Thiol-reactive metal compounds inhibit NF-κB activation by blocking IκB kinase

Journal of Immunology

Volumn 164, Issue 11, 2000, Pages 5981-5989

  Jeon, Kye Im ^a   Jeong, Jae Yeon ^a   Jue, Dae Myung ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AURANOFIN; AUROTHIOGLUCOSE; AUROTHIOMALATE; GOLD; GOLD DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; INHIBITOR PROTEIN IKB; INHIBITOR PROTEIN IKB KINASE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME SUBUNIT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; MACROPHAGE ACTIVATION; METAL BINDING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

EID: 0034120712     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.11.5981     Document Type: Article

References (64)

1. Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066.
2. May, M. J., and S. Ghosh. 1998. Signal transduction through NF-κB. Immunol. Today 19:80.
3. Handel, M. L., L. B. McMorrow, and E. M. Gravallese. 1995. Nuclear factor-κB in rheumatoid synovium: localization of p50 and p65. Arthritis Rheum. 38:1762.
4. Marok, R., P. G. Winyard, A. Coumbe, M. L. Kus, K. Gaffney, S. Blades, P. I. Mapp, C. J. Morris, D. R. Blake, C. Kaltschmidt, and P. A. Baeuerle. 1996. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum. 39:583.
5. Firestein, G. S., J. M Alvaro-Gracia, R. Maki, and J. M. Alvaro-Gracia. 1990. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J. Immunol. 144:3347.
6. Elliott, M. J., R. N. Maini, M. Feldmann, J. R. Kalden, C. Antoni, J. S. Smolen, B. Leeb, F. C. Breedveld, J. D. Macfarlane, H. Bijl, and J. N. Woody. 1994. Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105.
7. Moreland, L. W., S. W. Baumgartner, M. H. Schiff, E. A. Tindall, R. M. Fleischmann, A. L. Weaver, R. E. Ettlinger, S. Cohen, W. J. Koopman, K. Mohler, et al. 1997. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N. Engl. J. Med. 337:141.
8. Foxwell, B., K. Browne, J. Bondeson, C. Clarke, R. de Martin, F. Brennan, and M. Feldmann. 1998. Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent. Proc. Natl. Acad. Sci. USA 95:8211.
9. Miagkov, A. V., D. V. Kovalenko, C. E. Brown, J. R. Didsbury, J. P. Cogswell, S. A. Stimpson, A. S. Baldwin, and S. S. Makarov. 1998. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl. Acad. Sci. USA 95:13859.
10. Chen, Z. J., L. Parent, and T. Maniatis. 1996. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84:853.
11. DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. Cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548.
12. Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. W. Li, D. B. Young, M. Barbosa, and M. Mann. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860.
13. Regnier, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe. 1997. Identification and characterization of an IκB kinase. Cell 90:373.
14. Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866.
15. Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243.
16. Lee, F. S., R. T. Peters, L. C. Dang, and T. Maniatis. 1998. MEKK1 activates both IκB kinase α and IκB kinase β. Proc. Natl. Acad. Sci. USA 95:9319.
17. Zandi, E., Y. Chen, and M. Karin. 1998. Direct phosphorylation of IκB by IKKα and IKKβ: discrimination between free and NF-κB-bound substrate. Science 281:1360.
18. Yamaoka, S., G. Courtois, C. Bessia, S. T. Whiteside, R. Weil, F. Agou, H. E. Kirk, R. J. Kay, and A. Israel. 1998. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93:1231.
19. Rothwarf, D. M., E. Zandi, G. Natoli, and M. Karin. 1998. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395:297.
20. Mercurio, F., B. W. Murray, A. Shevchenko, B. L. Bennett, D. B. Young, J. W. Li, G. Pascual, A. Motiwala, H. Zhu, M. Mann, and A. M. Manning. 1999. IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell. Biol. 19:1526.
21. Cohen, L., W. J. Henzel, and P. A. Baeuerle. 1998. IKAP is a scaffold protein of the IκB kinase complex. Nature 395:292.
22. Research Subcommittee of the Empire Rheumatism Council. 1960. Gold therapy in rheumatoid arthritis: report of a multi-centre controlled trial. Ann. Rheum. Dis. 19:95.
23. Champion, G. D., G. G. Graham, and J. B. Ziegler. 1990. The gold complexes. Baillieres Clin. Rheumatol. 4:491.
24. Grahame, R., R. Billings, M. Laurence, V. Marks, and P. J. Wood. 1974. Tissue gold levels after chrysotherapy. Ann. Rheum. Dis. 33:536.
25. Vernon-Roberts, B., J. L. Dore, J. D. Jessop, and W. J. Henderson. 1976. Selective concentration and localization of gold in macrophages of synovial and other tissues during and after chrysotherapy in rheumatoid patients. Ann. Rheum. Dis. 35:477.
26. Ghadially, F. N., A. F. Oryschak, and D. M. Mitchell. 1976. Ultrastructural changes produced in rheumatoid synovial membrane by chrysotherapy. Ann. Rheum. Dis. 35:67.
27. Nakamura, H., and M. Igarashi. 1977. Localization of gold in syrovial membrane of rheumatoid arthritis treated with sodium aurothiomalate: studies by electron microscope and electron probe x-ray microanalysis. Ann. Rheum. Dis. 36:209.
28. Yanni, G., M. Nabil, M. R. Farahat, R. N. Poston, and G. S. Panayi. 1994. Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane. Ann. Rheum. Dis. 53:315.
29. Bondeson, J. 1997. The mechanisms of action of disease-modifying antirheumatic drugs: a review with emphasis on macrophage signal transduction and the induction of proinflammatory cytokines. Gen. Pharmacol. 29:127.
30. Bondeson, J., and R. Sundler. 1995. Auranofin inhibits the induction of interleukin 1β and tumor necrosis factor α mRNA in macrophages. Biochem. Pharmacol. 50:1753.
31. Yang, J. P., J. P. Merin, T. Nakano, T. Kato, Y. Kitade, and T. Okamoto. 1995. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro. FEBS Lett. 361:89.
32. Jeong, J.-Y., and D.-M. Jue. 1997. Chloroquine inhibits processing of tumor necrosis factor in lipopolysaccharide-stimulated RAW 264.7 macrophages. J. Immunol. 158:4901.
33. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55.
34. Shakhov, A. N., M. A. Collart, P. Vassalli, S. A. Nedospasov, and C. V. Jongeneel. 1990. κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages. J. Exp. Med. 171:35.
35. Collart, M. A., P. A. Baeuerle, and P. Vassalli. 1990. Regulation of tumor necrosis factor α transcription in macrophages: involvement of four IκB-like motifs and of constitutive and inducible forms of NF-κB. Mol. Cell. Biol. 10:1498.
36. Glusker, J. P. 1991. Structural aspects of metal liganding to functional groups in protein s. In Advances in Protein Chemistry, Vol. 42. C. B. Anfinsen, J. T. Edsall, D. Eisenberg, and F. M. Richards, eds. Academic Press, San Diego, p. 1.
37. Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and D. Wallach. 1997. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385:540.
38. Ling, L., Z. Cao, and D. V. Goeddel. 1998. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA 95:3792.
39. Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95:3537.
40. Lee, F. S., R. T. Peters, L. C. Dang, and T. Maniatis. 1998. MEKK1 activates both IκB kinase α and IκB kinase β. Proc. Natl. Acad. Sci. USA 95:9319.
41. Nemoto, S., J. A. DiDonato, and A. Lin. 1998. Coordinate regulation of IκB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-κB-inducing kinase. Mol. Cell. Biol. 18:7336.
42. Snyder, R. M., C. K. Mirabelli, and S. T. Crooke. 1986. Cellular association, intracellular distribution, and efflux of auranofin via sequential ligand exchange reactions. Biochem. Pharmacol. 35:923.
43. Dahl, S. L., M. L. Coleman, H. J. Williams, M. Altz-Smith, D. R. Kay, H. E. Paulus, A. Weinstein, and S. Kaplan. 1985. Lack of correlation between blood gold concentrations and clinical response in patients with definite or classic rheumatoid arthritis receiving auranofin or gold sodium thiomalate. Arthritis Rheum. 28:1211.
44. Rossi, A., P. Kapahi, G. Natoli, T. Takahashi, Y. Chen, M. Karin, and M. G. Santoro. 2000. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature 403:103.
45. Schreck, R., P. Rieber, and P. A. Baeuerle. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 10:2247.
46. Bauer, M. K. A., M. Vogt, M. Los, J. Siegel, S. Wesselborg, and K. Schulze-Osthoff. 1998. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression. J. Biol. Chem. 273:8048.
47. Manna, S. K., H. J. Zhang, T. Yan, L. W. Oberley, and B. B. Aggarwal. 1998. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1. J. Biol. Chem. 273:13245.
48. Schreck, R., K. Albermann, and P. A. Baeuerle. 1992. Nuclear factor κB: an oxidative stress-responsive transcription factor of eukaryotic cells. Free Radical Res. Commun. 17:221.
49. Kretz-Remy, C., P. Mehlen, M. E. Mirault, and A. P. Arrigo. 1997. Regulatory role for a novel human thioredoxin peroxidase in NF-κB activation. J. Biol. Chem. 272:30952.
50. Jin, D. Y., H. Z. Chae, S. G. Rhee, and K. T. Jeang. 1996. Inhibition of IκB-α phosphorylation and degradation and subsequent NF-κB activation by glutathione peroxidase Overexpression. J. Cell Biol. 133:1083.
51. Bonizzi, G., J. Piette, S. Schoonbroodt, R. Greimers, L. Havard, M. P. Merville, and V. Bours. 1999. Reactive oxygen intermediate-dependent NF-κB activation by interleukin-1β requires 5-lipoxygenase or NADPH oxidase activity. Mol. Cell. Biol. 19:1950.
52. Mihm, S., D. Galter, and W. Droge. 1995. Modulation of transcription factor NF-κB activity by intracellular glutathione levels and by variations of the extracellular cysteine supply. FASEB J. 9:246.
53. Flescher, E., J. A. Ledbetter, G. L. Schieven, N. Vela-Roch, D. Fossum, H. Dang, N. Ogawa, and N. Talal. 1994. Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction. J. Immunol. 153:4880.
54. Lahdenpohja, N., K. Savinainen, and M. Hurme. 1998. Pre-exposure to oxidative stress decreases the nuclear factor-κB-dependent transcription in T lymphocytes. J. Immunol. 160:1354.
55. Cornell, P., V. M. Young, M. Toborek, D. A. Cohen, S. Barve, C. J. McClain, and B. Hennig. 1997. Zinc attenuates tumor necrosis factor-mediated activation of transcription factors in endothelial cells. J. Am. Coll. Nutr. 16:411.
56. Kim, C. H., J. H. Kim, C. Y. Hsu, and Y. S. Ahn. 1999. Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-κB activation. FEBS Lett. 449:28.
57. Satake, H., K. Suzuki, T. Aoki, M. Otsuka, Y. Sugiura, T. Yamamoto, and J. Inoue. 1995. Cupric ion blocks NF-κB activation through inhibiting the signal-induced phosphorylation of IκBα. Biochem. Biophys. Res. Commun. 216:568.
58. Betts, W. H., R. Garret, and M. W. Whitehouse. 1985. Therapy with metal complexes. In Anti-inflammatory and Anti-rheumatic Drugs, Vol. 3. K. D. Rainsford and M. R. C. Path, eds. CRC Press, Boca Raton, p. 65.
59. Chandra, R. K. 1984. Excessive intake of zinc impairs immune responses. J. Am. Med. Assoc. 252:1443.
60. Milanino, R., M. Marrella, R. Gasperini, M. Pasqualicchio, and G. Velo. 1993. Copper and zinc body levels in inflammation: an overview of the data obtained from animal and human studies. Agents Actions 39:195.
61. Niedermeier, W., and J. H. Griggs. 1971. Trace metal composition of synovial fluid and blood serum of patients with rheumatoid arthritis. J. Chronic Dis. 23: 527.
62. Kopp, E., and S. Ghosh. 1994. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265: 956.
63. Yin, M. J., Y. Yamamoto, and R. B. Gaynor. 1998. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 396:77.
64. Wahl, C., S. Liptay, G. Adler, and R. M. Schmid. 1998. Sulfasalazine: a potent and specific inhibitor of nuclear factor κB. J. Clin. Invest. 101:1163.