Paracellular drug transport across intestinal epithelia: Influence of charge and induced water flux

European Journal of Pharmaceutical Sciences

Volumn 9, Issue 1, 1999, Pages 47-56

  Karlsson, Johan ^a   Ungell, Anna Lena ^b   Gråsjö, Johan ^a   Artursson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Caco 2 cells; Epithelial permeability; Epithelial water transport; Hypotonic glucose solution; Paracellular drug transport; Rat ileum; Solvent drag; Tight junctions

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; DRUG ABSORPTION; DRUG TRAFFIC; ELECTRIC POTENTIAL; FLUORESCENCE MICROSCOPY; ILEUM; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; RAT; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; WATER ABSORPTION;

ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CATIONS; CELL MEMBRANE PERMEABILITY; CREATINE; ELECTROPHYSIOLOGY; ERYTHRITOL; FOSCARNET; GLUCOSE; HUMANS; ILEUM; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; PHARMACEUTICAL PREPARATIONS; RATS; TIGHT JUNCTIONS; WATER;

EID: 0032872193     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(99)00041-X     Document Type: Article

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