Characterization of raloxifene glucuronidation in vitro: Contribution of intestinal metabolism to presystemic clearance

Drug Metabolism and Disposition

Volumn 30, Issue 6, 2002, Pages 694-700

  Kemp, Daniel C ^a   Fan, Peter W ^b   Stevens, Jeffrey C ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALAMETHICIN; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; RALOXIFENE;

ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE; LIVER MICROSOME; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ALAMETHICIN; BIOTRANSFORMATION; ESTROGEN ANTAGONISTS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; INTESTINAL ABSORPTION; INTESTINES; ISOENZYMES; MICROSOMES; MICROSOMES, LIVER; RALOXIFENE;

EID: 0036266936     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.6.694     Document Type: Article

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