Bradyzide, a potent non-peptide B2 bradykinin receptor antagonist with long-lasting oral activity in animal models of inflammatory hyperalgesia

British Journal of Pharmacology

Volumn 129, Issue 1, 2000, Pages 77-86

  Burgess, Gillian M ^a,b   Perkins, Martin N ^a,c   Rang, Humphrey P ^a   Campbell, Elizabeth A ^a,d   Brown, Michael C ^a,e   McIntyre, Peter ^a   Urban, Laszlo ^a   Dziadulewicz, Edward K ^a   Ritchie, Timothy J ^a   Hallett, Allan ^a   Snell, Christopher R ^a   Wrigglesworth, Roger ^a,f   Lee, Wai ^a   Davis, Clare ^a   Phagoo, Steve B ^a   Davis, Andrew J ^a   Phillips, Elsa ^a   Drake, Gillian S ^a   Hughes, Glyn A ^a   Dunstan, Andrew ^a,d   Bloomfield, Graham C ^a,d   more..

^a Novatis Inst for Medical Sciences   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c Astra Research Centre Montreal   (Canada)

^d NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

^e Packard Brook House   (United Kingdom)

^f Institut de Recherche Jouveinal   (France)

Author keywords

Hyperalgesia; Non peptide bradykinin antagonist

Indexed keywords

BRADYKININ; BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; BRADYZIDE; DICLOFENAC; ICATIBANT; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING KINETICS; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG TOLERANCE; EXTRAVASATION; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HYPERALGESIA; HYPOTENSION; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

EID: 0033969427     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703012     Document Type: Article

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