메뉴 건너뛰기




Volumn 58, Issue 2, 2006, Pages 323-342

Pathophysiology and treatment of pain in joint disease

Author keywords

ASIC; CB; Hypersensitivity; Nociception; Opioids; Prostaglandin; Sensitization; TRPV

Indexed keywords

APPLICATION SPECIFIC INTEGRATED CIRCUITS; BIOELECTRIC POTENTIALS; CELL MEMBRANES; DRUG PRODUCTS; MEDICAL PROBLEMS; NEUROPHYSIOLOGY; PATHOLOGY; PATIENT TREATMENT; PROTEINS;

EID: 33748041976     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2006.01.011     Document Type: Review
Times cited : (83)

References (226)
  • 1
    • 0032890162 scopus 로고    scopus 로고
    • The induction of pain: an integrative review
    • Millan M.J. The induction of pain: an integrative review. Prog. Neurobiol. 57 (1999) 1-164
    • (1999) Prog. Neurobiol. , vol.57 , pp. 1-164
    • Millan, M.J.1
  • 2
    • 0027433726 scopus 로고
    • Afferent and spinal mechanisms of joint pain
    • Schaible H.G., and Grubb B.D. Afferent and spinal mechanisms of joint pain. Pain 55 (1993) 5-54
    • (1993) Pain , vol.55 , pp. 5-54
    • Schaible, H.G.1    Grubb, B.D.2
  • 3
    • 0030479309 scopus 로고    scopus 로고
    • Neurogenic inflammation caused by cutaneous polymodal receptors
    • Lynn B. Neurogenic inflammation caused by cutaneous polymodal receptors. Prog. Brain Res. 113 (1996) 361-368
    • (1996) Prog. Brain Res. , vol.113 , pp. 361-368
    • Lynn, B.1
  • 4
    • 0031986099 scopus 로고    scopus 로고
    • Neurogenic vasodilatation and plasma leakage in the skin
    • Holzer P. Neurogenic vasodilatation and plasma leakage in the skin. Gen. Pharmacol. 30 (1998) 5-11
    • (1998) Gen. Pharmacol. , vol.30 , pp. 5-11
    • Holzer, P.1
  • 5
    • 0027170885 scopus 로고
    • Nociception from skeletal muscle in relation to clinical muscle pain
    • Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain 54 (1993) 241-289
    • (1993) Pain , vol.54 , pp. 241-289
    • Mense, S.1
  • 6
    • 0033571905 scopus 로고    scopus 로고
    • Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin
    • Weidner C., Schmelz M., Schmidt R., Hansson B., Handwerker H.O., and Torebjörk H.E. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J. Neurosci. 19 (1999) 10184-10190
    • (1999) J. Neurosci. , vol.19 , pp. 10184-10190
    • Weidner, C.1    Schmelz, M.2    Schmidt, R.3    Hansson, B.4    Handwerker, H.O.5    Torebjörk, H.E.6
  • 7
    • 0033975763 scopus 로고    scopus 로고
    • Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres
    • Schmelz M., Schmidt R., Handwerker H.O., and Torebjörk H.E. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain 123 (2000) 560-571
    • (2000) Brain , vol.123 , pp. 560-571
    • Schmelz, M.1    Schmidt, R.2    Handwerker, H.O.3    Torebjörk, H.E.4
  • 8
    • 0035875701 scopus 로고    scopus 로고
    • Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors
    • Ringkamp M., Peng Y.B., Wu G., Hartke T.V., Campbell J.N., and Meyer R.A. Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors. J. Neurosci. 21 (2001) 4460-4468
    • (2001) J. Neurosci. , vol.21 , pp. 4460-4468
    • Ringkamp, M.1    Peng, Y.B.2    Wu, G.3    Hartke, T.V.4    Campbell, J.N.5    Meyer, R.A.6
  • 10
    • 0037824535 scopus 로고    scopus 로고
    • Central origin of secondary mechanical hyperalgesia
    • Klede M., Handwerker H.O., and Schmelz M. Central origin of secondary mechanical hyperalgesia. J. Neurophysiol. 90 (2003) 353-359
    • (2003) J. Neurophysiol. , vol.90 , pp. 353-359
    • Klede, M.1    Handwerker, H.O.2    Schmelz, M.3
  • 11
    • 0033571905 scopus 로고    scopus 로고
    • Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin
    • Weidner C., Schmelz M., Schmidt R., Hansson B., Handwerker H.O., and Torebjörk H.E. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J. Neurosci. 19 (1999) 10184-10190
    • (1999) J. Neurosci. , vol.19 , pp. 10184-10190
    • Weidner, C.1    Schmelz, M.2    Schmidt, R.3    Hansson, B.4    Handwerker, H.O.5    Torebjörk, H.E.6
  • 13
    • 3042645799 scopus 로고    scopus 로고
    • The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats
    • Bär K.J., Schurigt U., Scholze A., Segond V.B., Stopfel N., Bräuer R., Halbhuber K.J., and Schaible H.G. The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats. Neuroscience 127 (2004) 197-206
    • (2004) Neuroscience , vol.127 , pp. 197-206
    • Bär, K.J.1    Schurigt, U.2    Scholze, A.3    Segond, V.B.4    Stopfel, N.5    Bräuer, R.6    Halbhuber, K.J.7    Schaible, H.G.8
  • 15
    • 0035370726 scopus 로고    scopus 로고
    • Tonic control of peripheral cutaneous nociceptors by somatostatin receptors
    • Carlton S.M., Du J., Zhou S., and Coggeshall R.E. Tonic control of peripheral cutaneous nociceptors by somatostatin receptors. J. Neurosci. 21 (2001) 4042-4049
    • (2001) J. Neurosci. , vol.21 , pp. 4042-4049
    • Carlton, S.M.1    Du, J.2    Zhou, S.3    Coggeshall, R.E.4
  • 16
    • 0033521573 scopus 로고    scopus 로고
    • Peripheral application of cyclo-somatostatin, a somatostatin antagonist, increases the mechanosensitivity of rat knee joint afferents
    • Heppelmann B., and Pawlak M. Peripheral application of cyclo-somatostatin, a somatostatin antagonist, increases the mechanosensitivity of rat knee joint afferents. Neurosci. Lett. 259 (1999) 62-64
    • (1999) Neurosci. Lett. , vol.259 , pp. 62-64
    • Heppelmann, B.1    Pawlak, M.2
  • 17
    • 0035215495 scopus 로고    scopus 로고
    • B2 receptor-mediated enhanced bradykinin sensitivity of rat cutaneous C-fiber nociceptors during persistent inflammation
    • Banik R.K., Kozaki Y., Sato J., Gera L., and Mizumura K. B2 receptor-mediated enhanced bradykinin sensitivity of rat cutaneous C-fiber nociceptors during persistent inflammation. J. Neurophysiol. 86 (2001) 2727-2735
    • (2001) J. Neurophysiol. , vol.86 , pp. 2727-2735
    • Banik, R.K.1    Kozaki, Y.2    Sato, J.3    Gera, L.4    Mizumura, K.5
  • 18
    • 0037150753 scopus 로고    scopus 로고
    • Inflammation-induced up-regulation of neurokinin 1 receptors in rat glabrous skin
    • Carlton S.M., and Coggeshall R.E. Inflammation-induced up-regulation of neurokinin 1 receptors in rat glabrous skin. Neurosci. Lett. 326 (2002) 29-32
    • (2002) Neurosci. Lett. , vol.326 , pp. 29-32
    • Carlton, S.M.1    Coggeshall, R.E.2
  • 19
    • 0034468154 scopus 로고    scopus 로고
    • Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats
    • von Banchet G.S., Petrow P.K., Bräuer R., and Schaible H.G. Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats. Arthritis Res. 2 (2000) 424-427
    • (2000) Arthritis Res. , vol.2 , pp. 424-427
    • von Banchet, G.S.1    Petrow, P.K.2    Bräuer, R.3    Schaible, H.G.4
  • 20
    • 0028584437 scopus 로고
    • Peripheral and central mechanisms of NGF-induced hyperalgesia
    • Lewin G.R., Rueff A., and Mendell L.M. Peripheral and central mechanisms of NGF-induced hyperalgesia. Eur. J. Neurosci. 6 (1994) 1903-1912
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 1903-1912
    • Lewin, G.R.1    Rueff, A.2    Mendell, L.M.3
  • 21
    • 0038001946 scopus 로고    scopus 로고
    • Prostaglandin E2 increases the expression of the neurokinin1 receptor in adult sensory neurones in culture: a novel role of prostaglandins
    • Segond V.B., Scholze A., and Schaible H.G. Prostaglandin E2 increases the expression of the neurokinin1 receptor in adult sensory neurones in culture: a novel role of prostaglandins. Br. J. Pharmacol. 139 (2003) 672-680
    • (2003) Br. J. Pharmacol. , vol.139 , pp. 672-680
    • Segond, V.B.1    Scholze, A.2    Schaible, H.G.3
  • 22
    • 0033932306 scopus 로고    scopus 로고
    • Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain
    • Liu C.N., Michaelis M., Amir R., and Devor M. Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain. J. Neurophysiol. 84 (2000) 205-215
    • (2000) J. Neurophysiol. , vol.84 , pp. 205-215
    • Liu, C.N.1    Michaelis, M.2    Amir, R.3    Devor, M.4
  • 23
    • 0035872078 scopus 로고    scopus 로고
    • Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers
    • (art-RC137)
    • Wu G., Ringkamp M., Hartke T.V., Murinson B.B., Campbell J.N., Griffin J.W., and Meyer R.A. Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers. J. Neurosci. 21 (2001) (art-RC137)
    • (2001) J. Neurosci. , vol.21
    • Wu, G.1    Ringkamp, M.2    Hartke, T.V.3    Murinson, B.B.4    Campbell, J.N.5    Griffin, J.W.6    Meyer, R.A.7
  • 24
    • 0034589382 scopus 로고    scopus 로고
    • Sodium channels and the molecular pathophysiology of pain
    • Cummins T.R., Dib-Hajj S.D., Black J.A., and Waxman S.G. Sodium channels and the molecular pathophysiology of pain. Prog. Brain Res. 129 3-19 (2000) 3-19
    • (2000) Prog. Brain Res. , vol.129 , Issue.3-19 , pp. 3-19
    • Cummins, T.R.1    Dib-Hajj, S.D.2    Black, J.A.3    Waxman, S.G.4
  • 26
    • 0030447315 scopus 로고    scopus 로고
    • Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma
    • Jänig W., Levine J.D., and Michaelis M. Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma. Prog. Brain Res. 113 (1996) 161-184
    • (1996) Prog. Brain Res. , vol.113 , pp. 161-184
    • Jänig, W.1    Levine, J.D.2    Michaelis, M.3
  • 28
    • 0002892160 scopus 로고    scopus 로고
    • The perception of pain
    • Kandell E.R., and Jessel T.M. (Eds), Mc Graw-Hill, New York
    • Basbaum A.I., and Jessell T.M. The perception of pain. In: Kandell E.R., and Jessel T.M. (Eds). Principles of Neural Science (1999), Mc Graw-Hill, New York 472-491
    • (1999) Principles of Neural Science , pp. 472-491
    • Basbaum, A.I.1    Jessell, T.M.2
  • 29
    • 0021014399 scopus 로고
    • Evidence for a central component of post-injury pain hypersensitivity
    • Woolf C.J. Evidence for a central component of post-injury pain hypersensitivity. Nature 306 (1983) 686-688
    • (1983) Nature , vol.306 , pp. 686-688
    • Woolf, C.J.1
  • 31
    • 0031810935 scopus 로고    scopus 로고
    • Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury
    • Sandkuhler J., and Liu X. Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury. Eur. J Neurosci. 10 (1998) 2476-2480
    • (1998) Eur. J Neurosci. , vol.10 , pp. 2476-2480
    • Sandkuhler, J.1    Liu, X.2
  • 32
    • 0020044719 scopus 로고
    • Somatic responses of ventrobasal thalamic neurones in polyarthritic rats
    • Gautron M., and Guilbaud G. Somatic responses of ventrobasal thalamic neurones in polyarthritic rats. Brain Res. 237 (1982) 459-471
    • (1982) Brain Res. , vol.237 , pp. 459-471
    • Gautron, M.1    Guilbaud, G.2
  • 33
    • 0020606134 scopus 로고
    • Altered properties and laminar distribution of neuronal responses to peripheral stimulation in the SmI cortex of the arthritic rat
    • Lamour Y., Guilbaud G., and Willer J.C. Altered properties and laminar distribution of neuronal responses to peripheral stimulation in the SmI cortex of the arthritic rat. Brain Res. 273 (1983) 183-187
    • (1983) Brain Res. , vol.273 , pp. 183-187
    • Lamour, Y.1    Guilbaud, G.2    Willer, J.C.3
  • 34
    • 9644279795 scopus 로고    scopus 로고
    • Descending control of persistent pain: inhibitory or facilitatory?
    • Vanegas H., and Schaible H.G. Descending control of persistent pain: inhibitory or facilitatory?. Brain Res. Rev. 46 (2004) 295-309
    • (2004) Brain Res. Rev. , vol.46 , pp. 295-309
    • Vanegas, H.1    Schaible, H.G.2
  • 35
    • 0035122546 scopus 로고    scopus 로고
    • Stage-dependent changes in the modulation of spinal nociceptive neuronal activity during the course of inflammation
    • Danziger N., Weil-Fugazza J., Le Bars D., and Bouhassira D. Stage-dependent changes in the modulation of spinal nociceptive neuronal activity during the course of inflammation. Eur. J. Neurosci. 13 (2001) 230-240
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 230-240
    • Danziger, N.1    Weil-Fugazza, J.2    Le Bars, D.3    Bouhassira, D.4
  • 36
    • 0035152963 scopus 로고    scopus 로고
    • Glutamate receptors and nociception: implications for the drug treatment of pain
    • Fundytus M.E. Glutamate receptors and nociception: implications for the drug treatment of pain. CNS Drugs 15 (2001) 29-58
    • (2001) CNS Drugs , vol.15 , pp. 29-58
    • Fundytus, M.E.1
  • 37
    • 0025104302 scopus 로고
    • Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes
    • Schaible H.G., Jarrott B., Hope P.J., and Duggan A.W. Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes. Brain Res. 529 (1990) 214-223
    • (1990) Brain Res. , vol.529 , pp. 214-223
    • Schaible, H.G.1    Jarrott, B.2    Hope, P.J.3    Duggan, A.W.4
  • 38
    • 0027987920 scopus 로고
    • Intraspinal release of immunoreactive calcitonin gene-related peptide during development of inflammation in the joint in vivo-a study with antibody microprobes in cat and rat
    • Schaible H.G., Freudenberger U., Neugebauer V., and Stiller R.U. Intraspinal release of immunoreactive calcitonin gene-related peptide during development of inflammation in the joint in vivo-a study with antibody microprobes in cat and rat. Neuroscience 62 (1994) 1293-1305
    • (1994) Neuroscience , vol.62 , pp. 1293-1305
    • Schaible, H.G.1    Freudenberger, U.2    Neugebauer, V.3    Stiller, R.U.4
  • 39
    • 0025027515 scopus 로고
    • Release and spread of immunoreactive neurokinin A in the cat spinal cord in a model of acute arthritis
    • Hope P.J., Jarrott B., Schaible H.G., Clarke R.W., and Duggan A.W. Release and spread of immunoreactive neurokinin A in the cat spinal cord in a model of acute arthritis. Brain Res. 533 (1990) 292-299
    • (1990) Brain Res. , vol.533 , pp. 292-299
    • Hope, P.J.1    Jarrott, B.2    Schaible, H.G.3    Clarke, R.W.4    Duggan, A.W.5
  • 40
    • 0028959583 scopus 로고
    • Involvement of substance P and neurokinin-1 receptors in the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint
    • Neugebauer V., Weiretter F., and Schaible H.G. Involvement of substance P and neurokinin-1 receptors in the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint. J. Neurophysiol. 73 (1995) 1574-1583
    • (1995) J. Neurophysiol. , vol.73 , pp. 1574-1583
    • Neugebauer, V.1    Weiretter, F.2    Schaible, H.G.3
  • 41
    • 0029879057 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide is involved in the spinal processing of mechanosensory input from the rat's knee joint and in the generation and maintenance of hyperexcitability of dorsal horn-neurons during development of acute inflammation
    • Neugebauer V., Rümenapp P., and Schaible H.G. Calcitonin gene-related peptide is involved in the spinal processing of mechanosensory input from the rat's knee joint and in the generation and maintenance of hyperexcitability of dorsal horn-neurons during development of acute inflammation. Neuroscience 71 (1996) 1095-1109
    • (1996) Neuroscience , vol.71 , pp. 1095-1109
    • Neugebauer, V.1    Rümenapp, P.2    Schaible, H.G.3
  • 42
    • 0030061488 scopus 로고    scopus 로고
    • The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat
    • Neugebauer V., Rümenapp P., and Schaible H.G. The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat. Eur. J. Neurosci. 8 (1996) 249-260
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 249-260
    • Neugebauer, V.1    Rümenapp, P.2    Schaible, H.G.3
  • 43
    • 0034718194 scopus 로고    scopus 로고
    • Differential effects of calcitonin gene-related peptide and calcitonin gene-related peptide 8-37 upon responses to N-methyl-D-aspartate or (R, S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate in spinal nociceptive neurons with knee joint input in the rat
    • Ebersberger A., Charbel I.P., Vanegas H., and Schaible H.G. Differential effects of calcitonin gene-related peptide and calcitonin gene-related peptide 8-37 upon responses to N-methyl-D-aspartate or (R, S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate in spinal nociceptive neurons with knee joint input in the rat. Neuroscience 99 (2000) 171-178
    • (2000) Neuroscience , vol.99 , pp. 171-178
    • Ebersberger, A.1    Charbel, I.P.2    Vanegas, H.3    Schaible, H.G.4
  • 44
    • 0027933184 scopus 로고
    • Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters
    • Urban L., Thompson S.W., and Dray A. Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters. Trends Neurosci. 17 (1994) 432-438
    • (1994) Trends Neurosci. , vol.17 , pp. 432-438
    • Urban, L.1    Thompson, S.W.2    Dray, A.3
  • 45
    • 0142105847 scopus 로고    scopus 로고
    • Painful neuropathies
    • Sommer C. Painful neuropathies. Curr. Opin. Neurol. 16 (2003) 623-628
    • (2003) Curr. Opin. Neurol. , vol.16 , pp. 623-628
    • Sommer, C.1
  • 46
    • 2342646193 scopus 로고    scopus 로고
    • Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia
    • Sommer C., and Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci. Lett. 361 (2004) 184-187
    • (2004) Neurosci. Lett. , vol.361 , pp. 184-187
    • Sommer, C.1    Kress, M.2
  • 47
    • 0038748399 scopus 로고    scopus 로고
    • Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain
    • Watkins L.R., Milligan E.D., and Maier S.F. Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv. Exp. Med. Biol. 521 1-21 (2003) 1-21
    • (2003) Adv. Exp. Med. Biol. , vol.521 , Issue.1-21 , pp. 1-21
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 50
    • 0031958705 scopus 로고    scopus 로고
    • Chronic pain
    • Russo C.M., and Brose W.G. Chronic pain. Annu. Rev. Med. 49 123-33 (1998) 123-133
    • (1998) Annu. Rev. Med. , vol.49 , Issue.123-33 , pp. 123-133
    • Russo, C.M.1    Brose, W.G.2
  • 51
    • 0033606449 scopus 로고    scopus 로고
    • Suffering: the contributions of persistent pain
    • Chapman C.R., and Gavrin J. Suffering: the contributions of persistent pain. Lancet 353 (1999) 2233-2237
    • (1999) Lancet , vol.353 , pp. 2233-2237
    • Chapman, C.R.1    Gavrin, J.2
  • 52
    • 0033373625 scopus 로고    scopus 로고
    • Psychosocial approaches to the prevention of chronic pain: the low back paradigm, Baillieres Best
    • Kendall N.A. Psychosocial approaches to the prevention of chronic pain: the low back paradigm, Baillieres Best. Pract. Res. Clin. Rheumatol. 13 (1999) 545-554
    • (1999) Pract. Res. Clin. Rheumatol. , vol.13 , pp. 545-554
    • Kendall, N.A.1
  • 53
    • 0036255649 scopus 로고    scopus 로고
    • Painful memories. Can we train chronic pain patients to 'forget' their pain?
    • Flor H. Painful memories. Can we train chronic pain patients to 'forget' their pain?. EMBO Rep. 3 (2002) 288-291
    • (2002) EMBO Rep. , vol.3 , pp. 288-291
    • Flor, H.1
  • 54
    • 0036149127 scopus 로고    scopus 로고
    • The role of operant conditioning in chronic pain: an experimental investigation
    • Flor H., Knost B., and Birbaumer N. The role of operant conditioning in chronic pain: an experimental investigation. Pain 95 (2002) 111-118
    • (2002) Pain , vol.95 , pp. 111-118
    • Flor, H.1    Knost, B.2    Birbaumer, N.3
  • 55
    • 0037975534 scopus 로고    scopus 로고
    • Operant behavioral treatment of fibromyalgia: a controlled study
    • Thieme K., Gromnica-Ihle E., and Flor H. Operant behavioral treatment of fibromyalgia: a controlled study. Arthritis Rheum. 49 (2003) 314-320
    • (2003) Arthritis Rheum. , vol.49 , pp. 314-320
    • Thieme, K.1    Gromnica-Ihle, E.2    Flor, H.3
  • 56
    • 0023750480 scopus 로고
    • Excitation and sensitization of fine articular afferents from cat's knee joint by prostaglandin E2
    • Schaible H.G., and Schmidt R.F. Excitation and sensitization of fine articular afferents from cat's knee joint by prostaglandin E2. J. Physiol. 403 91-104 (1988) 91-104
    • (1988) J. Physiol. , vol.403 , Issue.91-104 , pp. 91-104
    • Schaible, H.G.1    Schmidt, R.F.2
  • 57
    • 0028949218 scopus 로고
    • Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats
    • Malmberg A.B., and Yaksh T.L. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. J. Neurosci. 15 (1995) 2768-2776
    • (1995) J. Neurosci. , vol.15 , pp. 2768-2776
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 58
  • 59
    • 0025471841 scopus 로고
    • Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord
    • Woolf C.J., and King A.E. Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord. J. Neurosci. 10 (1990) 2717-2726
    • (1990) J. Neurosci. , vol.10 , pp. 2717-2726
    • Woolf, C.J.1    King, A.E.2
  • 60
    • 0026612750 scopus 로고
    • Prostaglandin E2 increases calcium conductance and stimulates release of substance P in avian sensory neurons
    • Nicol G.D., Klingberg D.K., and Vasko M.R. Prostaglandin E2 increases calcium conductance and stimulates release of substance P in avian sensory neurons. J. Neurosci. 12 (1992) 1917-1927
    • (1992) J. Neurosci. , vol.12 , pp. 1917-1927
    • Nicol, G.D.1    Klingberg, D.K.2    Vasko, M.R.3
  • 61
    • 0029023042 scopus 로고
    • Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3′,5′-cyclic monophosphate transduction cascade
    • Hingtgen C.M., Waite K.J., and Vasko M.R. Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3′,5′-cyclic monophosphate transduction cascade. J. Neurosci. 15 (1995) 5411-5419
    • (1995) J. Neurosci. , vol.15 , pp. 5411-5419
    • Hingtgen, C.M.1    Waite, K.J.2    Vasko, M.R.3
  • 63
    • 0036139423 scopus 로고    scopus 로고
    • PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons
    • Ahmadi S., Lippross S., Neuhuber W.L., and Zeilhofer H.U. PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat. Neurosci. 5 (2002) 34-40
    • (2002) Nat. Neurosci. , vol.5 , pp. 34-40
    • Ahmadi, S.1    Lippross, S.2    Neuhuber, W.L.3    Zeilhofer, H.U.4
  • 64
    • 0035283195 scopus 로고    scopus 로고
    • Direct activation of rat spinal dorsal horn neurons by prostaglandin E2
    • Baba H., Kohno T., Moore K.A., and Woolf C.J. Direct activation of rat spinal dorsal horn neurons by prostaglandin E2. J. Neurosci. 21 (2001) 1750-1756
    • (2001) J. Neurosci. , vol.21 , pp. 1750-1756
    • Baba, H.1    Kohno, T.2    Moore, K.A.3    Woolf, C.J.4
  • 65
    • 0031028391 scopus 로고    scopus 로고
    • Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons
    • Nicol G.D., Vasko M.R., and Evans A.R. Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons. J. Neurophysiol. 77 (1997) 167-176
    • (1997) J. Neurophysiol. , vol.77 , pp. 167-176
    • Nicol, G.D.1    Vasko, M.R.2    Evans, A.R.3
  • 66
    • 0033118638 scopus 로고    scopus 로고
    • The cAMP transduction cascade mediates the PGE2-induced inhibition of potassium currents in rat sensory neurones
    • Evans A.R., Vasko M.R., and Nicol G.D. The cAMP transduction cascade mediates the PGE2-induced inhibition of potassium currents in rat sensory neurones. J. Physiol. 516 (1999) 163-178
    • (1999) J. Physiol. , vol.516 , pp. 163-178
    • Evans, A.R.1    Vasko, M.R.2    Nicol, G.D.3
  • 67
    • 0032516793 scopus 로고    scopus 로고
    • Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord
    • Beiche F., Klein T., Nusing R., Neuhuber W., and Goppelt-Struebe M. Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord. J. Neuroimmunol. 89 (1998) 26-34
    • (1998) J. Neuroimmunol. , vol.89 , pp. 26-34
    • Beiche, F.1    Klein, T.2    Nusing, R.3    Neuhuber, W.4    Goppelt-Struebe, M.5
  • 68
    • 0034753651 scopus 로고    scopus 로고
    • Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice
    • Minami T., Nakano H., Kobayashi T., Sugimoto Y., Ushikubi F., Ichikawa A., Narumiya S., and Ito S. Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. Br. J. Pharmacol. 133 (2001) 438-444
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 438-444
    • Minami, T.1    Nakano, H.2    Kobayashi, T.3    Sugimoto, Y.4    Ushikubi, F.5    Ichikawa, A.6    Narumiya, S.7    Ito, S.8
  • 69
    • 0037220693 scopus 로고    scopus 로고
    • The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans
    • Sarkar S., Hobson A.R., Hughes A., Growcott J., Woolf C.J., Thompson D.G., and Aziz Q. The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans. Gastroenterology 124 (2003) 18-25
    • (2003) Gastroenterology , vol.124 , pp. 18-25
    • Sarkar, S.1    Hobson, A.R.2    Hughes, A.3    Growcott, J.4    Woolf, C.J.5    Thompson, D.G.6    Aziz, Q.7
  • 71
    • 0037148136 scopus 로고    scopus 로고
    • Central nociceptive role of prostacyclin (IP) receptor induced by peripheral inflammation
    • Doi Y., Minami T., Nishizawa M., Mabuchi T., Mori H., and Ito S. Central nociceptive role of prostacyclin (IP) receptor induced by peripheral inflammation. NeuroReport 13 (2002) 93-96
    • (2002) NeuroReport , vol.13 , pp. 93-96
    • Doi, Y.1    Minami, T.2    Nishizawa, M.3    Mabuchi, T.4    Mori, H.5    Ito, S.6
  • 73
    • 0037817373 scopus 로고    scopus 로고
    • Functional characterization of prostaglandin F2alpha receptor in the spinal cord for tactile pain (allodynia)
    • Muratani T., Nishizawa M., Matsumura S., Mabuchi T., Abe K., Shimamoto K., Minami T., and Ito S. Functional characterization of prostaglandin F2alpha receptor in the spinal cord for tactile pain (allodynia). J. Neurochem. 86 (2003) 374-382
    • (2003) J. Neurochem. , vol.86 , pp. 374-382
    • Muratani, T.1    Nishizawa, M.2    Matsumura, S.3    Mabuchi, T.4    Abe, K.5    Shimamoto, K.6    Minami, T.7    Ito, S.8
  • 74
    • 0842284041 scopus 로고    scopus 로고
    • Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint
    • Bär K.J., Natura G., Telleria-Diaz A., Teschner P., Vogel R., Vasquez E., Schaible H.G., and Ebersberger A. Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint. J. Neurosci. 24 (2004) 642-651
    • (2004) J. Neurosci. , vol.24 , pp. 642-651
    • Bär, K.J.1    Natura, G.2    Telleria-Diaz, A.3    Teschner, P.4    Vogel, R.5    Vasquez, E.6    Schaible, H.G.7    Ebersberger, A.8
  • 75
    • 0343415083 scopus 로고    scopus 로고
    • Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and-independent inhibition of cytokine-induced inducible nitric oxide synthase expression
    • Maggi Jr. L.B., Sadeghi H., Weigand C., Scarim A.L., Heitmeier M.R., and Corbett J.A. Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and-independent inhibition of cytokine-induced inducible nitric oxide synthase expression. Diabetes 49 (2000) 346-355
    • (2000) Diabetes , vol.49 , pp. 346-355
    • Maggi Jr., L.B.1    Sadeghi, H.2    Weigand, C.3    Scarim, A.L.4    Heitmeier, M.R.5    Corbett, J.A.6
  • 76
    • 0034809490 scopus 로고    scopus 로고
    • Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2
    • Tsubouchi Y., Kawahito Y., Kohno M., Inoue K., Hla T., and Sano H. Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. Biochem. Biophys. Res. Commun. 283 (2001) 750-755
    • (2001) Biochem. Biophys. Res. Commun. , vol.283 , pp. 750-755
    • Tsubouchi, Y.1    Kawahito, Y.2    Kohno, M.3    Inoue, K.4    Hla, T.5    Sano, H.6
  • 77
    • 10144226439 scopus 로고    scopus 로고
    • 15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways
    • Boyault S., Simonin M.A., Bianchi A., Compe E., Liagre B., Mainard D., Becuwe P., Dauca M., Netter P., Terlain B., and Bordji K. 15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways. FEBS Lett. 501 (2001) 24-30
    • (2001) FEBS Lett. , vol.501 , pp. 24-30
    • Boyault, S.1    Simonin, M.A.2    Bianchi, A.3    Compe, E.4    Liagre, B.5    Mainard, D.6    Becuwe, P.7    Dauca, M.8    Netter, P.9    Terlain, B.10    Bordji, K.11
  • 82
    • 0028361631 scopus 로고
    • The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat
    • Meller S.T., Cummings C.P., Traub R.J., and Gebhart G.F. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat. Neuroscience 60 (1994) 367-374
    • (1994) Neuroscience , vol.60 , pp. 367-374
    • Meller, S.T.1    Cummings, C.P.2    Traub, R.J.3    Gebhart, G.F.4
  • 83
    • 0027502194 scopus 로고
    • Nitric oxide (NO) and nociceptive processing in the spinal cord
    • Meller S.T., and Gebhart G.F. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 52 (1993) 127-136
    • (1993) Pain , vol.52 , pp. 127-136
    • Meller, S.T.1    Gebhart, G.F.2
  • 84
    • 13944259105 scopus 로고    scopus 로고
    • Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs
    • Whittle B.J. Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs. Curr. Opin. Pharmacol. 4 (2004) 538-545
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 538-545
    • Whittle, B.J.1
  • 87
    • 0033865189 scopus 로고    scopus 로고
    • Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity
    • al Swayeh O.A., Futter L.E., Clifford R.H., and Moore P.K. Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity. Br. J. Pharmacol. 130 (2000) 1453-1456
    • (2000) Br. J. Pharmacol. , vol.130 , pp. 1453-1456
    • al Swayeh, O.A.1    Futter, L.E.2    Clifford, R.H.3    Moore, P.K.4
  • 88
    • 0033960353 scopus 로고    scopus 로고
    • A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin
    • al Swayeh O.A., Clifford R.H., Del Soldato P., and Moore P.K. A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin. Br. J. Pharmacol. 129 (2000) 343-350
    • (2000) Br. J. Pharmacol. , vol.129 , pp. 343-350
    • al Swayeh, O.A.1    Clifford, R.H.2    Del Soldato, P.3    Moore, P.K.4
  • 89
    • 0036214807 scopus 로고    scopus 로고
    • NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up
    • Romero-Sandoval E.A., Mazario J., Howat D., and Herrero J.F. NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up. Br. J. Pharmacol. 135 (2002) 1556-1562
    • (2002) Br. J. Pharmacol. , vol.135 , pp. 1556-1562
    • Romero-Sandoval, E.A.1    Mazario, J.2    Howat, D.3    Herrero, J.F.4
  • 90
    • 0036791714 scopus 로고    scopus 로고
    • Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs
    • Keeble J.E., and Moore P.K. Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs. Br. J. Pharmacol. 137 (2002) 295-310
    • (2002) Br. J. Pharmacol. , vol.137 , pp. 295-310
    • Keeble, J.E.1    Moore, P.K.2
  • 92
    • 0038718727 scopus 로고    scopus 로고
    • Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lip ooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin
    • Fiorucci S., Distrutti E., de Lima O.M., Romano M., Mencarelli A., Barbanti M., Palazzini E., Morelli A., and Wallace J.L. Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lip ooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB J. 17 (2003) 1171-1173
    • (2003) FASEB J. , vol.17 , pp. 1171-1173
    • Fiorucci, S.1    Distrutti, E.2    de Lima, O.M.3    Romano, M.4    Mencarelli, A.5    Barbanti, M.6    Palazzini, E.7    Morelli, A.8    Wallace, J.L.9
  • 93
    • 0034863527 scopus 로고    scopus 로고
    • Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis
    • Gay R.E., Neidhart M., Pataky F., Tries S., Laufer S., and Gay S. Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis. J. Rheumatol. 28 (2001) 2060-2065
    • (2001) J. Rheumatol. , vol.28 , pp. 2060-2065
    • Gay, R.E.1    Neidhart, M.2    Pataky, F.3    Tries, S.4    Laufer, S.5    Gay, S.6
  • 94
    • 0034757607 scopus 로고    scopus 로고
    • In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis
    • Jovanovic D.V., Fernandes J.C., Martel-Pelletier J., Jolicoeur F.C., Reboul P., Laufer S., Tries S., and Pelletier J.P. In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis. Arthritis Rheum. 44 (2001) 2320-2330
    • (2001) Arthritis Rheum. , vol.44 , pp. 2320-2330
    • Jovanovic, D.V.1    Fernandes, J.C.2    Martel-Pelletier, J.3    Jolicoeur, F.C.4    Reboul, P.5    Laufer, S.6    Tries, S.7    Pelletier, J.P.8
  • 95
    • 0347320523 scopus 로고    scopus 로고
    • Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis
    • Lajeunesse D., Martel-Pelletier J., Fernandes J.C., Laufer S., and Pelletier J.P. Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis. Ann. Rheum. Dis. 63 (2004) 78-83
    • (2004) Ann. Rheum. Dis. , vol.63 , pp. 78-83
    • Lajeunesse, D.1    Martel-Pelletier, J.2    Fernandes, J.C.3    Laufer, S.4    Pelletier, J.P.5
  • 96
    • 1542286076 scopus 로고    scopus 로고
    • The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K
    • Pelletier J.P., Boileau C., Brunet J., Boily M., Lajeunesse D., Reboul P., Laufer S., and Martel-Pelletier J. The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone 34 (2004) 527-538
    • (2004) Bone , vol.34 , pp. 527-538
    • Pelletier, J.P.1    Boileau, C.2    Brunet, J.3    Boily, M.4    Lajeunesse, D.5    Reboul, P.6    Laufer, S.7    Martel-Pelletier, J.8
  • 97
    • 2342496237 scopus 로고    scopus 로고
    • The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial
    • Bias P., Buchner A., Klesser B., and Laufer S. The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial. Am. J. Gastroenterol. 99 (2004) 611-618
    • (2004) Am. J. Gastroenterol. , vol.99 , pp. 611-618
    • Bias, P.1    Buchner, A.2    Klesser, B.3    Laufer, S.4
  • 98
    • 0021842526 scopus 로고
    • Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation
    • Kobal G. Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation. Pain 22 (1985) 151-163
    • (1985) Pain , vol.22 , pp. 151-163
    • Kobal, G.1
  • 100
    • 0023550490 scopus 로고
    • Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat
    • Stein C., Millan M.J., Shippenberg T.S., and Herz A. Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat. Neurosci. Lett. 84 (1988) 225-228
    • (1988) Neurosci. Lett. , vol.84 , pp. 225-228
    • Stein, C.1    Millan, M.J.2    Shippenberg, T.S.3    Herz, A.4
  • 101
    • 0024506818 scopus 로고
    • Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors
    • Stein C., Millan M.J., Shippenberg T.S., Peter K., and Herz A. Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors. J. Pharmacol. Exp. Ther. 248 (1989) 1269-1275
    • (1989) J. Pharmacol. Exp. Ther. , vol.248 , pp. 1269-1275
    • Stein, C.1    Millan, M.J.2    Shippenberg, T.S.3    Peter, K.4    Herz, A.5
  • 102
    • 0025308436 scopus 로고
    • Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis
    • Parsons C.G., Czlonkowski A., Stein C., and Herz A. Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis. Pain 41 (1990) 81-93
    • (1990) Pain , vol.41 , pp. 81-93
    • Parsons, C.G.1    Czlonkowski, A.2    Stein, C.3    Herz, A.4
  • 103
    • 0024316834 scopus 로고
    • Involvement of the mu-opiate receptor in peripheral analgesia
    • Levine J.D., and Taiwo Y.O. Involvement of the mu-opiate receptor in peripheral analgesia. Neuroscience 32 (1989) 571-575
    • (1989) Neuroscience , vol.32 , pp. 571-575
    • Levine, J.D.1    Taiwo, Y.O.2
  • 104
    • 0030438459 scopus 로고    scopus 로고
    • Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance
    • Kolesnikov Y.A., Jain S., Wilson R., and Pasternak G.W. Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance. J. Pharmacol. Exp. Ther. 279 (1996) 502-506
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 502-506
    • Kolesnikov, Y.A.1    Jain, S.2    Wilson, R.3    Pasternak, G.W.4
  • 105
    • 0032835880 scopus 로고    scopus 로고
    • Effects of intraplantar morphine on paw edema and pain-related behaviour in a rat model of repeated acute inflammation
    • Perrot S., Guilbaud G., and Kayser V. Effects of intraplantar morphine on paw edema and pain-related behaviour in a rat model of repeated acute inflammation. Pain 83 (1999) 249-257
    • (1999) Pain , vol.83 , pp. 249-257
    • Perrot, S.1    Guilbaud, G.2    Kayser, V.3
  • 106
    • 0027221843 scopus 로고
    • Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue
    • Hassan A.H., Ableitner A., Stein C., and Herz A. Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue. Neuroscience 55 (1993) 185-195
    • (1993) Neuroscience , vol.55 , pp. 185-195
    • Hassan, A.H.1    Ableitner, A.2    Stein, C.3    Herz, A.4
  • 107
    • 0029047619 scopus 로고
    • Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia
    • Schäfer M., Imai Y., Uhl G.R., and Stein C. Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia. Eur. J. Pharmacol. 279 (1995) 165-169
    • (1995) Eur. J. Pharmacol. , vol.279 , pp. 165-169
    • Schäfer, M.1    Imai, Y.2    Uhl, G.R.3    Stein, C.4
  • 109
    • 0035795077 scopus 로고    scopus 로고
    • Beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue
    • Mousa S.A., Zhang Q., Sitte N., Ji R., and Stein C. Beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. J. Neuroimmunol. 115 (2001) 71-78
    • (2001) J. Neuroimmunol. , vol.115 , pp. 71-78
    • Mousa, S.A.1    Zhang, Q.2    Sitte, N.3    Ji, R.4    Stein, C.5
  • 110
    • 3142708596 scopus 로고    scopus 로고
    • Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue
    • Binder W., Mousa S.A., Sitte N., Kaiser M., Stein C., and Schäfer M. Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue. Eur. J. Neurosci. 20 (2004) 92-100
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 92-100
    • Binder, W.1    Mousa, S.A.2    Sitte, N.3    Kaiser, M.4    Stein, C.5    Schäfer, M.6
  • 112
    • 0029892848 scopus 로고    scopus 로고
    • Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia
    • Schäfer M., Mousa S.A., Zhang Q., Carter L., and Stein C. Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 6096-6100
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 6096-6100
    • Schäfer, M.1    Mousa, S.A.2    Zhang, Q.3    Carter, L.4    Stein, C.5
  • 113
    • 0343145704 scopus 로고    scopus 로고
    • Corticotropin-releasing factor in antinociception and inflammation
    • Schäfer M., Mousa S.A., and Stein C. Corticotropin-releasing factor in antinociception and inflammation. Eur. J. Pharmacol. 323 (1997) 1-10
    • (1997) Eur. J. Pharmacol. , vol.323 , pp. 1-10
    • Schäfer, M.1    Mousa, S.A.2    Stein, C.3
  • 114
    • 0034900301 scopus 로고    scopus 로고
    • Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain
    • Rittner H.L., Brack A., Machelska H., Mousa S.A., Bauer M., Schäfer M., and Stein C. Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain. Anesthesiology 95 (2001) 500-508
    • (2001) Anesthesiology , vol.95 , pp. 500-508
    • Rittner, H.L.1    Brack, A.2    Machelska, H.3    Mousa, S.A.4    Bauer, M.5    Schäfer, M.6    Stein, C.7
  • 117
    • 0030903963 scopus 로고    scopus 로고
    • The effect of tourniquet release time on the analgesic efficacy of intraarticular morphine after arthroscopic knee surgery
    • Whitford A., Healy M., Joshi G.P., McCarroll S.M., and O'Brien T.M. The effect of tourniquet release time on the analgesic efficacy of intraarticular morphine after arthroscopic knee surgery. Anesth. Analg. 84 (1997) 791-793
    • (1997) Anesth. Analg. , vol.84 , pp. 791-793
    • Whitford, A.1    Healy, M.2    Joshi, G.P.3    McCarroll, S.M.4    O'Brien, T.M.5
  • 118
    • 0027534401 scopus 로고
    • Intra-articular morphine for pain relief after anterior cruciate ligament repair
    • Joshi G.P., McCarroll S.M., Brady O.H., Hurson B.J., and Walsh G. Intra-articular morphine for pain relief after anterior cruciate ligament repair. Br. J. Anaesth. 70 (1993) 87-88
    • (1993) Br. J. Anaesth. , vol.70 , pp. 87-88
    • Joshi, G.P.1    McCarroll, S.M.2    Brady, O.H.3    Hurson, B.J.4    Walsh, G.5
  • 120
    • 0027302392 scopus 로고
    • Analgesia following arthroscopic knee surgery. A controlled study of intra-articular morphine, bupivacaine or both combined
    • McSwiney M.M., Joshi G.P., Kenny P., and McCarroll S.M. Analgesia following arthroscopic knee surgery. A controlled study of intra-articular morphine, bupivacaine or both combined. Anaesth. Intensive Care 21 (1993) 201-203
    • (1993) Anaesth. Intensive Care , vol.21 , pp. 201-203
    • McSwiney, M.M.1    Joshi, G.P.2    Kenny, P.3    McCarroll, S.M.4
  • 122
    • 0037110614 scopus 로고    scopus 로고
    • Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma
    • Cerchietti L.C., Navigante A.H., Bonomi M.R., Zaderajko M.A., Menendez P.R., Pogany C.E., and Roth B.M. Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer 95 (2002) 2230-2236
    • (2002) Cancer , vol.95 , pp. 2230-2236
    • Cerchietti, L.C.1    Navigante, A.H.2    Bonomi, M.R.3    Zaderajko, M.A.4    Menendez, P.R.5    Pogany, C.E.6    Roth, B.M.7
  • 126
    • 15844414166 scopus 로고    scopus 로고
    • Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw
    • Romero A., Planas E., Poveda R., Sanchez S., Pol O., and Puig M.M. Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw. Eur. J. Pharmacol. 511 (2005) 207-217
    • (2005) Eur. J. Pharmacol. , vol.511 , pp. 207-217
    • Romero, A.1    Planas, E.2    Poveda, R.3    Sanchez, S.4    Pol, O.5    Puig, M.M.6
  • 128
    • 17144401168 scopus 로고    scopus 로고
    • Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice
    • Tham S.M., Angus J.A., Tudor E.M., and Wright C.E. Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice. Br. J. Pharmacol. 144 (2005) 875-884
    • (2005) Br. J. Pharmacol. , vol.144 , pp. 875-884
    • Tham, S.M.1    Angus, J.A.2    Tudor, E.M.3    Wright, C.E.4
  • 129
    • 0031776783 scopus 로고    scopus 로고
    • The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain
    • Jaggar S.I., Hasnie F.S., Sellaturay S., and Rice A.S. The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. Pain 76 (1998) 189-199
    • (1998) Pain , vol.76 , pp. 189-199
    • Jaggar, S.I.1    Hasnie, F.S.2    Sellaturay, S.3    Rice, A.S.4
  • 130
    • 0035840818 scopus 로고    scopus 로고
    • HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test
    • Gühring H., Schuster J., Hamza M., Ates M., Kotalla C.E., and Brune K. HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test. Eur. J. Pharmacol. 429 (2001) 127-134
    • (2001) Eur. J. Pharmacol. , vol.429 , pp. 127-134
    • Gühring, H.1    Schuster, J.2    Hamza, M.3    Ates, M.4    Kotalla, C.E.5    Brune, K.6
  • 131
    • 0141738711 scopus 로고    scopus 로고
    • Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats
    • Lim G., Sung B., Ji R.R., and Mao J. Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. Pain 105 (2003) 275-283
    • (2003) Pain , vol.105 , pp. 275-283
    • Lim, G.1    Sung, B.2    Ji, R.R.3    Mao, J.4
  • 132
    • 1842685334 scopus 로고    scopus 로고
    • Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat
    • Scott D.A., Wright C.E., and Angus J.A. Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat. Pain 109 (2004) 124-131
    • (2004) Pain , vol.109 , pp. 124-131
    • Scott, D.A.1    Wright, C.E.2    Angus, J.A.3
  • 133
    • 1242296234 scopus 로고    scopus 로고
    • Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain
    • Costa B., Colleoni M., Conti S., Trovato A.E., Bianchi M., Sotgiu M.L., and Giagnoni G. Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain. Br. J. Pharmacol. 141 (2004) 4-8
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 4-8
    • Costa, B.1    Colleoni, M.2    Conti, S.3    Trovato, A.E.4    Bianchi, M.5    Sotgiu, M.L.6    Giagnoni, G.7
  • 134
    • 2942579681 scopus 로고    scopus 로고
    • The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat
    • Cox M.L., and Welch S.P. The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat. Eur. J. Pharmacol. 493 (2004) 65-74
    • (2004) Eur. J. Pharmacol. , vol.493 , pp. 65-74
    • Cox, M.L.1    Welch, S.P.2
  • 135
    • 1542283741 scopus 로고    scopus 로고
    • A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
    • Sumariwalla P.F., Gallily R., Tchilibon S., Fride E., Mechoulam R., and Feldmann M. A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. Arthritis Rheum. 50 (2004) 985-998
    • (2004) Arthritis Rheum. , vol.50 , pp. 985-998
    • Sumariwalla, P.F.1    Gallily, R.2    Tchilibon, S.3    Fride, E.4    Mechoulam, R.5    Feldmann, M.6
  • 136
    • 0035112856 scopus 로고    scopus 로고
    • Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints
    • Gauldie S.D., McQueen D.S., Pertwee R., and Chessell I.P. Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints. Br. J. Pharmacol. 132 (2001) 617-621
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 617-621
    • Gauldie, S.D.1    McQueen, D.S.2    Pertwee, R.3    Chessell, I.P.4
  • 138
    • 12744258068 scopus 로고    scopus 로고
    • Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage
    • Mbvundula E.C., Bunning R.A., and Rainsford K.D. Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage. Biochem. Pharmacol. 69 (2005) 635-640
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 635-640
    • Mbvundula, E.C.1    Bunning, R.A.2    Rainsford, K.D.3
  • 140
    • 0031779305 scopus 로고    scopus 로고
    • Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
    • Richardson J.D., Kilo S., and Hargreaves K.M. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75 (1998) 111-119
    • (1998) Pain , vol.75 , pp. 111-119
    • Richardson, J.D.1    Kilo, S.2    Hargreaves, K.M.3
  • 141
    • 8144229133 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naive rats and in rat models of inflammatory and neuropathic pain
    • Elmes S.J., Jhaveri M.D., Smart D., Kendall D.A., and Chapman V. Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naive rats and in rat models of inflammatory and neuropathic pain. Eur. J. Neurosci. 20 (2004) 2311-2320
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 2311-2320
    • Elmes, S.J.1    Jhaveri, M.D.2    Smart, D.3    Kendall, D.A.4    Chapman, V.5
  • 143
    • 8644274638 scopus 로고    scopus 로고
    • Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation
    • Nackley A.G., Zvonok A.M., Makriyannis A., and Hohmann A.G. Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. J. Neurophysiol. 92 (2004) 3562-3574
    • (2004) J. Neurophysiol. , vol.92 , pp. 3562-3574
    • Nackley, A.G.1    Zvonok, A.M.2    Makriyannis, A.3    Hohmann, A.G.4
  • 144
    • 4043096916 scopus 로고    scopus 로고
    • Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial
    • Svendsen K.B., Jensen T.S., and Bach F.W. Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial. BMJ 329 (2004) 253
    • (2004) BMJ , vol.329 , pp. 253
    • Svendsen, K.B.1    Jensen, T.S.2    Bach, F.W.3
  • 145
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • Auphan N., DiDonato J.A., Rosette C., Helmberg A., and Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270 (1995) 286-290
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    DiDonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 149
    • 0029836444 scopus 로고    scopus 로고
    • Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice
    • Neurath M.F., Pettersson S., Meyer zum Büschenfelde K.H., and Strober W. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat. Med. 2 (1996) 998-1004
    • (1996) Nat. Med. , vol.2 , pp. 998-1004
    • Neurath, M.F.1    Pettersson, S.2    Meyer zum Büschenfelde, K.H.3    Strober, W.4
  • 150
    • 0028167846 scopus 로고
    • Inhibition of NF-kappa B by sodium salicylate and aspirin
    • Kopp E., and Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265 (1994) 956-959
    • (1994) Science , vol.265 , pp. 956-959
    • Kopp, E.1    Ghosh, S.2
  • 151
    • 4444306858 scopus 로고    scopus 로고
    • The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis
    • Dai S., Hirayama T., Abbas S., and Abu-Amer Y. The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J. Biol. Chem. 279 (2004) 37219-37222
    • (2004) J. Biol. Chem. , vol.279 , pp. 37219-37222
    • Dai, S.1    Hirayama, T.2    Abbas, S.3    Abu-Amer, Y.4
  • 154
  • 155
    • 0029670083 scopus 로고    scopus 로고
    • Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
    • DiDonato J., Mercurio F., Rosette C., Wu-Li J., Suyang H., Ghosh S., and Karin M. Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16 (1996) 1295-1304
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1295-1304
    • DiDonato, J.1    Mercurio, F.2    Rosette, C.3    Wu-Li, J.4    Suyang, H.5    Ghosh, S.6    Karin, M.7
  • 157
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin Y.Z., Yao S.Y., Veach R.A., Torgerson T.R., and Hawiger J. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem. 270 (1995) 14255-14258
    • (1995) J. Biol. Chem. , vol.270 , pp. 14255-14258
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3    Torgerson, T.R.4    Hawiger, J.5
  • 158
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18 (1999) 6853-6866
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 159
    • 0032575379 scopus 로고    scopus 로고
    • Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate
    • Zandi E., Chen Y., and Karin M. Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science 281 (1998) 1360-1363
    • (1998) Science , vol.281 , pp. 1360-1363
    • Zandi, E.1    Chen, Y.2    Karin, M.3
  • 161
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
    • DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., and Karin M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388 (1997) 548-554
    • (1997) Nature , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 162
    • 0032541657 scopus 로고    scopus 로고
    • IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
    • Rothwarf D.M., Zandi E., Natoli G., and Karin M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 395 (1998) 297-300
    • (1998) Nature , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3    Karin, M.4
  • 163
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    • Delhase M., Hayakawa M., Chen Y., and Karin M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284 (1999) 309-313
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 164
    • 0034120712 scopus 로고    scopus 로고
    • Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase
    • Jeon K.I., Jeong J.Y., and Jue D.M. Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase. J. Immunol. 164 (2000) 5981-5989
    • (2000) J. Immunol. , vol.164 , pp. 5981-5989
    • Jeon, K.I.1    Jeong, J.Y.2    Jue, D.M.3
  • 165
    • 0028903290 scopus 로고
    • Inhibition of the DNA-binding activity of NF-kappa B by gold compounds in vitro
    • Yang J.P., Merin J.P., Nakano T., Kato T., Kitade Y., and Okamoto T. Inhibition of the DNA-binding activity of NF-kappa B by gold compounds in vitro. FEBS Lett. 361 (1995) 89-96
    • (1995) FEBS Lett. , vol.361 , pp. 89-96
    • Yang, J.P.1    Merin, J.P.2    Nakano, T.3    Kato, T.4    Kitade, Y.5    Okamoto, T.6
  • 166
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    • Ray A., and Prefontaine K.E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 752-756
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 167
    • 0028879819 scopus 로고
    • Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
    • Scheinman R.I., Cogswell P.C., Lofquist A.K., and Baldwin Jr. A.S. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 270 (1995) 283-286
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin Jr., A.S.4
  • 168
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
    • Yin M.J., Yamamoto Y., and Gaynor R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396 (1998) 77-80
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 170
    • 11844305963 scopus 로고    scopus 로고
    • Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation
    • Podolin P.L., Callahan J.F., Bolognese B.J., Li Y.H., Carlson K., Davis T.G., Mellor G.W., Evans C., and Roshak A.K. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation. J. Pharmacol. Exp. Ther. 312 (2005) 373-381
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 373-381
    • Podolin, P.L.1    Callahan, J.F.2    Bolognese, B.J.3    Li, Y.H.4    Carlson, K.5    Davis, T.G.6    Mellor, G.W.7    Evans, C.8    Roshak, A.K.9
  • 171
    • 20444504721 scopus 로고    scopus 로고
    • Evodiamine abolishes constitutive and inducible NF-{kappa}B activation by inhibiting I{kappa}B{alpha} kinase activation, thereby suppressing NF-{kappa}B-regulated antiapoptotic and metastatic gene expression, Up-regulating apoptosis, and inhibiting invasion
    • Takada Y., Kobayashi Y., and Aggarwal B.B. Evodiamine abolishes constitutive and inducible NF-{kappa}B activation by inhibiting I{kappa}B{alpha} kinase activation, thereby suppressing NF-{kappa}B-regulated antiapoptotic and metastatic gene expression, Up-regulating apoptosis, and inhibiting invasion. J. Biol. Chem. 280 (2005) 17203-17212
    • (2005) J. Biol. Chem. , vol.280 , pp. 17203-17212
    • Takada, Y.1    Kobayashi, Y.2    Aggarwal, B.B.3
  • 172
    • 8444239358 scopus 로고    scopus 로고
    • Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit
    • Park H.J., Lee S.H., Son D.J., Oh K.W., Kim K.H., Song H.S., Kim G.J., Oh G.T., Yoon d.Y., and Hong J.T. Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit. Arthritis Rheum. 50 (2004) 3504-3515
    • (2004) Arthritis Rheum. , vol.50 , pp. 3504-3515
    • Park, H.J.1    Lee, S.H.2    Son, D.J.3    Oh, K.W.4    Kim, K.H.5    Song, H.S.6    Kim, G.J.7    Oh, G.T.8    Yoon, d.Y.9    Hong, J.T.10
  • 173
    • 12144287622 scopus 로고    scopus 로고
    • The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1
    • Urushibara M., Takayanagi H., Koga T., Kim S., Isobe M., Morishita Y., Nakagawa T., Loeffler M., Kodama T., Kurosawa H., and Taniguchi T. The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1. Arthritis Rheum. 50 (2004) 794-804
    • (2004) Arthritis Rheum. , vol.50 , pp. 794-804
    • Urushibara, M.1    Takayanagi, H.2    Koga, T.3    Kim, S.4    Isobe, M.5    Morishita, Y.6    Nakagawa, T.7    Loeffler, M.8    Kodama, T.9    Kurosawa, H.10    Taniguchi, T.11
  • 174
    • 0033914968 scopus 로고    scopus 로고
    • Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation
    • Quinn J.M., Horwood N.J., Elliott J., Gillespie M.T., and Martin T.J. Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation. J. Bone Miner. Res. 15 (2000) 1459-1466
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 1459-1466
    • Quinn, J.M.1    Horwood, N.J.2    Elliott, J.3    Gillespie, M.T.4    Martin, T.J.5
  • 175
    • 0032854699 scopus 로고    scopus 로고
    • Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand
    • Udagawa N., Takahashi N., Jimi E., Matsuzaki K., Tsurukai T., Itoh K., Nakagawa N., Yasuda H., Goto M., Tsuda E., Higashio K., Gillespie M.T., Martin T.J., and Suda T. Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand. Bone 25 (1999) 517-523
    • (1999) Bone , vol.25 , pp. 517-523
    • Udagawa, N.1    Takahashi, N.2    Jimi, E.3    Matsuzaki, K.4    Tsurukai, T.5    Itoh, K.6    Nakagawa, N.7    Yasuda, H.8    Goto, M.9    Tsuda, E.10    Higashio, K.11    Gillespie, M.T.12    Martin, T.J.13    Suda, T.14
  • 178
    • 0142156483 scopus 로고    scopus 로고
    • Comparison of the efficacy of the tumour necrosis factor alpha blocking agents adalimumab, etanercept, and infliximab when added to methotrexate in patients with active rheumatoid arthritis
    • Hochberg M.C., Tracy J.K., Hawkins-Holt M., and Flores R.H. Comparison of the efficacy of the tumour necrosis factor alpha blocking agents adalimumab, etanercept, and infliximab when added to methotrexate in patients with active rheumatoid arthritis. Ann. Rheum. Dis. 62 Suppl 2:ii13-6 (2003) ii13-ii16
    • (2003) Ann. Rheum. Dis. , vol.62 SUPPL. II , Issue.13-16
    • Hochberg, M.C.1    Tracy, J.K.2    Hawkins-Holt, M.3    Flores, R.H.4
  • 179
  • 180
    • 17044417657 scopus 로고    scopus 로고
    • Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    • Ledeboer A., Sloane E.M., Milligan E.D., Frank M.G., Mahony J.H., Maier S.F., and Watkins L.R. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain 115 (2005) 71-83
    • (2005) Pain , vol.115 , pp. 71-83
    • Ledeboer, A.1    Sloane, E.M.2    Milligan, E.D.3    Frank, M.G.4    Mahony, J.H.5    Maier, S.F.6    Watkins, L.R.7
  • 181
    • 14044274118 scopus 로고    scopus 로고
    • Excitatory and modulatory effects of inflammatory cytokines and neurotrophins on mechanosensitive group IV muscle afferents in the rat
    • Hoheisel U., Unger T., and Mense S. Excitatory and modulatory effects of inflammatory cytokines and neurotrophins on mechanosensitive group IV muscle afferents in the rat. Pain 114 (2005) 168-176
    • (2005) Pain , vol.114 , pp. 168-176
    • Hoheisel, U.1    Unger, T.2    Mense, S.3
  • 182
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • Schäfers M., Svensson C.I., Sommer C., and Sorkin L.S. Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J. Neurosci. 23 (2003) 2517-2521
    • (2003) J. Neurosci. , vol.23 , pp. 2517-2521
    • Schäfers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 183
    • 0029020352 scopus 로고
    • A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro
    • Steen K.H., Steen A.E., and Reeh P.W. A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro. J. Neurosci. 15 (1995) 3982-3989
    • (1995) J. Neurosci. , vol.15 , pp. 3982-3989
    • Steen, K.H.1    Steen, A.E.2    Reeh, P.W.3
  • 185
    • 0029658192 scopus 로고    scopus 로고
    • 2+ permeability of the sustained proton-induced cation current in adult rat dorsal root ganglion neurons
    • 2+ permeability of the sustained proton-induced cation current in adult rat dorsal root ganglion neurons. J. Neurophysiol. 76 (1996) 2834-2840
    • (1996) J. Neurophysiol. , vol.76 , pp. 2834-2840
    • Zeilhofer, H.U.1    Swandulla, D.2    Reeh, P.W.3    Kress, M.4
  • 186
    • 0033051246 scopus 로고    scopus 로고
    • Capsaicin, protons and heat: new excitement about nociceptors
    • Kress M., and Zeilhofer H.U. Capsaicin, protons and heat: new excitement about nociceptors. Trends Pharmacol. Sci. 20 (1999) 112-118
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 112-118
    • Kress, M.1    Zeilhofer, H.U.2
  • 187
    • 14944354848 scopus 로고    scopus 로고
    • Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach
    • Sugiura T., Dang K., Lamb K., Bielefeldt K., and Gebhart G.F. Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach. J. Neurosci. 25 (2005) 2617-2627
    • (2005) J. Neurosci. , vol.25 , pp. 2617-2627
    • Sugiura, T.1    Dang, K.2    Lamb, K.3    Bielefeldt, K.4    Gebhart, G.F.5
  • 188
    • 0344305593 scopus 로고    scopus 로고
    • Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1
    • Sluka K.A., Price M.P., Breese N.M., Stucky C.L., Wemmie J.A., and Welsh M.J. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain 106 (2003) 229-239
    • (2003) Pain , vol.106 , pp. 229-239
    • Sluka, K.A.1    Price, M.P.2    Breese, N.M.3    Stucky, C.L.4    Wemmie, J.A.5    Welsh, M.J.6
  • 191
  • 192
    • 0034862157 scopus 로고    scopus 로고
    • Lactate enhances the acid-sensing Na+channel on ischemia-sensing neurons
    • Immke D.C., and McCleskey E.W. Lactate enhances the acid-sensing Na+channel on ischemia-sensing neurons. Nat. Neurosci. 4 (2001) 869-870
    • (2001) Nat. Neurosci. , vol.4 , pp. 869-870
    • Immke, D.C.1    McCleskey, E.W.2
  • 193
    • 0036521882 scopus 로고    scopus 로고
    • ASIC-like, proton-activated currents in rat hippocampal neurons
    • Baron A., Waldmann R., and Lazdunski M. ASIC-like, proton-activated currents in rat hippocampal neurons. J. Physiol. 539 (2002) 485-494
    • (2002) J. Physiol. , vol.539 , pp. 485-494
    • Baron, A.1    Waldmann, R.2    Lazdunski, M.3
  • 194
    • 6344281041 scopus 로고    scopus 로고
    • Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord
    • Wu L.J., Duan B., Mei Y.D., Gao J., Chen J.G., Zhuo M., Xu L., Wu M., and Xu T.L. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J. Biol. Chem. 279 (2004) 43716-43724
    • (2004) J. Biol. Chem. , vol.279 , pp. 43716-43724
    • Wu, L.J.1    Duan, B.2    Mei, Y.D.3    Gao, J.4    Chen, J.G.5    Zhuo, M.6    Xu, L.7    Wu, M.8    Xu, T.L.9
  • 196
    • 0037115054 scopus 로고    scopus 로고
    • Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels
    • Mamet J., Baron A., Lazdunski M., and Voilley N. Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. J. Neurosci. 22 (2002) 10662-10670
    • (2002) J. Neurosci. , vol.22 , pp. 10662-10670
    • Mamet, J.1    Baron, A.2    Lazdunski, M.3    Voilley, N.4
  • 197
    • 0037379464 scopus 로고    scopus 로고
    • Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability
    • Deval E., Baron A., Lingueglia E., Mazarguil H., Zajac J.M., and Lazdunski M. Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 44 (2003) 662-671
    • (2003) Neuropharmacology , vol.44 , pp. 662-671
    • Deval, E.1    Baron, A.2    Lingueglia, E.3    Mazarguil, H.4    Zajac, J.M.5    Lazdunski, M.6
  • 200
    • 0030059056 scopus 로고    scopus 로고
    • Dose-dependent competitive block by topical acetylsalicylic and salicylic acid of low pH-induced cutaneous pain
    • Steen K.H., Reeh P.W., and Kreysel H.W. Dose-dependent competitive block by topical acetylsalicylic and salicylic acid of low pH-induced cutaneous pain. Pain 64 (1996) 71-82
    • (1996) Pain , vol.64 , pp. 71-82
    • Steen, K.H.1    Reeh, P.W.2    Kreysel, H.W.3
  • 201
    • 0035887733 scopus 로고    scopus 로고
    • Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors
    • Voilley N., de Weille J., Mamet J., and Lazdunski M. Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J. Neurosci. 21 (2001) 8026-8033
    • (2001) J. Neurosci. , vol.21 , pp. 8026-8033
    • Voilley, N.1    de Weille, J.2    Mamet, J.3    Lazdunski, M.4
  • 202
    • 0037634059 scopus 로고    scopus 로고
    • Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels
    • Escoubas P., Bernard C., Lambeau G., Lazdunski M., and Darbon H. Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels. Protein Sci. 12 (2003) 1332-1343
    • (2003) Protein Sci. , vol.12 , pp. 1332-1343
    • Escoubas, P.1    Bernard, C.2    Lambeau, G.3    Lazdunski, M.4    Darbon, H.5
  • 203
    • 2342629343 scopus 로고    scopus 로고
    • A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons
    • Diochot S., Baron A., Rash L.D., Deval E., Escoubas P., Scarzello S., Salinas M., and Lazdunski M. A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. EMBO J. 23 (2004) 1516-1525
    • (2004) EMBO J. , vol.23 , pp. 1516-1525
    • Diochot, S.1    Baron, A.2    Rash, L.D.3    Deval, E.4    Escoubas, P.5    Scarzello, S.6    Salinas, M.7    Lazdunski, M.8
  • 204
    • 1942423228 scopus 로고    scopus 로고
    • Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia
    • Agarwal N., Offermanns S., and Kuner R. Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia. Genesis 38 (2004) 122-129
    • (2004) Genesis , vol.38 , pp. 122-129
    • Agarwal, N.1    Offermanns, S.2    Kuner, R.3
  • 209
    • 2442608827 scopus 로고    scopus 로고
    • Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function
    • Geppetti P., and Trevisani M. Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br. J. Pharmacol. 141 (2004) 1313-1320
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 1313-1320
    • Geppetti, P.1    Trevisani, M.2
  • 211
    • 0142059776 scopus 로고    scopus 로고
    • Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
    • Bhave G., Hu H.J., Glauner K.S., Zhu W., Wang H., Brasier D.J., Oxford G.S., and Gereau R.W. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12480-12485
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 12480-12485
    • Bhave, G.1    Hu, H.J.2    Glauner, K.S.3    Zhu, W.4    Wang, H.5    Brasier, D.J.6    Oxford, G.S.7    Gereau, R.W.8
  • 213
    • 0346118925 scopus 로고    scopus 로고
    • Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway
    • Mohapatra D.P., and Nau C. Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J. Biol. Chem. 278 (2003) 50080-50090
    • (2003) J. Biol. Chem. , vol.278 , pp. 50080-50090
    • Mohapatra, D.P.1    Nau, C.2
  • 214
    • 12744279751 scopus 로고    scopus 로고
    • Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons
    • Wilson-Gerwing T.D., Dmyterko M.V., Zochodne D.W., Johnston J.M., and Verge V.M. Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. J. Neurosci. 25 (2005) 758-767
    • (2005) J. Neurosci. , vol.25 , pp. 758-767
    • Wilson-Gerwing, T.D.1    Dmyterko, M.V.2    Zochodne, D.W.3    Johnston, J.M.4    Verge, V.M.5
  • 215
    • 0037179755 scopus 로고    scopus 로고
    • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    • Ji R.R., Samad T.A., Jin S.X., Schmoll R., and Woolf C.J. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36 (2002) 57-68
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3    Schmoll, R.4    Woolf, C.J.5
  • 216
    • 0038298197 scopus 로고    scopus 로고
    • Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice
    • Rashid M.H., Inoue M., Bakoshi S., and Ueda H. Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice. J. Pharmacol. Exp. Ther. 306 (2003) 709-717
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 709-717
    • Rashid, M.H.1    Inoue, M.2    Bakoshi, S.3    Ueda, H.4
  • 217
    • 12844286900 scopus 로고    scopus 로고
    • Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1
    • Hong S., and Wiley J.W. Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J. Biol. Chem. 280 (2005) 618-627
    • (2005) J. Biol. Chem. , vol.280 , pp. 618-627
    • Hong, S.1    Wiley, J.W.2
  • 220
    • 4644291444 scopus 로고    scopus 로고
    • Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis
    • Sainz I.M., Uknis A.B., Isordia-Salas I., Dela Cadena R.A., Pixley R.A., and Colman R.W. Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis. FASEB J. 18 (2004) 887-889
    • (2004) FASEB J. , vol.18 , pp. 887-889
    • Sainz, I.M.1    Uknis, A.B.2    Isordia-Salas, I.3    Dela Cadena, R.A.4    Pixley, R.A.5    Colman, R.W.6
  • 221
    • 0028172370 scopus 로고
    • The role of bradykinin B1 receptors in the maintenance of intra-articular plasma extravasation in chronic antigen-induced arthritis
    • Cruwys S.C., Garrett N.E., Perkins M.N., Blake D.R., and Kidd B.L. The role of bradykinin B1 receptors in the maintenance of intra-articular plasma extravasation in chronic antigen-induced arthritis. Br. J. Pharmacol. 113 (1994) 940-944
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 940-944
    • Cruwys, S.C.1    Garrett, N.E.2    Perkins, M.N.3    Blake, D.R.4    Kidd, B.L.5
  • 223
    • 1342265865 scopus 로고    scopus 로고
    • Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice
    • Rashid M.H., Inoue M., Matsumoto M., and Ueda H. Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice. J. Pharmacol. Exp. Ther. 308 (2004) 1158-1164
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 1158-1164
    • Rashid, M.H.1    Inoue, M.2    Matsumoto, M.3    Ueda, H.4
  • 224
    • 7444225294 scopus 로고    scopus 로고
    • Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF
    • Vellani V., Zachrisson O., and McNaughton P.A. Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF. J. Physiol. 560 (2004) 391-401
    • (2004) J. Physiol. , vol.560 , pp. 391-401
    • Vellani, V.1    Zachrisson, O.2    McNaughton, P.A.3
  • 225
    • 0030920014 scopus 로고    scopus 로고
    • Bradykinin-induced knee joint incapacitation involves bradykinin B2 receptor mediated hyperalgesia and bradykinin B1 receptor-mediated nociception
    • Tonussi C.R., and Ferreira S.H. Bradykinin-induced knee joint incapacitation involves bradykinin B2 receptor mediated hyperalgesia and bradykinin B1 receptor-mediated nociception. Eur. J. Pharmacol. 326 (1997) 61-65
    • (1997) Eur. J. Pharmacol. , vol.326 , pp. 61-65
    • Tonussi, C.R.1    Ferreira, S.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.