Potential role for P-glycoprotein in the non-proportional pharmacokinetics of UK-343,664 in man

Xenobiotica

Volumn 31, Issue 8-9, 2001, Pages 665-676

  Abel, S ^a   Beaumont, K C ^a   Crespi, C L ^a   Eve, M D ^a   Fox, L ^a   Hyland, R ^a   Jones, B C ^a   Muirhead, G J ^a   Smith, D A ^a   Venn, R F ^a   Walker, D K ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 3A4; GLYCOPROTEIN P; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V; PYRIMIDINONE DERIVATIVE; UK 343664; UK 343665; UK 347334; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG TRANSPORT; FIRST PASS EFFECT; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; LIPOPHILICITY; MALE; MAXIMUM ALLOWABLE CONCENTRATION; NONHUMAN; NONLINEAR SYSTEM; NORMAL HUMAN;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; LLC-PK1 CELLS; MALE; MICROSOMES, LIVER; MIDDLE AGED; MIXED FUNCTION OXYGENASES; P-GLYCOPROTEIN; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PROTEIN BINDING; PYRIMIDINONES; RECOMBINANT PROTEINS; SWINE;

EID: 17944379428     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250110052779     Document Type: Article

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