Central origin of secondary mechanical hyperalgesia

Journal of Neurophysiology

Volumn 90, Issue 1, 2003, Pages 353-359

  Klede, Monika ^a   Handwerker, Hermann O ^a   Schmelz, Martin ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LIDOCAINE; LOCAL ANESTHETIC AGENT; PROTEIN;

ADULT; ALLODYNIA; ARTICLE; CONTROLLED STUDY; DIALYSATE; ELECTRICITY; ELECTRODE; ELECTROSTIMULATION; EVALUATION; FEMALE; FOREARM; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; INFRARED PHOTOGRAPHY; LASER DOPPLER FLOWMETRY; LOCAL ANESTHESIA; MALE; MICRODIALYSIS; NERVE FIBER; NORMAL HUMAN; PERFUSION; PHOTOMETRY; PRIORITY JOURNAL; SKIN STIMULATION; VASODILATATION;

EID: 0037824535     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.01136.2002     Document Type: Article

References (29)

1. Baumann TK, Simone DA, Shain CN, and LaMotte RH. Neurogenic hyperalgesia the search for the primary cutaneous afferent fibers that contribute to capsaicin induced pain and hyperalgesia. J Neurophysiol 66: 212-227, 1991.
2. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
3. Cervero F, Meyer RA, and Campbell JN. A psychophysical study of secondary hyperalgesia: evidence for increased pain to input from nociceptors. Pain 58: 21-28, 1994.
4. Fuchs PN, Campbell JN, and Meyer RA. Secondary hyperalgesia persists in capsaicin desensitized skin. Pain 84: 141-149, 2000.
5. Greiner T, Nischik M, Schmelz M, Forster C, and Handwerker HO. Neurogenic flare responses are heterogeneous in superficial and deep layers of human skin. Neurosci Lett 185: 33-36, 1995.
6. Koltzenburg M. Neural mechanisms of cutaneous nociceptive pain. Clin J Pain 16: S131-S138, 2000.
7. Koltzenburg M, Lundberg LE, and Torebjörk HE. Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 51: 207-219, 1992.
8. Koltzenburg M, Torebjörk HE, and Wahren LK. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain 117: 579-591, 1994.
9. Koppert W, Dern SK, Sittl R, Albrecht S, Schuttler J, and Schmelz M. A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. Anesthesiology 95: 395-402, 2001.
10. LaMotte RH, Shain CN, Simone DA, and Tsai EFP. Neurogenic hyperalgesia psychophysical studies of underlying mechanisms. J Neurophysiol 66: 190-211, 1991.
11. Lewis T, Harris KE, and Grant RT. Observations relating to the influence of the cutaneous nerves on various reactions of the cutaneous vessels. Heart 14: 1-17, 1927.
12. Magerl W, Fuchs PN, Meyer RA, and Treede RD. Roles of capsaicinin-sensitive nociceptors in cutaneous pain and secondary hyperalgesia. Brain 124: 1754-1764, 2001.
13. Ochoa JL and Yarnitsky D. Mechanical hyperalgesias in neuropathic pain patients: dynamic and static subtypes. Ann Neurol 33: 465-472, 1993.
14. Peng YB, Ringkamp M, Campbell JN, and Meyer RA. Electrophysiological assessment of the cutaneous arborization of Adelta-fiber nociceptors. J Neurophysiol 82: 1164-1177, 1999.
15. Ringkamp M, Peng YB, Wu G, Hartke TV, Campbell JN and Meyer RA. Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors. J Neurosci 21: 4460-4468, 2001.
16. Schmelz M, Michael K, Weidner C, Schmidt R, Torebjörk HE, and Handwerker HO. Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport 11: 645-648, 2000a.
17. Schmelz M, Schmidt R, Handwerker HO, and Torebjörk HE. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain 123: 560-571, 2000b.
18. Schmelz M, Schmidt R, Weidner C, LaMotte RH, Torebjörk HE, and Handwerker HO. Capsaicin-induced punctate hyperalgesia crosses anesthetic strip in human skin. Soc Neurosci Abstr 25: 1433, 1999.
19. Schmidt R, Schmelz M, Weidner C, Handwerker HO, and Torebjörk HE. Innervation territories of mechano-insensitive C nociceptors in human skin. J Neurophysiol 88: 1859-1866, 2002.
20. Seno N and Dray A. Capsaicin-induced activation of fine afferent fibers from rat skin in vitro. Neuroscience 55: 563-569, 1993.
21. Serra J, Campero M, and Ochoa J. Flare and hyperalgesia after intradermal capsaicin injection in human skin. J Neurophysiol 80: 2801-2810, 1998.
22. Simone DA, Baumann TK, Collins JG, and LaMotte RH. Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin. Brain Res 486: 185-189, 1989a.
23. Simone DA, Baumann TK, and LaMotte RH. Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain 38: 99-107, 1989b.
24. Torebjörk HE, Lundberg LE, and LaMotte RH. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol 448: 765-780, 1992a.
25. Torebjörk HE, Lundberg LER, and LaMotte RH. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol 448: 765-780, 1992b.
26. Weidner C, Klede M, Rukwied R, Lischetzki G, Neisius U, Skov PS, Petersen LJ, and Schmelz M. Acute effects of substance P and calcitonin gene-related peptide in human skin - a microdialysis study. J Invest Dermatol 115: 1015-1020, 2000a.
27. Weidner C, Schmelz M, Schmidt R, Handwerker HO, and Torebjörk HE. Unidirectional conduction block at branching points of human nociceptive C-afferents: a peripheral mechanism for pain amplification. In: Progress in Pain Research and Management, edited by Devor M, Rowbotham M, and Wisenfeld-Hallin Z. Seattle, WA: IASP, 2000b.
28. Weidner C, Schmelz M, Schmidt R, Hansson B, Handwerker HO, and Torebjörk HE. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J Neurosci 19: 10184-10190, 1999.
29. Ziegler EA, Magerl W, Meyer RA, and Treede RD. Secondary hyperalgesia to punctate mechanical stimuli - central sensitization to A-fiber nociceptor input. Brain 122: 2245-2257, 1999.