-
1
-
-
0037335308
-
Delivering the power of discovery in large pharmaceutical organizations
-
Peakman T., et al. Delivering the power of discovery in large pharmaceutical organizations. Drug Discov. Today. 8:2003;203-211
-
(2003)
Drug Discov. Today
, vol.8
, pp. 203-211
-
-
Peakman, T.1
-
2
-
-
0037395605
-
A brief history of novel drug discovery technologies
-
Gershell L.J., Atkins J.H. A brief history of novel drug discovery technologies. Nat. Rev. Drug Discov. 2:2003;321-327
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 321-327
-
-
Gershell, L.J.1
Atkins, J.H.2
-
3
-
-
12844269680
-
Advances in high-throughput screening - Do they lead to new drugs?
-
Hefti, E. and Bolten, B.M. (2003) Advances in high-throughput screening - do they lead to new drugs? Decision Resources (http://www.dresources.com/ stellent/groups/public/documents/abstract/dr_005477.hcsp)
-
(2003)
Decision Resources
-
-
Hefti, E.1
Bolten, B.M.2
-
4
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C., et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23:1997;3-25
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.1
-
5
-
-
1842836381
-
In silico and ex silico ADME approaches for drug discovery
-
Darvas F., et al. In silico and ex silico ADME approaches for drug discovery. Curr. Top. Med. Chem. 2:2002;1287-1304
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 1287-1304
-
-
Darvas, F.1
-
6
-
-
0037523454
-
Profiling dug-like properties in discovery research
-
Di L., Kerns E.H. Profiling dug-like properties in discovery research. Curr. Opin. Chem. Biol. 7:2003;402-408
-
(2003)
Curr. Opin. Chem. Biol.
, vol.7
, pp. 402-408
-
-
Di, L.1
Kerns, E.H.2
-
7
-
-
0031741846
-
Physical chemical properties of oral drug candidates in the discovery and exploratory development setting
-
Curatolo W. Physical chemical properties of oral drug candidates in the discovery and exploratory development setting. Pharm. Sci. Technol. Today. 1:1998;387-393
-
(1998)
Pharm. Sci. Technol. Today
, vol.1
, pp. 387-393
-
-
Curatolo, W.1
-
8
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods. 44:2000;235-249
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
-
9
-
-
0037468884
-
A comparison of physicochemical property profiles of development and marketed oral drugs
-
Wenlock M.C., et al. A comparison of physicochemical property profiles of development and marketed oral drugs. J. Med. Chem. 46:2003;1250-1256
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1250-1256
-
-
Wenlock, M.C.1
-
10
-
-
0347361638
-
Characteristic physical properties and structural fragments of marketed oral drugs
-
Vieth M., et al. Characteristic physical properties and structural fragments of marketed oral drugs. J. Med. Chem. 47:2004;224-232
-
(2004)
J. Med. Chem.
, vol.47
, pp. 224-232
-
-
Vieth, M.1
-
11
-
-
0035424914
-
The application of non-combinatorial chemistry to lead discovery
-
Everett J., et al. The application of non-combinatorial chemistry to lead discovery. Drug Discov. Today. 6:2001;779-786
-
(2001)
Drug Discov. Today
, vol.6
, pp. 779-786
-
-
Everett, J.1
-
12
-
-
0030756360
-
Reactive compounds and in vitro false positives in HTS
-
Rishton G.M. Reactive compounds and in vitro false positives in HTS. Drug Discov. Today. 2:1997;382-384
-
(1997)
Drug Discov. Today
, vol.2
, pp. 382-384
-
-
Rishton, G.M.1
-
13
-
-
0037439447
-
Nonleadlikeness and leadlikeness in biochemical screening
-
Rishton G.M. Nonleadlikeness and leadlikeness in biochemical screening. Drug Discov. Today. 8:2003;86-96
-
(2003)
Drug Discov. Today
, vol.8
, pp. 86-96
-
-
Rishton, G.M.1
-
14
-
-
0037394124
-
Designing screens: How to make your hits a hit
-
Walters W.P., Namchuk M. Designing screens: how to make your hits a hit. Nat. Rev. Drug Discov. 2:2003;259-266
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 259-266
-
-
Walters, W.P.1
Namchuk, M.2
-
15
-
-
0033576601
-
The design of leadlike combinatorial libraries
-
Teague S.J., et al. The design of leadlike combinatorial libraries. Angew. Chem. Int. Ed. Engl. 38:1999;3743-3747
-
(1999)
Angew. Chem. Int. Ed. Engl.
, vol.38
, pp. 3743-3747
-
-
Teague, S.J.1
-
16
-
-
0034073605
-
Property distribution of drug-related chemical databases
-
Oprea T.I. Property distribution of drug-related chemical databases. J. Comput. Aided Mol. Des. 14:2000;251-264
-
(2000)
J. Comput. Aided Mol. Des.
, vol.14
, pp. 251-264
-
-
Oprea, T.I.1
-
17
-
-
0037404468
-
Selection criteria for drug-like compounds
-
Muegge I. Selection criteria for drug-like compounds. Med. Res. Rev. 23:2003;302-321
-
(2003)
Med. Res. Rev.
, vol.23
, pp. 302-321
-
-
Muegge, I.1
-
18
-
-
0035438391
-
Is there a difference between leads and drugs? a historical perspective
-
Oprea T.I., et al. Is there a difference between leads and drugs? A historical perspective. J. Chem. Inf. Comput. Sci. 41:2001;1308-1315
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 1308-1315
-
-
Oprea, T.I.1
-
19
-
-
0036589285
-
Current trends in lead discovery: Are we looking for the appropriate properties?
-
Opera T.I. Current trends in lead discovery: are we looking for the appropriate properties? J. Comput. Aided Mol. Des. 16:2002;325-334
-
(2002)
J. Comput. Aided Mol. Des.
, vol.16
, pp. 325-334
-
-
Opera, T.I.1
-
20
-
-
0036804362
-
The genesis of high-throughput structure-based drug discovery using protein crystallography
-
Kuhn P., et al. The genesis of high-throughput structure-based drug discovery using protein crystallography. Curr. Opin. Chem. Biol. 6:2002;704-710
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 704-710
-
-
Kuhn, P.1
-
21
-
-
0036010703
-
Methods for compound selection focused on hits and application in drug discovery
-
Stahura F.L., et al. Methods for compound selection focused on hits and application in drug discovery. J. Mol. Graph. Model. 20:2002;439-446
-
(2002)
J. Mol. Graph. Model.
, vol.20
, pp. 439-446
-
-
Stahura, F.L.1
-
22
-
-
3342888639
-
Structure-based generation of viable leads from small combinatorial libraries
-
Laird E.R., Blake J.F. Structure-based generation of viable leads from small combinatorial libraries. Curr. Opin. Drug Discov. Devel. 7:2004;354-359
-
(2004)
Curr. Opin. Drug Discov. Devel.
, vol.7
, pp. 354-359
-
-
Laird, E.R.1
Blake, J.F.2
-
23
-
-
4043107079
-
Strategies for designing GPCR-focused libraries and screening sets
-
Jimonet P., Jaeger R. Strategies for designing GPCR-focused libraries and screening sets. Curr. Opin. Drug Discov. Devel. 7:2004;325-333
-
(2004)
Curr. Opin. Drug Discov. Devel.
, vol.7
, pp. 325-333
-
-
Jimonet, P.1
Jaeger, R.2
-
24
-
-
0034237264
-
Diversity screening versus focussed screening in drug discovery
-
Valler M.J., Green D. Diversity screening versus focussed screening in drug discovery. Drug Discov. Today. 5:2000;286-293
-
(2000)
Drug Discov. Today
, vol.5
, pp. 286-293
-
-
Valler, M.J.1
Green, D.2
-
25
-
-
0002510887
-
Avoiding investments in doomed drugs
-
Lipinski C.A. Avoiding investments in doomed drugs. Curr. Drug Disc. 4:2001;17-19
-
(2001)
Curr. Drug Disc.
, vol.4
, pp. 17-19
-
-
Lipinski, C.A.1
-
26
-
-
0032401982
-
High-throughput screening of historic collections: Observations on file size, biological targets, and file diversity
-
Spencer R.W. High-throughput screening of historic collections: observations on file size, biological targets, and file diversity. Biotechnol. Bioeng. 61:1998;61-67
-
(1998)
Biotechnol. Bioeng.
, vol.61
, pp. 61-67
-
-
Spencer, R.W.1
-
27
-
-
1542724421
-
Design of a compound screening selection for use in high-throughput screening
-
Harper G., et al. Design of a compound screening selection for use in high-throughput screening. Comb. Chem. High Throughput Screen. 7:2004;63-71
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, pp. 63-71
-
-
Harper, G.1
-
28
-
-
0036835460
-
Integration of virtual and high-throughput screening
-
Bajorath J. Integration of virtual and high-throughput screening. Nat. Rev. Drug Discov. 1:2002;882-894
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 882-894
-
-
Bajorath, J.1
-
29
-
-
0034093179
-
Quantized surface complementarity diversity (QSCD): A model based small molecule-target complementarity
-
Wintner E.A., Moallemi C.C. Quantized surface complementarity diversity (QSCD): a model based small molecule-target complementarity. J. Med. Chem. 43:2000;1993-2006
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1993-2006
-
-
Wintner, E.A.1
Moallemi, C.C.2
-
30
-
-
0033400589
-
Molecular scaffold based design and comparison of combinatorial libraries focused on the ATP-binding site of protein kinases
-
Stahura F.L., et al. Molecular scaffold based design and comparison of combinatorial libraries focused on the ATP-binding site of protein kinases. J. Mol. Graph. Model. 17:1999;1-9
-
(1999)
J. Mol. Graph. Model.
, vol.17
, pp. 1-9
-
-
Stahura, F.L.1
-
31
-
-
0036827077
-
Property based design of GPCR-targeted libraries
-
Balakin K.V. Property based design of GPCR-targeted libraries. J. Chem. Inf. Comput. Sci. 42:2002;1332-1342
-
(2002)
J. Chem. Inf. Comput. Sci.
, vol.42
, pp. 1332-1342
-
-
Balakin, K.V.1
-
32
-
-
0036589928
-
Initial compound selection for sequential screening
-
Young S.S., et al. Initial compound selection for sequential screening. Curr. Opin. Drug Discov. Devel. 5:2002;422-427
-
(2002)
Curr. Opin. Drug Discov. Devel.
, vol.5
, pp. 422-427
-
-
Young, S.S.1
-
33
-
-
0033621044
-
The maximal affinity of ligands
-
Kuntz I.D., et al. The maximal affinity of ligands. Proc. Natl. Acad. Sci. U. S. A. 96:1999;9997-10002
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 9997-10002
-
-
Kuntz, I.D.1
-
34
-
-
0035324944
-
Molecular complexity and its impact on the probability of finding leads for drug discovery
-
Hann M.M., et al. Molecular complexity and its impact on the probability of finding leads for drug discovery. J. Chem. Inf. Comput. Sci. 41:2001;856-864
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 856-864
-
-
Hann, M.M.1
-
35
-
-
1942453243
-
Ligand efficiency: A useful metric for lead selection
-
Hopkins A.L., et al. Ligand efficiency: a useful metric for lead selection. Drug Discov. Today. 9:2004;430-431
-
(2004)
Drug Discov. Today
, vol.9
, pp. 430-431
-
-
Hopkins, A.L.1
-
36
-
-
0036589827
-
Knowledge-based approaches in the design and selection of compound libraries for drug discovery
-
Viswanadhan V.N.V., et al. Knowledge-based approaches in the design and selection of compound libraries for drug discovery. Curr. Opin. Drug Discov. Devel. 5:2002;400-406
-
(2002)
Curr. Opin. Drug Discov. Devel.
, vol.5
, pp. 400-406
-
-
Viswanadhan, V.N.V.1
-
37
-
-
0037323146
-
Lead generation - Enhancing the success of drug discovery by investing in the hit to lead process
-
Alanine A., et al. Lead generation - enhancing the success of drug discovery by investing in the hit to lead process. Comb. Chem. High Throughput Screen. 6:2003;51-66
-
(2003)
Comb. Chem. High Throughput Screen.
, vol.6
, pp. 51-66
-
-
Alanine, A.1
-
38
-
-
0038387389
-
Hit and lead generation: Beyond high-throughput screening
-
Bleicher K.H., et al. Hit and lead generation: beyond high-throughput screening. Nat. Rev. Drug Discov. 2:2003;369-378
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 369-378
-
-
Bleicher, K.H.1
-
39
-
-
0037376928
-
Pharmaceutical profiling in drug discovery
-
Kerns E.H., Di L. Pharmaceutical profiling in drug discovery. Drug Discov. Today. 8:2003;316-323
-
(2003)
Drug Discov. Today
, vol.8
, pp. 316-323
-
-
Kerns, E.H.1
Di, L.2
-
40
-
-
0035523085
-
The new pre-preclinical paradigm: Compound optimization in early and late phase drug discovery
-
Caldwell G.W., et al. The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery. Curr. Top Med. Chem. 1:2001;353-366
-
(2001)
Curr. Top Med. Chem.
, vol.1
, pp. 353-366
-
-
Caldwell, G.W.1
-
41
-
-
0036848427
-
Hello Drug Discovery, I am from Insilico, take me to your President
-
Smith D.A. Hello Drug Discovery, I am from Insilico, take me to your President. Drug Discov. Today. 7:2002;1080-1081
-
(2002)
Drug Discov. Today
, vol.7
, pp. 1080-1081
-
-
Smith, D.A.1
-
42
-
-
0036558199
-
1536-Well assay plates: When do they make sense?
-
Garyantes T. 1536-well assay plates: when do they make sense? Drug Discov. Today. 7:2002;489-490
-
(2002)
Drug Discov. Today
, vol.7
, pp. 489-490
-
-
Garyantes, T.1
-
43
-
-
0037107045
-
Should scientific innovation be managed?
-
Schmid E.F., Smith D.A. Should scientific innovation be managed? Drug Discov. Today. 7:2002;941-944
-
(2002)
Drug Discov. Today
, vol.7
, pp. 941-944
-
-
Schmid, E.F.1
Smith, D.A.2
-
44
-
-
0035358567
-
Lead compounds discovered from libraries
-
Golebiowski A., et al. Lead compounds discovered from libraries. Curr. Opin. Chem. Biol. 5:2001;273-284
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 273-284
-
-
Golebiowski, A.1
-
45
-
-
0037861159
-
Lead compounds discovered from libraries: Part 2
-
Golebiowski A., et al. Lead compounds discovered from libraries: Part 2. Curr. Opin. Chem. Biol. 7:2003;308-325
-
(2003)
Curr. Opin. Chem. Biol.
, vol.7
, pp. 308-325
-
-
Golebiowski, A.1
|