 116
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    • Zhang S, Reddick R, Piedrahita J, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992; 258:468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.1    Reddick, R.2    Piedrahita, J.3    Maeda, N.4
  • 117
    • 0029134887 scopus 로고
    • Apolipoprotein E and the apolipoprotein E-deficient mouse
    • Plump A, Breslow J. Apolipoprotein E and the apolipoprotein E-deficient mouse. Annu Rev Nutr 1995; 15:495-518.
    • (1995) Annu Rev Nutr , vol.15 , pp. 495-518
    • Plump, A.1    Breslow, J.2
  • 118
    • 0034123538 scopus 로고    scopus 로고
    • Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
    • Holtzman D, Fagan A, Mackey B, et al. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol 2000; 47:739-747.
    • (2000) Ann Neurol , vol.47 , pp. 739-747
    • Holtzman, D.1    Fagan, A.2    Mackey, B.3
  • 119
    • 33644855143 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer disease
    • Huang Y. Apolipoprotein E and Alzheimer disease. Neurology 2006; 66:S79-S85.
    • (2006) Neurology , vol.66
    • Huang, Y.1
  • 120
    • 0035527316 scopus 로고    scopus 로고
    • Apolipoprotein E: A major piece in the Alzheimer's disease puzzle
    • Cedazo-Minguez A, Cowburn R. Apolipoprotein E: a major piece in the Alzheimer's disease puzzle. J Cell Mol Med 2001; 5:254-266.
    • (2001) J Cell Mol Med , vol.5 , pp. 254-266
    • Cedazo-Minguez, A.1    Cowburn, R.2
  • 121
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999; 400:173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 122
    • 33646066257 scopus 로고    scopus 로고
    • Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: Lessons from mice, monkeys and humans
    • Lemere C, Maier M, Jiang L, et al. Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys and humans. Rejuvenation Res 2006; 9:77-84. In this review the authors discuss important steps made on the road to finding a safe and effective Abeta vaccine.
    • (2006) Rejuvenation Res , vol.9 , pp. 77-84
    • Lemere, C.1    Maier, M.2    Jiang, L.3
  • 123
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after Abeta-42 immunization
    • Orgogozo J, Gilman S, Dartigues J, et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta-42 immunization. Neurology 2003; 61:46-54.
    • (2003) Neurology , vol.61 , pp. 46-54
    • Orgogozo, J.1    Gilman, S.2    Dartigues, J.3
  • 124
    • 12144290846 scopus 로고    scopus 로고
    • Alzheimer Abeta vaccination of rhesus monkeys (Macaca mulatta)
    • Gandy S, DeMattos R, Lemere C, et al. Alzheimer Abeta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Dis Assoc Disord 2004; 18:44-46.
    • (2004) Alzheimer Dis Assoc Disord , vol.18 , pp. 44-46
    • Gandy, S.1    DeMattos, R.2    Lemere, C.3
  • 125
    • 33644761191 scopus 로고    scopus 로고
    • Microcebus murinus: A useful primate model for human cerebral aging and Alzheimer's disease?
    • Bons N, Rieger F, Prudhomme D, et al. Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease? Genes Brain Behav 2006; 5:120-130.
    • (2006) Genes Brain Behav , vol.5 , pp. 120-130
    • Bons, N.1    Rieger, F.2    Prudhomme, D.3
  • 126
    • 0026176190 scopus 로고
    • Homology of the amyloid beta precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease
    • Podlisny M, Tolan D, Selkoe D. Homology of the amyloid beta precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. Am J Pathol 1991; 138:1423-1435.
    • (1991) Am J Pathol , vol.138 , pp. 1423-1435
    • Podlisny, M.1    Tolan, D.2    Selkoe, D.3
  • 127
    • 0037317234 scopus 로고    scopus 로고
    • Vaccination with amyloid-beta peptide induces autoimmune enchephalomyelitis in C57/BL6 mice
    • Furlan R, Brambilla E, Sanvito F, et al. Vaccination with amyloid-beta peptide induces autoimmune enchephalomyelitis in C57/BL6 mice. Brain 2003; 126:285-291.
    • (2003) Brain , vol.126 , pp. 285-291
    • Furlan, R.1    Brambilla, E.2    Sanvito, F.3
  • 128
    • 3042694083 scopus 로고    scopus 로고
    • Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition
    • Leighty R, Nilsson L, Potter H, et al. Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition. Behav Brain Res 2004; 153:107-121.
    • (2004) Behav Brain Res , vol.153 , pp. 107-121
    • Leighty, R.1    Nilsson, L.2    Potter, H.3
  • 129
    • 20044377403 scopus 로고    scopus 로고
    • Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice
    • Lazarov O, Robinson J, Tang Y, et al. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 2005; 120:701-713. The study highlights the efficacy of environmental enrichment in reducing levels of brain Abeta and amyloid depositions in transgenic mice. The authors also present data showing that physical exercise lowers brain Abeta levels. These findings are intriguing in light of epidemiological data linking the risk for development of dementia to environmental factors such as education and life style.
    • (2005) Cell , vol.120 , pp. 701-713
    • Lazarov, O.1    Robinson, J.2    Tang, Y.3
  • 130
    • 0036456275 scopus 로고    scopus 로고
    • Environmental enrichment and the brain
    • Mohammed A, Zhu S, Darmopil S, et al. Environmental enrichment and the brain. Prog Brain Res 2002; 138:109-133.
    • (2002) Prog Brain Res , vol.138 , pp. 109-133
    • Mohammed, A.1    Zhu, S.2    Darmopil, S.3


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