GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization

Science

Volumn 304, Issue 5672, 2004, Pages 884-887

  Harvey, Robert J ^a,c   Depner, Ulrike B ^b   Wässle, Heinz ^c   Ahmadi, Seifollah ^b   Heindl, Cornelia ^b   Reinold, Heiko ^b   Smart, Trevor G ^d   Harvey, Kirsten ^a   Schütz, Burkhard ^e   Abo Salem, Osama M ^e   Zimmer, Andreas ^e   Poisbeau, Pierrick ^f   Welzl, Hans ^g   Wolfer, David P ^g   Betz, Heinrich ^c   Zeilhofer, Hanns Ulrich ^b   Müller, Ulrike ^c  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY HOSPITAL BONN   (Germany)

^f UNIVERSITÉ DE STRASBOURG   (France)

^g UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DRUG THERAPY; NEUROLOGY;

PAIN SENSITIZATION; PHOSPHORYLATION;

BIOMEDICAL ENGINEERING;

GLYCINE RECEPTOR; PROSTAGLANDIN E2; RECEPTOR SUBTYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FREUND ADJUVANT; GLYCINE; GLYCINE RECEPTOR ALPHA3 SUBUNIT; ZYMOSAN;

MEDICINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; INFLAMMATION; MOUSE; NEUROMODULATION; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; SPINAL CORD DORSAL HORN; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; FEMALE; GENETIC TRANSFECTION; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; NERVE CELL; PATCH CLAMP; PATHOPHYSIOLOGY; PHOSPHORYLATION; POSTERIOR HORN CELL; SIGNAL TRANSDUCTION; SPINAL CORD; SYNAPTIC TRANSMISSION;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; FEMALE; FREUND'S ADJUVANT; GLYCINE; HUMANS; INFLAMMATION; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NEURONS; PAIN; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; POSTERIOR HORN CELLS; RECEPTORS, GLYCINE; SIGNAL TRANSDUCTION; SPINAL CORD; SYNAPTIC TRANSMISSION; TRANSFECTION; ZYMOSAN;

EID: 2442417968     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094925     Document Type: Article

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27. Supported by Max-Planck-Gesellschaft, Bundesministerium für Bildung und Forschung, and Fonds der Chemischen Industrie (H.B. and U.M.), Deutsche Forschungsgemeinschaft Ze 377/6-1 and 377/7-1 (H.U.Z.), Swiss National Science Foundation (D.P.W.) and the Medical Research Council (R.J.H. and T.G.S.). We thank N. Fürst, E. Löwen, B. Layh, and R. Lang for technical assistance, M. Baier for help with preparetion of the manuscript and F. Nyberg (Uppsala, Sweden) for the CGRP antibody, and S. Narumlya (Kyoto, Japan) for the EP2 receptor cDNA clone.