Can selective ligands for glutamate binding proteins be rationally designed?

Current Topics in Medicinal Chemistry

Volumn 6, Issue 8, 2006, Pages 823-847

  Natale, Nicholas R ^a   Magnusson, Kathy R ^b   Nelson, Jared K ^c  

^a UNIVERSITY OF IDAHO   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Glutamate; Inhibitor; Isoxazole; Ligand; Receptor; Substrate; Transporter

Indexed keywords

2,4 PYRROLIDINE DICARBOXYLIC ACID; 6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; 6,7 DINITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CYCLOTHIAZIDE; DIZOCILPINE; EGLUMETAD; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; KYNURENIC ACID DERIVATIVE; LIGAND; MEMANTINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTRANSMITTER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANXIETY DISORDER; BINDING SITE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; COGNITIVE DEFECT; CROSS REACTION; DRUG STRUCTURE; HUMAN; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PHARMACOPHORE; PROTEIN BINDING; PSYCHOSIS; RECEPTOR DOWN REGULATION; REVIEW;

AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; DRUG DESIGN; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUTAMIC ACID; HUMANS; ISOXAZOLES; LIGANDS; MODELS, CHEMICAL; RECEPTORS, GLUTAMATE; VESICULAR GLUTAMATE TRANSPORT PROTEINS;

EID: 33646580043     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802606777057535     Document Type: Review

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