Neurogenic vasodilatation and plasma leakage in the skin

General Pharmacology

Volumn 30, Issue 1, 1998, Pages 5-11

  Holzer, Peter ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Afferent neurons; Allergy; Calcitonin gene related peptide; Chronic inflammation; Immue system; leukocyte emigration; Neurogenic inflammation; Nitric oxide; Plasma protein extravasation; Substance P; Vasodilatation

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CYTOKINE; HISTAMINE; HISTAMINE H3 RECEPTOR AGONIST; INTERLEUKIN 1; NEUROKININ A; NEUROPEPTIDE; NITRIC OXIDE; OPIATE PEPTIDE; PROSTANOID; SEROTONIN; SOMATOSTATIN; SUBSTANCE P; TACHYKININ;

EXTRAVASATION; HUMAN; MUSCLE SPINDLE AFFERENT NERVE; NERVE CONDUCTION; NEUROGENIC INFLAMMATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SKIN BLOOD FLOW; VASODILATATION;

EID: 0031986099     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(97)00078-5     Document Type: Review

References (30)

1. Benrath J., Eschenfelder C., Zimmermann M. and Gillardon F. (1995) Calcitonin gene-related peptide, substance P and nitric oxide are involved in cutaneous inflammation following ultraviolet irradiation. Eur. J. Pharmacol. 293, 87-96.
2. 1) receptors at sites of inflammation. Proc. Natl. Acad. Sci. USA 91, 8964-8968.
3. Brain, S. D. (1996) Sensory neuropeptides in the skin. In Neurogenic Inflammation (Edited by Geppetti P. and Holzer P.), pp. 229-244. CRC Press, Boca Raton, FL.
4. Donnerer J. and Amann R. (1993) The inhibition of neurogenic inflammation. Gen. Pharmacol. 24, 519-529.
5. Dray A. (1995) Inflammatory mediators of pain. Br. J. Anaesth. 75, 125-131.
6. Figini M., Javdan P., Cioncolini F. and Geppetti P. (1995) Involvement of tachykinins in plasma extravasation induced by bradykinin and low pH medium in the guinea-pig conjunctiva. Br. J. Pharmacol. 115, 128-132.
7. Geppetti P. and Holzer P. (1996) Neurogenic Inflammation. CRC Press, Boca Raton, FL.
8. Gillardon F., Moll I., Michel S., Benrath J., Weihe E. and Zimmermann M. (1995) Calcitonin gene-related peptide and nitric oxide are involved in ultraviolet radiation-induced immunosuppression. Eur. J. Pharmacol. 293, 395-400.
9. Goldsmith P. C., Leslie T. A., Hayes N. A., Levell N. J., Dowd P. M. and Foreman J. C. (1996) Inhibitors of nitric oxide synthase in human skin. J. Invest. Dermatol. 106, 113-118.
10. Hall J. M. and Geppetti P. (1995) Kinins and kinin receptors in the nervous system. Neurochem. Int. 26, 17-26.
11. Herbert M. K. and Holzer P. (1994a) Interleukin-1β enhances capsaicin-induced neurogenic vasodilatation in the rat skin. Br. J. Pharmacol. 111, 681-686.
12. Herbert M. K. and Holzer P. (1994b) Nitric oxide mediates the amplification by interleukin-1β of neurogenic vasodilatation in the rat skin. Eur. J. Pharmacol. 260, 89-93.
13. Holzer P. (1991) Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 43, 143-201.
14. Holzer P. (1992) Peptidergic sensory neurons in the control of vascular functions: mechanisms and significance in the cutaneous and splanchnic vascular beds. Rev. Physiol. Biochem. Pharmacol. 121, 49-146.
15. Holzer P. and Jocič M. (1994) Cutaneous vasodilatation induced by nitric oxide-evoked stimulation of afferent nerves in the rat. Br. J. Pharmacol. 112, 1181-1187.
16. Holzer P., Jocič M. and Peskar B. A. (1995) Mediation by prostaglandms of the nitric oxide-induced neurogenic vasodilatation in rat skin. Br. J. Pharmacol. 116, 2365-2370.
17. Hughes S. R. and Brain S. D. (1994) Nitric oxide-dependent release of vasodilator quantities of calcitonin gene-related peptide from capsaicin-sensitive nerves in rabbit skin. Br. J. Pharmacol. 111, 425-430.
18. 1 receptot agonist, CP-122,288, on oedema formation induced by stimulation of the rat saphenous nerve. Br. J. Pharmacol. 115, 1-2.
19. Kowalski M. L., Sliwinska-Kowalska M. and Kaliner M. A. (1990) Neurogenic inflammation, vascular permeability, and mast cells. 2. Additional evidence indicating that mast cells are not involved in neurogenic inflammation. J. Immunol. 145, 1214-1221.
20. Maggi C. A. (1995a) Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog. Neurobiol. 45, 1-98.
21. Maggi C. A. (1995b) The mammalian tachykinin receptors. Gen. Pharmacol. 26, 911-944.
22. Nadel J. A. (1996) Peptidase modulation of neurogenic inflammation. In Neurogenic Inflammation (Edited by Geppetti P. and Holzer P.), pp. 115-127. CRC Press, Boca Raton, FL.
23. Nuki C., Kawasaki H., Takasaki K. and Wada A. (1994) Pharmacological characterization of presynaptic calcitonin gene-related peptide (CGRP) receptors on CGRP-containing vasodilator nerves in rat mesenteric resistance vessels. J. Pharmacol. Exp. Ther. 268, 59-64.
24. 3 receptors. Eur. J. Pharmacol. 273, 83-88.
25. Siney L. and Brain S. D. (1996) Involvement of sensory neuropeptides in the development of plasma extravasation in rat dorsal skin following thermal injury. Br. J. Pharmacol. 117, 1065-1070.
26. Stein C. (1993) Peripheral mechanisms of opioid analgesia. Anesth. Analg. 76, 182-191.
27. 1 receptor antagonists on vasodilatation induced by chemical and electrical activation of sensory C-fibre afferents in different organs. Acta Physiol. Scand. 152, 153-161.
28. Tausk F. and Undem B. (1995) Exogenous but not endogenous substance P releases histamine from isolated human skin fragments. Neuropeptides 29, 351-355.
29. 1 receptor antagonists and the role of endogenous mediators. Br. J. Pharmacol. 114, 1343-1350.
30. Wang F., Millet I., Bottomly K. and Vignery A. (1992) Calcitonin generelated peptide inhibits interleukin 2 production by murine T lymphocytes. J. Biol. Chem. 267, 21052-21057.