Improved intestinal transport of PD 158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters

Journal of Pharmaceutical Sciences

Volumn 91, Issue 12, 2002, Pages 2579-2587

  Oh, Doo Man ^a   Han, Hyo Kyung ^a   Williamson, Rufus M ^a   Bigge, Christopher F ^a   Amidon, Gordon L ^b   Stewart, Barbra H ^a   Surendran, Narayanan ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Caco 2 cells; Di tripeptide transporter; Intestinal transport; Large neutral amino acid transporter; NMDA antagonist

Indexed keywords

AMINO ACID TRANSPORTER; CARBOXYLIC ACID; CARRIER PROTEIN; DIPEPTIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PD 158473; UNCLASSIFIED DRUG; DRUG DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NAPHTHALENE DERIVATIVE; PHENYLALANINE;

ANIMAL CELL; ANIMAL TISSUE; APICAL MEMBRANE; AREA UNDER THE CURVE; BASOLATERAL MEMBRANE; BINDING AFFINITY; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG CLEARANCE; DRUG STRUCTURE; DRUG TRANSPORT; DRUG UPTAKE; INTESTINE ABSORPTION; INTESTINE PERFUSION; INTRACELLULAR TRANSPORT; MALE; MODEL; NONHUMAN; PH; RAT; ANIMAL; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; NON-PROGRAMMATIC; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

NON-PROGRAMMATIC;

ANIMALS; AREA UNDER CURVE; CACO-2 CELLS; HUMANS; INTESTINAL ABSORPTION; MALE; MEMBRANE TRANSPORT PROTEINS; NAPHTHALENES; PHENYLALANINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0036891925     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10241     Document Type: Conference Paper

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