Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino- seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity

Journal of Medicinal Chemistry

Volumn 42, Issue 4, 1999, Pages 649-658

  Milbank, Jared B J ^a   Tercel, Moana ^a   Atwell, Graham J ^a   Wilson, William R ^b   Hogg, Alison ^b   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

3 (CHLOROMETHYL) 6 AMINOINDOLINE (6 AMINOCYCLOPROPYLINDOLE); 6 AMINO 3 (CHLOROMETHYL) 1 [[5 [2 (DIMETHYLAMINO)ETHOXY] 1H INDOL 2 YL]CARBONYL]INDOLINE; 6 AMINO 3 (CHLOROMETHYL) 1 [[6 [2 (DIMETHYLAMINO)ETHOXY] 5 METHOXY 1H INDOL 2 YL]CARBONYL]INDOLINE; ADOZELESIN; ANTINEOPLASTIC AGENT; CARZELESIN; DUOCARMYCIN SA; RACHELMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG MECHANISM; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CRICETINAE; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MICE; RATS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0033602220     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980545s     Document Type: Article

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