Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2- carboxylates analogues of TQX-173

Journal of Medicinal Chemistry

Volumn 44, Issue 19, 2001, Pages 3157-3165

  Catarzi, D ^a   Colotta, V ^a   Varano, F ^a   Filacchioni, G ^a   Galli, A ^a   Costagli, C ^a   Carla V ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4,5 DIHYDRO 4 OXO 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 2 CARBOXYLATE; AMPA RECEPTOR ANTAGONIST; CARBOXYLIC ACID DERIVATIVE; GLUTAMATE RECEPTOR; IONOTROPIC RECEPTOR; TQX 173; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR RECOGNITION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; POSTSYNAPTIC INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CEREBRAL CORTEX; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; LIGANDS; MALE; MICE; N-METHYLASPARTATE; QUINOXALINES; RATS; RECEPTORS, GLUTAMATE; RECEPTORS, KAINIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTIC MEMBRANES; TRIAZINES;

EID: 0035855816     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010862q     Document Type: Article

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