The impact of lipophilicity in drug research: A case report on β-blockers

Mini-Reviews in Medicinal Chemistry

Volumn 5, Issue 2, 2005, Pages 197-205

  Mannhold, Raimund ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Lipophilicity; LogP calculation programs; LogP compilation for blockers; Pharmacodynamic and clinical properties; Pharmacokinetic; blockers

Indexed keywords

ACEBUTOLOL; ALPRENOLOL; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETAXOLOL; BISOPROLOL; BOPINDOLOL; BUCINDOLOL; BUPRANOLOL; CARAZOLOL; CARTEOLOL; CARVEDILOL; CELIPROLOL; ESMOLOL; LABETALOL; LEVOBUNOLOL; MEDROXALOL; MEPINDOLOL; METIPRANOLOL; METOPROLOL; NADOLOL; NEBIVOLOL; OXPRENOLOL; PENBUTOLOL; PINDOLOL; PRACTOLOL; SOTALOL; TALINOLOL; TERTATOLOL; UNINDEXED DRUG;

ANTIARRHYTHMIC ACTIVITY; BINDING AFFINITY; CATECHOLAMINE BLOOD LEVEL; CENTRAL NERVOUS SYSTEM DISEASE; CORRELATION ANALYSIS; DOSE CALCULATION; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EFFICACY; DRUG HALF LIFE; DRUG INHIBITION; DRUG METABOLISM; DRUG PENETRATION; DRUG RESEARCH; DRUG STRUCTURE; EEG ABNORMALITY; FATIGUE; FIRST PASS EFFECT; HALLUCINATION; HEART PROTECTION; HEART VENTRICLE FIBRILLATION; HUMAN; ISCHEMIC HEART DISEASE; LIPOPHILICITY; LOW DRUG DOSE; MEMBRANE STABILIZATION; NONHUMAN; PROGNOSIS; RECEPTOR BINDING; REVIEW; RISK REDUCTION; SINGLE DRUG DOSE; SLEEP DISORDER; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUDDEN DEATH; SYSTEMATIC REVIEW; URINARY EXCRETION; VIVID DREAM;

EID: 14544302297     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389557053402701     Document Type: Review

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