메뉴 건너뛰기




Volumn 33, Issue 1, 2005, Pages 1-9

The roles of transporters and enzymes in hepatic drug processing

Author keywords

[No Author keywords available]

Indexed keywords

ENALAPRIL; ENALAPRILAT; LIVER ENZYME;

EID: 11144276585     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.001149     Document Type: Review
Times cited : (94)

References (37)
  • 1
    • 0033912867 scopus 로고    scopus 로고
    • Effect of zonal transport and metabolism on hepatic removal: Enalapril hydrolysis in zonal, isolated rat hepatocytes in vitro and correlation with perfusion data
    • Abu-Zahra TN and Pang KS (2000) Effect of zonal transport and metabolism on hepatic removal: enalapril hydrolysis in zonal, isolated rat hepatocytes in vitro and correlation with perfusion data. Drug Metab Dispos 28:807-813.
    • (2000) Drug Metab Dispos , vol.28 , pp. 807-813
    • Abu-Zahra, T.N.1    Pang, K.S.2
  • 2
    • 0033911581 scopus 로고    scopus 로고
    • Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes
    • Abu-Zahra TN, Wolkoff AW, Kim RB, and Pang KS (2000) Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos 28:801-806.
    • (2000) Drug Metab Dispos , vol.28 , pp. 801-806
    • Abu-Zahra, T.N.1    Wolkoff, A.W.2    Kim, R.B.3    Pang, K.S.4
  • 3
    • 0035478419 scopus 로고    scopus 로고
    • The drug efflux-metabolism alliance: Biochemical aspects
    • Benet LZ and Cummins CL (2001) The drug efflux-metabolism alliance: biochemical aspects. Adv Drug Deliv Rev 50 (Suppl 1):S3-S11.
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.1 SUPPL.
    • Benet, L.Z.1    Cummins, C.L.2
  • 4
    • 0036380025 scopus 로고    scopus 로고
    • Mechanisms of clinically relevant drug interactions associated with tacrolimus
    • Christians U, Jacobsen W, Benet LZ, and Lampen A (2002) Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet 41:813-851.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 813-851
    • Christians, U.1    Jacobsen, W.2    Benet, L.Z.3    Lampen, A.4
  • 5
    • 0036175307 scopus 로고    scopus 로고
    • Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4
    • Cummins CL, Jacobson W, and Benet LZ (2002) Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 300:1036-1045.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 1036-1045
    • Cummins, C.L.1    Jacobson, W.2    Benet, L.Z.3
  • 7
    • 0027752898 scopus 로고
    • Formed and preformed metabolite excretion clearances in liver, a metabolite formation: Studies on enalapril and enalaprilat in the single pass and recirculating perfused rat liver
    • de Lannoy IA, Barker F III, and Pang KS (1993) Formed and preformed metabolite excretion clearances in liver, a metabolite formation: studies on enalapril and enalaprilat in the single pass and recirculating perfused rat liver. J Pharmacokinet Biopharm 21:395-421.
    • (1993) J Pharmacokinet Biopharm , vol.21 , pp. 395-421
    • De Lannoy, I.A.1    Barker III, F.2    Pang, K.S.3
  • 8
    • 0024789612 scopus 로고
    • Renal handling of enalapril and enalaprilat: Studies in the isolated red blood cell-perfused rat kidney
    • de Lannoy IA, Nespeca R, and Pang KS (1989) Renal handling of enalapril and enalaprilat: studies in the isolated red blood cell-perfused rat kidney. J Pharmacol Exp Ther 251:1211-1222.
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 1211-1222
    • De Lannoy, I.A.1    Nespeca, R.2    Pang, K.S.3
  • 10
    • 0034235341 scopus 로고    scopus 로고
    • Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2
    • Fattinger K, Cattori V, Hagenbuch B, Meier PJ, and Stieger B (2000) Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology 32:82-86.
    • (2000) Hepatology , vol.32 , pp. 82-86
    • Fattinger, K.1    Cattori, V.2    Hagenbuch, B.3    Meier, P.J.4    Stieger, B.5
  • 12
    • 0033007704 scopus 로고    scopus 로고
    • Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption - Theoretical approach
    • Ito K, Kusuhara H, and Sugiyama Y (1999) Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption - theoretical approach. Pharm Res (NY) 16:225-231.
    • (1999) Pharm Res (NY) , vol.16 , pp. 225-231
    • Ito, K.1    Kusuhara, H.2    Sugiyama, Y.3
  • 13
    • 0035675648 scopus 로고    scopus 로고
    • The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil
    • Johnson BM, Charman WN, and Porter CJH (2001) The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil. J Pharm Pharmacol 53:1611-1619.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 1611-1619
    • Johnson, B.M.1    Charman, W.N.2    Porter, C.J.H.3
  • 14
    • 0032705762 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetics of digoxin in mdrIa knockout mice
    • Kawahara M, Sakata A, Miyashita T, Tamai I, and Tsuji A (1999) Physiologically based pharmacokinetics of digoxin in mdrIa knockout mice. J Pharm Sci 88:1281-1287.
    • (1999) J Pharm Sci , vol.88 , pp. 1281-1287
    • Kawahara, M.1    Sakata, A.2    Miyashita, T.3    Tamai, I.4    Tsuji, A.5
  • 15
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • Geick A, Eichelbaum M, and Burk O (2001) Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276:14581-14587.
    • (2001) J Biol Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 16
  • 18
    • 1342302110 scopus 로고    scopus 로고
    • Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: Hepatic enzyme-transporter interplay
    • Lau YY, Wu CY, Okochi H, and Benet LZ (2004) Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther 308:1040-1045.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1040-1045
    • Lau, Y.Y.1    Wu, C.Y.2    Okochi, H.3    Benet, L.Z.4
  • 19
    • 0031719032 scopus 로고    scopus 로고
    • Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells
    • Makhey VD, Guo A, Norris DA, Hu P, Yan J, and Sinko PJ (1998) Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells. Pharm Res (NY) 15:1160-1167.
    • (1998) Pharm Res (NY) , vol.15 , pp. 1160-1167
    • Makhey, V.D.1    Guo, A.2    Norris, D.A.3    Hu, P.4    Yan, J.5    Sinko, P.J.6
  • 20
    • 0023430998 scopus 로고
    • Competition between two enzymes for substrate removal in liver: Modulating effects of competitive pathways
    • Morris ME and Pang KS (1987) Competition between two enzymes for substrate removal in liver: modulating effects of competitive pathways. J Pharmacokinet Biopharm 15:473-496.
    • (1987) J Pharmacokinet Biopharm , vol.15 , pp. 473-496
    • Morris, M.E.1    Pang, K.S.2
  • 21
    • 0030886124 scopus 로고    scopus 로고
    • Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
    • Noé B, Hagenbuch B, Stieger B, and Meier PJ (1997) Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA 94:10346-10350.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10346-10350
    • Noé, B.1    Hagenbuch, B.2    Stieger, B.3    Meier, P.J.4
  • 22
    • 0025947940 scopus 로고
    • Esterases for enalapril hydrolysis are concentrated in the perihepatic venous region of the rat liver
    • Pang KS, Cherry WF, Barker F III, and Goresky CA (1991) Esterases for enalapril hydrolysis are concentrated in the perihepatic venous region of the rat liver. J Pharmacol Exp Ther 257:294-301.
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 294-301
    • Pang, K.S.1    Cherry, W.F.2    Barker III, F.3    Goresky, C.A.4
  • 23
    • 0021672148 scopus 로고
    • Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes
    • Pang KS, Cherry WF, Terrell JA, and Ulm EH (1984) Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes. Drug Metab Dispos 12:309-313.
    • (1984) Drug Metab Dispos , vol.12 , pp. 309-313
    • Pang, K.S.1    Cherry, W.F.2    Terrell, J.A.3    Ulm, E.H.4
  • 24
    • 0003140994 scopus 로고
    • Chapter 5: Metabolism: Scaling up from in vitro to organ and whole body
    • Welling PG and Balant LP eds, Springer-Verlag, Stuttgart
    • Pang KS and Chiba M (1994) Chapter 5: Metabolism: scaling up from in vitro to organ and whole body, in Handbook of Experimental Pharmacology (Welling PG and Balant LP eds) pp 101-187, Springer-Verlag, Stuttgart.
    • (1994) Handbook of Experimental Pharmacology , pp. 101-187
    • Pang, K.S.1    Chiba, M.2
  • 25
    • 11144346520 scopus 로고    scopus 로고
    • Abolition of biliary excretion of enalapril and enalaprilat in EHBR perfused livers and enalapril is transported by OATP-2 and OATP-8
    • AAPS Annual Meeting, Nov 12-14, 2002. Toronto
    • Pang KS, Chung A, Cui Y, and Keppler D (2002) Abolition of biliary excretion of enalapril and enalaprilat in EHBR perfused livers and enalapril is transported by OATP-2 and OATP-8. AAPS Annual Meeting, Nov 12-14, 2002. AAPS Pharm Sci 4:W4284. Toronto.
    • (2002) AAPS Pharm Sci , vol.4
    • Pang, K.S.1    Chung, A.2    Cui, Y.3    Keppler, D.4
  • 26
    • 17344364101 scopus 로고    scopus 로고
    • The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein
    • Pang KS, Wang PJ, Chung AY, and Wolkoff AW (1998) The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology 28:1341-1346.
    • (1998) Hepatology , vol.28 , pp. 1341-1346
    • Pang, K.S.1    Wang, P.J.2    Chung, A.Y.3    Wolkoff, A.W.4
  • 27
    • 0032601755 scopus 로고    scopus 로고
    • Drug disposition as determined by the interplay between drug-transporting and drug-metabolizing systems
    • Schuetz EG and Schinkel AH (1999) Drug disposition as determined by the interplay between drug-transporting and drug-metabolizing systems. J Biochem Mol Toxicol 13:219-222.
    • (1999) J Biochem Mol Toxicol , vol.13 , pp. 219-222
    • Schuetz, E.G.1    Schinkel, A.H.2
  • 28
    • 0031430085 scopus 로고    scopus 로고
    • Organ clearance concepts: New perspectives on old principles
    • Sirianni GL and Pang KS (1997) Organ clearance concepts: new perspectives on old principles. J Pharmacokinet Biopharm 25:457-478.
    • (1997) J Pharmacokinet Biopharm , vol.25 , pp. 457-478
    • Sirianni, G.L.1    Pang, K.S.2
  • 31
    • 0141569640 scopus 로고    scopus 로고
    • Influence of P-glycoprotein, transfer clearances and drug binding on intestinal metabolism in Caco-2 cell monolayers or membrane preparations: A theoretical analysis
    • Tam D, Sun H, and Pang KS (2003) Influence of P-glycoprotein, transfer clearances and drug binding on intestinal metabolism in Caco-2 cell monolayers or membrane preparations: a theoretical analysis. Drug Metab Dispos 31:1214-1226.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1214-1226
    • Tam, D.1    Sun, H.2    Pang, K.S.3
  • 33
    • 0031765907 scopus 로고    scopus 로고
    • Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
    • Wacher VJ, Silverman JA, Zhang Y, and Benet LZ (1998) Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 87:1322-1330.
    • (1998) J Pharm Sci , vol.87 , pp. 1322-1330
    • Wacher, V.J.1    Silverman, J.A.2    Zhang, Y.3    Benet, L.Z.4
  • 34
    • 0142212163 scopus 로고    scopus 로고
    • Disposition of tacrolimus in isolated perfused rat liver: Influence of troleandomycin, cyclosporine and GG918
    • Wu CY and Benet LZ (2003) Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine and GG918. Drug Metab Dispos 31:1292-1295.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1292-1295
    • Wu, C.Y.1    Benet, L.Z.2
  • 36
    • 0035152973 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of cytochrome P-450 3a-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone
    • Yumoto R, Murakami T, Sanemasa M, Nasu R, Nagai J, and Takano M (2001) Pharmacokinetic interaction of cytochrome P-450 3a-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone. Drug Metab Dispos 29:145-151.
    • (2001) Drug Metab Dispos , vol.29 , pp. 145-151
    • Yumoto, R.1    Murakami, T.2    Sanemasa, M.3    Nasu, R.4    Nagai, J.5    Takano, M.6
  • 37
    • 0016162986 scopus 로고
    • The isolation of hormone sensitive rat hepatocytes by a modified enzymatic technique
    • Zahlten RN and Stratman FW (1974) The isolation of hormone sensitive rat hepatocytes by a modified enzymatic technique. Arch Biochem Biophys 163:606-608.
    • (1974) Arch Biochem Biophys , vol.163 , pp. 606-608
    • Zahlten, R.N.1    Stratman, F.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.