Design, synthesis, and pharmacological characterization of (+)-2- aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties

Journal of Medicinal Chemistry

Volumn 40, Issue 4, 1997, Pages 528-537

  Monn, James A ^a   Valli, Matthew J ^b   Massey, Steven M ^b   Wright, Rebecca A ^b   Salhoff, Craig R ^b   Johnson, Bryan G ^b   Howe, Trevor ^a   Alt, Charles A ^a   Rhodes, Gary A ^a   Robey, Roger L ^a   Griffey, Kelly R ^a   Tizzano, Joseph P ^a   Kallman, Mary J ^a   Helton, David R ^a   Schoepp, Darryle D ^b  

^a ELI LILLY AND COMPANY   (United States)

^b Eli Lilly and Company ^*

Author keywords

[No Author keywords available]

Indexed keywords

EGLUMETAD; GLUTAMATE RECEPTOR; GLUTAMIC ACID DERIVATIVE; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY NEUROSIS; ARTICLE; BRAIN CORTEX; BRAIN SLICE; COMPLEX PARTIAL SEIZURE; DRUG CONFORMATION; LIMBIC SYSTEM; MALE; MAZE TEST; MOUSE; NONHUMAN; SEIZURE; STEREOSPECIFICITY; SYNAPTIC TRANSMISSION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BICYCLO COMPOUNDS; CYCLIC AMP; DRUG DESIGN; EXCITATORY AMINO ACID AGONISTS; FORSKOLIN; MICE; MODELS, MOLECULAR; RATS; RECEPTORS, GLUTAMATE;

EID: 15644369847     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9606756     Document Type: Article

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