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Volumn 107, Issue 3, 2005, Pages 271-285

The excitatory amino acid transporters: Pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes

Author keywords

Excitatory amino acids; Glutamate; Glutamate analogues; Transport; Uptake

Indexed keywords

2 (2' AMINOPROPIONIC ACID) 4,5 DIHYDROOXAZOLE 4 CARBOXYLIC ACID; 2 (CARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 3 (1 HYDROXY 1,2,3 TRIAZOL 5 YL)PROPIONIC ACID; 2 AMINO 3 (3 HYDROXY 1,2,5 THIADIAZOL 5 YL)PROPIONIC ACID; 2 PHENYL 4,5 DIHYDROOXAZOLE 4,5 DICARBOXYLIC ACID; 2,4 METHANOPYRROLIDINE 2,4 DICARBOXYLIC ACID; 3 [3 [4 (TRIFLUOROMETHYL)BENZOYLAMINO]BENZYLOXY]ASPARTIC ACID; 3 AMINOTRICYCLO[2.2.1.0 2,6 ]HEPTANE 1,3 DICARBOXYLIC ACID; 4 METHYL LEVO 2,4 PYRROLIDINE DICARBOXYLIC ACID; 4 METHYLGLUTAMIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; ASPARTIC ACID DERIVATIVE; CARBOXYL GROUP; DICARBOXYLIC AMINO ACID; DIHYDROKAINIC ACID; EXCITATORY AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 3; EXCITATORY AMINO ACID TRANSPORTER 4; EXCITATORY AMINO ACID TRANSPORTER 5; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; HYDROXYL GROUP; KAINIC ACID; LEVO 2,3 PYRROLIDINE DICARBOXYLIC ACID; LEVO 2,4 PYRROLIDINE DICARBOXYLIC ACID; LEVO 3,4 METHANOPYRROLIDINE DICARBOXYLIC ACID; OXAZOLE DERIVATIVE; PYRROLIDINE DERIVATIVE; THREO 3 METHYLGLUTAMIC ACID; THREO BENZYLOXYASPARTIC ACID; UNCLASSIFIED DRUG; WAY 855;

EID: 23844450692     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2005.01.002     Document Type: Review
Times cited : (114)

References (134)
  • 1
    • 0344907727 scopus 로고    scopus 로고
    • Neurotransmitter transporters
    • Academic Press San Diego
    • S.G. Amara Neurotransmitter transporters Methods Enzymol vol. 296 1998 Academic Press San Diego
    • (1998) Methods Enzymol , vol.296
    • Amara, S.G.1
  • 4
    • 1542304461 scopus 로고    scopus 로고
    • Binding and transport of [3H](2S,4R)-4-methylglutamate, a new ligand for glutamate transporters, demonstrate labeling of EAAT1 in cultured murine astrocytes
    • K. Aprico, P.M. Beart, D. Crawford, and R.D. O'Shea Binding and transport of [3H](2S,4R)-4-methylglutamate, a new ligand for glutamate transporters, demonstrate labeling of EAAT1 in cultured murine astrocytes J Neurosci Res 15 2004 751 759
    • (2004) J Neurosci Res , vol.15 , pp. 751-759
    • Aprico, K.1    Beart, P.M.2    Crawford, D.3    O'Shea, R.D.4
  • 5
    • 0028031487 scopus 로고
    • Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
    • J.L. Arriza, W.A. Fairman, J.I. Wadiche, G.H. Murdoch, M.P. Kavanaugh, and S.G. Amara Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex J Neurosci 14 1994 5559 5569
    • (1994) J Neurosci , vol.14 , pp. 5559-5569
    • Arriza, J.L.1    Fairman, W.A.2    Wadiche, J.I.3    Murdoch, G.H.4    Kavanaugh, M.P.5    Amara, S.G.6
  • 6
    • 0030932152 scopus 로고    scopus 로고
    • Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
    • J.L. Arriza, S. Eliasof, M.P. Kavanaugh, and S.G. Amara Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance Proc Natl Acad Sci U S A 94 1997 4155 4160
    • (1997) Proc Natl Acad Sci U S a , vol.94 , pp. 4155-4160
    • Arriza, J.L.1    Eliasof, S.2    Kavanaugh, M.P.3    Amara, S.G.4
  • 7
    • 0031046153 scopus 로고    scopus 로고
    • Extrasynaptic glutamate spillover in the hippocampus: Dependence on temperature and the role of active glutamate uptake
    • F. Asztely, G. Erdemli, and D.M. Kullmann Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake Neuron 18 1997 281 293
    • (1997) Neuron , vol.18 , pp. 281-293
    • Asztely, F.1    Erdemli, G.2    Kullmann, D.M.3
  • 8
    • 0034026565 scopus 로고    scopus 로고
    • Brain uptake of glutamate: Food for thought
    • D. Attwell Brain uptake of glutamate: food for thought J Nutr 130 2000 1023S 1025S
    • (2000) J Nutr , vol.130
    • Attwell, D.1
  • 9
    • 0037109669 scopus 로고    scopus 로고
    • The origin and neuronal function of in vivo nonsynaptic glutamate
    • D.A. Baker, Z.X. Xi, H. Shen, C.J. Swanson, and P.W. Kalivas The origin and neuronal function of in vivo nonsynaptic glutamate J Neurosci 22 2002 9134 9141
    • (2002) J Neurosci , vol.22 , pp. 9134-9141
    • Baker, D.A.1    X Z. Xi2    Shen, H.3    Swanson, C.J.4    Kalivas, P.W.5
  • 10
    • 0015426691 scopus 로고
    • The structural specificity of the high affinity uptake of l-glutamate and l-aspartate by rat brain slices
    • V.J. Balcar, and G.A.R. Johnston The structural specificity of the high affinity uptake of l-glutamate and l-aspartate by rat brain slices J Neurochem 19 1972 2657 2666
    • (1972) J Neurochem , vol.19 , pp. 2657-2666
    • Balcar, V.J.1    Johnston, G.A.R.2
  • 11
    • 0023152739 scopus 로고
    • Differences between substrate specificities of l-glutamate uptake by neurons and glia, studied in cell lines and primary cultures
    • V.J. Balcar, A. Schousboe, P.E. Spoerr, and J.R. Wolfe Differences between substrate specificities of l-glutamate uptake by neurons and glia, studied in cell lines and primary cultures Neurochem Int 10 1987 213 217
    • (1987) Neurochem Int , vol.10 , pp. 213-217
    • Balcar, V.J.1    Schousboe, A.2    Spoerr, P.E.3    Wolfe, J.R.4
  • 12
    • 0028238967 scopus 로고
    • Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells
    • B. Barbour, B.U. Keller, I. Liana, and A. Marty Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells Neuron 12 1994 1331 1343
    • (1994) Neuron , vol.12 , pp. 1331-1343
    • Barbour, B.1    Keller, B.U.2    Liana, I.3    Marty, A.4
  • 13
    • 0033152742 scopus 로고    scopus 로고
    • Clearance of glutamate inside the synapse and beyond
    • D.E. Bergles, J.S. Diamond, and C.E. Jahr Clearance of glutamate inside the synapse and beyond Curr Opin Neurobiol 9 1999 293 298
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 293-298
    • Bergles, D.E.1    Diamond, J.S.2    Jahr, C.E.3
  • 14
    • 0037539911 scopus 로고    scopus 로고
    • Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor dl-threo-beta-benzyloxyaspartate (dl-TBOA) during physiological and ischemia-like conditions
    • C. Bonde, A. Sarup, A. Schousboe, G. Gegelashvilli, J. Zimmer, and J. Noraberg Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor dl-threo-beta-benzyloxyaspartate (dl-TBOA) during physiological and ischemia-like conditions Neurochem Int 43 2003 371 380
    • (2003) Neurochem Int , vol.43 , pp. 371-380
    • Bonde, C.1    Sarup, A.2    Schousboe, A.3    Gegelashvilli, G.4    Zimmer, J.5    Noraberg, J.6
  • 15
    • 0031763592 scopus 로고    scopus 로고
    • AMPA receptors: Molecular and functional diversity
    • K. Borges, and R. Dingledine AMPA receptors: molecular and functional diversity Prog Brain Res 116 1999 153 170
    • (1999) Prog Brain Res , vol.116 , pp. 153-170
    • Borges, K.1    Dingledine, R.2
  • 16
    • 0342906539 scopus 로고    scopus 로고
    • A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2
    • H. Brauner-Osborne, M.B. Hermit, B. Nielsen, P. Krogsgaard-Larsen, and T.N. Johansen A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2 Eur J Pharmacol 406 2000 41 44
    • (2000) Eur J Pharmacol , vol.406 , pp. 41-44
    • Brauner-Osborne, H.1    Hermit, M.B.2    Nielsen, B.3    Krogsgaard-Larsen, P.4    Johansen, T.N.5
  • 17
    • 0026080845 scopus 로고
    • Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer
    • R.J. Bridges, M.S. Stanley, M.W. Anderson, C.W. Cotman, and A.R. Chamberlin Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer J Med Chem 34 1991 717 725
    • (1991) J Med Chem , vol.34 , pp. 717-725
    • Bridges, R.J.1    Stanley, M.S.2    Anderson, M.W.3    Cotman, C.W.4    Chamberlin, A.R.5
  • 18
    • 0028341707 scopus 로고
    • A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: L-anti-endo-3,4-methanopyrrolidine dicarboxylate
    • R.J. Bridges, F.E. Lovering, H. Koch, C.W. Cotman, and A.R. Chamberlin A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: l-anti-endo-3,4- methanopyrrolidine dicarboxylate Neurosci Lett 174 1994 193 197
    • (1994) Neurosci Lett , vol.174 , pp. 193-197
    • Bridges, R.J.1    Lovering, F.E.2    Koch, H.3    Cotman, C.W.4    Chamberlin, A.R.5
  • 19
    • 0032937403 scopus 로고    scopus 로고
    • A pharmacological review of competitive inhibitors and substrates of high-affinity, sodium-dependent glutamate transporters in the central nervous system
    • R.J. Bridges, M.P. Kavanaugh, and A.R. Chamberlin A pharmacological review of competitive inhibitors and substrates of high-affinity, sodium-dependent glutamate transporters in the central nervous system Curr Pharm Des 5 1999 363 379
    • (1999) Curr Pharm des , vol.5 , pp. 363-379
    • Bridges, R.J.1    Kavanaugh, M.P.2    Chamberlin, A.R.3
  • 20
    • 0035797358 scopus 로고    scopus 로고
    • A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3); New glutamate and aspartate analogues as potential neuroprotective agents
    • G. Campiani, M. De Angelis, S. Armaroli, C. Fattorusso, B. Catalanotti, and A. Ramunno A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3); new glutamate and aspartate analogues as potential neuroprotective agents J Med Chem 44 2001 2507 2510
    • (2001) J Med Chem , vol.44 , pp. 2507-2510
    • Campiani, G.1    De Angelis, M.2    Armaroli, S.3    Fattorusso, C.4    Catalanotti, B.5    Ramunno, A.6
  • 21
    • 0037286233 scopus 로고    scopus 로고
    • Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): Targets for the development of novel therapeutics against neurodegenerative diseases
    • G. Campiani, C. Fattorusso, M. De Angelis, B. Catalanotti, S. Butini, and R. Fattorusso Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases Curr Pharm Des 9 2003 599 625
    • (2003) Curr Pharm des , vol.9 , pp. 599-625
    • Campiani, G.1    Fattorusso, C.2    De Angelis, M.3    Catalanotti, B.4    Butini, S.5    Fattorusso, R.6
  • 22
    • 0034659742 scopus 로고    scopus 로고
    • Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse
    • A.G. Carter, and W.G. Regehr Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse J Neurosci 20 2000 4423 4434
    • (2000) J Neurosci , vol.20 , pp. 4423-4434
    • Carter, A.G.1    Regehr, W.G.2
  • 23
    • 0031660297 scopus 로고    scopus 로고
    • Design and synthesis of conformationally constrained inhibitors of high-affinity, sodium-dependent glutamate transporters
    • S.G. Amara Academic Press San Diego
    • A.R. Chamberlin, H.P. Koch, and R.J. Bridges Design and synthesis of conformationally constrained inhibitors of high-affinity, sodium-dependent glutamate transporters S.G. Amara Neurotransmitter transporters 1998 Academic Press San Diego 175 189
    • (1998) Neurotransmitter Transporters , pp. 175-189
    • Chamberlin, A.R.1    Koch, H.P.2    Bridges, R.J.3
  • 24
    • 0037088930 scopus 로고    scopus 로고
    • Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain
    • W. Chen, C. Aoki, V. Mahadomrongkul, C.E. Gruber, G.J. Wang, and R. Blitzbau Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain J Neurosci 22 2002 2142 2152
    • (2002) J Neurosci , vol.22 , pp. 2142-2152
    • Chen, W.1    Aoki, C.2    Mahadomrongkul, V.3    Gruber, C.E.4    Wang, G.J.5    Blitzbau, R.6
  • 25
    • 0028016077 scopus 로고
    • Glutamate receptors and the induction of excitotoxic neuronal death
    • D.W. Choi Glutamate receptors and the induction of excitotoxic neuronal death Prog Brain Res 100 1994 47 51
    • (1994) Prog Brain Res , vol.100 , pp. 47-51
    • Choi, D.W.1
  • 27
    • 0345830631 scopus 로고    scopus 로고
    • Physiological roles and therapeutic potential of metabotropic glutamate receptors
    • P.J. Conn Physiological roles and therapeutic potential of metabotropic glutamate receptors Ann N Y Acad Sci 1003 2003 12 21
    • (2003) Ann N Y Acad Sci , vol.1003 , pp. 12-21
    • Conn, P.J.1
  • 28
    • 0019399306 scopus 로고
    • An overview of glutamate as a neurotransmitter
    • G. Di Chiara G.L. Gessa Raven Press New York
    • C.W. Cotman, A. Foster, and T. Lanthorn An overview of glutamate as a neurotransmitter G. Di Chiara G.L. Gessa Glutamate as a neurotransmitter 1981 Raven Press New York 1 27
    • (1981) Glutamate As a Neurotransmitter , pp. 1-27
    • Cotman, C.W.1    Foster, A.2    Lanthorn, T.3
  • 29
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • N.C. Danbolt Glutamate uptake Prog Neurobiol 65 2001 1 105
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 30
    • 0030947654 scopus 로고    scopus 로고
    • Transporters buffer synaptically released glutamate on a submillisecond time scale
    • J.S. Diamond, and C.E. Jahr Transporters buffer synaptically released glutamate on a submillisecond time scale J Neurosci 17 1997 4672 4687
    • (1997) J Neurosci , vol.17 , pp. 4672-4687
    • Diamond, J.S.1    Jahr, C.E.2
  • 31
    • 0034127640 scopus 로고    scopus 로고
    • Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation
    • J.S. Diamond, and C.E. Jahr Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation J Neurophysiol 83 2000 2835 2843
    • (2000) J Neurophysiol , vol.83 , pp. 2835-2843
    • Diamond, J.S.1    Jahr, C.E.2
  • 32
    • 0029921679 scopus 로고    scopus 로고
    • +-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1)
    • +-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1) Mol Pharmacol 49 1996 465 473
    • (1996) Mol Pharmacol , vol.49 , pp. 465-473
    • Dowd, L.A.1    Coyle, A.J.2    Rothstein, J.D.3    Pritchett, D.B.4    Robinson, M.B.5
  • 33
    • 0000974147 scopus 로고    scopus 로고
    • Excitatory amino acid transporters as emerging targets for central nervous system therapeutics
    • J. Dunlop, M. Zaleska, S.H. Eliasof, and J.A. Moyer Excitatory amino acid transporters as emerging targets for central nervous system therapeutics Emerg Ther Targets 3 1999 543
    • (1999) Emerg Ther Targets , vol.3 , pp. 543
    • Dunlop, J.1    Zaleska, M.2    Eliasof, S.H.3    Moyer, J.A.4
  • 34
    • 0345304285 scopus 로고    scopus 로고
    • WAY-855 (3-amino-tricyclo[2.2.1.0.2.6]heptane-13,-docarboxylicacid): A novel EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake
    • J. Dunlop, S. Eliasof, G. Stack, H.B. McIlvain, A. Greenfield, and D.M. Kowal WAY-855 (3-amino-tricyclo[2.2.1.0.2.6]heptane-13,-docarboxylicacid): a novel EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake Br J Pharmacol 140 2003 839 846
    • (2003) Br J Pharmacol , vol.140 , pp. 839-846
    • Dunlop, J.1    Eliasof, S.2    Stack, G.3    McIlvain, H.B.4    Greenfield, A.5    Kowal, D.M.6
  • 35
    • 0031972667 scopus 로고    scopus 로고
    • Excitatory amino acid transporters of the salamander retina: Identification, localization, and function
    • S.H. Eliasof, J.L. Arriza, B.H. Leighton, M.P. Kavanaugh, and S.G. Amara Excitatory amino acid transporters of the salamander retina: identification, localization, and function J Neurosci 18 1998 698 712
    • (1998) J Neurosci , vol.18 , pp. 698-712
    • Eliasof, S.H.1    Arriza, J.L.2    Leighton, B.H.3    Kavanaugh, M.P.4    Amara, S.G.5
  • 36
    • 0035044675 scopus 로고    scopus 로고
    • Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems
    • S.H. Eliasof, H.B. McIlvain, R.E. Petroski, A.C. Foster, and J. Dunlop Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems J Neurochem 77 2001 550 557
    • (2001) J Neurochem , vol.77 , pp. 550-557
    • Eliasof, S.H.1    McIlvain, H.B.2    Petroski, R.E.3    Foster, A.C.4    Dunlop, J.5
  • 37
    • 0036836946 scopus 로고    scopus 로고
    • Methylation of l-trans-2,4-pyrrolidine dicarboxylate converts the glutamate transport inhibitor from a substrate to a non-substrate inhibitor
    • C.S. Esslinger, J. Titus, H.P. Koch, R.J. Bridges, and A.R. Chamberlin Methylation of l-trans-2,4-pyrrolidine dicarboxylate converts the glutamate transport inhibitor from a substrate to a non-substrate inhibitor Bioorg Med Chem 10 2002 3509 3515
    • (2002) Bioorg Med Chem , vol.10 , pp. 3509-3515
    • Esslinger, C.S.1    Titus, J.2    Koch, H.P.3    Bridges, R.J.4    Chamberlin, A.R.5
  • 38
    • 0032699070 scopus 로고    scopus 로고
    • Functional diversity of excitatory amino acid transporters: Ion channel and transport modes
    • W.A. Fairman, and S.G. Amara Functional diversity of excitatory amino acid transporters: ion channel and transport modes Am J Physiol 277 1999 F481 F486
    • (1999) Am J Physiol , vol.277
    • Fairman, W.A.1    Amara, S.G.2
  • 39
    • 0029076899 scopus 로고
    • An excitatory amino acid transporter with properties of a ligand-gated chloride channel
    • W. Fairman, R.J. Vandenberg, J.L. Arriza, M.P. Kavanaugh, and S.G. Amara An excitatory amino acid transporter with properties of a ligand-gated chloride channel Nature 375 1995 599 603
    • (1995) Nature , vol.375 , pp. 599-603
    • Fairman, W.1    Vandenberg, R.J.2    Arriza, J.L.3    Kavanaugh, M.P.4    Amara, S.G.5
  • 40
    • 0031563761 scopus 로고    scopus 로고
    • Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4
    • A. Furuta, L.J. Martin, C.-L.G. Lin, M. Dykes-Hoberg, and J.B. Rothstein Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4 Neuroscience 81 1997 1031 1042
    • (1997) Neuroscience , vol.81 , pp. 1031-1042
    • Furuta, A.1    Martin, L.J.2    Lin, C.-L.G.3    Dykes-Hoberg, M.4    Rothstein, J.B.5
  • 41
    • 0029038163 scopus 로고
    • Pharmacology of sodium-dependent high affinity l-[3H]glutamate transport in glial cultures
    • A. Garlin, A. Sinor, S. Lee, J. Grinspan, and M. Robinson Pharmacology of sodium-dependent high affinity l-[3H]glutamate transport in glial cultures J Neurochem 64 1995 2572 2580
    • (1995) J Neurochem , vol.64 , pp. 2572-2580
    • Garlin, A.1    Sinor, A.2    Lee, S.3    Grinspan, J.4    Robinson, M.5
  • 42
    • 0032006244 scopus 로고    scopus 로고
    • Cellular distribution and kinetic properties of the high-affinity glutamate transporters
    • G. Gegelashvili, and A. Schousboe Cellular distribution and kinetic properties of the high-affinity glutamate transporters Brain Res Bull 45 1998 233 238
    • (1998) Brain Res Bull , vol.45 , pp. 233-238
    • Gegelashvili, G.1    Schousboe, A.2
  • 43
    • 0742306071 scopus 로고    scopus 로고
    • Neurotransmitter transporters: Why dance with so many partners?
    • M.I. Gonzalez, and M.B. Robinson Neurotransmitter transporters: why dance with so many partners? Curr Opin Pharmacol 4 2004 30 35
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 30-35
    • Gonzalez, M.I.1    Robinson, M.B.2
  • 44
    • 2542625175 scopus 로고    scopus 로고
    • Protein kinase C-dependent remodeling of glutamate transporter function
    • M.I. Gonzalez, and M.B. Robinson Protein kinase C-dependent remodeling of glutamate transporter function Mol Interv 4 2004 48 58
    • (2004) Mol Interv , vol.4 , pp. 48-58
    • Gonzalez, M.I.1    Robinson, M.B.2
  • 45
    • 1242340323 scopus 로고    scopus 로고
    • The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins. Introduction
    • M.A. Hediger, M.F. Romero, J.B. Peng, A. Rolfs, H. Takanaga, and E.A. Bruford The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Introduction Pflugers Arch - Eur J Physiol 447 2004 465 468
    • (2004) Pflugers Arch - Eur J Physiol , vol.447 , pp. 465-468
    • Hediger, M.A.1    Romero, M.F.2    Peng, J.B.3    Rolfs, A.4    Takanaga, H.5    Bruford, E.A.6
  • 46
    • 0033562595 scopus 로고    scopus 로고
    • Glutamate uptake limits synaptic excitation of retinal ganglion cells
    • M.H. Higgs, and P.D. Lukasiewicz Glutamate uptake limits synaptic excitation of retinal ganglion cells J Neurosci 19 1999 3691 3700
    • (1999) J Neurosci , vol.19 , pp. 3691-3700
    • Higgs, M.H.1    Lukasiewicz, P.D.2
  • 48
    • 0033151664 scopus 로고    scopus 로고
    • Glutamate spillover mediates excitatory transmission in the rat olfactory bulb
    • J.S. Isaacson Glutamate spillover mediates excitatory transmission in the rat olfactory bulb Neuron 23 1999 377 384
    • (1999) Neuron , vol.23 , pp. 377-384
    • Isaacson, J.S.1
  • 49
    • 0027369524 scopus 로고
    • The uptake inhibitor l-trans-PDC enhances responses to glutamate but fails to alter kinetics of excitatory synaptic currents in the hippocampus
    • J.S. Isaacson, and R.A. Nicoll The uptake inhibitor l-trans-PDC enhances responses to glutamate but fails to alter kinetics of excitatory synaptic currents in the hippocampus J Neurophysiol 70 1993 2187 2191
    • (1993) J Neurophysiol , vol.70 , pp. 2187-2191
    • Isaacson, J.S.1    Nicoll, R.A.2
  • 50
    • 0025811150 scopus 로고
    • Changes in a preference for receptor subtypes of configurational variants of a glutamate analog: Conversion from the NMDA-type to the non-NMDA type
    • M. Ishida, Y. Ohfune, Y. Shimada, K. Shimamoto, and H. Shinozaki Changes in a preference for receptor subtypes of configurational variants of a glutamate analog: conversion from the NMDA-type to the non-NMDA type Brain Res 550 1991 152 156
    • (1991) Brain Res , vol.550 , pp. 152-156
    • Ishida, M.1    Ohfune, Y.2    Shimada, Y.3    Shimamoto, K.4    Shinozaki, H.5
  • 51
    • 0035282328 scopus 로고    scopus 로고
    • Modulation of the neuronal glutamate transporter EAAT4 by two interaction proteins
    • M. Jackson, W. Song, M.Y. Liu, L. Jin, M. Dykes-Hogerg, and C.G. Lin Modulation of the neuronal glutamate transporter EAAT4 by two interaction proteins Nature 2001 89 93
    • (2001) Nature , pp. 89-93
    • Jackson, M.1    Song, W.2    Liu, M.Y.3    Jin, L.4    Dykes-Hogerg, M.5    Lin, C.G.6
  • 53
    • 0027768619 scopus 로고
    • Quantal components of unitary EPSCs at the mossy fiber synapse on CA3 pyramidal cells of the rat hippocampus
    • P. Jonas, G. Major, and B. Sakmann Quantal components of unitary EPSCs at the mossy fiber synapse on CA3 pyramidal cells of the rat hippocampus J Physiol 472 1993 615 663
    • (1993) J Physiol , vol.472 , pp. 615-663
    • Jonas, P.1    Major, G.2    Sakmann, B.3
  • 54
    • 0026458124 scopus 로고
    • Primary structure and functional characterization of a high-affinity glutamate transporter
    • Y. Kanai, and M.A. Hediger Primary structure and functional characterization of a high-affinity glutamate transporter Nature 360 1992 467 471
    • (1992) Nature , vol.360 , pp. 467-471
    • Kanai, Y.1    Hediger, M.A.2
  • 55
    • 0035210295 scopus 로고    scopus 로고
    • Molecular characterization of substrate-binding sites in the glutamate transporter family
    • B.I. Kanner, M.P. Kavanaugh, and A. Bendahan Molecular characterization of substrate-binding sites in the glutamate transporter family Biochem Soc Trans 29 2001 707 710
    • (2001) Biochem Soc Trans , vol.29 , pp. 707-710
    • Kanner, B.I.1    Kavanaugh, M.P.2    Bendahan, A.3
  • 56
    • 0030966546 scopus 로고    scopus 로고
    • Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid B-peptide: Role of the lipid peroxidation product 4-hydroxynonemal
    • J.N. Keller, Z. Pang, J.W. Geddes, J.G. Begley, A. Germeyer, and G. Waeg Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid B-peptide: role of the lipid peroxidation product 4-hydroxynonemal J Neurochem 69 1997 273 284
    • (1997) J Neurochem , vol.69 , pp. 273-284
    • Keller, J.N.1    Pang, Z.2    Geddes, J.W.3    Begley, J.G.4    Germeyer, A.5    Waeg, G.6
  • 57
    • 0346434150 scopus 로고    scopus 로고
    • Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): Cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes
    • S.Y. Kim, S.Y. Choi, W. Chao, and W. Volsky Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes J Neurochem 87 2003 1485
    • (2003) J Neurochem , vol.87 , pp. 1485
    • Kim, S.Y.1    Choi, S.Y.2    Chao, W.3    Volsky, W.4
  • 58
    • 0030759961 scopus 로고    scopus 로고
    • Prolonged physiological entrapment of glutamate in the synaptic cleft of cerebellar unipolar brush cells
    • G.A. Kinney, L.S. Overstreet, and N.T. Slater Prolonged physiological entrapment of glutamate in the synaptic cleft of cerebellar unipolar brush cells J Neurophysiol 78 1997 1320 1333
    • (1997) J Neurophysiol , vol.78 , pp. 1320-1333
    • Kinney, G.A.1    Overstreet, L.S.2    Slater, N.T.3
  • 59
    • 0032976901 scopus 로고    scopus 로고
    • Nontransportable inhibitors attenuate reversal of glutamate uptake in synaptosomes following a metabolic insult
    • H.P. Koch, A.R. Chamberlin, and R.J. Bridges Nontransportable inhibitors attenuate reversal of glutamate uptake in synaptosomes following a metabolic insult Mol Pharmacol 55 1999 1044 1048
    • (1999) Mol Pharmacol , vol.55 , pp. 1044-1048
    • Koch, H.P.1    Chamberlin, A.R.2    Bridges, R.J.3
  • 60
    • 0032732281 scopus 로고    scopus 로고
    • Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters
    • H.P. Koch, M.P. Kavanaugh, C.S. Esslinger, N. Zerangue, J.M. Humphrey, and S.G. Amara Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters Mol Pharmacol 56 1999 1095 1104
    • (1999) Mol Pharmacol , vol.56 , pp. 1095-1104
    • Koch, H.P.1    Kavanaugh, M.P.2    Esslinger, C.S.3    Zerangue, N.4    Humphrey, J.M.5    Amara, S.G.6
  • 61
    • 0034925118 scopus 로고    scopus 로고
    • The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: The role of Abeta1-42
    • C.M. Lauderback, J.M. Hackett, F.F. Huang, J.N. Keller, L.I. Szweda, and W.R. Markesbery The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42 J Neurochem 78 2001 413 416
    • (2001) J Neurochem , vol.78 , pp. 413-416
    • Lauderback, C.M.1    Hackett, J.M.2    Huang, F.F.3    Keller, J.N.4    Szweda, L.I.5    Markesbery, W.R.6
  • 62
    • 0030808979 scopus 로고    scopus 로고
    • New β-hydroxyaspartate derivatives are competitive blockers for the bovine glutamate/aspartate transporter
    • B. Lebrun, M. Sakaitani, K. Shimamoto, Y. Yasuda-Kamatani, and T. Nakajima New β-hydroxyaspartate derivatives are competitive blockers for the bovine glutamate/aspartate transporter J Biol Chem 272 1997 20336 20339
    • (1997) J Biol Chem , vol.272 , pp. 20336-20339
    • Lebrun, B.1    Sakaitani, M.2    Shimamoto, K.3    Yasuda-Kamatani, Y.4    Nakajima, T.5
  • 63
    • 0033963248 scopus 로고    scopus 로고
    • Quantitative autoradiography of Na+-dependent [3H]l-aspartate binding to l-glutamate transporters in rat brain: Structure-activity studies using l-trans-pyrrolidine-2,4-dicarboxylate (l-t-PDC) and 2-(carboxycyclopropyl)- glycine (CCG)
    • I. Lieb, M.B.C. Chebib, L.S. Dias, and V.J. Balcar Quantitative autoradiography of Na+-dependent [3H]l-aspartate binding to l-glutamate transporters in rat brain: structure-activity studies using l-trans-pyrrolidine- 2,4-dicarboxylate (l-t-PDC) and 2-(carboxycyclopropyl)-glycine (CCG) Neurochem Int 36 2000 319 327
    • (2000) Neurochem Int , vol.36 , pp. 319-327
    • Lieb, I.1    Chebib, M.B.C.2    Dias, L.S.3    Balcar, V.J.4
  • 64
    • 0035282612 scopus 로고    scopus 로고
    • Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18
    • C.G. Lin, I. Orlov, A.M. Ruggiero, M. Dykes-Hogerg, A. Lee, and M. Jackson Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18 Nature 410 2001 84 88
    • (2001) Nature , vol.410 , pp. 84-88
    • Lin, C.G.1    Orlov, I.2    Ruggiero, A.M.3    Dykes-Hogerg, M.4    Lee, A.5    Jackson, M.6
  • 65
    • 0015517461 scopus 로고
    • High affinity uptake systems for glycine, glutamic and aspartic acids in synaptosomes of rat central nervous tissues
    • W.J. Logan, and S.H. Snyder High affinity uptake systems for glycine, glutamic and aspartic acids in synaptosomes of rat central nervous tissues Brain Res 42 1972 413 431
    • (1972) Brain Res , vol.42 , pp. 413-431
    • Logan, W.J.1    Snyder, S.H.2
  • 66
    • 0028896256 scopus 로고
    • Excitatory amino acid release from astrocytes during energy failure by reversal of sodium-dependent uptake
    • M.C. Longuemare, and R.A. Swanson Excitatory amino acid release from astrocytes during energy failure by reversal of sodium-dependent uptake J Neurosci Res 40 1995 379 386
    • (1995) J Neurosci Res , vol.40 , pp. 379-386
    • Longuemare, M.C.1    Swanson, R.A.2
  • 67
    • 1842524064 scopus 로고    scopus 로고
    • Glutamate transporters: Animal models to neurologic disease
    • N.J. Maragakis, and J.D. Rothstein Glutamate transporters: animal models to neurologic disease Neurobiol Dis 15 2004 461 473
    • (2004) Neurobiol Dis , vol.15 , pp. 461-473
    • Maragakis, N.J.1    Rothstein, J.D.2
  • 68
    • 0029811226 scopus 로고    scopus 로고
    • Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease
    • E. Masliah, M. Alford, R. DeTeresa, M. Mallory, and L. Hansen Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease Ann Neurol 40 1996 759 766
    • (1996) Ann Neurol , vol.40 , pp. 759-766
    • Masliah, E.1    Alford, M.2    Deteresa, R.3    Mallory, M.4    Hansen, L.5
  • 69
    • 0033566784 scopus 로고    scopus 로고
    • Active role of glutamate uptake in the synaptic transmission from retinal nonspiking neurons
    • K. Matsui, N. Hosoi, and M. Tachibana Active role of glutamate uptake in the synaptic transmission from retinal nonspiking neurons J Neurosci 19 1999 6755 6766
    • (1999) J Neurosci , vol.19 , pp. 6755-6766
    • Matsui, K.1    Hosoi, N.2    Tachibana, M.3
  • 70
    • 0043180531 scopus 로고    scopus 로고
    • Excitotoxic and excitoprotective mechanisms: Abundant targets for the prevention and treatment of neurodegenerative disorders
    • M.P. Mattson Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders Neuromol Med 3 2003 65 94
    • (2003) Neuromol Med , vol.3 , pp. 65-94
    • Mattson, M.P.1
  • 71
    • 2342462388 scopus 로고    scopus 로고
    • Structure and function of glutamate receptor ion channels
    • M.L. Mayer, and N. Armstrong Structure and function of glutamate receptor ion channels Annu Rev Physiol 66 2004 161 181
    • (2004) Annu Rev Physiol , vol.66 , pp. 161-181
    • Mayer, M.L.1    Armstrong, N.2
  • 72
    • 0021924355 scopus 로고
    • Neurotoxicity of l-glutamate and d,l-threo-3-hydroxyaspartate in the rat striatum
    • G.J. McBean, and P.J. Roberts Neurotoxicity of l-glutamate and d,l-threo-3-hydroxyaspartate in the rat striatum J Neurochem 44 1985 247 254
    • (1985) J Neurochem , vol.44 , pp. 247-254
    • McBean, G.J.1    Roberts, P.J.2
  • 73
    • 0032716796 scopus 로고    scopus 로고
    • The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals
    • T. Meyer, A. Fromm, C. Munch, B. Schwalenstocker, A.E. Fray, and P.G. Ince The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals J Neurol Sci 170 1999 45 50
    • (1999) J Neurol Sci , vol.170 , pp. 45-50
    • Meyer, T.1    Fromm, A.2    Munch, C.3    Schwalenstocker, B.4    Fray, A.E.5    Ince, P.G.6
  • 74
    • 0034732122 scopus 로고    scopus 로고
    • Glutamate spillover suppresses inhibition by activating presynaptic mGluRs
    • S.J. Mitchell, and R.A. Silver Glutamate spillover suppresses inhibition by activating presynaptic mGluRs Nature 404 2000 498 502
    • (2000) Nature , vol.404 , pp. 498-502
    • Mitchell, S.J.1    Silver, R.A.2
  • 75
    • 0036129245 scopus 로고    scopus 로고
    • Effects of l-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1′S,2′R)-2-(carboxycyclopropyl) glycine (l-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy
    • C.E. Moussa, A.D. Mitrovic, R.J. Vandenberg, T. Provis, C. Rae, and W.A. Bubb Effects of l-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1′S,2′R)-2-(carboxycyclopropyl) glycine (l-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy Neurochem Res 27 2002 27 35
    • (2002) Neurochem Res , vol.27 , pp. 27-35
    • Moussa, C.E.1    Mitrovic, A.D.2    Vandenberg, R.J.3    Provis, T.4    Rae, C.5    Bubb, W.A.6
  • 76
    • 0025079146 scopus 로고
    • (2S,3S,4S)α-(carboxycyclopropyl)glycine is a novel agonist of metabotropic glutamate receptors
    • Y. Nakagawa, K. Saitoh, T. Ishihara, M. Ishida, and H. Shinozaki (2S,3S,4S)α-(carboxycyclopropyl)glycine is a novel agonist of metabotropic glutamate receptors Eur J Pharmacol 184 1990 205 206
    • (1990) Eur J Pharmacol , vol.184 , pp. 205-206
    • Nakagawa, Y.1    Saitoh, K.2    Ishihara, T.3    Ishida, M.4    Shinozaki, H.5
  • 77
    • 0027216795 scopus 로고
    • (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate
    • Y. Nakamura, K. Kataoka, M. Ishida, and H. Shinozaki (2S,3S,4R)-2- (carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate Neuropharmacology 32 1993 833 837
    • (1993) Neuropharmacology , vol.32 , pp. 833-837
    • Nakamura, Y.1    Kataoka, K.2    Ishida, M.3    Shinozaki, H.4
  • 78
    • 0037304154 scopus 로고    scopus 로고
    • Excitotoxicity, apoptosis and neuropsychiatric disorders
    • J.W. Olney Excitotoxicity, apoptosis and neuropsychiatric disorders Curr Opin Pharmacol 3 2003 101 109
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 101-109
    • Olney, J.W.1
  • 79
    • 0034655871 scopus 로고    scopus 로고
    • Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2
    • T.S. Otis, and M. Kavanaugh Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2 J Neurosci 20 2000 2749 2757
    • (2000) J Neurosci , vol.20 , pp. 2749-2757
    • Otis, T.S.1    Kavanaugh, M.2
  • 80
    • 0030761115 scopus 로고    scopus 로고
    • Postsynaptic glutamate transporter at the climbing fiber-Purkinje cell synapse
    • T.S. Otis, M.P. Kavanaugh, and C.E. Jahr Postsynaptic glutamate transporter at the climbing fiber-Purkinje cell synapse Science 277 1997 1515 1518
    • (1997) Science , vol.277 , pp. 1515-1518
    • Otis, T.S.1    Kavanaugh, M.P.2    Jahr, C.E.3
  • 81
    • 0033232782 scopus 로고    scopus 로고
    • Glutamate transporters contribute to the time course of synaptic transmission in cerebellar granule cells
    • L.S. Overstreet, G.A. Kinney, Y.B. Liu, D. Billups, and N.T. Slater Glutamate transporters contribute to the time course of synaptic transmission in cerebellar granule cells J Neurosci 19 1999 9663 9673
    • (1999) J Neurosci , vol.19 , pp. 9663-9673
    • Overstreet, L.S.1    Kinney, G.A.2    Liu, Y.B.3    Billups, D.4    Slater, N.T.5
  • 82
    • 1642458175 scopus 로고    scopus 로고
    • Effect of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus by recombinant adenoviruses on morphine physical dependence in rats
    • T. Ozawa, T. Kakagawa, Y. Sekiya, M. Minami, and M. Satoh Effect of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus by recombinant adenoviruses on morphine physical dependence in rats Eur J Neurosci 19 2004 221 226
    • (2004) Eur J Neurosci , vol.19 , pp. 221-226
    • Ozawa, T.1    Kakagawa, T.2    Sekiya, Y.3    Minami, M.4    Satoh, M.5
  • 83
    • 0031751209 scopus 로고    scopus 로고
    • Molecular biology of mammalian plasma membrane amino acid transporters
    • M. Palacin, R. Estevez, J. Bertran, and A. Zorzano Molecular biology of mammalian plasma membrane amino acid transporters Physiol Rev 78 1998 969 1053
    • (1998) Physiol Rev , vol.78 , pp. 969-1053
    • Palacin, M.1    Estevez, R.2    Bertran, J.3    Zorzano, A.4
  • 84
    • 0029984610 scopus 로고    scopus 로고
    • Rat C6 and human astrocytic tumor cells express a neuronal type of glutamate transporter
    • T.P. Palos, B. Ramachandran, R. Boado, and B.D. Howard Rat C6 and human astrocytic tumor cells express a neuronal type of glutamate transporter Mol Brain Res 37 1996 297 303
    • (1996) Mol Brain Res , vol.37 , pp. 297-303
    • Palos, T.P.1    Ramachandran, B.2    Boado, R.3    Howard, B.D.4
  • 85
    • 0036887265 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Pathogenesis, differential diagnoses, and potential interventions
    • S. Patel, and N.J. Maragakis Amyotrophic lateral sclerosis: pathogenesis, differential diagnoses, and potential interventions J Spinal Cord Med 25 2002 274 276
    • (2002) J Spinal Cord Med , vol.25 , pp. 274-276
    • Patel, S.1    Maragakis, N.J.2
  • 86
    • 0347480436 scopus 로고    scopus 로고
    • Differentiation of substrate and non-substrate inhibitors of transport system xc(-): An obligate exchanger of l-glutamate and l-cystine
    • S. Patel, B.A. Warren, J.F. Rhoderick, and R.J. Bridges Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of l-glutamate and l-cystine Neuropharmacology 46 2004 273 284
    • (2004) Neuropharmacology , vol.46 , pp. 273-284
    • Patel, S.1    Warren, B.A.2    Rhoderick, J.F.3    Bridges, R.J.4
  • 89
    • 0016438450 scopus 로고
    • Structural requirements for the inhibition for l-glutamate uptake by glia and nerve endings
    • P.J. Roberts, and J.C. Watkins Structural requirements for the inhibition for l-glutamate uptake by glia and nerve endings Brain Res 85 1975 120 125
    • (1975) Brain Res , vol.85 , pp. 120-125
    • Roberts, P.J.1    Watkins, J.C.2
  • 90
    • 0036274472 scopus 로고    scopus 로고
    • Regulated trafficking of neurotransmitter transporters: Common notes but different melodies
    • M.B. Robinson Regulated trafficking of neurotransmitter transporters: common notes but different melodies J Neurochem 80 2002 1 11
    • (2002) J Neurochem , vol.80 , pp. 1-11
    • Robinson, M.B.1
  • 91
    • 0027489707 scopus 로고
    • Inhibition of glutamate uptake with l-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures
    • M.B. Robinson, S. Djali, and J.R. Buchhalter Inhibition of glutamate uptake with l-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures J Neurochem 61 1993 586 593
    • (1993) J Neurochem , vol.61 , pp. 586-593
    • Robinson, M.B.1    Djali, S.2    Buchhalter, J.R.3
  • 92
    • 0027441565 scopus 로고
    • Subtypes of sodium-dependent high-affinity l-[3H]glutamate transport activity: Pharmacologic specificity and regulation by sodium and potassium
    • M.B. Robinson, J.D. Sinor, L.A. Dowd, and J.F. Kerwin Subtypes of sodium-dependent high-affinity l-[3H]glutamate transport activity: pharmacologic specificity and regulation by sodium and potassium J Neurochem 60 1993 167 179
    • (1993) J Neurochem , vol.60 , pp. 167-179
    • Robinson, M.B.1    Sinor, J.D.2    Dowd, L.A.3    Kerwin, J.F.4
  • 93
    • 0034688312 scopus 로고    scopus 로고
    • Glutamate release in severe brain ischemia is mainly by reversed uptake
    • D. Rossi, T. Oshima, and D. Attwell Glutamate release in severe brain ischemia is mainly by reversed uptake Nature 403 2000 316 321
    • (2000) Nature , vol.403 , pp. 316-321
    • Rossi, D.1    Oshima, T.2    Attwell, D.3
  • 94
    • 0028872674 scopus 로고
    • Excitotoxicity and the NMDA receptor-still lethal after eight years
    • S.M. Rothman, and J.W. Olney Excitotoxicity and the NMDA receptor-still lethal after eight years TINS 18 1995 57 58
    • (1995) TINS , vol.18 , pp. 57-58
    • Rothman, S.M.1    Olney, J.W.2
  • 96
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • J.D. Rothstein, L. Jin, M. Dykes-Hoberg, and R.W. Kuncl Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity Proc Natl Acad Sci U S A 90 1993 6591 6595
    • (1993) Proc Natl Acad Sci U S a , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 97
    • 0029030610 scopus 로고
    • Selective loss of the glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • J.D. Rothstein, M. Van Kammen, A.I. Levey, L.J. Martin, and R.W. Kuncl Selective loss of the glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis Ann Neurol 38 1995 73 84
    • (1995) Ann Neurol , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3    Martin, L.J.4    Kuncl, R.W.5
  • 98
    • 13344286293 scopus 로고    scopus 로고
    • Knockout of glutamate transporters reveals a major role of the astroglial transport in excitotoxicity and clearance of glutamate
    • J.D. Rothstein, M. Dykes-Hoberg, C.A. Pardo, L.A. Bristol, L. Jin, and R.W. Kuncl Knockout of glutamate transporters reveals a major role of the astroglial transport in excitotoxicity and clearance of glutamate Neuron 16 1996 675 686
    • (1996) Neuron , vol.16 , pp. 675-686
    • Rothstein, J.D.1    Dykes-Hoberg, M.2    Pardo, C.A.3    Bristol, L.A.4    Jin, L.5    Kuncl, R.W.6
  • 99
    • 0027375540 scopus 로고
    • Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current
    • M. Sarantis, L. Ballerini, B. Miller, R.A. Silver, M. Edwards, and D. Attwell Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current Neuron 11 1993 541 549
    • (1993) Neuron , vol.11 , pp. 541-549
    • Sarantis, M.1    Ballerini, L.2    Miller, B.3    Silver, R.A.4    Edwards, M.5    Attwell, D.6
  • 100
    • 0031036195 scopus 로고    scopus 로고
    • Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors
    • M. Scanziani, P.A. Salin, K.E. Vogt, R.C. Malenka, and R. Nicoll Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors Nature 385 1997 630 634
    • (1997) Nature , vol.385 , pp. 630-634
    • Scanziani, M.1    Salin, P.A.2    Vogt, K.E.3    Malenka, R.C.4    Nicoll, R.5
  • 101
    • 0037126986 scopus 로고    scopus 로고
    • A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons, cloning and localization in rat nervous system
    • A. Schmitt, E. Asan, K.P. Lesch, and P. Kugler A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons, cloning and localization in rat nervous system Neurosci 109 2002 45 61
    • (2002) Neurosci , vol.109 , pp. 45-61
    • Schmitt, A.1    Asan, E.2    Lesch, K.P.3    Kugler, P.4
  • 102
    • 0034811597 scopus 로고    scopus 로고
    • Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system
    • D.D. Schoepp Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system J Pharmacol Exp Ther 299 2001 12 20
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 12-20
    • Schoepp, D.D.1
  • 103
    • 0018695520 scopus 로고
    • Differences in glutamate uptake in astrocytes cultured from different brain regions
    • A. Schousboe, and I. Divac Differences in glutamate uptake in astrocytes cultured from different brain regions Brain Res 177 1979 407 409
    • (1979) Brain Res , vol.177 , pp. 407-409
    • Schousboe, A.1    Divac, I.2
  • 104
    • 0036479889 scopus 로고    scopus 로고
    • Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
    • H.L. Scott, D.V. Pow, A.E. Tannenberg, and P.R. Dodd Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease J Neurosci 22 2002 RC206
    • (2002) J Neurosci , vol.22 , pp. 206
    • Scott, H.L.1    Pow, D.V.2    Tannenberg, A.E.3    Dodd, P.R.4
  • 105
    • 0032925862 scopus 로고    scopus 로고
    • Excitatory amino acid transporters: A family in flux
    • R.P. Seal, and S.G. Amara Excitatory amino acid transporters: a family in flux Annu Rev Pharmacol Toxicol 39 1999 431 456
    • (1999) Annu Rev Pharmacol Toxicol , vol.39 , pp. 431-456
    • Seal, R.P.1    Amara, S.G.2
  • 106
    • 33645352841 scopus 로고    scopus 로고
    • Enhancement of EAAT2-mediated glutamate uptake in mouse organotypic hippocampal slice cultures following cell type specific gene delivery with recombinant adeno-associated viral vectors
    • J.V. Selkirk, T.H. Stiefel, G.S. Naeve, A. Foster, and D.A. Poulsen Enhancement of EAAT2-mediated glutamate uptake in mouse organotypic hippocampal slice cultures following cell type specific gene delivery with recombinant adeno-associated viral vectors Abstr - Soc Neurosci 29 2003 687 688
    • (2003) Abstr - Soc Neurosci , vol.29 , pp. 687-688
    • Selkirk, J.V.1    Stiefel, T.H.2    Naeve, G.S.3    Foster, A.4    Poulsen, D.A.5
  • 107
    • 0033710845 scopus 로고    scopus 로고
    • Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors
    • A. Semyanov, and D.M. Kullmann Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors Neuron 25 2000 663 672
    • (2000) Neuron , vol.25 , pp. 663-672
    • Semyanov, A.1    Kullmann, D.M.2
  • 108
    • 0036703472 scopus 로고    scopus 로고
    • A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy
    • J.P. Sepkuty, A.S. Cohen, C. Eccles, A. Rafiq, K. Behar, and R. Ganel A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy J Neurosci 22 2002 6372 6379
    • (2002) J Neurosci , vol.22 , pp. 6372-6379
    • Sepkuty, J.P.1    Cohen, A.S.2    Eccles, C.3    Rafiq, A.4    Behar, K.5    Ganel, R.6
  • 109
    • 0034770385 scopus 로고    scopus 로고
    • Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)
    • Y. Shigeri, K. Shimamoto, Y. Yasuda-Kamatani, R.P. Seal, N. Yumoto, and T. Nakajima Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5) J Neurochem 79 2001 297 302
    • (2001) J Neurochem , vol.79 , pp. 297-302
    • Shigeri, Y.1    Shimamoto, K.2    Yasuda-Kamatani, Y.3    Seal, R.P.4    Yumoto, N.5    Nakajima, T.6
  • 112
    • 1842585550 scopus 로고    scopus 로고
    • Characterization of novel l-threo-b-benzyloxyaspartate derivatives, potent blockers of glutamate transporters
    • K. Shimamoto, R. Sakai, K. Takaoka, N. Yumoto, T. Nakajima, and S.G. Amara Characterization of novel l-threo-b-benzyloxyaspartate derivatives, potent blockers of glutamate transporters Mol Pharmacol 65 2004 1008 1015
    • (2004) Mol Pharmacol , vol.65 , pp. 1008-1015
    • Shimamoto, K.1    Sakai, R.2    Takaoka, K.3    Yumoto, N.4    Nakajima, T.5    Amara, S.G.6
  • 113
  • 114
    • 0037081113 scopus 로고    scopus 로고
    • Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: A reappraisal using a new HPLC method with coulometric detection in a large cohort of patients
    • O. Spreux-Varoquaux, G. Bensimon, L. Lacomblez, F. Salachas, P.F. Pradat, and N. Le Forestier Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients J Neurol Sci 193 2002 73 78
    • (2002) J Neurol Sci , vol.193 , pp. 73-78
    • Spreux-Varoquaux, O.1    Bensimon, G.2    Lacomblez, L.3    Salachas, F.4    Pradat, P.F.5    Le Forestier, N.6
  • 115
    • 0036247222 scopus 로고    scopus 로고
    • The AMPA receptor binding site: Focus on agonists and competitive antagonists
    • T.B. Stensbol, U. Madsen, and P. Krogsgaard-Larsen The AMPA receptor binding site: focus on agonists and competitive antagonists Curr Pharm Des 8 2002 857 872
    • (2002) Curr Pharm des , vol.8 , pp. 857-872
    • Stensbol, T.B.1    Madsen, U.2    Krogsgaard-Larsen, P.3
  • 116
    • 0037011909 scopus 로고    scopus 로고
    • Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology
    • T.B. Stensbol, P. Uhlmann, S. Morel, B.L. Eriksen, J. Felding, and H. Kromann Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology J Med Chem 45 2002 19 31
    • (2002) J Med Chem , vol.45 , pp. 19-31
    • Stensbol, T.B.1    Uhlmann, P.2    Morel, S.3    Eriksen, B.L.4    Felding, J.5    Kromann, H.6
  • 117
    • 0026489330 scopus 로고
    • Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain
    • T. Storck, S. Schulte, K. Hofmann, and W. Stoffel Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain Proc Natl Acad Sci U S A 89 1992 10955 10959
    • (1992) Proc Natl Acad Sci U S a , vol.89 , pp. 10955-10959
    • Storck, T.1    Schulte, S.2    Hofmann, K.3    Stoffel, W.4
  • 118
    • 0036793766 scopus 로고    scopus 로고
    • Excitatory amino acid trasnporter EAAT-2 in tangle-bearing neurons in Alzheimer's disease
    • D.R. Thai Excitatory amino acid trasnporter EAAT-2 in tangle-bearing neurons in Alzheimer's disease Brain Pathol 12 2002 405 411
    • (2002) Brain Pathol , vol.12 , pp. 405-411
    • Thai, D.R.1
  • 119
    • 0028061339 scopus 로고
    • Block of glutamate transporters potentiates postsynaptic excitation
    • G. Tong, and C.E. Jahr Block of glutamate transporters potentiates postsynaptic excitation Neuron 13 1994 1195 1203
    • (1994) Neuron , vol.13 , pp. 1195-1203
    • Tong, G.1    Jahr, C.E.2
  • 120
    • 0032145886 scopus 로고    scopus 로고
    • Glutamate transporters are oxidant-vulnerable: A molecular link between oxidative and excitotoxic neurodegeneration
    • D. Trotti, N.C. Danbolt, and A. Volterra Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration TIPS 19 1998 328 334
    • (1998) TIPS , vol.19 , pp. 328-334
    • Trotti, D.1    Danbolt, N.C.2    Volterra, A.3
  • 121
    • 0033366461 scopus 로고    scopus 로고
    • SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
    • D. Trotti, A. Rolfs, N.C. Danbolt, R.H. Brown, and M.A. Hediger SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter Nature 1999 1 7
    • (1999) Nature , pp. 1-7
    • Trotti, D.1    Rolfs, A.2    Danbolt, N.C.3    Brown, R.H.4    Hediger, M.A.5
  • 122
    • 0343341215 scopus 로고    scopus 로고
    • Control of synaptic depression by glutamate transporters
    • R. Turecek, and L.O. Trussell Control of synaptic depression by glutamate transporters J Neurosci 20 2000 2054 2063
    • (2000) J Neurosci , vol.20 , pp. 2054-2063
    • Turecek, R.1    Trussell, L.O.2
  • 123
    • 0032504238 scopus 로고    scopus 로고
    • Arachidonic acid activates a proton current in the rat glutamate transporter EAAT4
    • A.V. Tzingounis, C. Lin, J.D. Rothstein, and M.P. Kavanaugh Arachidonic acid activates a proton current in the rat glutamate transporter EAAT4 J Biol Chem 273 1998 17315 17317
    • (1998) J Biol Chem , vol.273 , pp. 17315-17317
    • Tzingounis, A.V.1    Lin, C.2    Rothstein, J.D.3    Kavanaugh, M.P.4
  • 124
    • 0031833248 scopus 로고    scopus 로고
    • Molecular pharmacology and physiology of glutamate transporters in the central nervous system
    • R.J. Vandenberg Molecular pharmacology and physiology of glutamate transporters in the central nervous system Clin Exp Pharmacol Physiol 25 1998 393 400
    • (1998) Clin Exp Pharmacol Physiol , vol.25 , pp. 393-400
    • Vandenberg, R.J.1
  • 125
    • 0030946093 scopus 로고    scopus 로고
    • Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2
    • R.J. Vandenberg, A.D. Mitrovic, M. Chebib, V.J. Balcar, and G.A.R. Johnston Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2 Mol Pharmacol 51 1997 809 815
    • (1997) Mol Pharmacol , vol.51 , pp. 809-815
    • Vandenberg, R.J.1    Mitrovic, A.D.2    Chebib, M.3    Balcar, V.J.4    Johnston, G.A.R.5
  • 126
    • 0033514444 scopus 로고    scopus 로고
    • Glutamate and γ-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus
    • K.E. Vogt, and R.A. Nicoll Glutamate and γ-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus Proc Natl Acad Sci U S A 96 1999 1118 1122
    • (1999) Proc Natl Acad Sci U S a , vol.96 , pp. 1118-1122
    • Vogt, K.E.1    Nicoll, R.A.2
  • 127
    • 0035950191 scopus 로고    scopus 로고
    • Multivesicular release at climbing fiber-Purkinje cell synapses
    • J.I. Wadiche, and C.E. Jahr Multivesicular release at climbing fiber-Purkinje cell synapses Neuron 32 2001 301 313
    • (2001) Neuron , vol.32 , pp. 301-313
    • Wadiche, J.I.1    Jahr, C.E.2
  • 128
    • 0032189020 scopus 로고    scopus 로고
    • Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel
    • J.I. Wadiche, and M.P. Kavanaugh Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel J Neurosci 18 1998 7650 7661
    • (1998) J Neurosci , vol.18 , pp. 7650-7661
    • Wadiche, J.I.1    Kavanaugh, M.P.2
  • 129
    • 0029142729 scopus 로고
    • Ion fluxes associated with excitatory amino acid transport
    • J.I. Wadiche, S.G. Amara, and M.P. Kavanaugh Ion fluxes associated with excitatory amino acid transport Neuron 15 1995 721 728
    • (1995) Neuron , vol.15 , pp. 721-728
    • Wadiche, J.I.1    Amara, S.G.2    Kavanaugh, M.P.3
  • 132
    • 0028987452 scopus 로고
    • Inhibition by folded isomers of l-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-1
    • H. Yamashita, H. Kawakami, Y. Zhang, T. Hagiwara, K. Tanaka, and S. Nakamura Inhibition by folded isomers of l-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-1 Eur J Pharmacol 289 1995 387 390
    • (1995) Eur J Pharmacol , vol.289 , pp. 387-390
    • Yamashita, H.1    Kawakami, H.2    Zhang, Y.3    Hagiwara, T.4    Tanaka, K.5    Nakamura, S.6
  • 133
    • 0029860263 scopus 로고    scopus 로고
    • Flux coupling in a neuronal glutamate transporter
    • N. Zerangue, and M.P. Kavanaugh Flux coupling in a neuronal glutamate transporter Nature 383 1996 634 637
    • (1996) Nature , vol.383 , pp. 634-637
    • Zerangue, N.1    Kavanaugh, M.P.2
  • 134
    • 0028911077 scopus 로고
    • Differential modulation of human glutamate transporter subtypes by arachidonic acid
    • N. Zerangue, J.L. Arriza, S.G. Amara, and M.P. Kavanaugh Differential modulation of human glutamate transporter subtypes by arachidonic acid J Biol Chem 270 1995 6433 6435
    • (1995) J Biol Chem , vol.270 , pp. 6433-6435
    • Zerangue, N.1    Arriza, J.L.2    Amara, S.G.3    Kavanaugh, M.P.4


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